Solid‐Phase Combinatorial Chemistry

M Patek, M Smrcina, E Wegrzyniak… - Small Molecule …, 2015 - Wiley Online Library
This chapter presents a general overview, the author's perspective and experience that goes
back to split–mix one‐bead–one compound technology and involves two decades …

From one-bead one-compound combinatorial libraries to chemical microarrays

KS Lam, R Liu, J Marik, PR Kumaresan - BioMEMS and Biomedical …, 2007 - Springer
In 1984, Geysen et al. reported the synthesis of peptides on polyethylene pins in a 96-well
foot-print (the multi-pin system)[45]. In 1992, Frank et al. described the synthesis of multiple …

[BOOK][B] Design, synthesis and screening of small libraries of potential topoisomerase I poisons

KL Mlodnosky - 2004 - search.proquest.com
Topoisomerase I (topo I) is a ubiquitous enzyme that relaxes the supercoiling introduced into
DNA during normal cellular processes such as replication and transcription. The topo I …