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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Immunol. 2013 Nov 29;192(1):151–159. doi: 10.4049/jimmunol.1301453

Figure 3. Proliferation of VM and TNa CD8+ T cells from adult and old OT-I Rag+ mice in response to homeostatic cytokines.

Figure 3

Sorted splenic VM and TNa CD8+ T cells from 3 mo. and 14 mo. OT-I Rag+ mice were cultured with IL7/IL-15 for 7 days. Frequency of live CD8+ cells divided for (A) 3 mo. and (B) 14 mo. on day 7 was determined by CFSE dilution. 14 mo. (C) VM and (D) TNa cells have increased proliferation compared to adult counterparts. *p<0.05, **p<0.01, ***p<0.001 by two-way ANOVA and Bonferonni post test. Data shows mean ± SEM; n=4–5, representative of 2 experiments.