Continuous revision of the histologic and stage-wise classification of lung cancer by the
World Health Organization (WHO) provides the foundation for therapeutic advances by …

More and more clinical trials have explored the role of liquid biopsy in the diagnosis and
treatment of EGFR-mutated NSCLC. In certain circumstances, liquid biopsy has unique …

Asthma and chronic obstructive pulmonary disease (COPD) are among the most common
chronic respiratory diseases. Chronic inflammation of the airways leads to an increased …

Exhaled breath condensate (EBC), the liquid form of expired air, is noninvasively collected
and can be considered a lung-specific liquid biopsy (1, 2). We hypothesized that EBC could …

Cell-free DNA is an advancing technology with increasing applications in screening,
diagnosis, and treatment for several disease processes. The shared physiologic, genetic …

In the last ten years, liquid biopsy has been slowly joining the traditional invasive techniques
for the diagnosis and monitoring of tumors. Liquid biopsies allow easy repeated sampling of …

Abstract Background Circulating tumor DNA (ctDNA) revolutionized the molecular
diagnostics of lung cancer by enabling non-invasive, sensitive identification of actionable …

This Special Issue of eleven articles, including six original works and five reviews,
demonstrates the modern heterogenous approach to lung cancer by means of various …

Fluctuations pervade biology at all length scales. Inherent randomness in biochemical
reactions and fluctuations in various cellular processes contribute to stochastic gene …

Objectives Despite the outstanding results achieved by osimertinib for the treatment of
advanced EGFR-mutated NSCLC, the development of resistance is almost inevitable. While …