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WO2016043462A3 - 칼코부트롤의 제조방법 - Google Patents

칼코부트롤의 제조방법 Download PDF

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Publication number
WO2016043462A3
WO2016043462A3 PCT/KR2015/009413 KR2015009413W WO2016043462A3 WO 2016043462 A3 WO2016043462 A3 WO 2016043462A3 KR 2015009413 W KR2015009413 W KR 2015009413W WO 2016043462 A3 WO2016043462 A3 WO 2016043462A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcobutrol
highly pure
preparing
gadobutrol
present
Prior art date
Application number
PCT/KR2015/009413
Other languages
English (en)
French (fr)
Other versions
WO2016043462A2 (ko
Inventor
임근조
장순기
변창호
윤회진
김문수
Original Assignee
에스티팜 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에스티팜 주식회사 filed Critical 에스티팜 주식회사
Priority to EP15842251.9A priority Critical patent/EP3196196B1/en
Priority to JP2017514915A priority patent/JP6389565B2/ja
Priority to PL15842251T priority patent/PL3196196T3/pl
Priority to CN201580054809.5A priority patent/CN107108532B/zh
Priority to US15/511,882 priority patent/US9822084B2/en
Priority to ES15842251T priority patent/ES2718930T3/es
Publication of WO2016043462A2 publication Critical patent/WO2016043462A2/ko
Publication of WO2016043462A3 publication Critical patent/WO2016043462A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/04—Calcium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

본 발명은 고순도의 가도부트롤을 이용하지 않고 가도부트롤의 중간체(부트롤)를 이용하여 고순도의 칼코부트롤을 제조하는 신규한 방법을 제공한다. 본 발명은 간단하고 친환경적인 공정을 통해 높은 순도를 가지는 칼코부트롤을 높은 수율로 수득할 수 있어 대량 생산에 용이하게 적용될 수 있다.
PCT/KR2015/009413 2014-09-17 2015-09-07 칼코부트롤의 제조방법 WO2016043462A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP15842251.9A EP3196196B1 (en) 2014-09-17 2015-09-07 Method for preparing calcobutrol
JP2017514915A JP6389565B2 (ja) 2014-09-17 2015-09-07 カルコブトロールの製造方法
PL15842251T PL3196196T3 (pl) 2014-09-17 2015-09-07 Sposób wytwarzania kalcobutrolu
CN201580054809.5A CN107108532B (zh) 2014-09-17 2015-09-07 制备考布曲钙的方法
US15/511,882 US9822084B2 (en) 2014-09-17 2015-09-07 Method for preparing calcobutrol
ES15842251T ES2718930T3 (es) 2014-09-17 2015-09-07 Método de preparación de calcobutrol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140123532A KR101693400B1 (ko) 2014-09-17 2014-09-17 칼코부트롤의 제조방법
KR10-2014-0123532 2014-09-17

Publications (2)

Publication Number Publication Date
WO2016043462A2 WO2016043462A2 (ko) 2016-03-24
WO2016043462A3 true WO2016043462A3 (ko) 2016-07-28

Family

ID=55533979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/009413 WO2016043462A2 (ko) 2014-09-17 2015-09-07 칼코부트롤의 제조방법

Country Status (10)

Country Link
US (1) US9822084B2 (ko)
EP (1) EP3196196B1 (ko)
JP (1) JP6389565B2 (ko)
KR (1) KR101693400B1 (ko)
CN (1) CN107108532B (ko)
ES (1) ES2718930T3 (ko)
PL (1) PL3196196T3 (ko)
PT (1) PT3196196T (ko)
TR (1) TR201907789T4 (ko)
WO (1) WO2016043462A2 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
MX2019003540A (es) * 2016-09-27 2019-08-14 Bayer Pharma AG Metodo para producir la forma cristalina de modificacion a de calcobutrol.
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR20190088793A (ko) 2018-01-19 2019-07-29 주식회사 엔지켐생명과학 칼코부트롤의 제조방법
EP3820853A4 (en) * 2018-07-10 2022-08-17 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF 2,2',2''-( 10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECAN-1,4 ,7-TRIYL)-TRIACETIC ACID AND THEIR COMPLEXES
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
EP3883613A1 (en) * 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법
KR20210114742A (ko) * 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100269081B1 (ko) * 1992-06-04 2000-10-16 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 N-베타-히드록시알킬-트리-n-카르복시알킬-1,4,7,10-테트라아자시클로도데칸및n-베타-히드록시알킬-트리-n-카르복시알킬-1,4,8,11-테트라아자시클로테트라데칸유도체및그들의금속착화합물의제조방법
KR20110058746A (ko) * 2009-11-04 2011-06-01 바이엘 쉐링 파마 악티엔게젤샤프트 칼코부트롤의 제조 방법
KR20140035911A (ko) * 2011-04-21 2014-03-24 바이엘 인텔렉쳐 프로퍼티 게엠베하 고순도 가도부트롤의 제조
KR20140097411A (ko) * 2011-11-25 2014-08-06 바이오포어 인디아 파머슈티컬스 피브이티. 엘티디. 폴리아미노카르복실레이트의 정제 공정

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100269081B1 (ko) * 1992-06-04 2000-10-16 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 N-베타-히드록시알킬-트리-n-카르복시알킬-1,4,7,10-테트라아자시클로도데칸및n-베타-히드록시알킬-트리-n-카르복시알킬-1,4,8,11-테트라아자시클로테트라데칸유도체및그들의금속착화합물의제조방법
KR20110058746A (ko) * 2009-11-04 2011-06-01 바이엘 쉐링 파마 악티엔게젤샤프트 칼코부트롤의 제조 방법
KR20140035911A (ko) * 2011-04-21 2014-03-24 바이엘 인텔렉쳐 프로퍼티 게엠베하 고순도 가도부트롤의 제조
KR20140097411A (ko) * 2011-11-25 2014-08-06 바이오포어 인디아 파머슈티컬스 피브이티. 엘티디. 폴리아미노카르복실레이트의 정제 공정

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PLATZEK, J. ET AL.: "Synthesis and Structure of a New Macrocyclic Polyhydroxylated Gadolinium Chelate Used as a Contrast Agent for Magnetic Resonance Imaging", INORGANIC CHEMISTRY, vol. 36, 1997, pages 6086 - 6093, XP002199426 *

Also Published As

Publication number Publication date
WO2016043462A2 (ko) 2016-03-24
EP3196196A2 (en) 2017-07-26
EP3196196B1 (en) 2019-02-27
US9822084B2 (en) 2017-11-21
CN107108532B (zh) 2020-05-12
JP2017530971A (ja) 2017-10-19
EP3196196A4 (en) 2018-04-18
KR20160032872A (ko) 2016-03-25
PT3196196T (pt) 2019-05-30
TR201907789T4 (tr) 2019-06-21
PL3196196T3 (pl) 2019-09-30
JP6389565B2 (ja) 2018-09-12
CN107108532A (zh) 2017-08-29
KR101693400B1 (ko) 2017-01-05
ES2718930T3 (es) 2019-07-05
US20170260148A1 (en) 2017-09-14

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