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Parietal and Frontal Cortex Encode Stimulus-Specific Mnemonic Representations during Visual Working Memory

Neuron. 2015 Aug 19;87(4):893-905. doi: 10.1016/j.neuron.2015.07.013. Epub 2015 Aug 6.

Abstract

Working memory (WM) enables the storage and manipulation of information in an active state. WM storage has long been associated with sustained increases in activation across a network of frontal and parietal cortical regions. However, recent evidence suggests that these regions primarily encode information related to general task goals rather than feature-selective representations of specific memoranda. These goal-related representations are thought to provide top-down feedback that coordinates the representation of fine-grained details in early sensory areas. Here, we test this model using fMRI-based reconstructions of remembered visual details from region-level activation patterns. We could reconstruct high-fidelity representations of a remembered orientation based on activation patterns in occipital visual cortex and in several sub-regions of frontal and parietal cortex, independent of sustained increases in mean activation. These results challenge models of WM that postulate disjoint frontoparietal "top-down control" and posterior sensory "feature storage" networks.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping / methods*
  • Female
  • Frontal Lobe / physiology*
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Memory, Short-Term / physiology*
  • Orientation / physiology*
  • Parietal Lobe / physiology*
  • Photic Stimulation / methods
  • Visual Perception / physiology*
  • Young Adult