Bone is the second most commonly transplanted tissue worldwide, with over four million
operations using bone grafts or bone substitute materials annually to treat bone defects …

This review is intended to give a state of the art description of scaffold-based strategies
utilized in Bone Tissue Engineering. Numerous scaffolds have been tested in the orthopedic …

In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …

The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

Bone biomaterials play a vital role in bone repair by providing the necessary substrate for
cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In …

Three-dimensional (3D) printing is becoming an increasingly common technique to fabricate
scaffolds and devices for tissue engineering applications. This is due to the potential of 3D …

Over the last decade, significant effort has been devoted to the applications of hierarchically
structured porous materials owing to their outstanding properties such as high surface area …

Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis
are among the most common reasons for mortality in humans at present. Nanostructured …

Highlights•Alternative bone regenerative therapeutics are needed.•Ions have been
proposed to regenerate skeletal tissue.•Drug delivery systems have been studied to deliver …

Hydrogels are a class of advanced material forms that closely mimic properties of the soft
biological tissues. Several polymers have been explored for preparing hydrogels with …