Studies of the translation and reception history of Dante’s Divina Commedia have rarely included the use of either distant reading (aka large-scale literary analysis) or Digital Humanities, much less both. However, using both these methods allows innovative research questions to be pursued and answered with regard to Dante’s fortuna, as I have shown in four previous articles regarding Dante and other writers. This contribution draws on three new datasets that I constructed myself in order to study canons of world literature, using Dante’s Divine Comedy as a case study: a comprehensive catalogue of all the worldwide complete translations of the Commedia (or single canticles such as Inferno, Purgatorio and Paradiso), published from the 16th century until 2021; readership data pertaining to all the Wikipedia entries dedicated to Dante’s biographical entry and his works; and Commedia holdings, in both Italian and translation, in all national libraries with online searchable catalogues. The aim is to see where Dante’s text is translated and circulates the most, and whether his work is globally popular.