The effect of dexamethasone on constitutive production of cytokines and perforin is illustrated. NK92 cells were treated for 24 hr with dexamethasone (10−7 M). Supernatants were collected and assayed for (a) IFN-gamma, (b) IL-6 and (c) perforin by ELISA. Results are expressed as mean ± SEM; N = at least three independent experiments. NT=No Treatment. p values represent statistically significant difference, No Treatment (NT) vs. Dexamethasone at indicated concentration,*, P < 0.05; **, P < 0.01; ***, P < 0.001.