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YU48892B - Novi steroidi - Google Patents

Novi steroidi

Info

Publication number
YU48892B
YU48892B YU6592A YU6592A YU48892B YU 48892 B YU48892 B YU 48892B YU 6592 A YU6592 A YU 6592A YU 6592 A YU6592 A YU 6592A YU 48892 B YU48892 B YU 48892B
Authority
YU
Yugoslavia
Prior art keywords
novel steroids
epimer
compound
fluorine atom
steroids
Prior art date
Application number
YU6592A
Other languages
English (en)
Other versions
YU6592A (sh
Inventor
Paul Andersson
Beugt Axelsson
Ralph Brattsand
Arne Thalen
Original Assignee
Astra Aktiebolaget
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolaget filed Critical Astra Aktiebolaget
Priority to SI9210065A priority Critical patent/SI9210065B/sl
Publication of YU6592A publication Critical patent/YU6592A/sh
Publication of YU48892B publication Critical patent/YU48892B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Jedinjenje opšte formule gde X1 predstavlja atom fluora i X2 predstavlja vodonik ili atom fluora; jedinjenje koje je o obluku 22R epimera i sadrži ne više od 2 tež. % 22S epimera. Prijava sadrži još 2 nezavisna i 1 zavisan zahtev.
YU6592A 1991-02-04 1992-01-22 Novi steroidi YU48892B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI9210065A SI9210065B (en) 1991-02-04 1992-01-22 Novel antiinflamatory and antialergic active compounds, glucocorticosteroids and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100341A SE9100341D0 (sv) 1991-02-04 1991-02-04 Novel steroids

Publications (2)

Publication Number Publication Date
YU6592A YU6592A (sh) 1995-01-31
YU48892B true YU48892B (sh) 2002-10-18

Family

ID=20381806

Family Applications (1)

Application Number Title Priority Date Filing Date
YU6592A YU48892B (sh) 1991-02-04 1992-01-22 Novi steroidi

Country Status (40)

Country Link
US (2) US5674861A (sh)
EP (1) EP0570454B1 (sh)
JP (1) JPH06505232A (sh)
KR (1) KR100216720B1 (sh)
CN (3) CN1034868C (sh)
AP (1) AP366A (sh)
AT (1) ATE178611T1 (sh)
BG (1) BG62211B1 (sh)
CA (1) CA2103924A1 (sh)
CZ (1) CZ281685B6 (sh)
DE (1) DE69228870T2 (sh)
DK (1) DK0570454T3 (sh)
DZ (1) DZ1553A1 (sh)
EE (1) EE03111B1 (sh)
ES (1) ES2133315T3 (sh)
FI (1) FI933450A0 (sh)
GR (1) GR3030657T3 (sh)
HK (1) HK1010733A1 (sh)
HU (1) HU218275B (sh)
IE (1) IE920166A1 (sh)
IL (1) IL100532A (sh)
IS (1) IS1601B (sh)
MA (1) MA22406A1 (sh)
MX (1) MX9200324A (sh)
NO (1) NO304073B1 (sh)
NZ (1) NZ241210A (sh)
PH (1) PH31284A (sh)
PL (1) PL170000B1 (sh)
PT (1) PT100086B (sh)
RO (1) RO111195B1 (sh)
RU (1) RU2111212C1 (sh)
SE (1) SE9100341D0 (sh)
SG (1) SG52557A1 (sh)
SI (1) SI9210065B (sh)
SK (1) SK281801B6 (sh)
TN (1) TNSN92007A1 (sh)
UA (1) UA41267C2 (sh)
WO (1) WO1992013872A1 (sh)
YU (1) YU48892B (sh)
ZA (1) ZA92233B (sh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
NZ259596A (en) * 1993-01-08 1997-04-24 Astra Ab Sugar-substituted glucocorticosteroid and use in medicaments specific to the colon or ileum
US5983956A (en) 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
GB9423919D0 (en) * 1994-11-26 1995-01-11 Rhone Poulenc Rorer Ltd Chemical process
SE9700135D0 (sv) 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
WO1999061055A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
GB0009592D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009607D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Medical compositions
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
GB0110411D0 (en) * 2001-04-27 2001-06-20 Astrazeneca Ab Chemical process
JP2005505578A (ja) * 2001-09-25 2005-02-24 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー ステロイドｃ−２２位アセトニドの立体選択的トランスアセタール化
NZ537717A (en) 2002-07-08 2006-04-28 Pliva Istrazivacki Inst D New compounds, compositions and methods for treatment of inflammatory diseases and conditions
JP4530851B2 (ja) 2002-07-08 2010-08-25 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ ステロイド／非ステロイド抗炎症活性分子、抗新生物活性分子および抗ウイルス活性分子用担体としての新規な化合物、組成物
AU2003265576A1 (en) * 2002-08-23 2004-03-11 The Mclean Hospital Corporation Corticosteroid conjugates and uses thereof
TW200417371A (en) * 2003-02-21 2004-09-16 Upjohn Co A continuous process for the production of R-rofleponide
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
JP2008517993A (ja) 2004-10-27 2008-05-29 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗炎症作用を有するコンジュゲート
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
WO2007008155A1 (en) * 2005-07-11 2007-01-18 Astrazeneca Ab New combination 1
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
CN104208718B (zh) 2009-02-20 2017-12-29 2-Bbb医疗股份有限公司 基于谷胱甘肽的药物递送系统
MY163048A (en) 2009-05-06 2017-08-15 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378110B (sh) * 1972-05-19 1975-08-18 Bofors Ab
SE378109B (sh) * 1972-05-19 1975-08-18 Bofors Ab
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
CN1060471A (zh) * 1985-04-04 1992-04-22 得拉科公司 新的16，17-缩醛取代雄甾烷-17β-酮类的制备方法
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
HU203562B (en) * 1989-03-09 1991-08-28 Richter Gedeon Vegyeszet Process for producing new steroide diols and pharmaceutical compositions containing them
HU203769B (en) * 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters

Also Published As

Publication number Publication date
MX9200324A (es) 1992-09-01
NO932761L (no) 1993-08-02
RU2111212C1 (ru) 1998-05-20
RO111195B1 (ro) 1996-07-30
SI9210065A (en) 1995-02-28
YU6592A (sh) 1995-01-31
IS1601B (is) 1996-10-18
PL170000B1 (pl) 1996-10-31
EP0570454B1 (en) 1999-04-07
AP366A (en) 1994-10-21
CN1140059A (zh) 1997-01-15
FI933450A (fi) 1993-08-03
HU9302244D0 (en) 1993-10-28
CN1064079A (zh) 1992-09-02
WO1992013872A1 (en) 1992-08-20
SK281801B6 (sk) 2001-08-06
MA22406A1 (fr) 1992-10-01
NZ241210A (en) 1993-08-26
DE69228870T2 (de) 1999-08-19
SK79693A3 (en) 1994-03-09
HK1010733A1 (en) 1999-06-25
EP0570454A1 (en) 1993-11-24
DK0570454T3 (da) 1999-10-18
AU661471B2 (en) 1995-07-27
PT100086A (pt) 1994-05-31
IL100532A (en) 1996-05-14
ATE178611T1 (de) 1999-04-15
KR100216720B1 (ko) 1999-10-01
UA41267C2 (uk) 2001-09-17
CA2103924A1 (en) 1992-08-05
SI9210065B (en) 2001-12-31
HUT64973A (en) 1994-03-28
PT100086B (pt) 1999-06-30
GR3030657T3 (en) 1999-10-29
DE69228870D1 (de) 1999-05-12
CN1058724C (zh) 2000-11-22
CZ281685B6 (cs) 1996-12-11
NO932761D0 (no) 1993-08-02
ES2133315T3 (es) 1999-09-16
BG62211B1 (bg) 1999-05-31
JPH06505232A (ja) 1994-06-16
ZA92233B (en) 1992-10-28
HU218275B (en) 2000-07-28
NO304073B1 (no) 1998-10-19
BG97971A (bg) 1994-04-29
AU1230792A (en) 1992-09-07
IE920166A1 (en) 1992-08-12
IL100532A0 (en) 1992-09-06
CN1052155C (zh) 2000-05-10
TNSN92007A1 (fr) 1993-06-08
CN1034868C (zh) 1997-05-14
US5939409A (en) 1999-08-17
SE9100341D0 (sv) 1991-02-04
EE03111B1 (et) 1998-08-17
AP9200353A0 (en) 1992-01-31
CZ149693A3 (en) 1994-03-16
PH31284A (en) 1998-07-06
US5674861A (en) 1997-10-07
SG52557A1 (en) 1998-09-28
DZ1553A1 (fr) 2002-02-17
CN1140178A (zh) 1997-01-15
FI933450A0 (fi) 1993-08-03
IS3808A (is) 1992-08-05

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