The role of the transcription factor Nrf2 in Alzheimer's disease: therapeutic opportunities
LM De Plano, G Calabrese, MG Rizzo, S Oddo… - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a common neurodegenerative disorder that affects the elderly.
One of the key features of AD is the accumulation of reactive oxygen species (ROS), which …
One of the key features of AD is the accumulation of reactive oxygen species (ROS), which …
The effect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: A systematic review of human intervention trials
T Clifford, JP Acton, SP Cocksedge, KAB Davies… - Molecular biology …, 2021 - Springer
We conducted a systematic review of human trials examining the effects of dietary
phytochemicals on Nrf2 activation. In accordance with the PRISMA guidelines, Medline …
phytochemicals on Nrf2 activation. In accordance with the PRISMA guidelines, Medline …
Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration
Z Tang, B Hu, F Zang, J Wang, X Zhang, H Chen - Cell death & disease, 2019 - nature.com
Intervertebral disc (IVD) degeneration is known to aggravate with age and oxidative stress is
implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid …
implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid …
Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation
H Li, FJ Chen, WL Yang, HZ Qiao, SJ Zhang - Food & Function, 2021 - pubs.rsc.org
Quercetin is one of the most abundant dietary flavonoid compounds, and its mechanism for
combating age-related neurodegenerative diseases is unclear. In this study, quercetin (35 …
combating age-related neurodegenerative diseases is unclear. In this study, quercetin (35 …
Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice
R Zapata‐Pérez, A Tammaro… - The FASEB …, 2021 - Wiley Online Library
Nicotinamide adenine dinucleotide (NAD+) homeostasis is constantly compromised due to
degradation by NAD+‐dependent enzymes. NAD+ replenishment by supplementation with …
degradation by NAD+‐dependent enzymes. NAD+ replenishment by supplementation with …
[HTML][HTML] Targeting Nrf2/HO-1 anti-oxidant signaling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions
S Upadhayay, S Mehan - Brain Disorders, 2021 - Elsevier
The nuclear factor erythroid 2-related factor (Nrf2) transcription factor/Hemoxygenase 1 (HO-
1) is a primary regulator of essential cytoprotective responses in the brain. It activates the …
1) is a primary regulator of essential cytoprotective responses in the brain. It activates the …
Comparison of the protective effects of ginsenosides Rb1 and Rg1 on improving cognitive deficits in SAMP8 mice based on anti-neuroinflammation mechanism
Y Yang, S Li, H Huang, J Lv, S Chen… - Frontiers in …, 2020 - frontiersin.org
This present study was designed to investigate the different effects of ginsenosides Rb1 and
Rg1 on improving cognitive deficits in 4-month-old SAMP8 mice. Mice were divided into six …
Rg1 on improving cognitive deficits in 4-month-old SAMP8 mice. Mice were divided into six …
Resveratrol supplementation attenuates cognitive and molecular alterations under maternal high-fat diet intake: epigenetic inheritance over generations
V Izquierdo, V Palomera-Ávalos, M Pallàs… - International journal of …, 2021 - mdpi.com
Environmental factors such as maternal high-fat diet (HFD) intake can increase the risk of
age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link …
age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link …
Targeting transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) for the intervention of vascular cognitive impairment and dementia
T Yang, F Zhang - Arteriosclerosis, Thrombosis, and Vascular …, 2021 - Am Heart Assoc
Vascular cognitive impairment and dementia (VCID) is an age-related, mild to severe mental
disability due to a broad panel of cerebrovascular disorders. Its pathobiology involves …
disability due to a broad panel of cerebrovascular disorders. Its pathobiology involves …
Sulforaphane increase mitochondrial biogenesis-related gene expression in the hippocampus and suppresses age-related cognitive decline in mice
S Shimizu, S Kasai, H Yamazaki, Y Tatara… - International Journal of …, 2022 - mdpi.com
Sulforaphane (SFN) is a potent activator of the transcriptional factor, Nuclear Factor
Erythroid 2 (NF-E2)-Related factor 2 (NRF2). SFN and its precursor, glucoraphanin …
Erythroid 2 (NF-E2)-Related factor 2 (NRF2). SFN and its precursor, glucoraphanin …