A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

The adult mammalian brain retains neural stem cells that continually generate new neurons
within two restricted regions: the subventricular zone (SVZ) of the lateral ventricle and the …

Activation of Notch signaling induces the expression of transcriptional repressor genes such
as Hes1, leading to repression of proneural gene expression and maintenance of neural …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …

A fundamental question in hematopoietic stem cell (HSC) biology is how self-renewal is
controlled. Here we show that the molecular regulation of two critical elements of self …

Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

During development of the mammalian nervous system, neural stem cells generate neurons
first and glia second, thereby allowing the initial establishment of neural circuitry, and …

Neural stem cells, which exhibit self-renewal and multipotentiality, are generated in early
embryonic brains and maintained throughout the lifespan. The mechanisms of their …

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

▪ Abstract Intensive studies of three proteins—Presenilin, Notch, and the amyloid precursor
protein (APP)—have led to the recognition of a direct intersection between early …