Papers by Ali Keshavarzian
Journal of Pharmacology and Experimental Therapeutics, Jul 31, 2003
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Frontiers in Neuroscience, Sep 1, 2015
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Alcoholism: Clinical and Experimental Research, Apr 1, 1996
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Proceedings of the National Academy of Sciences of the United States of America, Jun 14, 2021
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European Journal of Neurology, Jan 18, 2023
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BMC Microbiology, Jun 28, 2019
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The American Journal of Gastroenterology, Oct 1, 2014
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British Journal of Nutrition, Dec 21, 2009
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The American Journal of Gastroenterology, Aug 1, 2005
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International Journal of Clinical and Experimental Hypnosis, Aug 31, 2007
Hypnotically assisted treatments have been used to reduce stress, improve gastrointestinal motili... more Hypnotically assisted treatments have been used to reduce stress, improve gastrointestinal motility, strengthen immune function, and potentially reduce inflammation. Such treatments may also help reduce disease flares and improve quality of life in inflammatory bowel diseases (IBD). The authors report the results of a case series of 8 white female patients with inactive IBD. All participants initiated and completed treatment, supporting the general acceptability of hypnotically assisted treatment among IBD patients. There was a significant improvement in IBD-quality of life scores for the group posttreatment, t(7) = -3.38, p = .01, with a mean improvement in quality of life of 29 points with significant changes in all 4 subscales. No negative effects of treatment were found.
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The American Journal of Gastroenterology, Sep 1, 2006
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Gastroenterology, Oct 1, 1990
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The American Journal of Gastroenterology, Oct 1, 2009
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Hepatology, 2003
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Gastroenterology, May 1, 2023
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Gastroenterology, May 1, 2023
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Scientific Data, Jun 2, 2023
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Current Neurology and Neuroscience Reports, May 28, 2022
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Gastrointestinal (GI) symptoms are common in soldiers in combat or high-pressure operational situ... more Gastrointestinal (GI) symptoms are common in soldiers in combat or high-pressure operational situations and often lead to compromised performance. Underlying mechanisms are unclear, but neuroendocrine dysregulation, immune activation and increased intestinal permeability may be involved in stress-related GI dysfunction. To study the effects of prolonged, intense, mixed psychological and physical stress on intestinal permeability, systemic inflammatory and stress markers in soldiers during high-intensity combat-training. In 37 male army medical rapid response troops, GI symptoms, stress markers, segmental intestinal permeability using the 4-sugar test (sucrose, lactulose, mannitol and sucralose) and immune activation were assessed during the 4th week of an intense combat-training and a rest period. Combat-training elicited higher stress, anxiety and depression scores (all P < 0.01) as well as greater incidence and severity of GI symptoms [irritable bowel syndrome symptom severity score (IBS-SSS), P < 0.05] compared with rest. The IBS-SSS correlated with depression (r = 0.41, P < 0.01) and stress (r = 0.40, P < 0.01) ratings. Serum levels of cortisol, interleukin-6, and tumour necrosis factor-α, and segmental GI permeability increased during combat-training compared with rest (all P < 0.05). The lactulose:mannitol ratio was higher in soldiers with GI symptoms (IBS-SSS ≥75) during combat-training than those without (IBS-SSS <75) (P < 0.05). Prolonged combat-training not only induces the expected increases in stress, anxiety and depression, but also GI symptoms, pro-inflammatory immune activation and increased intestinal permeability. Identification of subgroups of individuals at high-risk of GI compromise and of long-term deleterious effects of operational stress as well as the development of protective measures will be the focus of future studies.
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Life Sciences, May 1, 1997
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Papers by Ali Keshavarzian