Objectives Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely
used in the treatment of inflammation and pain. Most effects of NSAIDs are attributed to the …

Manganese enhanced magnetic resonance imaging (MEMRI) is a method used primarily in
basic science experiments to advance the understanding of information processing in …

Subjective tinnitus, the phantom ringing or buzzing sensation that occurs in the absence of
sound, affects 12–14% of adults; in some cases the tinnitus is so severe or disabling that …

Tinnitus is one of the most prevalent auditory disorders worldwide, manifesting in both
chronic and acute forms. The pathology of tinnitus has been mechanistically linked to …

Animal models continue to improve our understanding of tinnitus pathogenesis and aid in
development of new treatments. However, there are no diagnostic biomarkers for tinnitus …

Systemic administration of salicylate at high doses can induce reversible tinnitus and
hyperacusis in humans and animals. For this reason, a number of studies have investigated …

Olfactory sensory neurons (OSNs) fire spontaneously as well as in response to odor; both
forms of firing are physiologically important. We studied voltage-gated Na+ channels in …

Tinnitus is associated with neural hyperactivity, which is regulated by neuronal plasticity in
the auditory central system, especially the auditory cortex (AC). Excitatory neurons constitute …

Aspirin and its main metabolite salicylate are widely used to relieve pain, treat inflammatory
diseases, and prevent ischemic stroke. Multiple pathways are responsible for the therapeutic …

Amitriptyline (AMI) is widely used for migraine prophylaxis, but its mechanism is
undetermined. Cortical spreading depression (CSD), reflected by alterations in calcium …