DNA repair in eukaryotes
RD Wood - Annual review of biochemistry, 1996 - annualreviews.org
Eukaryotic cells have multiple mechanisms for repairing damaged DNA. 06-methylguanine-
DNA methyltransferase directly reverses some simple alkylation adducts. However, most …
DNA methyltransferase directly reverses some simple alkylation adducts. However, most …
Structural and functional relationships of the XPF/MUS81 family of proteins
Proteins belonging to the XPF/MUS81 family play important roles in the repair of DNA
lesions caused by UV-light or DNA cross-linking agents. Most eukaryotes have four family …
lesions caused by UV-light or DNA cross-linking agents. Most eukaryotes have four family …
[HTML][HTML] Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease
AM Sijbers, WL De Laat, RR Ariza, M Biggerstaff… - Cell, 1996 - cell.com
Nucleotide excision repair, which is defective in xeroderma pigmentosum (XP), involves
incision of a DNA strand on each side of a lesion. We isolated a human gene homologous to …
incision of a DNA strand on each side of a lesion. We isolated a human gene homologous to …
Mus81-Eme1 are essential components of a Holliday junction resolvase
Mus81, a fission yeast protein related to the XPF subunit of ERCC1-XPF nucleotide excision
repair endonuclease, is essential for meiosis and important for coping with stalled …
repair endonuclease, is essential for meiosis and important for coping with stalled …
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH
KA Henning, L Li, N Iyer, LD McDaniel, MS Reagan… - Cell, 1995 - cell.com
The hereditary disease Cockayne syndrome (CS) is characterized by a complex clinical
phenotype. CS cells are abnormally sensitive to ultraviolet radiation and are defective in the …
phenotype. CS cells are abnormally sensitive to ultraviolet radiation and are defective in the …
Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae
JR Mullen, V Kaliraman, SS Ibrahim, SJ Brill - Genetics, 2001 - academic.oup.com
Abstract The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of
DNA helicases and is required for genome stability, but not cell viability. To identify proteins …
DNA helicases and is required for genome stability, but not cell viability. To identify proteins …
Functional overlap between Sgs1–Top3 and the Mms4–Mus81 endonuclease
V Kaliraman, JR Mullen, WM Fricke… - Genes & …, 2001 - genesdev.cshlp.org
The RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase
III (Top3) and are thought to act during DNA replication to restart forks that have paused due …
III (Top3) and are thought to act during DNA replication to restart forks that have paused due …
Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease
AJ Bardwell, L Bardwell, AE Tomkinson, EC Friedberg - Science, 1994 - science.org
The RAD1 and RAD10 genes of Saccharomyces cerevisiae are required for both nucleotide
excision repair and certain mitotic recombination events. Here, model recombination and …
excision repair and certain mitotic recombination events. Here, model recombination and …
Identification and characterization of the human mus81-eme1 endonuclease
The faithful and complete replication of DNA is necessary for the maintenance of genome
stability. It is known, however, that replication forks stall at lesions in the DNA template and …
stability. It is known, however, that replication forks stall at lesions in the DNA template and …
The ERCC1 and ERCC4 (XPF) genes and gene products
M Manandhar, KS Boulware, RD Wood - Gene, 2015 - Elsevier
The ERCC1 and ERCC4 genes encode the two subunits of the ERCC1–XPF nuclease. This
enzyme plays an important role in repair of DNA damage and in maintaining genomic …
enzyme plays an important role in repair of DNA damage and in maintaining genomic …