RGD Reference Report - Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4. - Rat Genome Database
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Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4.

Authors: Xu, Xiaohua  Liu, Yilun 
Citation: Xu X and Liu Y, EMBO J. 2009 Mar 4;28(5):568-77. doi: 10.1038/emboj.2009.13. Epub 2009 Jan 29.
RGD ID: 13207505
Pubmed: PMID:19177149   (View Abstract at PubMed)
PMCID: PMC2657580   (View Article at PubMed Central)
DOI: DOI:10.1038/emboj.2009.13   (Journal Full-text)

Human RECQ helicases have been linked to distinct clinical diseases with increased cancer rates and premature ageing. All RECQ proteins, except RECQ4, have been shown to be functional helicases. Mutations in RECQ4 lead to Rothmund-Thomson syndrome (RTS), and mouse models reveal that the conserved helicase motifs are required for avoidance of RTS. Furthermore, the amino (N) terminus of RECQ4 shares homology with yeast DNA replication initiation factor, Sld2, and is vital for embryonic development. Here, in contrast to previous reports, we show that RECQ4 exhibits DNA helicase activity. Importantly, two distinct regions of the protein, the conserved helicase motifs and the Sld2-like N-terminal domain, each independently promote ATP-dependent DNA unwinding. Taken together, our data provide the first biochemical clues underlying the molecular function of RECQ4 in DNA replication and genome maintenance.




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