Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The
disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a
silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type …

Successful reproduction in female mammals is precisely timed and must be able to
withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin …

Mammalian reproductive function includes puberty onset and completion, reproductive
cyclicity, steroidogenesis, gametogenesis, fertilization, pregnancy, and lactation; all are …

Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive
functions, recent data described its action in the control of metabolism. Of particular interest …

Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet,
whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of …

In humans and other mammals, a hallmark of female reproductive function is the capacity to
episodically release fertilizable oocytes under the precise control of a cascade of hormonal …

Kisspeptin (KISS1) is encoded by the KISS1 gene and was initially found to be a repressor
of metastasis. Natural mutations in the KISS1 receptor gene (KISS1R) were subsequently …

While kisspeptin was initially found to function as a metastasis suppressor, after
identification of its receptor KISS1R and their expression profiles in tissues such as the …