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In the present study, the effect of the polymeric additive Pluronic F127 on the growth rate of Ibuprofen (IBU) crystals from ethanol–water mixtures and its temperature and additive concentration dependence is investigated quantitatively. It is found that the addition of Pluronic F127 (PF127) to the solvent mixture slows the growth rate. At a temperature of 15 °C and an initial supersaturation of 1.5, for instance, 4 and 8 wt % of PF127 lead to a growth rate of 70% and 55%, respectively, of the value without additive. To characterize the growth kinetics, seeded desupersaturation experiments are carried out and monitored using in situ measurement techniques such as attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and focused beam reflectance measurement (FBRM). The solubility of IBU at different temperatures and PF127 concentrations is determined by using a multivariate calibration …