Table 4.
Genetic biomarkers linked to CIPN by neurotoxic drug classification
| Agent | Relevance tochemotherapeutic agent | SNPs in genes |
|---|---|---|
| Paclitaxel | Pharmacokinetic, transport, and pharmacodynamic properties of paclitaxel | OATP1, CYP3A5, CYP3A4, CYP1B1, CYP2C8, ABCB1, ABCC1, ABCG1 |
| Cisplatin and oxaliplatin | Drug transporters | ABCC1 and ABCG1 |
| Detoxification enzymes | MPO, GSTA1, GSTM1/3, GSTP1 and GSTT1 | |
| DNA repair mechanisms | ERCC2, XPA, XRCC1 and ERCC1 | |
| Oxaliplatin-specific | Cell adhesion and in cell surface-mediated signaling | Integrin B3 Leu33Pro |
| Voltage-gated sodium channels | SCN4A-rs2302237 and SCN10A-rs1263292 | |
| Bortezomib | Immune function | CTLA4, CTSS |
| Reflexive coupling within Schwann cells | GJE1 | |
| Drug binding | PSMB1 | |
| Neuron function | TCF4, DYNC1/1 | |
| Steroid hormone biosynthesis | rs619824 in CYP17A1 |
Abbreviations: CIPN, chemotherapy-induced peripheral neuropathy; SNPs, single-nucleotide polymorphisms.