Figure 9: Effects of intrastriatal perfusion of a D2 antagonist analyzed with respect to pre-drug basal levels.
A. Pre- vs. post-eticlopride percent basal levels for dopamine, 3-methyltyramine (3-MT), and serotonin (5-HT). B. Time courses before and during intrastriatal perfusion of eticlopride (100 μM) showing basal and stimulated neurochemical levels expressed as percents of pre-drug basal levels. C. Optically evoked overflow expressed as area under the curve for data normalized to pre-drug basal levels (AUC (%)). Data are means ± SEMs for N=4 mice. Serotonin levels for one mouse were not detectable. *P<0.05 vs. pre-drug. %Basal data points in A represent the means of six measurements just prior to the first stimulation (errors not shown). The AUC datapoints in C are the means of the three stimuli (errors not shown).