The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

This review summarizes synthetic developments reported from 1987 to 2019 that exploit C–
C single bond cleavage of cyclopropylamine-based systems. The synthetic and mechanistic …

A comprehensive program for the synthesis of natural (or unnatural) products is analogous
to the construction of a pyramid. Careful planning followed by installation of numerous levels …

From its humble origins as a mere 'chemical curiosity,'radical chemistry has developed into
one of the most powerful tools for preparative organic synthesis. Initially considered too …

The discovery in 1959 of stable nitroxide‐based free radicals such as the prototypical 2, 2, 6,
6‐tetramethylpiperidine‐1‐oxyl (TEMPO) led to their use as electron spin resonance (ESR) …

Nitrogen-substituted cyclopropane compounds encompass a range of molecules with very
diverse chemical properties: aminocyclopropanes, N-cyclopropyl amides …

Over the last thirty years the use of sulfones in organic chemistry has become a very
important synthetic strategy, especially for the formation of carbon-carbon single and double …

Kainoid amino acids are a unique group of non‐proteinogenic pyrrolidinedicarboxylic acids.
The parent member,(–)‐α‐kainic acid (originally known as digenic acid), has attracted …

Terminal alkene substrates can be converted to methyl ketone products via a palladium‐
catalyzed process known as the Wacker oxidation. This process has found widespread …

Abstract (S)‐Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian
central nervous system, activating the plethora of glutamate receptors (GluRs). In broad …