Abstract
Two new cytochalasans, trichalasins C (1) and D (2) together with known cytochalasans aspochalasins D (3), M (4) and P (5) were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H.Chen. The structures for the new compounds 1 and 2 were determined by NMR and HRESIMS, and their relative configurations were established by analysis of coupling constants and NOESY correlations. Compound 3 displaying inhibitory activity with EC₅₀ value 5.72 μM, whereas the EC₅₀ values for compounds 1, 2 and 4, 5 are more than 40 μM.
Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Biological Products / chemistry*
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Biological Products / pharmacology
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Biological Products / therapeutic use
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Cytochalasins / isolation & purification*
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Cytochalasins / pharmacology
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Cytochalasins / therapeutic use
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Endophytes / chemistry
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Female
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HeLa Cells
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Humans
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Molecular Structure
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Panax notoginseng / microbiology*
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Trichoderma / chemistry*
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Uterine Cervical Neoplasms / drug therapy
Substances
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Antineoplastic Agents
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Biological Products
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Cytochalasins
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aspochalasin D
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trichalasin C
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trichalasin D