Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …

As an organ critically important for targeting and clearing viruses, bacteria, and other foreign
material, the liver operates via immune-tolerant, anti-inflammatory mechanisms …

Drug induced liver injury (DILI) is one of the major reasons of drug withdrawal during the
different phases of drug development. The later in the drug development a drug is …

Quinoline or Benzopyridine moiety remained an attraction among researchers in the 21st
century. Quinoline is a heterocyclic aromatic organic compound with the chemical formula …

Drug-induced liver injury (DILI) is a major contributor to high attrition rates among candidate
and market drugs and a key regulatory, industry, and global health concern. While acute and …

Estrogen-induced intrahepatic cholestasis (IHC) is a mild but potentially serious risk and
urges for new therapeutic targets and effective treatment. Our previous study demonstrated …

Hepatotoxicity or drug-induced liver injury (DILI) is a major safety issue in drug development
as a primary reason for drug failure in clinical trials and the main cause for post-marketing …

A simple and economical approach has been proposed for the transformation of 2-
(quinolylpropanoyl)-N-phenylhydrazine-1-carbothioamide into 4-methyl-3-[2-(4-phenyl-5 …

[ES] El hígado es el mayor órgano glandular del cuerpo, que desempeña una elevada
cantidad de funciones vitales. Una de las principales alteraciones asociadas a dicho órgano …