TABLE 6.
Sensitivity of Env clones to neutralization by V3-specific MAbs
| Env clonea | Panel designationa | ID50 in TZM-bl cells (μg/ml)b
|
|||||
|---|---|---|---|---|---|---|---|
| 2182 | 2442 | 2191 | 2219 | 2456 | 447D | ||
| SF162.LS | None | 2 | <0.04 | <0.04 | <0.04 | 0.04 | 0.04 |
| 6101.10 | SVPB1 | >25 | >25 | >25 | >25 | >25 | >25 |
| 5768.4 | SVPB2 | >25 | >25 | >25 | >25 | >25 | >25 |
| 3988.25 | SVPB3 | >25 | >25 | >25 | >25 | >25 | >25 |
| 7165.18 | SVPB4 | >25 | 0.04 | 0.90 | 25 | >25 | >25 |
| 6535.3* | SVPB5* | >25 | 0.04 | 0.40 | 1.5 | 5 | 0.1 |
| QH0692.42* | SVPB6* | 1 | >25 | >25 | >25 | >25 | >25 |
| QH0515.1 | SVPB7 | >25 | >25 | >25 | >25 | >25 | >25 |
| SC422661.8* | SVPB8* | >25 | >25 | >25 | >25 | >25 | >25 |
| SS1196.1 | SVPB9 | <0.04 | 0.04 | 0.40 | 0.1 | 0.1 | <0.04 |
| BG1168.1 | SVPB10 | >25 | >25 | >25 | >25 | >25 | >25 |
| PVO.4* | SVPB11* | >25 | >25 | >25 | >25 | >25 | >25 |
| TRO.11* | SVPB12* | >25 | >25 | >25 | >25 | >25 | >25 |
| AC10.0.29* | SVPB13* | >25 | >25 | >25 | >25 | >25 | >25 |
| RHPA4259.7* | SVPB14* | >25 | >25 | 25 | >25 | >25 | >25 |
| THRO4156.18* | SVPB15* | >25 | >25 | >25 | >25 | >25 | >25 |
| REJO4541.67* | SVPB16* | >25 | >25 | 20 | 1 | >25 | >25 |
| TRJO4551.58* | SVPB17* | >25 | >25 | >25 | >25 | >25 | >25 |
| WITO4160.33* | SVPB18* | >25 | >25 | >25 | >25 | >25 | >25 |
| CAAN5342.A2* | SVPB19* | >25 | >25 | >25 | >25 | >25 | >25 |
a
Clones selected as standard reference strains are marked with an asterisk.
b
Values are the concentration at which RLU were reduced 50% compared to those in virus control wells.