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WO2020101414A1 - Composition favorisant la régénération cutanée et la poussée capillaire, contenant de l'apigénine - Google Patents

Composition favorisant la régénération cutanée et la poussée capillaire, contenant de l'apigénine Download PDF

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Publication number
WO2020101414A1
WO2020101414A1 PCT/KR2019/015615 KR2019015615W WO2020101414A1 WO 2020101414 A1 WO2020101414 A1 WO 2020101414A1 KR 2019015615 W KR2019015615 W KR 2019015615W WO 2020101414 A1 WO2020101414 A1 WO 2020101414A1
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Prior art keywords
composition
hair growth
skin regeneration
apigenin
extract
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PCT/KR2019/015615
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English (en)
Korean (ko)
Inventor
신승현
김수나
박원석
Original Assignee
(주)아모레퍼시픽
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Priority to CN201980074400.8A priority Critical patent/CN113015513B/zh
Publication of WO2020101414A1 publication Critical patent/WO2020101414A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Definitions

  • the present invention relates to a composition for promoting skin regeneration and hair growth comprising apigenin.
  • the skin Since the skin exists at the outermost part of the human body and is directly in contact with the external environment, it protects the human body from external damage and prevents excessive evaporation of moisture and heat in the body.
  • the skin is composed of three layers of epidermis, dermis, and subcutaneous tissue. Most of the outermost epidermis is composed of keratinocytes. Keratinocytes in the epidermis protect the skin by forming keratin through the proliferation, migration and differentiation process from the base layer, and produce various cytokines to participate in inflammatory and immune responses. In addition, proliferation and migration of keratinocytes not only provides wound healing and skin regeneration, but also induces collagen synthesis to improve skin elasticity and basement membrane formation, thereby controlling adhesion and proliferation of skin cells and harmful.
  • Apigenin is a nutritional component well known as an antioxidant contained in vegetables, and is used as a component for skin whitening, skin regeneration, and hair growth promotion.
  • Korean Patent Publication No. 2017-0119757 discloses that a cosmetic composition using apigenin, germanium, and amino acids, can exhibit skin regeneration and stabilizing effects by synergistically expressing the effects of each component.
  • Cipheral Patent No. 106880693 discloses a composition comprising apigenin and ginseng extract, which has the effect of preventing hair loss.
  • apigenin which is effective in promoting skin regeneration and hair growth, is used, but research and development of a product capable of maximizing the efficacy by using apigenin and synergistic ingredients are continuously required.
  • the present inventors prepared a composition containing at least one of caffeine, ginseng extract, and green tea extract and apigenin at the same time, and confirmed that the composition was excellent in promoting skin regeneration and hair growth.
  • an object of the present invention is to provide a composition for promoting skin regeneration and hair growth comprising apigenin.
  • apigenin (apigenin); And caffeine, ginseng extract and one or more selected from the group consisting of green tea extract; provides a composition for promoting skin regeneration and hair growth comprising a.
  • the apigenin may be contained in 40 to 60% by weight based on the total weight of the composition.
  • the caffeine, ginseng extract and one or more selected from the group consisting of green tea extract may be included in 40 to 60% by weight based on the total weight of the composition.
  • the composition may be to activate the Wnt / beta-catenin signal.
  • the concentration of the composition may be 10 to 40 ppm based on the solid content concentration.
  • the composition may include apigenin and caffeine.
  • the composition may include apigenin and ginseng extract.
  • the composition may include apigenin and green tea extract.
  • the composition may be one or more selected from the group consisting of cosmetic compositions, food compositions and pharmaceutical compositions.
  • composition for promoting skin regeneration and growth of hair growth of the present invention includes apigenin, at least one of caffeine, ginseng extract, and green tea extract, resulting in synergistic effect of the efficacy of each component, specifically excellent skin It can exhibit wound healing and scar reduction effects.
  • composition for promoting skin regeneration and hair growth has an effect of preventing or improving hair loss by promoting hair growth.
  • composition for promoting skin regeneration and hair growth promotes cell differentiation through signaling of Wnt / beta-catenin, thereby further improving skin regeneration and hair growth growth promoting effects.
  • composition for promoting skin regeneration and hair growth can be widely applied to cosmetic compositions, food compositions, and pharmaceutical compositions having skin regeneration and hair growth promoting effects.
  • Composition for skin regeneration and hair growth promotion Composition for skin regeneration and hair growth promotion
  • the present invention relates to a composition for promoting skin regeneration and hair growth, wherein the composition for promoting skin regeneration and hair growth comprises apigenin; And one or more selected from the group consisting of caffeine, ginseng extract, and green tea extract.
  • the composition for promoting skin regeneration and hair growth may include apigenin and caffeine, or apigenin and ginseng extract, or a combination of apigenin and green tea extract.
  • the composition for promoting skin regeneration and hair growth includes components of such a combination, synergy for promoting skin regeneration and hair growth may be the best.
  • the apigenin is a kind of flavonoid component contained in a fruit, vegetable or herb, and may be extracted from these fruits, vegetables or herbs.
  • the apigenin may be included in an amount of 40 to 60% by weight, preferably 42 to 58% by weight, and more preferably 45 to 55% by weight based on the total weight of the composition for promoting skin regeneration or hair growth. If it is less than or equal to the above range, the synergistic effect with one or more selected from the group consisting of the caffeine, ginseng extract and green tea extract may be lowered.
  • At least one selected from the group consisting of the caffeine, ginseng extract and green tea extract may exhibit a synergistic effect for promoting skin regeneration and hair growth by combining with the apigenone.
  • One or more selected from the group consisting of the caffeine, ginseng extract and green tea extract is 40 to 60% by weight, preferably 42 to 58% by weight, more preferably based on the total weight of the composition for promoting skin regeneration or hair growth 45 to 55% by weight. If it is less than or equal to the above range, the synergistic effect with the apigenone may be reduced.
  • the caffeine is not particularly limited, synthetic caffeine; Alternatively, a form of at least one natural caffeine extract selected from the group consisting of guarana extract, coffee extract and tea extract may be used.
  • the caffeine may have a concentration of 5 to 20 ppm, preferably 5 to 15 ppm, and preferably 7 to 12 ppm, based on the solid content concentration. If it is less than the above range, the effect of promoting skin regeneration and hair growth may be negligible, and if it is more than the above range, the optimum concentration for synergistic action with apigenone may be exceeded, and thus the effect of promoting skin regeneration and hair growth may be reduced.
  • the concentration of caffeine means the concentration of an aqueous solution of caffeine in the case of synthetic caffeine, and the concentration of solid content in the form of a natural caffeine extract.
  • the ginseng extract may be one or more selected from the group consisting of ginseng root extract, ginseng leaf extract, ginseng fruit extract, and ginseng seed extract, preferably ginseng root extract.
  • the ginseng extract may have a concentration of 5 to 20 ppm, preferably 5 to 15 ppm, and preferably 7 to 12 ppm based on the solid content concentration. If it is less than the above range, the effect of promoting skin regeneration and hair growth may be negligible, and if it is more than the above range, the optimum concentration for synergistic action with apigenone may be exceeded, and thus the effect of promoting skin regeneration and hair growth may be reduced.
  • the ginseng extract may be extracted using an extraction solvent selected from the group consisting of water, an organic solvent and a mixed solvent of water and an organic solvent.
  • the organic solvent may be one or more selected from the group consisting of ethanol, methanol, butanol, ether, ethyl acetate and chloroform.
  • the extraction solvent may be ethanol.
  • the method for preparing the ginseng extract is not particularly limited as long as it is a common extraction method used in the art, for example, it can be prepared by extracting for 3 to 24 hours at 10 to 80 ° C using the extraction solvent. have.
  • the green tea extract may be at least one selected from the group consisting of green tea leaf extract, green tea flower extract and green tea stem extract, preferably green tea leaf extract.
  • the green tea extract may have a concentration of 5 to 20 ppm, preferably 5 to 15 ppm, and preferably 7 to 12 ppm, based on the solid content concentration. If it is less than the above range, the effect of promoting skin regeneration and hair growth may be negligible, and if it is more than the above range, the optimum concentration for synergistic action with apigenone may be exceeded, and thus the effect of promoting skin regeneration and hair growth may be reduced.
  • the green tea extract may be a hot water extract or a lower alcohol extract of C 1 to C 5 .
  • the green tea extract may be an ethanol extract.
  • the method for preparing the green tea extract is not particularly limited as long as it is a conventional extraction method used in the art.
  • the green tea extract when the green tea extract is a hot water extract, it may be obtained through the processes of green tea input, hot water extraction, filtration, concentration under reduced pressure, and spray drying.
  • the green tea extract is an ethanol extract, it may be prepared by extracting for 3 to 24 hours at 10 to 80 ° C using ethanol.
  • the concentration of the composition for promoting skin regeneration and hair growth may be 10 to 40 ppm, preferably 10 to 30 ppm, more preferably 15 to 25 ppm, based on the solid content concentration. If it is less than or equal to the above range, the effect of promoting skin regeneration and hair growth may be reduced. In addition, when the composition is in the concentration range, it is possible to enable the win / beta-catenin signal activation as described below.
  • composition for promoting skin regeneration and hair growth can promote skin regeneration and hair growth by activating the Wnt / beta-catenin signal.
  • Wnt / beta-catenin signaling is a signaling system related to the development of living organisms and is known to act on skin formation and hair follicle development. Furthermore, when a wound is formed on the skin, it is known that wind signal transmission is essentially expressed in the process of skin tissue recovery to promote differentiation of epithelial cells (Fathke et al ., "Wnt signaling induces epithelial differentiation during cutaneous wound healing", BMC Cell Biology 2006, 7: 4). Therefore, when the wind signal transmission is promoted, differentiation of epithelial cells is promoted, skin regeneration can be promoted, and further, healing of skin wounds can be promoted. Gardenia extract promotes stem cell wint / beta-catenin signaling. Therefore, formulations containing the same can promote skin regeneration and specifically promote healing of skin wounds (Kateri A. Moore et al ., “Stem Cells and Their Niches", Science, VOL 311, p1880-1885 ).
  • the composition for promoting skin regeneration and hair growth may be at least one selected from the group consisting of cosmetic compositions, food compositions and pharmaceutical compositions.
  • the composition for promoting skin regeneration and hair growth is a cosmetic composition
  • it may be formulated by containing a cosmetic or dermatologically acceptable medium or base.
  • the cosmetic composition for promoting skin regeneration and hair growth may be provided in any formulation suitable for topical application, for example, a solution, an emulsion obtained by dispersing an oil phase in an aqueous phase, an emulsion obtained by dispersing an oil phase in an oil phase, a suspension, It can be provided in the form of a solid, gel, powder, paste, foam or aerosol composition. Compositions of these formulations can be prepared according to conventional methods in the art.
  • the cosmetic composition for promoting skin regeneration and growth of hair growth may include other ingredients that can give a synergistic effect to the main effect, within a range that does not impair the main effect other than the above-mentioned substances.
  • the cosmetic composition for promoting skin regeneration and hair growth may further include a moisturizing agent, an emollient, an ultraviolet absorbent, a preservative, a disinfecting agent, an antioxidant, a pH adjusting agent, organic and inorganic pigments, flavoring agents, cooling agents, or limiting agents.
  • the compounding amount of the components can be easily selected by those skilled in the art within a range that does not impair the objects and effects of the present invention, and the blending amount may be 0.01 to 5% by weight, specifically 0.01 to 3% by weight, based on the total weight of the composition. .
  • composition for promoting skin regeneration and hair growth is a food composition
  • it may be applied to various types of food additives or functional foods. It can be processed into fermented milk, cheese, yogurt, juice, probiotic and health supplements including the food composition for promoting skin regeneration and hair growth, and can be used in the form of various other food additives.
  • the food composition for promoting skin regeneration and hair growth may contain other ingredients and the like that can give a synergistic effect to the main effect within a range that does not impair the main effect targeted by the present invention.
  • additives such as fragrances, pigments, disinfectants, antioxidants, preservatives, moisturizers, thickeners, inorganic salts, emulsifiers, and synthetic polymer materials may be further included.
  • auxiliary components such as water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, and seaweed extract may be further included.
  • the ingredients may be appropriately selected and blended without difficulty by a person skilled in the art depending on the formulation or the purpose of use, and the amount added may be selected within a range not impairing the objects and effects of the present invention.
  • the added amount of the components may be in the range of 0.01 to 5% by weight, more specifically 0.01 to 3% by weight, based on the total weight of the composition.
  • the food composition for promoting skin regeneration and hair growth according to the present invention may be formulated in various forms such as solutions, emulsions, viscous mixtures, tablets, powders, etc., such as simple drinking, injection, spray, or squeeze methods. It can be administered in a variety of ways.
  • composition for promoting skin regeneration and growth of hair growth is a pharmaceutical composition
  • it can be applied to pharmaceuticals, orally or in a solid, semi-solid or liquid form by adding an inorganic or organic carrier compatible with the active ingredient used in the present invention, or It can be formulated as a parenteral administration agent, and the pharmaceutical composition according to the present invention can be administered orally, parenterally, rectal, topical, transdermal, intravenous, intramuscular, intraperitoneal, subcutaneous, and the like.
  • Examples of the dosage form for oral administration include tablets, pills, granules, capsules, powders, granules, powders, emulsions, syrups, pellets, and the like.
  • formulations for parenteral administration include injections, drops, ointments, lotions, sprays, suspensions, emulsions, suppositories, and the like.
  • the composition according to the present invention can be easily formulated into an active ingredient by carrying out according to the commercial method, in which case surfactants, excipients, colorants, spices, preservatives, stabilizers, buffers, suspending agents, and other commonly used adjuvants can be suitably used. have.
  • the dosage of the active ingredient of the pharmaceutical composition of the present invention will vary depending on the age, gender, weight, pathology and severity of the subject to be administered, the route of administration or the judgment of the prescriber. Determination of a suitable dose based on these factors is within the level of those skilled in the art, and the daily dose administered is, for example, 0.1 mg / kg / day to 100 mg / kg / day, more specifically 5 mg / kg / day to 50 mg / kg. / Can be a day, but is not limited to this.
  • the composition for promoting skin regeneration and hair growth as described above includes apigenin, and at least one of caffeine, ginseng extract, and green tea extract, resulting in a skin regeneration effect due to synergistic effect of the efficacy of each component, specifically excellent It has the effect of healing skin wounds and reducing scars, and has the effect of promoting hair growth, and thus can be widely applied to the fields of cosmetics, food, and pharmaceuticals having such effects.
  • the present invention also relates to a method for promoting skin regeneration and hair growth using the composition for promoting skin regeneration and hair growth.
  • the composition may be applied to the skin, including the scalp, to regenerate the skin or promote hair growth.
  • composition may be administered orally depending on the formulation of the composition.
  • Thistle (circium japonicum) was collected and used in mountainous areas of Chungbuk province. What was purchased from Gyeongdong Market (Seoul, Korea) was dried and used. The dried thistle (circium japonicum) was extracted by adding 95% alcohol, and concentrated using a vacuum concentrator to prepare a spirit crude extract.
  • the crude crude extract was dissolved in distilled water and ethyl acetate, mixed at a ratio of 1: 1 (v / v), and the distribution between the abnormalities was repeated three times, and the ethyl acetate extract was reduced, concentrated, and dried.
  • Caffeine was purchased from Sigma Chemical Corporation (St. Louis, MO, USA).
  • Apigenin 50 wt% and green tea extract 50 wt% were mixed to prepare a 20 ppm composition.
  • compositions as described in Table 1 below were prepared at 20 ppm each.
  • the Wnt reporter cell line was seeded at 1x10 4 cells / well in a 96well plate on a white / clear flat bottom coated with Collagen type I.
  • compositions of Examples and Comparative Examples were treated at 100 ⁇ l for each concentration.
  • a positive control 10 mM of LiCl was used (depending on the cell state, 10 mM shows 150-300% of control compared to control, and 50mM shows 1000-4000% of activity compared to control).
  • ONE-Glo TM Luciferase Assay reagent 100 ⁇ L was added and the light was blocked and reacted for 3 minutes at room temperature.
  • the value obtained by converting the luminescence intensity of the material treatment group to the control group as a percentage value was taken as a response ratio (%).
  • the larger the response ratio the better the Wnt signal transduction activity.
  • a composition comprising a combination of apigenin and caffeine in Example 1, a combination of apigenin and ginseng extract in Example 2, and a combination of apigenin and green tea extract in Example 3 has Wnt signal transduction activity. You can see that it is excellent.
  • composition comprising a combination of apigenin and caffeine in Example 1, a combination of apigenin and ginseng extract in Example 2, and a combination of apigenin and green tea extract in Example 3, synergistic action by combination of each component As a result, it was confirmed that the efficiency of Wnt signaling was greatly improved.

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Abstract

La présente invention porte sur une composition favorisant la régénération cutanée et la poussée capillaire, contenant de l'apigénine. Plus particulièrement, la composition favorisant la régénération cutanée et la poussée capillaire favorise la différenciation cellulaire par la signalisation Wnt/β-caténine, présentant ainsi des effets favorisant la régénération cutanée et la régénération capillaire.
PCT/KR2019/015615 2018-11-15 2019-11-15 Composition favorisant la régénération cutanée et la poussée capillaire, contenant de l'apigénine WO2020101414A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201980074400.8A CN113015513B (zh) 2018-11-15 2019-11-15 包含芹菜素的皮肤再生以及毛发生长促进用组合物

Applications Claiming Priority (2)

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KR10-2018-0140423 2018-11-15
KR1020180140423A KR102645621B1 (ko) 2018-11-15 2018-11-15 아피게닌을 포함하는 피부 재생 및 육모 촉진용 조성물

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WO2020101414A1 true WO2020101414A1 (fr) 2020-05-22

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CN111973583A (zh) * 2020-07-29 2020-11-24 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用
WO2023105103A1 (fr) 2022-06-17 2023-06-15 Mesoestetic Pharma Group, S.L Composition cosmétique synergique pour la dépigmentation de la peau

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US20030105031A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Methods for the treatment of skin disorders
KR101090593B1 (ko) * 2009-04-21 2011-12-08 이정남 모시풀을 이용한 탈모방지용 한방추출물 및 이를 이용한 탈모방지 샴푸
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111973583A (zh) * 2020-07-29 2020-11-24 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用
WO2023105103A1 (fr) 2022-06-17 2023-06-15 Mesoestetic Pharma Group, S.L Composition cosmétique synergique pour la dépigmentation de la peau

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