Wright MC - Search Results

1

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

Marek CJ, Tucker SJ, Konstantinou DK, Elrick LJ, Haefner D, Sigalas C, Murray GI, Goodwin B, Wright MC. Marek CJ, et al. Among authors: wright mc. Biochem J. 2005 May 1;387(Pt 3):601-8. doi: 10.1042/BJ20041598. Biochem J. 2005. PMID: 15595924 Free PMC article.

2

The cytochrome P450 3A4 inducer metyrapone is an activator of the human pregnane X receptor.

Wright MC. Wright MC. Biochem Soc Trans. 1999 Aug;27(4):387-91. doi: 10.1042/bst0270387. Biochem Soc Trans. 1999. PMID: 10917608 No abstract available.

3

Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.

Wright MC, Issa R, Smart DE, Trim N, Murray GI, Primrose JN, Arthur MJ, Iredale JP, Mann DA. Wright MC, et al. Gastroenterology. 2001 Sep;121(3):685-98. doi: 10.1053/gast.2001.27188. Gastroenterology. 2001. PMID: 11522753

4

Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro.

Marek CJ, Cameron GA, Elrick LJ, Hawksworth GM, Wright MC. Marek CJ, et al. Among authors: wright mc. Biochem J. 2003 Mar 15;370(Pt 3):763-9. doi: 10.1042/BJ20021545. Biochem J. 2003. PMID: 12542397 Free PMC article.

5

Identification of a truncated ratp28-related protein expressed in kidney.

Leel V, Elrick LJ, Solares J, Ingram N, Charlton KA, Porter AJ, Wright MC. Leel V, et al. Among authors: wright mc. Biochem Biophys Res Commun. 2004 Apr 9;316(3):872-7. doi: 10.1016/j.bbrc.2004.02.137. Biochem Biophys Res Commun. 2004. PMID: 15033482

6

Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells.

Orr JG, Leel V, Cameron GA, Marek CJ, Haughton EL, Elrick LJ, Trim JE, Hawksworth GM, Halestrap AP, Wright MC. Orr JG, et al. Among authors: wright mc. Hepatology. 2004 Jul;40(1):232-42. doi: 10.1002/hep.20254. Hepatology. 2004. PMID: 15239107

7

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC, Mann DA. Oakley F, et al. Among authors: wright mc. Gastroenterology. 2005 Jan;128(1):108-20. doi: 10.1053/j.gastro.2004.10.003. Gastroenterology. 2005. PMID: 15633128

8

Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.

Elrick LJ, Leel V, Blaylock MG, Duncan L, Drever MR, Strachan G, Charlton KA, Koruth M, Porter AJ, Wright MC. Elrick LJ, et al. Among authors: wright mc. J Hepatol. 2005 Jun;42(6):888-96. doi: 10.1016/j.jhep.2005.01.028. Epub 2005 Apr 8. J Hepatol. 2005. PMID: 15885360

9

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.

Haughton EL, Tucker SJ, Marek CJ, Durward E, Leel V, Bascal Z, Monaghan T, Koruth M, Collie-Duguid E, Mann DA, Trim JE, Wright MC. Haughton EL, et al. Among authors: wright mc. Gastroenterology. 2006 Jul;131(1):194-209. doi: 10.1053/j.gastro.2006.04.012. Gastroenterology. 2006. PMID: 16831602

10

The impact of pregnane X receptor activation on liver fibrosis.

Wright MC. Wright MC. Biochem Soc Trans. 2006 Dec;34(Pt 6):1119-23. doi: 10.1042/BST0341119. Biochem Soc Trans. 2006. PMID: 17073765

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