WO2010024852A1 - Gene expression profiles associated with lean phenotype and uses thereof - Google Patents

Abstract

Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed

Description

GENE EXPRESSION PROFILES ASSOCIATED WITH LEAN PHENOTYPE AND USES THEREOF

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional Application Serial No. 61/190369 filed

August 28, 2008, the disclosure of which is incorporated herein by reference.

BACKGROUND OF THE INVENTION

Field of the Invention

[0002] The invention relates generally to nutritional or pharmaceutical modulation of body composition and particularly to gene expression profiles associated with improved or maintained lean body mass or reduced body fat and the use of such profiles for the identification of pharmaceutical, nutraceutical, or dietary substances that modulate or contribute to desired phenotypes in animals.

Description of the Related Art

[0003] Body weight is primarily a function of lean body mass and fat mass in an individual. Lean body mass is the weight of bones, muscles, organs, body water, and all other non-fat constituents of the body. Fat mass is the weight of the body's storage lipids. Disproportionate or excessive fat mass is a hallmark for an individual being overweight or obese.

[0004] Excess fat mass and obesity are recognized as a worldwide health problem among humans. The World Health Organization estimates that there are over 1 billion overweight adults, with just under one third of them classified as obese. In addition, obesity is also increasingly recognized as a problem for animals, particularly for companion animals such as dogs and cats. According to the Centers for Disease Control (CDC), obesity is closely associated with at least a risk of other health problems, including hypertension, dyslipidemia, Type II diabetes, heart disease, stroke, sleep apnea, and certain cancers such as breast, endometrial, and colon cancers. Risk factors for an individual becoming obese include genetics, emotions/stress, overeating, and a sedentary lifestyle.

[0005] Enhancing lean body mass can enhance the body's basal metabolic rate. Enhancing metabolic rate can facilitate the loss of excess fat mass when dietary caloric intake is insufficient to meet the body's energy needs or can reduce the accumulation of fat mass when dietary caloric intake exceeds the body's maintenance energy requirement. Various approaches to increase lean body mass have been described. One such approach is dietary supplementation with conjugated linoleic acid (CLA). CLA is a term used to describe isomers of octadecdienoic acid that are found in many foods such as dairy products (Terpstra AHM (2004) Am. J. Clin. Nutr. 79:352-61). CLA has been shown to reduce fat mass in mice and humans and has been implicated in an increase in lean body mass (Bhattacharya A et al. (2005) J. Nutr. 135: 1 124- 30; Gaullier J-M et al. (2004) Am. J. Clin. Nutr. 79: 1118-25; Blankson H et al. (2000) J. Nutr. 130:2943- 8; and, Park Y et al. (1997) Lipids 32:853-8). Another approach to increase lean body mass is consumption of a high protein diet. Studies suggest that diets with higher protein content, coupled with reduced carbohydrate consumption and/or regular exercise, can enhance the loss of fat mass and reduce the loss of lean body mass (Layman DK et al. (2005) J. Nutr. 135: 1903-10; Layman DK et al. (2004) J. Nutr. 134:968S-73S; Marsset-Baglieri A et al. (2004) J. Nutr. 134:2646-52; and, Due A et al. (2004) Int. J. Obes. Relat. Metab. Disord. 28: 1283-90). A third approach to increase lean body mass and decrease fat mass is regular exercise (Bhattacharya A et al. (2005) J. Nutr. 135: 1124-30; Layman DK et al. (2005) J. Nutr. 135: 1903-10; and, Tsai AC et al. (2003) J. Nutr. Biochem. 14:541-9).

[0006] Various studies have evaluated different aspects of the genetics of lean body mass and obesity. Association studies have revealed links between bodyweight, overweight, and obesity and polymorphisms in various genes (Chagnon YC et al. (2003) Obesity Res. 1 1 :313-67). Similarly, association studies have identified genes relating to body fat mass, percentage of body fat, and skin folds, body fat distribution (waist-to-hip ratio, waist circumference, etc.), resting energy expenditure, and adipocyte lipolysis (Chagnon YC et al. (2003) Obesity Res. 1 1 :313-67). In addition, studies have evaluated associations between candidate genes and changes in body weight, including genes associated with spontaneous weight gain over time, genes associated with endurance training-induced changes in fat mass, and genes associated with weight loss during a three year lifestyle change (Chagnon YC et al. (2003) Obesity Res. 1 1 :313-67). A listing of all such genes can be found in the prior art (Chagnon YC et al. (2003) Obesity Res. 1 1 :313-67). Studies have also analyzed the genetic aspects of lean body mass. Lean body mass studies have linked polymorphisms in Type 1 Deiodinase with higher lean body mass and muscle strength (Peeters RP et al. (2005) J. Clin. Endocrinol. 90:256-63), and polymorphisms in the glucocorticoid receptor with higher muscle mass and muscle strength (van Rossum EFC et al. (2004) J. Clin. Endocrinol. 89:4004-9).

[0007] Although lean body mass and fat mass are directly related, few studies have attempted to explore the genetic mechanisms that mediate a higher proportion of one type relative to the other. A detailed knowledge of these mechanisms would provide a better understanding of the conditions that favor a high level of lean body mass and/or reduced body fat and would provide a better understanding of how to promote a lean phenotype in an animal. Because a higher proportion of lean body mass, especially relative to fat mass, has positive implications for improved health and decreased risk for obesity-related ailments, it is desirable for an individual to increase the ratio of lean body mass to fat mass, either by increasing lean body mass and/or by reducing body fat.

SUMMARY OF THE INVENTION

[0008] It is, therefore, an object of the invention to provide one or more genes or gene segments that are differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype- promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise.

[0009] It is another object of the invention to provide a combination comprising a plurality of polynucleotides that are differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise.

[0010] It is another object of the invention to provide compositions of two or more polynucleotide or polypeptide probes suitable for detecting the expression of genes differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, and devices such as substrate arrays containing the probes.

[0011] It is a further object of the invention to provide methods for detecting differential expression of one or more genes differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, as compared with normal or untreated animals. [0012] It is another object of the invention to provide a method for measuring the effect of a test substance (e.g., lean body mass promoting nutrients or bioactives) on the expression profile of one or more genes differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, as compared with normal or untreated animals. [0013] One or more of these other objects are achieved using novel combinations of polynucleotides or polypeptides representing genes and gene segments that are differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise. The polynucleotides are used to produce compositions, probes, devices based on the probes, and methods for determining the status of polynucleotides differentially expressed in animals exhibiting a lean phenotype as compared to normal or untreated animals, which are useful for achieving the above- identified objects, e.g., prognosing and diagnosing conditions relating to the phenotype and for screening substances to determine if they are likely to be useful for promoting the phenotype. Such substances, once identified, may be used to promote the phenotype. Various kits comprising combinations of probes, devices utilizing the probes, and substances are also provided, as are various computer programs for manipulating information, and communication media for communicating information pertaining to the differentially expressed genes and methods of their use.

[0014] Other and further objects, features, and advantages of the invention will be readily apparent to those skilled in the art.

DETAILED DESCRIPTION OF THE INVENTION

Definitions

[0015] All percentages expressed herein are by weight of the composition on a dry matter basis unless specifically stated otherwise. The skilled artisan will appreciate that the term "dry matter basis" means that an ingredient's concentration in a composition is measured after any free moisture in the composition is removed.

[0016] As used throughout, ranges are used herein as shorthand, so as to avoid having to set out at length and describe each and every value within the range. Any appropriate value within the range can be selected, where appropriate, as the upper value, lower value, or the terminus of the range. It is understood that any and all whole or partial integers between any ranges or intervals set forth herein are included herein.

[0017] As used herein and in the appended claims, the singular form of a word includes the plural, and vice versa, unless the context clearly dictates otherwise. Thus, the references "a," "an," and "the" are generally inclusive of the plurals of the respective terms. For example, reference to "an animal", "a method", or "a substance" includes a plurality of such "animals", "methods", or "substances". Similarly, the words "comprise", "comprises", and "comprising" are to be interpreted inclusively rather than exclusively.

[0018] The term "animal" means a human or other animal, including avian, bovine, canine, equine, feline, hicrine, murine, ovine, and porcine animals, that has adipose tissue. When the term is used in the context of comparing test subjects, the animals that are compared are animals of the same species and possibly of the same race or breed. A "companion animal" is any domesticated animal, and includes, without limitation, cats, dogs, rabbits, guinea pigs, ferrets, hamsters, mice, gerbils, horses, cows, goats, sheep, donkeys, pigs, and the like. Preferably, the animal is a human or a companion animal such as a canine or feline.

[0019] The term "antibody" means any immunoglobulin that binds to a specific antigen, including IgG, IgM, IgA, IgD, and IgE antibodies. The term includes polyclonal, monoclonal, monovalent, humanized, heteroconjugate, antibody compositions with polyepitopic specificity, chimeric, bispecific antibodies, diabodies, single-chain antibodies, and antibody fragments such as Fab, Fab', F(ab')2, and Fv, or other antigen-binding fragments. [0020] The term "array" means an ordered arrangement of at least two probes on a substrate. At least one of the probes is a control or standard and at least one of the probes is a diagnostic probe. The arrangement of from about two to about 40,000 probes on a substrate assures that the size and signal intensity of each labeled complex formed between a probe and a sample polynucleotide or polypeptide is individually distinguishable.

[0021] The term "binding complex" refers to a complex formed when a polypeptide in a sample specifically binds (as defined herein) to a binding partner, such as an antibody or functional fragment thereof.

[0022] The term "dietary supplement" means a product that is intended to be ingested in addition to the normal diet of an animal. Dietary supplements may be in any form - e.g., solid, lid, gel, tablets, capsules, powder, and the like. Preferably they are provided in convenient dosage forms. In some embodiments they are provided in bulk consumer packages such as bulk powders or liquids. In other embodiments, supplements are provided in bulk quantities to be included in other food items such as snacks, treats, supplement bars, beverages and the like.

[0023] The term "differential expression" or "differentially expressed" means increased or unregulated gene expression or means decreased or downregulated gene expression as detected by the absence, presence, or at least statistically significant in the amount of transcribed messenger RNA or translated protein in a sample.

[0024] The term "food" or "food composition" means a composition that is intended for consumption by an animal, including a human, and provides nutrition thereto. A "food product formulated for human consumption" is any composition specifically intended for ingestion by a human being. "Pet foods" are compositions intended for consumption by pets, preferably by companion animals. A "complete and nutritionally balanced pet food," is one that contains all known required nutrients for the intended recipient or consumer of the food, in appropriate amounts and proportions, based for example on recommendations of recognized authorities in the field of companion animal nutrition. Such foods are therefore capable of serving as a sole source of dietary intake to maintain life or promote production, without the addition of supplemental nutritional sources. Nutritionally balanced pet food compositions are widely known and widely used in the art.

[0025] The term "fragment" means (1) an oligonucleotide or polynucleotide sequence that is a portion of a complete sequence and that has the same or similar activity for a particular use as the complete polynucleotide sequence or (2) a peptide or polypeptide sequence that is a portion of a complete sequence and that has the same or similar activity for a particular use as the complete polypeptide sequence. Such fragments can comprise any number of nucleotides or amino acids deemed suitable for a particular use.

Generally, oligonucleotide or polynucleotide fragments contain at least about 10, 50, 100, or 1000 nucleotides and polypeptide fragments contain at least about 4, 10, 20, or 50 consecutive amino acids from the complete sequence. The term encompasses polynucleotides and polypeptides variants of the fragments.

[0026] The term "gene" or "genes" means a complete or partial segment of DNA involved in producing a polypeptide, including regions preceding and following the coding region (leader and trailer) and intervening sequences (introns) between individual coding segments (exons). The term encompasses any

DNA sequence that hybridizes to the complement of gene coding sequences.

[0027] The term "gene product" means the product of transcription of a gene, such as mRNA or derivatives thereof (e.g., cDNA), or translation of a gene transcript. The term "gene product" generally refers to the translation product, which is a protein. The term "gene product" may be used interchangeably with the term "protein" herein.

[0028] The term "high protein diet" refers to a diet comprising foods or dietary supplements that result in an animal's intake of protein on a regular basis being at least about 10% higher than a comparable control animal. In certain embodiments, the animal's protein intake may be 20, 30, 40, 50, 60, 70, 80, 90 or 100% (i.e., two-fold in the latter case) higher than that of a comparable control animal. In other embodiments, the animal's protein intake may be three- or four-fold or more higher than that of a comparable control animal. Typically, a high protein diet is formulated to comprise the same calorie intake as a regular diet. Often, but not always, this is accomplished by lowering the carbohydrate content of the diet. Alternatively or in addition, the fat content of the diet may be lowered. In particular embodiments, the protein content of a high protein diet may comprise at least about 25% of the total calories as protein. In other embodiments, the protein content of a high protein diet may comprise at least about 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75% or 80% of the total calories as protein. [0029] The term "homolog" means (1) a polynucleotide, including polynucleotides from the same or different animal species, having greater than 30%, 50%, 70%, or 90% sequence similarity to a reference polynucleotide, and having the same or substantially the same properties and performing the same or substantially the same function as the reference polynucleotide, or having the capability of specifically hybridizing to a reference polynucleotide under stringent conditions or (2) a polypeptide, including polypeptides from the same or different animal species, having greater than 30%, 50%, 70%, or 90% sequence similarity to a reference polypeptide and having the same or substantially the same properties and performing the same or substantially the same function as the reference polypeptide, or having the capability of specifically binding to a reference polypeptide. When referring to fragments of full length coding sequences, the function of those fragments may simply be to encode a selected portion of a polypeptide of a certain sequence, or to be of suitably similar sequence to hybridize to another polynucleotide fragment encoding that polypeptide. When referring to fragments of polypeptides, the function of those fragments may simply be to form an epitope suitable for generation of an antibody. Sequence similarity of two polypeptide sequences or of two polynucleotide sequences is determined using methods known to skilled artisans, e.g., the algorithm of Karlin and Altschul (Proc. Natl. Acad. Sci. USA 87:2264-2268 (1990)). Such an algorithm is incorporated into the NBLAST and XBLAST programs of Altschul et al. (J. MoI. Biol. 215:403-410 (1990)). To obtain gapped alignments for comparison purposes, Gapped Blast can be utilized as described in Altschul et al. (Nucl. Acids Res. 25: 3389-3402 (1997)). When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) are used. See http://ww.ncbi.nlm.nih.gov.

[0030] The term "hybridization complex" means a complex that is formed between sample polynucleotides when the purines of one polynucleotide hydrogen bond with the pyrimidines of the complementary polynucleotide, e.g., 5'-A-G-T-C-3' base pairs with 3'-T-C-A-G-5'. The degree of complementarily and the use of nucleotide analogs affect the efficiency and stringency of hybridization reactions.

[0031] The term "increased exercise" refers to an increase in physical activity of least about 10% higher than that of a comparable control animal in the same period of time. In certain embodiments, the animal's physical activity may be 20, 30, 40, 50, 60, 70, 80, 90 or 100% (ι.e., two-fold in the latter case) higher than that of a comparable control animal. In other embodiments, the animal's activity may be three- or four-fold or more higher than that of a comparable control animal. An animal's physical activity may be measured by a variety of techniques well known to the person of skill in the art. [0032] The term "individual" when referring to an animal means an individual animal of any species or kind.

[0033] The term "lean phenotype" refers to any molecular, biochemical, physiologic, cellular, systemic, and physical effects observed in an animal resulting from the differential expression of genes that occurs when the animal exercises, consumes a specialized diet regimen such as a high protein diet, and/or is administered a compound, composition, or dietary supplement to modulate the expression of genes associated with increasing or maintaining lean body mass, and/or reducing body fat. An exemplary compound of this type is CLA. The term "lean phenotype" also includes the "transition to lean phenotype," which refers to any molecular, biochemical, physiologic, cellular, systemic, and physical effects observed in an animal resulting from the differential expression of genes that occurs when the animal is undergoing the change from normal (as defined below) to lean phenotype. [0034] The term "administration" means to administer a substance, a diet, or a test treatment (such as increased physical exercise) to an animal. Administration periods include terms consistent with the particular substance, diet, or treatment and the animal. "Long term administration" generally refers to periods in excess of one week. Periods of longer than two or three weeks, or one, two, three, or four months are contemplated. Also included are more extended periods that include longer than 5, 6, 7, 8, 9, or 10 months. Periods in excess of 1 1 months or 1 year are also included. Long term use extending over 1, 2, 3 years or more is also contemplated herein. In the case of certain animals, it is envisioned that the animal would be administered substances or treatment regimens identified by the present methods on a regular basis. "Regular basis" refers to at least monthly administration. More frequent administration, such as weekly or two or three times weekly is included. Also included are regimens that comprise at least once, twice, three times or more daily administration. Any dosing frequency, regardless of whether expressly exemplified herein, is considered useful. The skilled artisan will appreciate that dosing frequency will be a function of the substance that is being administered, and some compositions may require more or less frequent administration to maintain a desired biochemical, physiological or gene expression effects, namely effects including one or more of food intake, satiety, lipid metabolism, and fat utilization, and the gene expression profile associated therewith. The term "extended regular basis" refers to long term administration of a substance on a regular basis.

[0035] "Normal" as used in relation to animals manifesting a lean phenotype, refers to the absence of molecular, biochemical, physiologic, cellular, systemic, and physical effects resulting from the differential expression of genes associated with a lean phenotype.

[0036] The term "oral administration" means that an animal ingests, or a human is directed to feed, or does feed, the animal one or more of the substances described herein. The term "ingestion" is used herein interchangeably with the term "oral administration." The term "consumption" is also used herein to refer to ingestion of a substance, particularly a food composition, on an extended regular basis. When a human is directed to orally administer or feed the substance, such direction may be that which instructs and/or informs the human that use of the substance may and/or will provide the referenced benefit. Such direction may be oral direction (e.g., through oral instruction from, for example, a physician, veterinarian, or other health professional, or radio or television media (i.e., advertisement), or written direction (e.g., through written direction from, for example, a physician, veterinarian, or other health professional (e.g., prescriptions), sales professional or organization (e.g., through, for example, marketing brochures, pamphlets, or other instructive paraphernalia), written media (e.g., internet, electronic mail, or other computer-related media), and/or packaging associated with the substance. [0037] The term "polynucleotide" or "oligonucleotide" means a polymer of nucleotides. The term encompasses DNA and RNA (including cDNA and mRNA) molecules, either single or double stranded and, if single stranded, its complementary sequence in either linear or circular form. The term also encompasses fragments, variants, homologs, and alleles, as appropriate for the sequences, which have the same or substantially the same properties and perform the same or substantially the same function as the original sequence. In particular, the term encompasses homologs from different species, e.g., a mouse and a dog or cat. The sequences may be fully complementary (no mismatches) when aligned or may have up to about a 30% sequence mismatch. Preferably, for polynucleotides, the chain contains from about 50 to 10,000 nucleotides, more preferably from about 150 to 3,500 nucleotides. Preferably, for oligonucleotides, the chain contains from about 2 to 100 nucleotides, more preferably from about 6 to 30 nucleotides. The exact size of a polynucleotide or oligonucleotide will depend on various factors and on the particular application and use of the polynucleotide or oligonucleotide. The term includes nucleotide polymers that are synthesized and that are isolated and purified from natural sources. The term "polynucleotide" is inclusive of "oligonucleotide."

[0038] The term "polypeptide," "peptide," or "protein" means a polymer of amino acids. The term encompasses naturally occurring and non-naturally occurring (synthetic) polymers and polymers in which artificial chemical mimetics are substituted for one or more amino acids. The term also encompasses fragments, variants, and homologs that have the same or substantially the same properties and perform the same or substantially the same function as the original sequence. The term encompass polymers of any length, preferably polymers containing from about 2 to 1000 amino acids, more preferably from about 5 to 500 amino acids. The term includes amino acid polymers that are synthesized and that are isolated and purified from natural sources.

[0039] The term "probe" means (1) an oligonucleotide or polynucleotide, either RNA or DNA, whether occurring naturally as in a purified restriction enzyme digest or produced synthetically, that is capable of annealing with or specifically hybridizing to a polynucleotide with sequences complementary to the probe or (2) a compound or substance, including a peptide or polypeptide, capable of specifically binding a particular protein or protein fragment to the substantial exclusion of other proteins or protein fragments. An oligonucleotide or polynucleotide probe may be either single or double stranded. The exact length of the probe will depend upon many factors, including temperature, source, and use. For example, for diagnostic applications, depending on the complexity of the target sequence, an oligonucleotide probe typically contains about 10 to 100, 15 to 50, or 15 to 25 nucleotides. In certain diagnostic applications, a polynucleotide probe contains about 100-1000, 300-600, nucleotides, preferably about 300 nucleotides. The probes herein are selected to be "substantially" complementary to different strands of a particular target sequence. This means that the probes must be sufficiently complementary to specifically hybridize or anneal with their respective target sequences under a set of predetermined conditions. Therefore, the probe sequence need not reflect the exact complementary sequence of the target. For example, a noncomplementary nucleotide fragment may be attached to the 5' or 3' end of the probe, with the remainder of the probe sequence being complementary to the target sequence. Alternatively, noncomplementary bases or longer sequences can be interspersed into the probe provided that the probe sequence has sufficient complementarity with the sequence of the target polynucleotide to specifically anneal to the target polynucleotide. A peptide or polypeptide probe may be any molecule to which the protein or peptide specifically binds, including DNA (for DNA binding proteins), antibodies, cell membrane receptors, peptides, cofactors, lectins, sugars, polysaccharides, cells, cell membranes, organelles and organellar membranes. [0040] The term "sample" means any animal tissue or fluid containing, e.g., polynucleotides, polypeptides, antibodies, metabolites, and the like, including cells and other tissue containing DNA and RNA. Examples include adipose, blood, cartilage, connective, epithelial, lymphoid, muscle, nervous, sputum, and the like. A sample may be solid or liquid and may be DNA, RNA, cDNA, bodily fluids such as blood or urine, cells, cell preparations or soluble fractions or media aliquots thereof, chromosomes, organelles, and the like.

[0041] The term "single package" means that the components of a kit are physically associated in or with one or more containers and considered a unit for manufacture, distribution, sale, or use. Containers include, but are not limited to, bags, boxes, bottles, shrink wrap packages, stapled or otherwise affixed components, or combinations thereof. A single package may be containers of individual food compositions physically associated such that they are considered a unit for manufacture, distribution, sale, or use.

[0042] The term "specifically bind" means a special and precise interaction between two molecules which is dependent upon their structure, particularly their molecular side groups. For example, the intercalation of a regulatory protein into the major groove of a DNA molecule, the hydrogen bonding along the backbone between two single stranded nucleic acids, or the binding between an epitope of a protein and an agonist, antagonist, or antibody.

[0043] The term "specifically hybridize" means an association between two single stranded polynucleotides of sufficiently complementary sequence to permit such hybridization under predetermined conditions generally used in the art (sometimes termed "substantially complementary"). For example, the term may refer to hybridization of a polynucleotide probe with a substantially complementary sequence contained within a single stranded DNA or RNA molecule according to an aspect of the invention, to the substantial exclusion of hybridization of the polynucleotide probe with single stranded polynucleotides of non-complementary sequence.

[0044] The term "standard" means (1) a control sample that contains tissue from an animal administered a control or reference substance, or no substance, as compared with a sample that contains tissue from an animal administered a test substance, for example, to determine if the test substance causes differential gene expression, as appropriate for the context of its use.

[0045] The term "stringent conditions" means (1) hybridization in 50% (vol/vol) formamide with 0.1% bovine serum albumin, 0.1% Ficoll, 0.1% polyvinylpyrrolidone, 50 mM sodium phosphate buffer at pH 6.5 with 750 mM NaCl, 75 mM sodium citrate at 42⁰C, (2) hybridization in 50% formamide, 5x SSC (0.75 M NaCl, 0.075 M sodium citrate), 50 mM sodium phosphate (pH 6.8), 0.1% sodium pyrophosphate, 5x Denhardt's solution, sonicated salmon sperm DNA (50 μg/ml), 0.1% SDS, and 10% dextran sulfate at 42°C; with washes at 42°C in 0.2x SSC and 0.1% SDS or washes with 0.015 M NaCl, 0.0015 M sodium citrate, 0.1% Na2SO4 at 50⁰C or similar procedures employing similar low ionic strength and high temperature washing agents and similar denaturing agents.

[0046] The term "variant" means (1) a polynucleotide sequence containing any substitution, variation, modification, replacement, deletion, or addition of one or more nucleotides from or to a polynucleotide sequence and that has the same or substantially the same properties and performs the same or substantially the same function as the original sequence and (2) a polypeptide sequence containing any substitution, variation, modification, replacement, deletion, or addition of one or more amino acids from or to a polypeptide sequence and that has the same or substantially the same properties and performs the same or substantially the same function as the original sequence. The term therefore includes single nucleotide polymorphisms (SNPs) and allelic variants and includes conservative and non-conservative amino acid substitutions in polypeptides. The term also encompasses chemical derivatization of a polynucleotide or polypeptide and substitution of nucleotides or amino acids with nucleotides or amino acids that do not occur naturally, as appropriate.

[0047] The term "virtual package" means that the components of a kit are associated by directions on one or more physical or virtual kit components instructing the user how to obtain the other components, e.g., in a bag containing one component and directions instructing the user to go to a website, contact a recorded message, view a visual message, or contact a caregiver or instructor to obtain instructions on how to use the kit.

[0048] The combinations, compositions, devices, methods, probes, and other advances disclosed herein are not limited to particular methodology, protocols, and reagents described herein because, as the skilled artisan will appreciate, they may vary. Further, the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to and does not limit the scope of that which is disclosed or claimed.

[0049] Unless defined otherwise, all technical and scientific terms, terms of art, and acronyms used herein have the meanings commonly understood by one of ordinary skill in the art in the field(s) of the invention, or in the field(s) where the term is used. Although any compositions, methods, articles of manufacture, or other means or materials similar or equivalent to those described herein can be used in the practice of the invention, the preferred compositions, methods, articles of manufacture, or other means or materials are described herein.

[0050] All patents, patent applications, publications, and other references cited or referred to herein are incorporated herein by reference to the extent allowed by controlling law. The discussion of those references is intended merely to summarize the assertions made therein. No admission is made that any such patents, patent applications, publications or references, or any portion thereof, is relevant, material, or prior art. The right to challenge the accuracy and pertinence of any assertion of such patents, patent applications, publications, and other references as relevant, material, or prior art is specifically reserved.

The Invention

[0051] The invention is based in part on the clear demonstration that treatments known to promote a lean phenotype as defined herein are associated with significant changes in the gene expression profiles in three different tissues of animals subjected to those treatments. The association was determined by comparing expression of the genes in normal tissue, namely muscle, liver and adipose tissue, with tissue from animals manifesting a lean phenotype (LP) as a result of one or more LP-promoting treatments, namely (1) administration of CLA, (2) consumption of a high protein diet, and/or (3) increased exercise. [0052] In one embodiment, several hundred genes were found to be differentially expressed as a result of all three treatments (sometimes referred to herein as "three treatments"); i.e., CLA supplementation, a high protein diet, or increased exercise caused the differential expression of this subset of genes, the encoded proteins of which are listed in Table 6 (Example 3) herein. The proteins set forth in Table 6 are divided into groups based upon different criteria. First, the proteins are listed by tissue in Table 6, representing genes differentially expressed in adipose tissue (Table 6A), liver (Table 6B) and muscle (quadriceps) (Table 6C). Table 6 also lists subsets of proteins representing genes differentially expressed in two or more of the three tissue types, namely (1) adipose and liver (Table 6D), (2) adipose and muscle (Table 6E), (3) liver and muscle (Table 6F), and (4) all three tissues (Table 6G). Second, the proteins are divided into groups based upon the function or physiological role of the encoded protein, as well as the tissue in which the differential expression occurs. Those groupings are set forth in Table 7 (adipose), Table 8 (liver) and Table 9 (muscle). Those functions include: (1) in adipose tissue, cholesterol biosynthetic pathway, statin pathway, adipogenesis, apoptosis, cell motility, mitochondrial fatty acid betaoxidation, fatty acid biosynthesis, fatty acid metabolism, glycolysis, regulation of cell proliferation, inflammation, immunity and stress response (including the subcategories of Rn T-cell receptor, Rn B-cell receptor, leukocyte transendothelial migration, tight junction, adherens junction, antigen processing, response to unfolded proteins, response to wounding, response to external stimulus, inflammatory response, immune response, T-cell activation and Rn IL-4), multicellular organismal development, and regulation of apoptosis; (2) in liver, PPAR signaling pathway, and fatty acid metabolism; and (3) in muscle, lipid metabolism.

[0053] In another embodiment, the high protein diet treatment, analyzed singly, was found to cause differential expression of several thousand genes. The proteins encoded by these genes are listed in Table 10 (Example 4) herein. As with the "three treatments" subset, the proteins set forth in Table 10 are divided into groups based upon different criteria. First, the proteins are listed by tissue in Table 10, representing genes differentially expressed in adipose tissue (Table 10A), liver (Table 10B) and muscle (quadriceps) (Table 10C). Table 10 also lists subsets of proteins representing genes differentially expressed in two or more of the three tissue types, namely (1) adipose and liver (Table 10D), (2) adipose and muscle (Table 10E), (3) liver and muscle (Table 10F), and (4) all three tissues (Table 10G). Second, the proteins are divided into groups based upon the function or physiological role of the encoded protein, as well as the tissue in which the differential expression occurs. Those groupings are set forth in Table 1 1 (adipose), Table 12 (liver) and Table 13 (muscle). Those functions include: (1) in adipose tissue, immune response, inflammatory response, response to stress, chemotaxis, response to unfolded protein, defense response, cell activation, lymphocyte activation, locomotory behavior, lipid metabolic process, lipid biosynthetic process, steroid biosynthetic process, cholesterol metabolic process, steroid metabolic process, glycolysis, glucose metabolic process, organ development, muscle development, positive regulation of cell proliferation, angiogenesis, blood vessel morphogenesis, anti-apoptosis, muscle contraction, phosphate transport, protein complex assembly, calcium-mediated signaling, regulation of GTPase activity, protein amino acid glycosylation, regulation of cell shape, Rattus norvegicus (Rn) B cell receptor NetPath 12 (Johns Hopkins University and the Institute of Bioinformatics (www.netpath.org/)), Rn T-cell receptor NetPath 1 1, Rn IL-4 NetPath 16, Rn IL-7 NetPath 19, Rn eicosanoid synthesis, Rn insulin signaling, Rn cholesterol biosynthesis, Rn fatty acid synthesis BiGCaT (University of Maastricht (www.bigcat.unimass.nl/index.html)), Rn Krebs-TCA cycle, Rn mitochondrial fatty acid betaoxidation, Rn striated muscle contraction, leukocyte transendothelial migration, T cell receptor signaling pathway, tight junction, B cell receptor signaling pathway, complement and coagulation cascades, Fc epsilon RI signaling pathway, toll-like receptor signaling pathway, PPAR signaling pathway, biosynthesis of steroids, glycolysis/gluconeogenesis, arachidonic acid metabolism, pyruvate metabolism, and riboflavin metabolism; (2) in liver, lipid metabolic process, fatty acid metabolic process, lipid biosynthetic process, fatty acid biosynthetic process, steroid metabolic process, proteolysis, carbohydrate metabolic process, glucose metabolic process, gluconeogenesis, amino acid metabolic process, amine metabolic process, nitrogen compound metabolic process, one-carbon compound metabolic process, xenobiotic metabolic process, sodium ion transport, multicellular organismal development, regulation of cell growth, myelination, regulation of progression through cell cycle, antigen processing and presentation, Rn adipogenesis, Rn fatty acid synthesis BiGCaT, Rn glycolysis and gluconeogenesis, Rn nuclear receptors in lipid metabolism and toxicity, Rn fatty acid beta oxidation 1 BiGCaT, Rn fatty acid omega oxidation BiGCaT, PPAR signaling pathway, metabolism of xenobiotics by cytochrome P450, fatty acid metabolism, alanine and aspartate metabolism, arginine and proline metabolism, pyruvate metabolism, glutamate metabolism, nitrogen metabolism, cysteine metabolism, and tyrosine metabolism; and (3) in muscle, immune response, defense response, inflammatory response, and Rn circadian exercise. [0054] Thus, a number of genes have been identified that are differentially expressed in animals manifesting a lean phenotype, resulting from LP-promoting treatments including a high protein diet, administration of CLA and/or increased exercise. Polynucleotides and fragments thereof that form these genes, as well as their encoded proteins and fragments, can be used, for example, in diagnostic or prognostic assays to measure a shift to a lean phenotype, or assays useful for screening test substances for their effectiveness to promote or support a lean phenotype.

[0055] In certain embodiments, expression of at least one differentially expressed gene is measured. In preferred embodiments, expression of two or more differentially expressed genes is measured, providing a gene expression pattern or gene expression profile. More preferably, measurement of a multiplicity of differentially expressed genes is performed, providing additional information for a gene expression pattern or profile.

[0056] In various embodiments of the invention, changes in gene expression may be measured in one or both of two ways: (1) measuring transcription through detection of mRNA produced by a particular gene; and (2) measuring translation through detection of protein produced by a particular transcript. [0057] Decreased or increased expression can be measured at the RNA level using any of the methods well known in the art for the quantitation of polynucleotides, such as, for example, PCR (including, without limitation, RT-PCR and qPCR), RNase protection, Northern blotting, microarray, macroarray, and other hybridization methods. The genes that are assayed or interrogated according to the invention are typically in the form of mRNA or reverse transcribed mRNA. The genes may be cloned and/or amplified. The cloning itself does not appear to bias the representation of genes within a population. However, it may be preferable to use polyA+ RNA as a source, as it can be used with fewer processing steps. [0058] Thus, in one aspect, the invention provides a combination comprising a plurality of polynucleotides or proteins expressed therefrom that are differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, wherein the polynucleotides are selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof.

[0059] In one embodiment, the polynucleotides are differentially expressed in each of the lean phenotype promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, and the polynucleotides are selected from genes encoding proteins listed in Table 6, or fragments thereof. In more specific embodiments, the polynucleotides are selected from genes encoding proteins listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof. In other embodiments, the polynucleotides are differentially expressed in adipose tissue and encode proteins involved in functions selected from those recited hereinabove and set forth in Table 7. In other embodiments, the polynucleotides are differentially expressed in liver and encode proteins involved in the functions recited hereinabove and set forth in Table 8. In yet another embodiment, the polynucleotides are differentially expressed in muscle and encode proteins involved in lipid metabolism, as set forth in Table 9. [0060] In another embodiment, the polynucleotides are differentially expressed in the lean phenotype promoting treatment comprising consumption of a high protein diet, and the polynucleotides are selected from genes encoding proteins listed in Table 10, or fragments thereof. In more specific embodiments, the polynucleotides are selected from genes encoding proteins listed in tissue-specific subsets of Table 10 selected from: Table 1OA, Table 1OB, Table 1OC, Table 1OD, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof. In other embodiments, the polynucleotides are differentially expressed in adipose tissue and encode proteins involved in functions selected from those recited above, and listed in Table 1 1. In other embodiments, the polynucleotides are differentially expressed in liver and encode proteins involved in functions selected from those recited above and set forth in Table 12. In yet another embodiment, the polynucleotides are differentially expressed in muscle and encode proteins involved in functions selected from those recited above and listed in Table 13.

[0061] In one embodiment, the combination comprises two or more polynucleotides or proteins expressed from the polynucleotides. Preferably, the combination comprises a plurality of polynucleotides or proteins expressed from polynucleotides, generally about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100 or more polynucleotides or proteins, or fragments thereof, as appropriate for a particular Group and use. When the combination comprises one or more fragments, the fragments can be of any size that retains the properties and function of the original polynucleotide or protein, preferably from about 30%, 60%, or 90% of the original.

[0062] The polynucleotides and proteins can be from any animal, preferably canines and felines, most preferable canines. Homologs of the polynucleotides and proteins from different animal species are obtainable by standard information mining and molecular methods well known to the skilled artisan. For example, the name, or description of function of a gene or protein may be entered into one of several publicly available databases, which will generate a list of sources providing information about that gene from different species, including sequence information. One such database is the "Information Hyperlinked over Proteins (iHOP) database, which is accessible on the internet via the url: ihop-net.org. Alternatively, a public database accession number of a known gene or protein may be utilized to access sequence information for that gene or protein and to search for homologs or orthologs in other species using a sequence comparison search. For example, the GenBank accession number of a gene or protein from mouse may be entered into the National Institutes of Health's National Center for Biotechnology Information (NCBI) database, thereby accessing DNA or polypeptide sequences for that mouse gene. Using the same database, a BLAST search may be performed on the mouse DNA or protein sequence, or fragments thereof of sufficient length to define the gene or protein, to identify sequences of sufficient homology from other species, e.g., a canine. Accession numbers of the sequences from the other species of interest may then be entered into the database to obtain information pertaining to those full-length nucleotide or protein sequences, as well as other descriptive information.

[0063] In another aspect, the invention provides a composition comprising two or more probes for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, wherein the probes comprise (a) polynucleotides that specifically hybridize to two or more genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, or (b) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins listed in Table 6 (genes differentially expressed in all three treatments) or Table 10 (genes differentially expressed in high protein diet treatment), or fragments thereof.

[0064] In certain embodiments, the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof. In other embodiments, the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins having certain functions or biochemical roles, as listed in Table 7, Table 8 or Table 9. [0065] In other embodiments, the probes specifically hybridize to genes encoding proteins listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 1OD, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof. In other embodiments, the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins having certain functions or biochemical roles, as listed in Table 11, Table 12 or Table 13.

[0066] Preferably, the composition comprises a plurality of probes, generally about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 200, 500 or more probes for detecting the polynucleotides or proteins, or fragments thereof, as appropriate for a particular Group and use. It will be understood by the skilled artisan that multiple different probes for a single target gene or protein may be utilized, in order to refine the sensitivity or accuracy of an assay utilizing the probes. For example, several oligonucleotide probes, specifically hybridizing to different sequences on a target polynucleotide, may be employed. Likewise, several antibodies, immunologically specific for different epitopes on a target protein, may be utilized. [0067] One or more oligonucleotide or polynucleotide probes for interrogating a sample may be prepared using the sequence information for any of the genes listed herein, from any species, preferably canine or feline. The probes should be of sufficient length to specifically hybridize substantially exclusively with appropriate complementary genes or transcripts. In certain embodiments, the oligonucleotide probes will be at least about 10, 12, 14, 16, 18, 20 or 25 nucleotides in length. In some embodiments, longer probes of at least about 30, 40, 50, 60, 70, 80, 90 or 100 nucleotides are desirable, and probes longer than about 100 nucleotides may be suitable in some embodiments. The probes may comprise full length sequences encoding functional proteins. The nucleic acid probes are made or obtained using methods known to skilled artisans, e.g., in vitro synthesis from nucleotides, isolation and purification from natural sources, or enzymatic cleavage of the polynucleotides of the invention. [0068] Hybridization complexes comprising nucleic acid probes hybridized to a polynucleotide of the invention may be detected by a variety of methods known in the art. In certain embodiments of the invention, immobilized nucleic acid probes may be used for the rapid and specific detection of polynucleotides and their expression patterns. Typically, a nucleic acid probe is linked to a solid support and a target polynucleotide (e.g., a gene, a transcription product, an amplicon, or, most commonly, an amplified mixture) is hybridized to the probe. Either the probe, or the target, or both, can be labeled, typically with a fluorophore or other tag, such as streptavidin. Where the target is labeled, hybridization may be detected by detecting bound fluorescence. Where the probe is labeled, hybridization is typically detected by quenching of the label. Where both the probe and the target are labeled, detection of hybridization is typically performed by monitoring a color shift resulting from proximity of the two bound labels. A variety of labeling strategies, labels, and the like, particularly for fluorescent based applications, are known in the art.

[0069] In another embodiment, the probes comprise polypeptide binding agents that specifically bind to polypeptides produced by expression of one or more of the polypeptides listed herein, or fragments thereof. Such protein binding probes may be prepared using the sequence information available for any of the proteins identified in Table 6 and Table 10, or fragments thereof. [0070] Assay techniques that can be used to determine levels of a protein in a sample are also well known to those of skill in the art. Such assay methods include radioimmunoassays, competitive-binding assays, Western blot analysis and ELISA assays. In the assay methods utilizing antibodies, both polyclonal and monoclonal antibodies are suitable for use in the invention. Such antibodies may be immunologically specific for a particular protein, or an epitope of the protein, or a protein fragment, as would be well understood by those of skill in the art. Methods of making polyclonal and monoclonal antibodies immunologically specific for a protein or peptide are also well known in the art. [0071] Preferred embodiments of the invention may utilize antibodies for the detection and quantification of proteins produced by expression of the genes described herein. Though proteins may be detected by immunoprecipitation, affinity separation, Western blot analysis and the like, a preferred method utilizes ELISA-type methodology wherein the antibody is immobilized on a solid support and a target protein or peptide is exposed to the immobilized antibody. Either the probe, or the target, or both, can be labeled. A variety of labeling strategies, labels, and the like, are known in the art. [0072] In another aspect, the invention provides a device comprising a solid support to which is affixed an array comprising a plurality of probes for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise. In particularly preferred embodiments of the invention, expression patterns or profiles of a plurality of genes differentially expressed in lean versus normal phenotypes as defined herein, are observed utilizing arrays of probes for detecting target polynucleotides or proteins. The device may be used to detect differential expression of genes encoding the gene products set forth in Table 6 or table 10, or in subsets thereof, namely tissue-specific subsets as listed in Table 6A-G and Table 10A-G, or functional subsets as set forth in Tables 7, 8 and 9 (for three-treatment analysis) and Tables 1 1, 12 and 13 (for high protein diet analysis). In a preferred embodiment, the device is uses to detect differential expression of genes from canines or felines.

[0073] In one embodiment, arrays of oligonucleotide or polynucleotide probes may be utilized, whereas another embodiment may utilize arrays of antibodies or other proteins that bind specifically to the differentially expressed gene products. Such arrays may be custom made according to known methods, such as, for example, in-situ synthesis on a solid support or attachment of pre-synthesized probes to a solid support via micro-printing techniques. In preferred embodiments, arrays of nucleic acid or protein- binding probes are custom made to specifically detect transcripts or proteins produced by two or more of the differentially expressed genes or gene fragments described herein.

[0074] In a further aspect, the invention provides a method for detecting differential expression of one or more genes differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, as compared with normal or untreated animals. The method generally comprises: (a) providing probes comprising (i) polynucleotides that specifically hybridize to two or more genes encoding proteins listed in Table 6 or Table 10, or fragments thereof; or (ii) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins listed in Table 6 or Table 10, or fragments thereof; (b) adding the probes to a sample comprising mRNA or proteins from an animal exhibiting the lean phenotype, in a manner enabling hybridization or binding of the probes to the mRNA or proteins in the sample, thereby forming hybridization or binding complexes in the sample (c) optionally, adding the probes to another sample comprising mRNA or proteins from a normal animal, in a manner enabling hybridization or binding of the probes to the mRNA or proteins in the second sample, thereby forming hybridization or binding complexes in the other sample; (d) detecting the hybridization complexes in the sample or samples; and (e) comparing the hybridization or binding complexes from the first sample with the hybridization or binding complexes from a standard or, optionally, from the other sample, wherein at least one difference between the amount of hybridization or binding in the sample as compared with the standard or the optional other sample indicates differential expression of the one or more genes differentially expressed in animals exhibiting the lean phenotype, as compared to animals that do not exhibit the phenotype.

[0075] The method may be used to detect differential expression of genes encoding the gene products set forth in Table 6 or table 10, or in subsets thereof, namely tissue-specific subsets as listed in Table 6A- G and Table 10A-G, or functional subsets as set forth in Tables 7, 8 and 9 (for three-treatment analysis) and Tables 11, 12 and 13 (for high protein diet analysis). In a preferred embodiment, the device is uses to detect differential expression of genes from canines or felines. In particular embodiments, the probes are bound to a substrate, preferably in an array.

[0076] Step (c) and part of steps (d) and (e) are optional and are used if a relatively contemporaneous comparison of two or more test systems is to be conducted. However, in a preferred embodiment, the standard used for comparison is based upon data previously obtained using the method. [0077] These probes are exposed to a sample to form hybridization or binding complexes that are detected and compared with those of a standard. The differences between the hybridization or binding complexes from the sample and standard indicate differential expression of polynucleotides and therefore genes differentially expressed in the lean phenotype versus normal phenotype in the sample. In a preferred embodiment, probes are made to specifically detect polynucleotides or fragments thereof produced by one or more of the genes or gene fragments identified by the invention. Methods for detecting hybridization complexes are known to skilled artisans.

[0078] In one embodiment, the method further comprises exposing the animal or sample to a test substance before performing the assay. Then, the comparison is indicative of whether the test substance altered the expression of genes differentially expressed in treated versus untreated animals. [0079] The assays described herein for the detection of lean phenotype-associated transcription and translation products are useful in methods for identifying a lean phenotype in an animal, or the absence of a lean phenotype in the animal. Such methods may be useful for implementing, facilitating, or guiding a weight-loss regimen (especially for loss of fat mass, and particular for loss of fat while preserving or improving lean body mass) or physical fitness regimen, or for diagnostic purposes to identify animals at risk for obesity or obesity-associated health risks or diseases. Such methods comprise obtaining a sample of cells or tissue from an animal manifesting a lean phenotype as defined herein, or an overweight or obese animal. Such cells or tissues can include, without limitation, adipose, muscle, or liver tissues. The cell or tissue sample is then analyzed for modulated expression of one or more genes associated with a lean phenotype, via detection of mRNA or protein, or for a particular lean phenotype-associated gene expression profile using a gene- or protein-array as described herein. The results of the analysis will reveal whether the animal is manifesting a lean phenotype or transitioning to a lean phenotype. The methods can also provide information regarding the efficacy of an animal's weight loss or physical fitness regimen, or to monitor an animal's relative risk for obesity or obesity-associated health risks or diseases over time. In these situations, the method is carried out at intervals during the animal's weight loss or physical fitness regimen, or life generally, wherein a change in expression or pattern of expression of a target gene associated with a lean phenotype is indicative of the animal's progress, improvement, or continued risk. [0080] In another aspect, the invention provides a method of determining if a test substance is likely to be useful in promoting a lean phenotype when administered to an animal. The method typically comprises (a) determining a first gene expression profile by measuring the transcription or translation products of two or more polynucleotides selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, in a test system in the absence of the test substance; (b) determining a second gene expression profile by measuring the transcription or translation products of two or more polynucleotides selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, in a test system in the presence of the test substance; and (c) comparing the first gene expression profile with the second gene expression profile, wherein a change in the second gene expression profile as compared with the first gene expression profile indicates that the test substance is likely to be useful in promoting a lean phenotype when administered to an animal.

[0081] In certain embodiments, the method may further include the step of comparing at least the second gene expression profile with a reference or standard gene expression profile obtained by measuring the transcription or translation products of two or more polynucleotides selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, in a test system in the presence of a reference substance known to promote a lean phenotype when administered to animals. Such a substance may be, for example, CLA.

[0082] In one embodiment, the test system comprises a population of cultured cells. A nucleic acid construct comprising a lean phenotype-associated gene according to the invention is introduced into cultured host cells. The host cells can be mammalian cell lines, such as but are not limited, to NIH3T3, CHO, HELA, and COS, although non-mammalian cells such as yeast, bacteria and insect cells can also be used. The coding sequences of the genes are operably linked to appropriate regulatory expression elements suitable for the particular host cell to be utilized. The nucleic acid constructs can be introduced into the host cells according to any acceptable means in the art, including but not limited to, transfection, transformation, calcium phosphate precipitation, electroporation and lipofection. Such techniques are well known and routine in the art. Transformed cells can be also used to identify compounds that modulate expression of the lean phenotype-associated genes.

[0083] Gene expression assays can be carried out using a gene construct comprising the promoter of a selected lean phenotype-associated gene operably linked to a reporter gene. The reporter construct may be introduced into a suitable cultured cell, including, without limitation, the standard host cell lines described above, or cells freshly isolated from an animal such as adipose, muscle, or liver cells. The assay is performed by monitoring expression of the reporter gene in the presence or absence of a test substance such as a test compound.

[0084] In a preferred embodiment, the test system comprises animals. Typically, a test substance is administered to an animal and the gene expression profile of the animal is analyzed to determine the effect of the test substance on transcription or the translation of the genes or gene products of the invention. Gene expression can be analyzed in situ or ex vivo to determine the effect of the test substance. In another embodiment, a test substance is administered to an animal and the activity of a protein expressed from a gene is analyzed in situ or ex vivo according to any means suitable in the art to determine the effect of the test substance on the activity of the proteins of interest. In addition, where a test substance is administered to an animal, the physiological, systemic, and physical effects of the compound, as well as potential toxicity of the compound can also be evaluated. Test substances can be administered to the animals for periods appropriate for the test substance, the animal, and the objective, including long term administration, administration on a regular basis, and on an extended regular basis. Administration can be via any suitable route, including, but are not limited to, oral, rectal, nasal, topical, intradermal, subcutaneous, intravenous, intramuscular, and intraparenteral modes of administration. Oral administration is preferred, most preferably oral administration as a food component. [0085] Test substances can be any substance that may have an effect on polynucleotides or genes differentially expressed in animals exhibiting a lean phenotype. Suitable test substances include, but are not limited to, amino acids; proteins, peptides, polypeptides, nucleic acids, oligonucleotides, polynucleotides, small molecules, macromolecules, vitamins, minerals, simple sugars; complex sugars; polysaccharides; carbohydrates; medium-chain triglycerides (MCTs); triacylglycerides (TAGs); n-3 (omega-3) fatty acids including DHA, EPA, ALA; n-6 (omega-6) fatty acids including LA, γ-linolenic acid (GLA) and ARA; SA, conjugated linoleic acid (CLA); choline sources such as lecithin; fat-soluble vitamins including vitamin A and precursors thereof such as carotenoids (e.g., (β-carotene), vitamin D sources such as vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), vitamin E sources such as tocopherols (e.g., α-tocopherol) and tocotrienols, and vitamin K sources such as vitamin Kl (phylloquinone) and vitamin K2 (menadione); water-soluble vitamins including B vitamins such as riboflavin, niacin (including nicotinamide and nicotinic acid), pyridoxine, pantothenic acid, folic acid, biotin and cobalamin; and vitamin C (ascorbic acid); antioxidants, including some of the vitamins listed above, especially vitamins E and C; also bioflavonoids such as catechin, quercetin and theaflavin; quinones such as ubiquinone; carotenoids such as lycopene and lycoxanthin; resveratrol; and α-lipoic acid; L-carnitine; D-limonene; glucosamine; S-adenosylmethionine; and chitosan. In a preferred embodiment, test substances are nutrients that may be added to food or consumed as a supplement. Substances identified by the foregoing method are also contemplated as part of the invention. [0086] In a further aspect, the invention provides a computer system comprising a database containing information identifying expression levels of one or more polynucleotides that are differentially expressed in animals administered a substance that affects one or more of food intake, satiety, lipid metabolism, and fat utilization, wherein the polynucleotides are selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, and a user interface that enables a user to access or manipulate the information in the database. The system comprises a database containing information identifying the expression level of one or more polynucleotides selected from genes encoding proteins listed in Table 6 or Table 10 and/or polypeptides that specifically bind to the proteins listed in Table 6 or Table 10, and a user interface to interact with the database, particularly to input, manipulate, and review the information for different animals or categories of animals. In one embodiment, the database further contains information identifying the activity level of one or more polypeptides listed in Table 6 or Table 10. In another, the database further comprises sequence information for one or more of the polynucleotides or polypeptides as listed in Table 6 or Table 10, preferably from a variety of species. In other embodiments, the database contains additional information pertaining to the description of the genes in one or more animal species. The computer system is any electronic device capable of containing and manipulating the data and interacting with a user, e.g., a typical computer or an analytical instrument designed to facilitate using the invention and outputting the results relating to the status of an animal.

[0087] In another aspect, the invention provides kits comprising a container containing a collection of two or more probes for detecting differential gene expression of the lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise. The kits comprise in separate containers in a single package or in separate containers in a virtual package, as appropriate for the use and kit component, two or more probes for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, wherein the probes comprise: (a) polynucleotides that specifically hybridize to two or more genes encoding proteins listed in Table 6 or Table 10, or fragments thereof; or (b) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins listed in Table 6 or Table 10, or fragments thereof; and further comprises at least one of (1) instructions for how to use the probes in a gene expression assay for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising administration of CLA, consumption of a high protein diet, and/or increased exercise, (2) reagents and equipment for using the probes, and (3) a composition known to induce the lean phenotype. Preferably, the probes are affixed to a solid support at known locations. Suitable reference substances known to induce the lean phenotype include CLA, for example.

[0088] When the kit comprises a virtual package, the kit is limited to instructions in a virtual environment in combination with one or more physical kit components. In one embodiment, the kit contains probes and/or other physical components and the instructions for using the probes and other components are available via the internet. The kit may contain additional items such as a device for mixing samples, probes, and reagents and device for using the kit, e.g., test tubes or mixing utensils. [0089] In another aspect, the invention provides a means for communicating information about or instructions for one or more of the compositions and methods described herein. Such means typically comprise documents, digital storage media, optical storage media, audio presentations, visual displays or the like, containing the information or instructions. For example, the communication means may be a displayed web site, a kiosk, brochure, product label, package insert, advertisement, handout, public announcement audiotape, videotape, DVD, CD, computer-readable chip, computer-readable card, computer-readable disk, computer memory, or any combination thereof. Useful information includes one or more of (1) methods for promoting the health and wellness of animals and (2) contact information for the animal's caregivers to use if they have a question about the invention and its use. Useful instructions include techniques for using the probes, instructions for performing a gene expression assay, and administration amounts and frequency for the substances. The communication means is useful for instructing on the benefits of using the invention.

EXAMPLES

[0090] Various aspects of the invention can be further illustrated by the following examples. It will be understood that these examples are provided merely for purposes of illustration and do not limit the scope of the invention disclosed herein unless otherwise specifically indicated.

Example 1

[0091] The experimental results set forth in this example demonstrate that animals can be induced to transition to a lean phenotype in three ways: (1) dietary supplementation with CLA, (2) high protein diet, and (3) increased exercise.

Materials and Methods

[0092] Four-week old male Sprague Dawley rats were allowed to acclimate for two weeks on a control diet comprising AIN-93M (American Institute of Nutrition purified diet formula for maintenance of mature rodents). Rats were divided into four groups of 12. Group 1 was fed the control diet supplemented with CLA (Table 1). Group 2 was fed a modified diet increased in protein and decreased in carbohydrate (Table 1). Group 3 was fed the control diet, and was given the opportunity to engage in supplemental exercise. Specifically, a running wheel was placed in the cage of each rat in group 3, and daily use of the wheel was monitored by recording each turn of the wheel using a sensor connected to a computer. Group 4 was fed the control diet (Table 1). The energy content of the control and test diets is shown in Table 2.

Table 1 : Control and Test Diet Composition

Table 2: Energy Density of Control and Test Diets

[0093] Measurements were taken at 7 and 60 days after initiation of the feeding or exercise protocols. At the completion of the 60-day feeding protocol, all animals were sacrificed and analyses were performed.

Results

[0094] Body composition analyses were performed on the test animals. Compared with the control group, none of the test regimens (CLA supplementation, exercise or high dietary protein) had any substantial effect on (1) food intake or final body weight, (2) stripped carcass weight, (3) total organ weight, digestive tract weight, heart weight, kidney weight, liver weight, lung weight or spleen weight (with the exception of the high protein regimen, which resulted in increased kidney and spleen weight), (4) protein and fat content of the carcass, or (5) protein and fat content of the organs (except that high protein regimen increased the protein content and decreased the fat content of the organs). [0095] By comparison, as can be seen from Table 3, each of the three treatments decreased total fat pad weight and retroperitoneal fat pad weight, as compared with the Control group. Thus, the data showed that CLA supplementation, increased exercise or high protein diet reduced body fat, resulting in the lean body mass (LBM) phenotype.

Table 3: Body Fat Analysis Following 60 Days of Treatment

[0096] Biochemical analyses of blood were performed on the test animals; results are shown in Table 4.

Table 4. Blood Analysis at Day 7 and Day 60

Control CLA I Exercise | High Protein

[0097] After seven days of the respective treatments, it was found that the increased exercise treatment reduced blood insulin as compared with the CLA supplementation and the high protein diet. The high protein diet treatment increased blood glucagon level compared with the control, the CLA supplementation and the exercise treatment. Blood glucose was not affected by any treatment after 7 days. After 60 days of the respective treatments, it was found that the CLA supplementation and the high protein diet reduced blood glucose level compared with the control diet and the exercise treatment. The CLA supplementation and high protein diet also reduced blood insulin compared with the control diet and the exercise treatment. Blood glucagon was highest in the high protein diet group as compared with the other groups. These data show that CLA supplementation, exercise or the high protein diet altered the test animals' biochemical profiles in a manner consistent with the LBM phenotype.

Example 2

[0098] This example sets forth the initial analysis of gene expression profiles in liver, muscle and/or adipose of the control and test animals comprising three treatments that promote a LBM phenotype, as described in the previous example at day 60.

Materials and Methods

[0099] Messenger RNA was prepared in accordance with standard techniques applicable to the various tissues. Affymetrix GeneChip® Rat Genome 230 2.0 Arrays were interrogated with mRNA from adipose (subcutaneous), liver and quadricep muscle from 6 rats from each of the four groups: (1) control, (2) CLA supplementation, (3) high protein diet, and (4) increased exercise regimen (total 72 samples, utilizing 72 GeneChip® arrays).

[00100] The RMA (Robust Multi-chip Analysis) procedure was used to normalize; correlation matrix and PCA were used to assess the quality control. Two-way Analysis of Variance (ANOVA) for repeated measures was used for a first step analysis (gene by gene). Then as a second step, the GEA (Global Error Assessment) procedure was applied, the robust statistic then replaced the error term of the ANOVA calculated in the first step. Genes were selected based on p<0.01 for overall treatment effect within tissue and then p<0.01 for a specific treatment versus control within that tissue.

Results

[00101] The aforementioned processes identified several hundred genes that were differentially expressed between the control group and at least one of the three treatments, in at least one of the three tissues that were analyzed. Table 5 below shows a breakdown of results from an analysis of (1) the high protein diet treatment alone and (2) a combination of all three treatments, i.e., genes found to be differentially expressed in each of the three treatments as compared with the control group. Table 5: Numbers of Genes Differentially Expressed in Treated Versus Control Animals in Three Tissues and Combinations of Three Tissues

* Combination of all three treatments: number of genes differentially expressed in each of the three treatments, i.e., CLA supplementation and high protein diet and increased exercise.

Example 3

[00102] This example sets forth the further analysis of gene expression profiles in liver, muscle and/or adipose of the control and test animals comprising three treatments that promote a LBM phenotype, as described in Example 1 at day 60 and initially analyzed in Example 2.

[00103] Table 6 sets forth database identifiers and the names of the genes found to be differentially expressed in each of the three treatments.

Table 6: Genes Differentially Expressed in Three Tissues Individually, or in Two or More Tissues, or in all Three Tissues as a Result of CLA Supplementation, High Protein Diet and Increased Exercise

A. Adipose

Public ID Gene Symbol Gene Title

AA800587 Gpx2 glutathione peroxidase 2

AA801220 — Transcribed locus

AA817708 LOC310190 similar to hypothetical protein FLJl 1 127

AA817742 Ms4al_predicted membrane-spanning 4-domains, subfamily A, member 1

(predicted)

AA818807 Emp2 epithelial membrane protein 2

AA818954 — Transcribed locus

AA848820 Hpgd hydroxyprostaglandin dehydrogenase 15 (N AD)

AA848821 LOC684681 similar to Histone H 1.2 (H 1 VAR.1 ) (H 1 c)

AA848944 — Transcribed locus

AA850195 Pankl_predicted pantothenate kinase 1 (predicted)

AA850618 Sorll sortilin-related receptor, LDLR class A repeats-containing

AA850773 —

AA851046 —

AA851313 —

AA851345 — Transcribed locus

AA859029 — Transcribed locus

AA859235 Cdca7 cell division cycle associated 7

AA859277 — Transcribed locus

AA859508 RGD 1564315 _predi similar to RIKEN cDNA 9330161F08 (predicted) cted

AA859652 — Transcribed locus

AA859982 Dhx36_predicted DEAH (Asp-Glu-Ala-His) box polypeptide 36 (predicted)

AA875132 — Transcribed locus

AA875609 Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

AA875647 Transcribed locus

AA891634 --- Transcribed locus, weakly similar to XP 343521.3

PREDICTED: similar to Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg) [Rattus norvegicus]

AA891826 Tacstd2 tumor-associated calcium signal transducer 2

AA892778 Transcribed locus AA893195 Transcribed locus

AA894233 Amid_predicted apoptosis-inducing factor (AIF)-like mitochondrion- associated inducer of death (predicted)

AA894262 1-Sep septin 1

AA894336 Ly96 lymphocyte antigen 96

AA899923 Eml4_predicted echinoderm microtubule associated protein like 4 (predicted)

AA900322 Transcribed locus

AA900477 Vav2_predicted Vav2 oncogene (predicted)

AA901088 RGD1561302_predi similar to Hypothetical protein A030013D21 (predicted) cted

AA901290 — Transcribed locus

AA924459 RGD1560293_predi similar to RIKEN cDNA 1200013 B08 (predicted) cted

AA925583 Blnk B-cell linker

AA925804 Pmpcb peptidase (mitochondrial processing) beta

AA925924 Crlfl_predicted cytokine receptor-like factor 1 (predicted)

AA926072 — Transcribed locus

AA926082 LOC500046 similar to hypothetical protein FLJ21986

AA943147 Hercό potential ubiquitin ligase

AA943808 — Transcribed locus

AA944073 Rpl41 ribosomal protein L41

AA944162 Olftnl2a_predicted olfactomedin-like 2A (predicted)

AA944574 — Transcribed locus

AA945727 Cardl l_predicted caspase recruitment domain family, member 1 1

(predicted)

AA946353 Satbl Special AT-rich sequence binding protein 1

AA955354 Stat4 signal transducer and activator of transcription 4

AA955771 —

AA957260 Rrm2 ribonucleotide reductase M2

AA957585 Ehd3 EH-domain containing 3

AA964146 LOC498662 similar to RIKEN cDNA 2610019F03

AA964219 Lipg lipase, endothelial

AA964492 — Transcribed locus

AA965084 Tnn_predicted tenascin N (predicted)

AA965250 LOC314964 similar to PHD finger protein 20-like 1 isoform 1

AA996557 LOC678701 /// similar to immunoglobulin heavy chain 6 (Igh-6) ///

RGD1359202 hypothetical protein LOC678701

AA996717 RGD1307583_predi LOC361 1 11 (predicted) cted

AA996804 — Transcribed locus

AA996885 Ccll9_predicted chemokine (C-C motif) ligand 19 (predicted)

AA996927 LOC690795 similar to H2A histone family, member J

AA997873 — Transcribed locus

AA998001 — Transcribed locus

AA998516 Ccna2 cyclin A2

AA998540 LOC313934 similar to Intersectin-2 (SH3 domain-containing protein

IB) (SH3P18) (SH3P18-like WASP-associated protein)

AA998903 CDNA clone IMAGE:7374368

AA998997 — Transcribed locus

AB012232 Nfib nuclear factor I/B

AB035507 Mcam melanoma cell adhesion molecule

AB039823 LOC259244 /// alpha-2u globulin PGCL3 /// alpha-2u globulin PGCL5 ///

LOC259245 /// alpha-2u globulin PGCLl /// alpha-2u globulin PGCU ///

LOC259246 /// major urinary protein 5 /// alpha-2u globulin PGCL2 ///

LOC298109 /// alpha2u globulin /// alpha-2u-globulin (L type) /// major

LOC29811 1 /// urinary protein 4 /// alpha 2U globulin /// similar to alpha-

LOC298116 /// 2u globulin PGCL2 /// similar to alpha-2u-globulin (L

LOC366380 /// type) /// similar to alpha-2u globulin PGCL4 isoform 1 /// LOC500473 /// similar to major urinary protein 5 /// similar to alpha2u

LOC502954 /// globulin /// similar to Major urinary protein precursor

LOC681426 /// (MUP) (Alpha-2u-globulin) (Alpha(2)-euglobulin)

LOC682731 /// (Allergen Rat n 1) (Rat n I) /// similar to major urinary

LOC685482 /// protein 4

LOC685577 ///

LOC688457 ///

LOC688547 ///

Mup4 /// Mup5 ///

Obp3

AB039826 LOC259245 /// alpha-2u globulin PGCL5 /// major urinary protein 5

Mup5

AB039828 LOC259244 /// alpha-2u globulin PGCL3 /// alpha-2u globulin PGCL5 ///

LOC259245 /// alpha-2u globulin PGCLl /// alpha-2u globulin PGCL4 ///

LOC259246 /// major urinary protein 5 /// alpha-2u globulin PGCL2 ///

LOC298109 /// alpha2u globulin /// alpha-2u-globulin (L type) /// major

LOC2981 1 1 /// urinary protein 4 /// alpha 2U globulin /// similar to alpha-

LOC2981 16 /// 2u globulin PGCL2 /// similar to alpha-2u-globulin (L

LOC366380 /// type) /// similar to alpha-2u globulin PGCL4 isoform 1 ///

LOC500473 /// similar to major urinary protein 5 /// similar to alpha2u

LOC502954 /// globulin /// similar to Major urinary protein precursor

LOC681426 /// (MUP) (Alpha-2u-globulin) (Alpha(2)-euglobulin)

LOC682731 /// (Allergen Rat n 1) (Rat n I) /// similar to major urinary

LOC685482 /// protein 4

LOC685577 ///

LOC688457 ///

LOC688547 ///

Mup4 /// Mup5 ///

Obp3

AF002251 Rassf5 Ras association (RalGDS/AF-6) domain family 5

AF035963 Haver 1 kidney injury molecule 1

AF068860 Defbl defensin beta 1

AF228917 Zdhhc2 zinc finger, DHHC domain containing 2

AF255614 Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3

AF283276 Gabbrl gamma-aminobutyric acid (GABA) B receptor 1

AF41 1318 MtIa metallothionein Ia

AI008369 Coro7 coronin 7

AI009791 — Transcribed locus

AI009823 Sectmlb secreted and transmembrane 1 B

AI009944 Txk TXK tyrosine kinase

AI010107 — Transcribed locus

AIO 10237 — Transcribed locus

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2

AIOl I lOl RGD1560320_predi similar to brain specific protein 4 (predicted) cted

AI011713 — CDNA clone IMAGE:7320582

AIO 12081 Rhoh ras homolog gene family, member H

AIO 12247 — Transcribed locus, strongly similar to XP 892770.1

PREDICTED: similar to Tyrosine-protein kinase FLK

[Mus musculus]

AIO 12250 Transcribed locus

AIO 12520 —

AI012590 — Transcribed locus

AI012884 — Transcribed locus

AI029631 Igl@ Immunoglobulin light chain, lambda gene cluster

AI029798 Transcribed locus

AI029975 -__ Transcribed locus, strongly similar to NP 038482.3 ATP- binding cassette 1, sub-family A, member 1 [Mus musculus] AI030203 Irx3_predicted Iroquois related homeobox 3 (Drosophila) (predicted) AI030853 CaImB calmodulin-like 3 AI043752 Transcribed locus AI043753 Transcribed locus AI044494 Transcribed locus AI044500 Ctdspl_predicted CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (predicted)

AI044622 MGC125004 similar to T cell receptor interacting molecule AI044631 Cd3g CD3 antigen, gamma polypeptide AI044632 AI044784 Transcribed locus AI045116 Transcribed locus AI045155 Ccr6 chemokine (C-C motif) receptor 6 AI045311 Bin2a beta-galactosidase-like protein AI045321 Transcribed locus AI045904 AI045965 RGD131 1456_predi similar to RIKEN cDNA B230380D07 (predicted) cted

AI058292 Sox7_predicted SRY-box containing gene 7 (predicted) AI058307 Phemx pan hematopoietic expression AI059204 Cpne8_predicted copine VIII (predicted) AI059295 RGD 1561653 _predi similar to HECT domain containing 1 (predicted) cted

AI059468 LOC308990 hypothetical protein LOC308990 AI059486 Dennd2d_predicted DENN/MADD domain containing 2D (predicted) AI060043 Transcribed locus AI070558 AI070991 Transcribed locus AI071227 RGD1563603_predi similar to DNA repair protein RAD51 homolog 1 cted (predicted)

AI071569 I17r_predicted interleukin 7 receptor (predicted) AI071674 Transcribed locus AI071686 Transcribed locus AI072042 AI072252 RGDl 565169_predi similar to apolipoprotein B48 receptor (predicted) cted

AI072663 Transcribed locus AI072892 Frzb frizzled-related protein AI073219 Transcribed locus AI101659 AI101952 MGC 125215 multiple coiled-coil GABABRl -binding protein AI102190 Transcribed locus AI102482 RGD1561521_predi similar to 1 1 10014F24Rik protein (predicted) cted

AI103939 LOC363091 similar to hypothetical protein FLJ30973 AI104533 Ttn Titin AI105042 Cabcl chaperone, ABCl activity of bcl complex like (S. pombe) AI136525 Degs2 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase

AI136555 Ciparl castration induced prostatic apoptosis-related protein 1 AI137113 Tmed5 transmembrane emp24 protein transport domain containing 5

AI137137 Lck lymphocyte protein tyrosine kinase AI137640 Cldnl claudin 1 AI137791 Transcribed locus AI144946 Dynlrb2_predicted dynein light chain roadblock-type 2 (predicted) AI144948 Transcribed locus AI145398 Transcribed locus AI146108 Transcribed locus AI169601 Tnfrsfl4 tumor necrosis factor receptor superfamily, member 14

(herpesvirus entry mediator)

AI170002 LOC689134 similar to Protein transport protein SEC61 gamma subunit AI170541 Transcribed locus AI170987 Transcribed locus AI171093 Prkcq protein kinase C, theta AI172110 AI175668 AI175728 AI176129 LOC686611 similar to Protein FAM60A (Tera protein) AI176327 RGD1562408_predi similar to SH2 domain protein IA (Signaling lymphocyte cted activation molecule-associated protein) (predicted)

AI176755 Ptpn22_predicted protein tyrosine phosphatase, non-receptor type 22

(lymphoid) (predicted)

AI177373 Cr2_predicted Complement receptor 2 (predicted) AI177589 Sorll sortilin-related receptor, LDLR class A repeats-containing AI177645 RGD1310168_predi similar to cDNA sequence BC032204 (predicted) cted

AI177743 Transcribed locus, strongly similar to XP 573486.1 PREDICTED: hypothetical protein XP 573486 [Rattus norvegicus]

AI177934 LOC474169 pre-eosinophil-associated ribonuclease-2 AI178243 Donson downstream neighbor of SON AI178384 Klhl6_predicted kelch-like 6 (Drosophila) (predicted) AI178618 AI178693 RGD1305754_predi similar to 3110080A02Rik protein (predicted) cted

AI178784 RGD1310174_predi hypothetical LOC298504 (predicted) cted AI178808 H2rg interleukin 2 receptor, gamma (severe combined immunodefic iency)

AI179227 Cybasc3 cytochrome b, ascorbate dependent 3 AI179665 RGD1305755 Similar to RIKEN cDNA 5033406L14 AI179988 End ectodermal-neural cortex 1 AI180352 Hercl_predicted hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCCl (CHCl)-like domain (RLD)

1 (predicted)

AI180370 RGD1304592_predi similar to KIAA0528 protein (predicted) cted

AI227638 Satbl special AT-rich sequence binding protein 1 AI227800 Kifap3_predicted kinesin-associated protein 3 (predicted) AI230591 RGD1565540_predi similar to ctla-2-beta protein (141 AA) (predicted) cted

AI231826 Transcribed locus AI233243 Rhot2 ras homolog gene family, member T2 AI233902 Transcribed locus AI234943 SObI Splicing factor 3b, subunit 1 AI235414 AI235468 Dst_predicted dystonin (predicted) AI235528 Transcribed locus AI236141 LOC686590 similar to IQ motif and Sec7 domain 1 AI237227 Transcribed locus AI237640 LOC683446 /// similar to killer activatory receptor-like protein p91D

RGD1562625_predi (predicted) /// similar to paired-Ig-like receptor Al 1 cted

AI406660 AI406854 Transcribed locus AI407163 Transcribed locus AI407239 ... Transcribed locus

AI408164 RGD1306176 similar to FCRL

AI408343 RGDl 562552_predi similar to hypothetical protein LOC340061 (predicted) cted

AI408425 Tlr7_predicted toll-like receptor 7 (predicted)

AI408839 Rwdd2_predicted RWD domain containing 2 (predicted)

AI408948 Ca2 carbonic anhydrase 2

AI409142 LOC679811 similar to RIKEN cDNA D930015E06

AI409262 Rhebll Ras homolog enriched in brain like 1

AI409635 — Transcribed locus

AI409904 — Transcribed locus

AI410068 Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide

AI41 1 185 — Transcribed locus

AI41 1326 LOC303057 /// Slu7 similar to step II splicing factor SLU7; DNA segment, Chr

1 1, ERATO Doi 730, expressed; DNA segment, Chr 3,

Brigham & Womens Genetics 0878 expressed /// step II splicing factor SLU7 (S. cerevisiae)

AI41 1413 LOC685778 /// pyruvate dehydrogenase El alpha 1 /// pyruvate

Pdhal dehydrogenase El alpha 1 pseudogene

AI411425 Esd esterase D/formylglutathione hydrolase

AI411563 Fgd2_predicted FYVE, RhoGEF and PH domain containing 2 (predicted)

AI41 1747 Art2b ADP-ribosyltransferase 2b

AI412322 Acat2 acetyl-Coenzyme A acetyltransferase 2

AI412781 LOC680281 /// similar to RIKEN cDNA 4930555G01 (predicted) ///

LOC685769 /// similar to Discs large homolog 5 (Placenta and prostate

LOC690576 /// DLG) (Discs large protein P-dlg) /// hypothetical protein

LOC691414 /// LOC691414

RGDl 563862_predi cted

AI412866 RGD1306100_predi similar to RRP22 (predicted) cted

AI454224 — Transcribed locus

AI501 187 Dsglc_predicted /// desmoglein 1 gamma (predicted) /// similar to

LOC679010 Desmoglein-1 alpha precursor (Dsgl -alpha) (Desmoglein- 1) (Desmosomal glycoprotein I) (DGl) (DGI)

AI5021 14 Abcal ATP-binding cassette, sub-family A (ABCl), member 1

AI502349 — Transcribed locus

AI502459 —

AI502837 — Transcribed locus

AI5351 13 — Transcribed locus

AI547876 ... Transcribed locus

AI547937 — Transcribed locus

AI548897 Soatl Sterol O-acyltransferase 1

AI549199 Ptger4 Prostaglandin E receptor 4 (subtype EP4)

AI549209 — Transcribed locus

AI549335 Dockl 1 dedicator of cytokinesis 1 1

AI549450 Cd209b CD209b antigen

AI555257 RGD1562305_predi similar to suprabasal-specific protein suprabasin cted (predicted)

AI555447 RGD1565975_predi RGD 1565975 (predicted) cted

AI555526 — Transcribed locus

AI555855 — Transcribed locus

AI556056 Cr2_predicted complement receptor 2 (predicted)

AI556235 RGD1310061 similar to hypothetical protein FLJlO 154

AI556638 ...

AI556957 Aff4_predicted AF4/FMR2 family, member 4 (predicted)

AI575442 Ryrl ryanodine receptor 1 , skeletal muscle

AI576002 ... Transcribed locus AI576184 Transcribed locus

AI576518 — Transcribed locus

AI577567 Rasal2_predicted RAS protein activator like 2 (predicted)

AI578087 Tm4sfl_predicted transmembrane 4 superfamily member 1 (predicted)

AI578566 Ubnl_predicted ubinuclein 1 (predicted)

AI599133 LOC363060 similar to RIKEN cDNA 1600029D21

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI638986 Neb_predicted nebulin (predicted)

AI639108 —

AI639117 Cfb complement factor B

AI706673 Wasl Wiskott-Aldrich syndrome-like (human)

AI710604 — Transcribed locus

AI713204 MgIl Monoglyceride lipase

AI714002 Mki67_predicted antigen identified by monoclonal antibody Ki-67

(predicted)

AI715999 LOC688864 similar to transmembrane protein 61

AI716456 Tiaml T-cell lymphoma invasion and metastasis 1

AI716987 Dsglc_predicted /// desmoglein 1 gamma (predicted) /// similar to

LOC679010 Desmoglein-1 alpha precursor (Dsgl -alpha) (Desmoglein-

1) (Desmosomal glycoprotein I) (DGl) (DGI)

AI717644 RGD1563764_predi similar to PHD finger protein 14 isoform 1 (predicted) cted

AI948410 —

AJ243304 Trdn Triadin

AW141642 RGD 1306067 similar to chromosome 20 open reading frame 6

AW142773 — Transcribed locus

AW142978 Traf3ip3 TRAF3 interacting protein 3

AW144132 ... Transcribed locus

AW144509 Dsp Desmoplakin

AW144823 Sorll sortilin-related receptor, LDLR class A repeats-containing

AW251280 —

AW251860 Tcf7_predicted transcription factor 7, T-cell specific (predicted)

AW433901 Celsrl cadherin EGF LAG seven-pass G-type receptor 1

AW433947 Tnfrsf5 tumor necrosis factor receptor superfamily, member 5

AW434166 Nicnl nicolin 1

AW434972 Rbm25_predicted /// RNA binding motif protein 25 (predicted) /// similar to

RGD1565486_predi RNA binding motif protein 25 (predicted) cted

AW522357 — Transcribed locus

AW523955 — Transcribed locus

AW524359 — Transcribed locus

AW526072 — Transcribed locus

AW526268 RGD1561817_predi Similar to Traf2 and NCK interacting kinase, splice cted variant 4 (predicted)

AW526631 Sorl l sortilin-related receptor, LDLR class A repeats-containing

AW526982 Ttr2 toll-like receptor 2

AW527270 RGD 1309360 hypothetical LOC294715

AW527313 Rdx Radixin

AW528106 — Transcribed locus

AW528448 — Transcribed locus

AW529736 Wfdc5_predicted WAP four-disulfide core domain 5 (predicted)

AW530769 Fdftl farnesyl diphosphate famesyl transferase 1

AW530812 RGD131 1224_predi similar to fatty acid desaturase 2; linoleoyl-CoA cted desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase (predicted)

AW531 135 ... Transcribed locus

AW5321 14 Rasgro2_predicted RAS guanyl releasing protein 2 (calcium and DAG- regulated) (predicted)

AW532165 Sema3d sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D

AW532179 LOC500449 similar to SHP2-interacting transmembrane adaptor protein

AW533234 LOC688915 similar to cardiomyopathy associated 5

AW533569 Clca2_predicted chloride channel, calcium activated, family member 2

(predicted)

AW534046

AW534218 RGD1310722_predi similar to RIKEN cDNA D130059P03 gene (predicted) cted

AW534561 — Transcribed locus

AW534965 RGD1560358_predi similar to cell division cycle and apoptosis regulator 1 cted (predicted)

AW915049 — Transcribed locus

AW915948 Cd3e_predicted CD3 antigen, epsilon polypeptide (predicted)

AW916093 — Transcribed locus

AW917933 — Transcribed locus

AW918480 — Transcribed locus

AW918614 Spnb2 spectrin beta 2

AW919180 Pygm muscle glycogen phosphorylase

AW919569 MGC156825 similar to MIR-interacting saposin-like protein precursor

(Transmembrane protein 4) (Putative secreted protein

ZSIG9)

AW920026 LOC364393 /// PHD finger protein 11 /// similar to RIKEN cDNA

LOC684778 /// 4933417L10 /// hypothetical protein LOC684778

Phfl l

AW920881 Actr2 /// ARP2 actin-related protein 2 homolog (yeast) /// similar to

LOC301861 ARP2 actin-related protein 2 homolog (yeast) (predicted)

BE096652 Ly6g6c lymphocyte antigen 6 complex, locus G6C

BE096750 RGD1305928_predi hypothetical LOC300207 (predicted) cted

BE096812 — Transcribed locus

BE097933 Mitf microphthalmia-associated transcription factor

BE098153 Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

BE098726 Transcribed locus

BE098732 Uhrfl ubiquitin-like, containing PHD and RING finger domains,

1

BE099050 Nfib nuclear factor I/B

BE099838 — Non-coding RNA expressed in the brain, repeat sequence, clone 12

BE100543 Ncorl nuclear receptor co-repressor 1

BE10081 1 Epb4.114a_predicted erythrocyte protein band 4.1 -like 4a (predicted)

BE102340 —

BE 102861 — Transcribed locus

BE 104676 ... Transcribed locus, strongly similar to NP 001029332.1 hypothetical protein LOC619476 [Rattus norvegicus]

BE 104961 Cenpj_predicted centromere protein J (predicted)

BE105050 — Transcribed locus

BE 105498 — Transcribed locus

BE106199 Rora_predicted RAR-related orphan receptor alpha (predicted)

BE 106791 — Transcribed locus

BE 106891 — Transcribed locus

BE 107024 — Transcribed locus

BE 107282 von 6 ischemia related factor vof-16

BE107351 — Transcribed locus

BE108131 Wdfyl WD repeat and FYVE domain containing 1

BE108135 Transcribed locus BE108165 Cepl_predicted centrosomal protein 1 (predicted)

BE 108294 — Transcribed locus

BEl 08409 — Transcribed locus

BE108587 Nisch Nischarin

BE108716 — Transcribed locus

BE108758 — Transcribed locus

BE108849 — Transcribed locus

BE108905 Naplll Nucleosome assembly protein 1-like 1

BE 109260 — Transcribed locus

BE 109322 Plk4_predicted polo-like kinase 4 (Drosophila) (predicted)

BE 109926 Pik3cd_predicted phosphatidylinositol 3-kinase catalytic delta polypeptide

(predicted)

BEl 10332 RGDl 307829 _predi similar to chromosome 14 open reading frame 6 cted /// Rnasel l (predicted) /// ribonuclease 1 1

BEl 10369 Arhgefl 8_predicted rho/rac guanine nucleotide exchange factor (GEF) 18

(predicted)

BEl 10674 LOC686259 /// hypothetical protein LOC686259 /// hypothetical protein

LOC690243 LOC690243

BEl 11706 Marcks myristoylated alanine rich protein kinase C substrate

BEl 12261 Ctdspl_predicted CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (predicted)

BEl 12895 Pea 15 phosphoprotein enriched in astrocytes 15

BEl 12927 Cyfip2_predicted cytoplasmic FMRl interacting protein 2 (predicted)

BEl 13247 —

BEl 13270 Igfbp5 insulin-like growth factor binding protein 5

BEl 13961 — Transcribed locus

BEl 15061 Lefl Lymphoid enhancer binding factor 1

BE1 15155 Rhpn2_predicted rhophilin, Rho GTPase binding protein 2 (predicted)

BEl 15432 Utrn Utrophin

BEl 15521 RGD1310433_predi similar to mKIAA1757 protein (predicted) cted

BEl 15641 —

BEl 16021 Slc5a3 solute carrier family 5 (inositol transporters), member 3

BE116111 — Transcribed locus

BEl 16127 —

BE116152 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast)

BEl 16698 RGD1564964_predi similar to WD repeat domain 11 protein (predicted) cted

BEl 16855 — CDNA clone IMAGE:7384525

BEl 17044 Cd8a CD8 antigen, alpha chain

BEl 17361 LOC681423 /// Nipped-B homolog (Drosophila) /// similar to delangin

NIPBL isoform A

BEl 17736 Tgfb2 Transforming growth factor, beta 2

BEl 18096 — Transcribed locus

BEl 18580 — Transcribed locus

BEl 18901 Gata3 GATA binding protein 3

BE119167 — Transcribed locus

BE 120370 — Transcribed locus

BE120660 ... Transcribed locus

BE120816 — Transcribed locus

BE120823 Smc411 SMC4 structural maintenance of chromosomes 4-like 1

(yeast)

BE120852 Transcribed locus

BE126475 Prrxl paired related homeobox 1

BE328934 RGD1310958_predi similar to RIKEN cDNA C130090K23 (predicted) cted

BE328951 Cldn4 claudin 4

BE329244 — BF281337 Krt2-8 keratin complex 2, basic, gene 8 BF282187 Transcribed locus BF283053 Atp6vlc2 ATPase, H+ transporting, Vl subunit C, isoform 2 BF283556 Plxncl_predicted plexin Cl (predicted) BF283610 Transcribed locus BF283642 LOC363060 similar to RlKEN cDNA 1600029D21 BF283924 Lamp3 lysosomal-associated membrane protein 3 BF284262 IrfB Interferon regulatory factor 8 BF285731 Transcribed locus BF287629 I127ra_predicted interleukin 27 receptor, alpha (predicted) BF288000 BF288109 Transcribed locus BF288130 Ptprc protein tyrosine phosphatase, receptor type, C BF288177 Csnk2al casein kinase II, alpha 1 polypeptide BF288361 BF288533 Transcribed locus BF289150 Transcribed locus BF290113 RGD131 1584 similar to stem cell adaptor protein STAP-I BF290181 BF290410 Transcribed locus BF290784 BF386742 Transcribed locus BF387238 RGD131 1 1 17_predi similar to KIAA 1409 protein (predicted) cted

BF387865 Transcribed locus BF388585 Znf292 zinc finger protein 292 BF389793 Crabpl cellular retinoic acid binding protein 1 BF390257 RGD1309863 similar to hypothetical protein DKFZp434K1421 BF391127 Arid4a_predicted AT rich interactive domain 4A (Rbp 1 like) (predicted) BF393607 LOC689147 hypothetical protein LOC689147 BF394095 Transcribed locus BF395171 Ehd4 EH-domain containing 4 BF396210 Trim59_predicted tripartite motif-containing 59 (predicted) BF396282 KiH 5 kinesin family member 15 BF396319 Transcribed locus BF397627 Transcribed locus BF397719 Plekhg2_predicted pleckstrin homology domain containing, family G (with

RhoGef domain) member 2 (predicted)

BF398050 Chd6_predicted chromodomain helicase DNA binding protein 6

(predicted)

BF398091 CDNA clone IMAGE:7374368 BF398122 Synaptogenesis-related mRNA sequence 6 BF398614 Transcribed locus BF399329 BF399587 Transcribed locus BF399855 SerpinblO serine (or cysteine) peptidase inhibitor, clade B

(ovalbumin), member 10

BF401586 Transcribed locus BF402012 Zbtb20_predicted zinc finger and BTB domain containing 20 (predicted) BF404462 Transcribed locus BF405616 Transcribed locus BF406973 RGD131 1490_predi similar to DKFZP434P1750 protein (predicted) cted

BF408105 BF409092 Transcribed locus BF410101 Transcribed locus BF410240 BF410953 BF411408 BF414018 Tmem97 transmembrane protein 97 BF414285 Transcribed locus BF415030 Pigp_predicted phosphatidylinositol glycan, class P (predicted) BF416343 LOC681423 /// Nipped-B homolog (Drosophila) /// similar to delangin

NIPBL isoform A

BF416764 LOC363326 hypothetical LOC363326 BF417048 LOC499300 similar to protein tyrosine phosphatase, receptor type, C polypeptide-associated protein

BF417079 Transcribed locus BF417479 Dhcr24 24-dehydrocholesterol reductase BF417582 Myolg myosin IG BF417625 Transcribed locus BF418025 Grap GRB2-related adaptor protein BF418487 Med3 l_predicted mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) (predicted)

BF418522 Transcribed locus BF418649 RGD1305645_predi similar to RIKEN cDNA 1500015010 (predicted) cted

BF419134 Acbd3 acyl-Coenzyme A binding domain containing 3 BF420720 RGDl 563128_predi similar to ADP-ribosylation-like factor 12 protein cted (predicted)

BF420722 Nfix nuclear factor I/X BF420803 Transcribed locus BF521859 Tnnt3 troponin T3, skeletal, fast BF522317 Transcribed locus BF523248 Ankrdl l_predicted ankyrin repeat domain 11 (predicted) BF524010 BF542615 Ptplad2_predicted protein tyrosine phosphatase-like A domain containing 2

(predicted)

BF545080 Cox6b2 cytochrome c oxidase subunit VIb testes-specific isoform precursor

BF545930 Transcribed locus BF547251 LOC685707 /// neuron navigator 1 (predicted) /// similar to neuron Navl_predicted navigator 1

BF548081 BF553172 Transcribed locus BF554283 Ogfrll opioid growth factor receptor-like 1 BF555968 Nedd9 neural precursor cell expressed, developmentally down- regulated gene 9

BF555972 RGD 1359529 similar to chromosome 1 open reading frame 63 BF556622 BF558056 BF558512 Transcribed locus BF558946 LOC688717 similar to CG33714-PB, isoform B BF561454 Fgl2 fibrinogen-like 2 BF562507 Sorll sortilin-related receptor, LDLR class A repeats-containing BF565167 Rdx Radixin BF565756 Transcribed locus BG371683 Transcribed locus, moderately similar to NP 598678.1 mondoA isoform 2 [Mus musculus]

BG371843 Pkpl_predicted plakophilin 1 (predicted) BG372056 Transcribed locus BG372342 RGD131 1019_predi similar to hypothetical protein DKFZp434H2010 cted (predicted)

BG372602 RGDl 30660 l_predi similar to cDNA sequence BCO 19755 (predicted) cted

BG372891 Transcribed locus BG372987 BG373166 Elf5_predicted E74-like factor 5 (predicted)

BG373580 Chchdl_predicted coiled-coil-helix-coiled-coil-helix domain containing 1

(predicted)

BG374493 Cyp2j lO_predicted cytochrome P450, family 2, subfamily j, polypeptide 10

(predicted)

BG375315 Sdc 1 syndecan 1

BG376030 RGDl 306107_predi similar to chromosome 1 open reading frame 2 (predicted) cted

BG376644 Rsbnl l_predicted round spermatid basic protein 1-like (predicted)

BG3771 16 Atp6v0a4_predicted ATPase, H+ transporting, lysosomal VO subunit A isoform

4 (predicted)

BG377979 LOC690528 similar to POU domain class 2, associating factor 1 (B- cell-specific coactivator OBF-I) (OCT binding factor 1)

(BOB-I) (BOBl) (OCA-B)

BG378166 Map4k2_predicted mitogen activated protein kinase kinase kinase kinase 2

(predicted)

BG378310 Scel_predicted sciellin (predicted)

BG378588 Mybpc2_predicted myosin binding protein C, fast-type (predicted)

BG378607 LOC362350 /// Tcrb T-cell receptor beta chain /// similar to T-cell receptor beta-2 chain C region

BG378613 Agpat3_predicted l-acylglycerol-3-phosphate O-acyltransferase 3

(predicted)

BG378874 Wbp5_predicted WW domain binding protein 5 (predicted)

BG378912 Wdr47 WD repeat domain 47

BG379338 Rrm2 ribonucleotide reductase M2

BG380122 Serpinbόb serine (or cysteine) proteinase inhibitor, clade B, member

6b

BG380816 LOC29141 1 similar to Potential phospholipid-transporting ATPase HB

BG381555 — CDNA clone IMAGE:7388962

BG662519 Ank Progressive ankylosis homolog (mouse)

BG663208 Jakl Janus kinase 1

BG664221 Ogn_predicted osteoglycin (predicted)

BG665051 —

BG665934 Oact2 O-acyltransferase (membrane bound) domain containing 2

BG668816 Etnkl_predicted ethanolamine kinase 1 (predicted)

BG668988 Elovl4_predicted elongation of very long chain fatty acids (FEN1/Elo2,

SUR4/Elo3, yeast)-like 4 (predicted)

BG670310 Tgfa transforming growth factor alpha

BG670822 Non-coding RNA expressed in the brain, repeat sequence, clone 2 /// Non-coding RNA expressed in the brain, repeat sequence, clone 7 /// Non-coding RNA expressed in the brain, repeat sequence, clone 3 /// Non-coding RNA expressed in the brain, repeat sequence, clone 12

BG671521 Hspca heat shock protein 1, alpha

BG671686 —

BG672572 — Transcribed locus

BG673248 — Transcribed locus

BI274308 Ttc7b_predicted tetratricopeptide repeat domain 7B (predicted)

BI274326 Mucl mucin 1 , transmembrane

BI274480 Fnbp4 formin binding protein 4

BI274533 RGD1309534 similar to RIKEN cDNA 4931406C07

BI275633 Pygm muscle glycogen phosphorylase

BI275677 —

BI275765 Uhrf2_predicted ubiquitin-like, containing PHD and RING finger domains

2 (predicted)

BI275827 Transcribed locus

BI275873 Centbl_predicted centaurin, beta 1 (predicted)

BI276075 — Transcribed locus

BI276959 LOC679341 /// similar to Calsequestrin-1 precursor (Calsequestrin, LOC686019 skeletal muscle isofoπn)

BI277513 LOC360975 similar to oxoglutarate dehydrogenase (lipoamide)

BI277545 Myhl /// Myh2 myosin, heavy polypeptide 1, skeletal muscle, adult /// myosin, heavy polypeptide 2, skeletal muscle, adult

BI278180 Transcribed locus

BI278186 Crctl_predicted cysteine-rich C-terminal 1 (predicted)

BI278721 Calm4_predicted calmodulin 4 (predicted)

BI278952 —

BI279486 LOC494538 ABP beta

BI279605 Krtl-19 keratin complex 1, acidic, gene 19

BI279646 Krtl-14 keratin complex 1, acidic, gene 14

BI279663 Dsc2 desmocollin 2

BI279786 Myold myosin ID

BI280124 RGDl 565500_predi RGD 1565500 (predicted) cted

BI282076 Prdx4 peroxiredoxin 4

B12821 14 — Endogenous retrovirus mRNA, partial sequence

BI282164 Cyb561_predicted cytochrome b-561 (predicted)

BI282567 Klk8 kallikrein 8 (neuropsin/ovasin)

BI282568 Krtdap keratinocyte differentiation associated protein

BI282576 RGD1310935_predi similar to Dermal papilla derived protein 7 (predicted) cted

BI282584 RGD1560328_predi similar to UPFO 197 protein Cl lorflO homolog (predicted) cted

BI282694 RGD1565037_predi similar to selenoprotein SeIM (predicted) cted

BI282819 — Transcribed locus

BI282860 LOC685652 similar to keratin 6L

BI282914 Kctdl4_predicted potassium channel tetramerisation domain containing 14

(predicted)

BI283346 KIkIO kallikrein 10

BI283648 — Transcribed locus, moderately similar to XP 919392.1

PREDICTED: hypothetical protein XP_914299 [Mus musculus]

BI285064 Transcribed locus

BI285065 — Transcribed locus

BI285092 LOC682044 /// hypothetical protein LOC682044 /// hypothetical protein

LOC684972 LOC684972

BI285443 RGD1560859_predi similar to 2300003P22Rik protein (predicted) cted

BI285676 — Transcribed locus

BI285700 Hspcb heat shock 9OkDa protein 1 , beta

BI285951 RGD1308734 similar to RIKEN cDNA 1 100001H23

BI286012 Krtl-18 keratin complex 1, acidic, gene 18

BI286166 LOC298795 /// similar to 14-3-3 protein sigma /// stratifin (predicted)

Sfh_predicted

BI286340 RGD1305779_predi similar to NSEl (predicted) cted

BI286387 LOC499660 similar to Cornifin A (Small proline-rich protein IA)

(SPR1A) (SPRR1)

BI286389 Kal7 type I keratin KA 17

BI286396 Peφ_predicted PERP, TP53 apoptosis effector (predicted)

BI286411 — Ultraviolet B radiation-activated UV 103 mRNA, partial sequence

BI286411 LOC683295 similar to keratin complex 2, basic, gene 6a

BI286421 — Transcribed locus, strongly similar to NP_001007709.1 hypothetical protein LOC315126 [Rattus norvegicus]

BI288162 Transcribed locus

BI288898 LOC680692 /// similar to Golgi phosphoprotein 2 (Golgi membrane LOC682869 protein GP73)

BI289371 Rhbdl6_predicted rhomboid, veinlet-like 6 (Drosophila) (predicted)

BI289386 Bcor_predicted Bcl6 interacting corepressor (predicted)

BI289641 RGD1566064_predi similar to KIAA 1096 protein (predicted) cted

BI289662 LOC690326 hypothetical protein LOC690326

BI289840 — Transcribed locus

BI290053 — Transcribed locus

BI290551 Fnbpl Formin binding protein 1

BI290737 — Transcribed locus

BI290909 Scapl src family associated phosphoprotein 1

BI291230 —

BI291604 LOC687609 similar to ras homolog gene family, member f

BI291798 — Immunoglobulin delta heavy chain transmembrane form (IgD)

BI291804 Transcribed locus

BI292034 —

BI292036 LOC683839 /// hypothetical protein LOC683839 /// hypothetical protein

LOC688495 LOC688495

BI292056 — Transcribed locus

BI292090 Cldnδ claudin 8

BI292231 Lpo_predicted lactoperoxidase (predicted)

BI292758 — Transcribed locus

BI293796 Nckap 1 l_predicted NCK associated protein 1 like (predicted)

BI294141 Angpt4_predicted angiopoietin 4 (predicted)

BI294158 — Transcribed locus

BI294178 — Transcribed locus

BI294722 — Transcribed locus, weakly similar to XP_487464.2

PREDICTED: similar to zinc finger protein 85, related sequence 1 [Mus musculus]

BI294788 Transcribed locus

BI295614 — Transcribed locus, strongly similar to NP 001041317.1

BCL2-associated transcription factor 1 [Rattus norvegicus]

BI295900 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

BI296641 — Transcribed locus

BI297744 RGDl 310507 similar to RIKEN cDNA 1300017J02

BI299761 — Transcribed locus

BI301 1 17 — Transcribed locus

BI301495 LOC688276 similar to epidermodysplasia verruciformis 2

BI302005 Mlfl_predicted myeloid leukemia factor 1 (predicted)

BI303106 Traβ_predicted Tnf receptor-associated factor 3 (predicted)

BI395810 Npylr neuropeptide Y receptor Yl

BM382988 — Transcribed locus

BM383065 RGD1310587 similar to hypothetical protein FLJ14146

BM383423 Ehf_predicted ets homologous factor (predicted)

BM383428 LOC367976 /// minichromosome maintenance deficient 3 (S. cerevisiae)

Mcm3_predicted (predicted) /// similar to DNA replication licensing factor

MCM3 (DNA polymerase alpha holoenzyme-associated protein Pl) (Pl -MCM3)

BM383464 ... Transcribed locus

BM383995 — Transcribed locus

BM384008 Arhgap5 Rho GTPase activating protein 5

BM385071 RGDl 563060 _predi similar to AVLV472 (predicted) cted

BM385951 — Transcribed locus

BM386010 RGD1359684 similar to T-cell receptor alpha chain precursor V and C regions (TRA29)

BM386036 — Transcribed locus, strongly similar to XP 345296.2 PREDICTED: similar to AVIEF [Rattus norvegicus]

BM386334 Ankrd23_predicted ankyrin repeat domain 23 (predicted)

BM386413 Trim2 tripartite motif protein 2

BM387106 Amid_predicted Apoptosis-inducing factor (AIF)-like mitochondrion- associated inducer of death (predicted)

BM387112 Transcribed locus

BM387125 — Transcribed locus

BM387197 —

BM387754 — Transcribed locus

BM387797 LOC360619 similar to gasdermin 1

BM387946 Zap70 zeta-chain (TCR) associated protein kinase 70

BM388077 RGD1562629_predi similar to neurobeachin (predicted) cted

BM388319 Gimap7 GTPase, IMAP family member 7

BM388334 Spink5_predicted serine protease inhibitor, Kazal type 5 (predicted)

BM388738 —

BM389005 Gpr68_predicted G protein-coupled receptor 68 (predicted)

BM389254 Anxaδ annexin A8

BM389444 — Transcribed locus

BM389513 LOC688090 /// RTl class II, locus Bb /// similar to RTl class II

RTl-Bb histocompatibility antigen, B- 1 beta chain precursor

(RTl.B-beta(l))

BM389585 Capnl3 calpain 13

BM390176 Spink5_predicted serine protease inhibitor, Kazal type 5 (predicted)

BM390226 — Transcribed locus

BM390227 Bcll lb_predicted B-cell leukemia/lymphoma 1 IB (predicted)

BM390324 Eppb9_predicted endothelial precursor protein B9 (predicted)

BM390325 RGD1562868_predi similar to squamous cell carcinoma antigen 2 (predicted) cted

BM390378 RGD1562732_predi similar to Glutathione S-transferase, theta 3 (predicted) cted

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

BM390440 — Transcribed locus

BM390872 RGD1560293_predi similar to RIKEN cDNA 1200013B08 (predicted) cted

BM390965 RGD 1305592 similar to RIKEN cDNA 2900092E17

BM391096 — Transcribed locus

BM391169 Myh4 myosin, heavy polypeptide 4

BM391471 Atf5 activating transcription factor 5

BM391538 Frzb frizzled-related protein

BM392106 CaId 1 caldesmon 1

BM392321 Hipk2_predicted homeodomain interacting protein kinase 2 (predicted)

D13555 Cd3z CD3 antigen, zeta polypeptide

D50306 Slcl5al solute carrier family 15 (oligopeptide transporter), member

1

D88586 Earl l eosinophil-associated, ribonuclease A family, member 11

H31078 —

J00710 Csnlsl casein alpha si

J02612 Ugtlal /// UgtlalO UDP glycosyltransferase 1 family, polypeptide Al /// UDP

/// Ugtla2 /// Ugtla3 glycosyltransferase 1 family, polypeptide A6 /// UDP

/// Ugtla5 /// Ugtla6 glycosyltransferase 1 family, polypeptide A7 /// UDP

/// Ugtla7 /// Ugtla8 glycosyltransferase 1 family, polypeptide A8 /// UDP glycosyltransferase 1 family polypeptide A2 /// UDP glycosyltransferase 1 family polypeptide A3 /// UDP glycosyltransferase 1 family polypeptide AlO /// UDP glycosyltransferase 1 family, polypeptide A5

J02705 Ocm Oncomodulin J03867 Cyb5r3 cytochrome b5 reductase 3 L17138 Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6

L19933 Ptprd protein tyrosine phosphatase, receptor type, D L22654 IgG-2a gamma-2a immunoglobulin heavy chain M 10072 Ptprc protein tyrosine phosphatase, receptor type, C M 13706 Prkcbl protein kinase C, beta 1 M17153 Fcerla Fc receptor, IgE, high affinity I, alpha polypeptide M24024 RT1-Aw2 RTl class Ib, locus Aw2 M30596 Mel malic enzyme 1 M61142 Thopl thimet oligopeptidase 1 NM O 12488 A2m alpha-2-macroglobulin NM O 12502 Ar androgen receptor NM_012524 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha NM_012532 Cp Ceruloplasmin NM_012555 Ets 1 v-ets erythroblastosis virus E26 oncogene homolog 1

(avian)

NM_012559 Fgg fibrinogen, gamma polypeptide NM_012594 Lalba lactalbumin, alpha NM_012600 Mel malic enzyme 1 NM_012640 Rbp2 retinol binding protein 2, cellular NM 012646 RTl-Nl /// RT 1-N2 RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl

/// RT1-N3 class Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene, H2-TL-like, grc region(N2)

NM_012703 Thrsp thyroid hormone responsive protein NM_012745 Klrdl killer cell lectin-like receptor, subfamily D, member 1 NM_012760 Plagll pleomorphic adenoma gene-like 1 NM_012777 Apod apolipoprotein D NM_012794 Glycaml glycosylation dependent cell adhesion molecule 1 NM_012812 Cox6a2 cytochrome c oxidase, subunit Via, polypeptide 2 NM O 12824 Apocl apolipoprotein C-I NM O 12888 Tshr thyroid stimulating hormone receptor NMJ 12893 Actg2 actin, gamma 2 NM_012938 Ctse cathepsin E NM_012949 Eno3 enolase 3, beta NMJ 13026 Sdc 1 syndecan 1 NM_013041 Sycp3 synaptonemal complex protein 3 NMJ) 13092 Cmal chymase 1 , mast cell NMJH3134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase NM_013169 Cd3d CD3 antigen delta polypeptide NMJ)13186 Kcnbl potassium voltage gated channel, Shab-related subfamily, member 1

NMJ) 13200 Cptlb carnitine palmitoyltransferase Ib, muscle NM O 16986 Acadm acetyl-Coenzyme A dehydrogenase, medium chain NMJ) 16998 Cpal carboxypeptidase A 1 NMJ) 17028 Mx2 myxovirus (influenza virus) resistance 2 NMJ)17120 Csn2 casein beta NMJ) 17124 Cd37 CD37 antigen NMJ)17156 Cyp2bl 5 cytochrome P450, family 2, subfamily b, polypeptide 15 NMJ) 17206 Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6

NMJ) 17259 Btg2 B-cell translocation gene 2, anti-proliferative NMJ) 17328 Pgam2 phosphoglycerate mutase 2 NMJH9131 Tpml tropomyosin 1 , alpha NMJH9171 LOC685608 /// salivary protein 1 /// hypothetical protein LOC685608 ///

LOC688807 /// Sptl hypothetical protein LOC688807

NMJ) 19175 Klk6 kallikrein 6 NM 019206 StklO serine/threonine kinase 10 NM_019212 Actal actin, alpha 1 , skeletal muscle

NM_019225 SIc Ia3 solute carrier family 1 (glial high affinity glutamate transporter), member 3

NM_019238 Fdftl farnesyl diphosphate farnesyl transferase 1

NM_019240 Gjb3 gap junction membrane channel protein beta 3

NM_019241 Gjb5 gap junction membrane channel protein beta 5

NM_019282 Greml gremlin 1 homolog, cysteine knot superfamily (Xenopus laevis)

NM_019291 Ca2 carbonic anhydrase 2

NM_019295 Cd5 CD5 antigen

NM_019334 Pitx2 paired-like homeodomain transcription factor 2

NM_019371 Egln3 EGL nine homolog 3 (C. elegans)

NM_020072 Acpp acid phosphatase, prostate

NM 021694 Arhgefl Rho guanine nucleotide exchange factor (GEF) 1

NM_021760 Col5a3 procollagen, type V, alpha 3

NM_022193 Acaca acetyl-coenzyme A carboxylase alpha

NM_022268 Pygl liver glycogen phosphorylase

NM_022282 Dlgh2 discs, large homolog 2 (Drosophila)

NM_022389 Dhcr7 7-dehydrocholesterol reductase

NM_022392 Insigl insulin induced gene 1

NM_022582 Lgals7 lectin, galactose binding, soluble 7

NM_022603 Fgfbpl fibroblast growth factor binding protein 1

NM_022628 Nphsl nephrosis 1 homolog, nephrin (human)

NM_022705 Thedcl thioesterase domain containing 1

NM 023021 Kcnn4 potassium intermediate/small conductance calcium- activated channel, subfamily N, member 4

NM_023092 Myolc myosin IC

NM_023987 Birc3 baculoviral IAP repeat-containing 3

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM_024364 Hr hairless homolog (mouse)

NM_024390 Hpgd hydroxyprostaglandin dehydrogenase 15 (N AD)

NM 024398 Aco2 aconitase 2, mitochondrial

NM 030852 Mial melanoma inhibitory activity 1

NM_030853 Lat linker for activation of T cells

NM 030863 Msn Moesin

NM 031031 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase)

NM_031337 St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5

NM_031538 Cd8a CD8 antigen, alpha chain

NM_031562 CsnlO casein kappa

NM 031598 Pla2g2a phospholipase A2, group HA (platelets, synovial fluid)

NM_053328 Bhlhb2 basic helix-loop-helix domain containing, class B2

NM 053388 Gjb6 gap junction membrane channel protein beta 6

NM_053587 S100a9 SlOO calcium binding protein A9 (calgranulin B)

NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4

NM_053633 Egr2 early growth response 2

NM_053669 Aps adaptor protein with pleckstrin homology and src homology 2 domains

NM_053688 Pdeόh phosphodiesterase 6H, cGMP-specific, cone, gamma

NM_053751 Wap whey acidic protein

NM_053806 Kcnkό /// potassium channel, subfamily K, member 6 /// similar to

LOC501662 potassium channel, subfamily K, member 6

NM_053822 S100a8 SlOO calcium binding protein A8 (calgranulin A)

NM_053887 Map3kl mitogen activated protein kinase kinase kinase 1

NM_053999 Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform

NM_058213 Atp2al ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

NM 080770 Scgb2al /// Scgb2a2 secretoglobin, family 2A, member 1 /// secretoglobin, family 2A, member 2

NM_080787 Dgka diacylglycerol kinase, alpha

NM_080906 Ddit4 DNA-damage-inducible transcript 4

NM_13041 1 Corola coronin, actin binding protein IA

NM_130429 Lefl lymphoid enhancer binding factor 1

NM_133424 Actn3 actinin alpha 3

NMJ33513 MuclO mucin 10, submandibular gland salivary mucin

NM_133522 Sstr3 somatostatin receptor 3

NM_133533 Cd79b CD79B antigen

NM_133561 Bφ441 brain protein 44-like

NM l 33566 Cst6 cystatin E/M

NM_133572 Cdc25b cell division cycle 25 homolog B (S. pombe)

NM_134334 Ctsd cathepsin D

NM_134382 Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast)

NM_134389 Acsbgl acyl-CoA synthetase bubblegum family member 1

U13253 Fabp5 fatty acid binding protein 5, epidermal

U23407 Crabp2 cellular retinoic acid binding protein 2

U35025 Acvrlc activin A receptor, type IC

U54791 Cxcr4 chemokine (C-X-C motif) receptor 4

U67914 Cpa3 carboxypeptidase A3

X74293 Itga7 integrin alpha 7

X74294 Itga7 integrin alpha 7

B. Liver

Public ID Gene Symbol Gene Title

AA817761 Adhl alcohol dehydrogenase 1 (class I)

AA818759 RGD1560745_predict similar to OTTHUMP00000018508 (predicted) ed

AA859049 Es2 esterase 2

AA859663 LOC301 1 13 similar to solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

AA900547 Nfxl Nuclear transcription factor, X-box binding 1

AA901337 Spic_predicted Spi-C transcription factor (Spi-1/PU.l related) (predicted)

AA945955 Ogn_predicted osteoglycin (predicted)

AA955091 Itga6 integrin, alpha 6

AA955771 —

AA957990 — Transcribed locus

AA997683 Aldhlbl aldehyde dehydrogenase 1 family, member B 1

AA997980 — Transcribed locus

AA998264 LOC307495 similar to biliverdin reductase B (flavin reductase

(NADPH))

AF41 1318 MtIa metallothionein Ia

AI045015 RGD1560736_predict similar to solute carrier family 9 (sodium/hydrogen ed exchanger), isoform 9 (predicted)

AI045533 LOC679725 Similar to MASK-4E-BP3 protein

AI060139 Atxn2_predicted Ataxin 2 (predicted)

AI060227 Rnd3 Rho family GTPase 3

AI071547 RGD1308329_predict Similar to KIAA0869 protein (predicted) ed

AI073272 Tor Ib torsin family 1, member B

AI 102035 — Transcribed locus

AI 137045 — Transcribed locus

AI 137640 Cldnl claudin 1

AI 146237 — Transcribed locus

AI 176583 Mrvldcl MARVEL (membrane-associating) domain containing 1

AI 180253 RGD1563825_predict similar to ENSANGP00000020885 (predicted) ed

AI228307 MIc 1 predicted megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) (predicted)

AI232328 Hgd homogentisate 1, 2-dioxygenase

AI232806 — Transcribed locus

AI406662 Sec63_predicted SEC63-like (S. cerevisiae) (predicted)

AI410749 — Transcribed locus

AI41 1693 LOC299458 /// similar to immunoglobulin heavy chain 6 (Igh-6) ///

LOC366747 /// similar to Ig H-chain V-region precursor /// similar to Ig

LOC678701 /// heavy chain V region MC 101 precursor /// hypothetical

RGD1359202 protein LOC678701

AI535089 Zfpl31 zinc finger protein 131

AI547628 LOC367485 /// similar to spermatogenesis associated glutamate (E)-rich

LOC501235 /// protein 4d /// similar to RIKEN cDNA 5031410106

LOC501339 ///

LOC688687 ///

LOC689870 ///

LOC690439 ///

LOC690577 ///

LOC691712

AI555855 — Transcribed locus

AI556941 Slc39a4_predicted solute carrier family 39 (zinc transporter), member 4

(predicted)

AW435376 Lrp5_predicted low density lipoprotein receptor-related protein 5

(predicted)

AW522341 Transcribed locus

AW525662 Cdc27 cell division cycle 27 homolog (S. cerevisiae)

AW530264 — Transcribed locus

AW533569 Clca2_predicted chloride channel, calcium activated, family member 2

(predicted)

AW916957 — Transcribed locus, strongly similar to XP 579758.1

PREDICTED: hypothetical protein XP 579758 [Rattus norvegicus]

BE097702

BE 100625 Emrl EGF-like module containing, mucin-like, hormone receptor-like sequence 1

BE108648 Transcribed locus

BEl 14778 Cgn_predicted cingulin (predicted)

BE1 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BEl 19164

BE121383 Ncam2 neural cell adhesion molecule 2

BE329244 —

BE349751 —

BF282112 — Transcribed locus

BF284288 — Transcribed locus

BF389489 Tbcldl2_predicted TBC1D12: TBCl domain family, member 12 (predicted)

BF393945 — Transcribed locus

BF394166 Gpm6a glycoprotein m6a

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF397095 LOC681234 similar to debranching enzyme homolog 1

BF401705 — Transcribed locus

BF403483 — Transcribed locus, moderately similar to NP 997413.2 oxysterol binding protein-like 1 [Mus musculus]

BF404957 Transcribed locus

BF414655 Maoa Monoamine oxidase A

BF418138 — Transcribed locus

BG377595 LOC367746 similar to Spindlin-like protein 2 (SPIN-2)

BG378056 — Transcribed locus

BG378637 Hrasls3 HRAS like suppressor 3 BI273908 Transcribed locus

BI275030 RGDl 308694 _predict similar to hypothetical protein MGC47256 (predicted) ed

BI276183 — Transcribed locus

BI277600 LOC362972 similar to adiponutrin

BI279384 — Transcribed locus

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

BI285941 — Transcribed locus

BI289506 — Transcribed locus

BI290154 RGD1309578 similar to Aa2- 174

BI290769 RGD1309634_predict hypothetical LOC305452 (predicted) ed

BI290794 — Transcribed locus, strongly similar to XP 347073.1

PREDICTED: hypothetical protein XP 347072 [Rattus norvegicus]

BI293584 Tmem55a transmembrane protein 55 A

BI297291 — Transcribed locus

BI301687 — Transcribed locus

BM382879 Pura_predicted Purine rich element binding protein A (predicted)

BM386775 Aimll_predicted absent in melanoma 1-like (predicted)

L19180 Ptprd protein tyrosine phosphatase, receptor type, D

M 10094 RT1-Aw2 RTl class Ib, locus Aw2

M24024 RT1-Aw2 RTl class Ib, locus Aw2

M30596 Mel malic enzyme 1

M63991 Serpina7 serine (or cysteine) peptidase inhibitor, clade A (alpha- 1 antipeptidase, antitrypsin), member 7

NM O 12600 Mel malic enzyme 1

NM_012646 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl

RT1-N3 class Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene, H2-TL-like, grc region(N2)

NM O 13068 Fabp2 fatty acid binding protein 2, intestinal

NM_017077 Foxa3 forkhead box A3

NM_017149 Meox2 mesenchyme homeobox 2

NM_019203 Tsx testis specific X-linked gene

NM_021653 Dio 1 deiodinase, iodothyronine, type I

NM_023969 Edg7 putative G protein-coupled receptor snGPCR32

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM_031561 RGD1562323_predict similar to fatty acid translocase/CD36 (predicted) ed

NM_031641 Sult4al sulfotransferase family 4A, member 1

NM_053639 Ltc4s leukotriene C4 synthase

NM_053962 Sds serine dehydratase

NM_053999 Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B

(PR 52), alpha isoform

NM_133525 RGD620382 Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382

NM_133547 Sultlc2 /// Sultlc2a sulfotransferase family, cytosolic, 1C, member 2 /// sulfotransferase family, cytosolic, 1C, member 2a

NM_134379 UST4r integral membrane transport protein UST4r

Z78279 Col IaI procollagen, type 1 , alpha 1

C. Quadricep

Public ID Gene Symbol Gene Title

AA800285 — Transcribed locus

AA901290 — Transcribed locus

AA998276 — Transcribed locus

AF368860 LOC680367 similar to Urinary protein 3 precursor (RUP-3)

AIO 13568 RGD131 1 123 Similar to 1300013J15Rik protein

AI 169092 Thrsp thyroid hormone responsive protein AI 170665 Chacl_predicted ChaC, cation transport regulator-like 1 (E. coli) (predicted)

AI 179334 Fasn fatty acid synthase

AI231999 LOC689256 similar to Tumor protein D53 (mD53) (Tumor protein

D52-like 1)

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)

AI23725 I —

AI502757 Cst7_predicted cystatin F (leukocystatin) (predicted)

AI555855 — Transcribed locus

AI579422 Bexl brain expressed X-linked 1

AW25128 —

0

AW53021 Ryrl ryanodine receptor 1 , skeletal muscle

9

AW53349 —

0

AW53451 — Transcribed locus

9

AW53589 — Transcribed locus

7

AW53602 — Transcribed locus

2

BE 102861 — Transcribed locus

BE 106279 — Transcribed locus

BEl 18382 Nek9_predicted NIMA (never in mitosis gene a)- related kinase 9

(predicted)

BEl 18557

BEl 18639 Tpr translocated promoter region

BF281984 LOC360570 similar to myosin XVIIIa

BF284535 — Transcribed locus

BF290088 Nkx2-3_predicted NK2 transcription factor related, locus 3 (Drosophila)

(predicted)

BF404113 Transcribed locus

BF409456 LOC688018 similar to SH3-domain binding protein 3

BF409997 — Transcribed locus

BF524010 —

BF559640 — Transcribed locus

BF559746 Dyrk2_predicted dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (predicted)

BF564825 LOC500591 similar to calmodulin-binding transcription activator 1

BF565278 Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4

BF568007 LOC501069 similar to golgi autoantigen golgin subtype a4; tGolgin-1

BI275261 —

BI282114 — Endogenous retrovirus mRNA, partial sequence

H31802 —

J00710 Csnlsl casein alpha si

J02585 Scdl stearoyl-Coenzyme A desaturase 1

L81 174 Ankrdl ankyrin repeat domain 1 (cardiac muscle)

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NM 0125 Lalba lactalbumin, alpha

94

NM 0127 Thrsp thyroid hormone responsive protein

03

NM 0132 Ankrdl ankyrin repeat domain 1 (cardiac muscle)

20

NM 0173 Fasn fatty acid synthase

32

NM 0533 Atplb4 ATPase, (Na+)/K+ transporting, beta 4 polypeptide

81

NM 1343 Alb Albumin 26

D. Adipose + Liver*

Public ID Gene Symbol Gene Title

AA955771 —

AF41 1318 MtIa metallothionein Ia

AI 137640 Cldnl claudin 1

AI555855 — Transcribed locus

AW533569 Clca2_predicted chloride channel, calcium activated, family member 2

(predicted)

BE1 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BE329244

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

M24024 RT1-Aw2 RTl class Ib, locus Aw2

M30596 Mel malic enzyme 1

NM 01260 Mel malic enzyme 1

0

NM 01264 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl

6 RT1-N3 class Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene, H2-TL-like, grc region(N2)

NM 02414 EvI Ena-vasodilator stimulated phosphoprotein

7

NM 05399 Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B

9 (PR 52), alpha isoform

E. Adipose + Quadricep*

Public ID Gene Symbol Gene Title

AA901290 — Transcribed locus

AI555855 — Transcribed locus

AW251280 ...

BE 102861 — Transcribed locus

BF524010 —

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

J00710 Csnlsl casein alpha si

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NM 01259 Lalba lactalbumin, alpha

4

NM 01270 Thrsp thyroid hormone responsive protein

3

F. Liver + Quadricep*

Public ID Gene Symbol Gene Title

AI555855 — Transcribed locus

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

M24024 RT1-Aw2 RTl class Ib, locus Aw2

G. Adipose + Liver + Quadricep*

Public ID Gene Symbol Gene Title

AI555855 — Transcribed locus

M24024 RT1-Aw2 RTl class Ib, locus Aw2

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

* "Adipose + Liver", for example refers to genes that are differentially expressed in both adipose and liver tissue in response to all three treatments as compared with the control. "Adipose + Quadricep," "Liver + Quadricep," and "Adipose + Liver + Quadricep" are defined analogously.

[00104] Biological pathway analysis was conducted using commercially available mapping programs and public databases. The major pathways represented by the differentially expressed genes in adipose, liver, and muscle are set forth below in Tables 7, 8 and 9. As stated above, these genes were found to be differentially expressed as a result any one of the three treatments.

Table 7: Biochemical Pathways Associated with Genes Differentially Expressed in Adipose Tissue as a Result of CLA Supplementation, High Protein Diet and Increased Exercise

Cholesterol Biosynthetic Pathway

Public ID Gene Symbol Gene Title

AW530769 Fdftl farnesyl diphosphate famesyl transferase 1

BF417479 Dhcr24 24-dehydrocholesterol reductase

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

J03867 Cyb5r3 cytochrome b5 reductase 3

NM_013134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NMJ)19238 Fdftl farnesyl diphosphate farnesyl transferase 1

NM_022389 Dhcr7 7-dehydrocholesterol reductase

Statin Pathway

Public ID Gene Symbol Gene Title

AI5021 14 Abcal ATP-binding cassette, sub-family A (ABCl), member 1

AI548897 Soatl Sterol O-acyltransferase 1

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NM_012824 Apocl apolipoprotein C-I

NM_013134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Adipogenesis

Public ID Gene Symbol Gene Title

AI072892 Frzb frizzled-related protein

AI235414 Rora_predicted RAR-related orphan receptor alpha (predicted)

AI407163 PrIr Prolactin receptor

BE100543 Ncorl nuclear receptor co-repressor 1

BE106199 Rora_predicted RAR-related orphan receptor alpha (predicted)

BEl 18901 Gata3 GATA binding protein 3

BM391538 Frzb frizzled-related protein

NM_012524 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha

NM_053633 Egr2 early growth response 2

Apoptosis

Public ID Gene Symbol Gene Title

NM_022582 Lgals7 lectin, galactose binding, soluble 7

NM_080906 Ddit4 DNA-damage-inducible transcript 4

NM_019371 Egln3 EGL nine homolog 3 (C. elegans)

NM_053388 Gjb6 gap junction membrane channel protein beta 6

NM_053887 Map3kl mitogen activated protein kinase kinase kinase 1 gremlin 1 homolog, cysteine knot superfamily (Xenopus

NM_019282 Greml laevis)

AF002251 Rassf5 Ras association (RalGDS/AF-6) domain family 5

U35025 Acvrlc activin A receptor, type IC

AI136555 Ciparl castration induced prostatic apoptosis-related protein 1

BF417479 Dhcr24 24-dehydrocholesterol reductase

AI233243 Rhot2 ras homolog gene family, member T2 tumor necrosis factor receptor superfamily, member 14

AI 169601 Tnfrsfl4 (herpesvirus entry mediator)

AW433947 Tnfrsf5 tumor necrosis factor receptor superfamily, member 5

BM383464 RT1-Aw2 RTl class Ib, locus Aw2

AI137137 Lck lymphocyte protein tyrosine kinase

AI044631 Cd3g CD3 antigen, gamma polypeptide NM_013041 Sycp3 synaptonemal complex protein 3

NM O 12594 Lalba lactalbumin, alpha

BEl 12895 Pea 15 phosphoprotein enriched in astrocytes 15

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

Cell Motility

Public ID Gene Symbol Gene Title

AA875132 Tpml Tropomyosin 1 , alpha

AI045155 Ccr6 chemokine (C-C motif) receptor 6

ARP2 actin-related protein 2 homolog (yeast) similar to

AW920881 Actr2 LOC301861 ARP2 actin-related protein 2 homolog (yeast) (predicted)

LOC685707 neuron navigator 1 (predicted) similar to neuron navigator

BF547251 Navl_predicted 1

BM392106 CaId 1 caldesmon 1

NM_019131 Tpml tropomyosin 1 , alpha

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM_030863 Msn moesin

NM_053887 Map3kl mitogen activated protein kinase kinase kinase 1

NMJ3041 1 Corola coronin, actin binding protein 1 A

Mitochondrial Fatty Acid Betaoxidatii

Public ID Gene Symbol Gene Title

NM_016986 Acadm acetyl-Coenzyme A dehydrogenase, medium chain

NM_013200 Cptlb carnitine palmitoyltransferase 1 b, muscle

NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4

Fatty Acid Biosynthesis

Public ID Gene Symbol Gene Title

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

NM_022193 Acaca acetyl-coenzyme A carboxylase alpha

NM_022705 Thedcl thioesterase domain containing 1

Fatty Acid Metabolism

Public ID Gene Symbol Gene Title

AA848820 Hpgd hydroxyprostaglandin dehydrogenase 15 (N AD)

ELOVL family member 6, elongation of long chain fatty

BEl 16152 Elovl6 acids (yeast)

NM_013200 Cptlb carnitine palmitoyltransferase 1 b, muscle

NM_016986 Acadm acetyl-Coenzyme A dehydrogenase, medium chain

NM_024390 Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD)

NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4

ELOVL family member 5, elongation of long chain fatty

NM_134382 Elovl5 acids (yeast)

Glycolysis

Public ID Gene Symbol Gene Title

NM_017328 Pgam2 phosphoglycerate mutase 2 pyruvate dehydrogenase E 1 alpha 1 pyruvate

AI41 1413 LOC685778 Pdhal dehydrogenase El alpha 1 pseudogene lsfM 012949 Eno3 enolase 3, beta dihydrolipoamide S-acetyltransferase (E2 component of

BI295900 Dlat pyruvate dehydrogenase complex)

Regulation of Cell Proliferation

Public ID Gene Symbol Gene Title AA859235 Cdca7 cell division cycle associated 7 SWI/SNF related, matrix associated, actin dependent

AA875609 Smarca2 regulator of chromatin, subfamily a, member 2

AW251860 Tcf7_predicted transcription factor 7, T-cell specific (predicted)

BE097933 Mitf microphthalmia-associated transcription factor

BEl 17736 Tgfb2 Transforming growth factor, beta 2

BF288177 Csnk2al casein kinase II, alpha 1 polypeptide

NMJ) 19334 Pitx2 paired-like homeodomain transcription factor 2

NM O 19371 Egln3 EGL nine homolog 3 (C. elegans)

NM 022389 Dhcr7 7-dehydrocholesterol reductase Inflammation, Immunity and Stress Response*

^♦Category includes the subcategories of Rn T-cell receptor, Rn B-cell receptor, leukocyte transendothelial migration, tight junction, adherens junction, antigen processing, response to unfolded proteins, response to wounding, response to external stimulus, inflammatory response, immune response, T-cell activation and Rn IL-4.

Public ID Gene Symbol Gene Title membrane-spanning 4-domains, subfamily A, member 1

AA817742 Ms4al_predicted (predicted)

AA900477 Vav2_predicted Vav2 oncogene (predicted)

AA925583 Blnk B-cell linker

AA996885 Ccll9_predicted chemokine (C-C motif) ligand 19 (predicted)

AA998516 Ccna2 cyclin A2

AF002251 Rassf5 Ras association (RalGDS/AF-6) domain family 5 membrane associated guanylate kinase, WW and PDZ

AF255614 Magi3 domain containing 3

AI009823 Sectm 1 b secreted and transmembrane IB

AI009944 Txk TXK tyrosine kinase

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2

AI012081 Rhoh ras homolog gene family, member H

AI012250 RT1-Aw2 RTl class Ib, locus Aw2

AI044622 MGC 125004 similar to T cell receptor interacting molecule

AI044631 Cd3g CD3 antigen, gamma polypeptide

AI137137 Lck lymphocyte protein tyrosine kinase

AI 137640 Cldnl claudin 1 tumor necrosis factor receptor superfamily, member 14

AI 169601 Tnfrsfl4 (herpesvirus entry mediator)

AI171093 PRKCQ protein kinase C, theta protein tyrosine phosphatase, non-receptor type 22

AI 176755 Ptpn22_predicted (lymphoid) (predicted)

AI177373 Cr2_predicted complement receptor 2 (predicted) interleukin 2 receptor, gamma (severe combined

AI 178808 I12rg immunodefic iency)

AI407163 PrIr Prolactin receptor

AI549199 Ptger4 Prostaglandin E receptor 4 (subtype EP4)

AI556056 Cr2_predicted complement receptor 2 (predicted)

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

AI639117 Cfb complement factor B

AW251860 Tcf7_predicted transcription factor 7, T-cell specific (predicted)

AW433947 Tnfrsf5 tumor necrosis factor receptor superfamily, member 5

AW526982 Tlr2 toll-like receptor 2

RAS guanyl releasing protein 2 (calcium and DAG-

AW5321 14 Rasgrp2_predicted regulated) (predicted) similar to SHP2-interacting transmembrane adaptor

AW532179 LOC500449 protein

AW915948 Cd3e_predicted CD3 antigen, epsilon polypeptide (predicted)

ARP2 actin-related protein 2 homolog (yeast) similar to

AW920881 Actr2 LOC301861 ARP2 actin-related protein 2 homolog (yeast) (predicted) BE096652 Ly6g6c lymphocyte antigen 6 complex, locus G6C phosphatidylinositol 3-kinase catalytic delta polypeptide

BE 109926 Pik3cd_predicted (predicted)

BEl 15061 Lefl Lymphoid enhancer binding factor 1

BEl 17044 Cd8a CD8 antigen, alpha chain

BE328951 Cldn4 claudin 4

BF288109 RT1-Aw2 RTl class Ib, locus Aw2

BF288130 Ptprc protein tyrosine phosphatase, receptor type, C

BF288177 Csnk2al casein kinase II, alpha 1 polypeptide

BF2901 13 RGD1311584 similar to stem cell adaptor protein STAP-I

BF386742 Catnal Catenin (cadherin-associated protein), alpha 1

BF401586 Prkcbl Protein kinase C, beta 1

BF418025 Grap GRB2-related adaptor protein neural precursor cell expressed, developmentally down-

BF555968 Nedd9 regulated gene 9 mitogen activated protein kinase kinase kinase kinase 2

BG378166 Map4k2_predicted (predicted)

BG663208 Jakl Janus kinase 1

BI274326 Mucl mucin 1, transmembrane

BI285700 Hspcb heat shock 9OkDa protein 1 , beta

BI290909 Scapl src family associated phosphoprotein 1

BI292090 Cldn8 claudin 8

BM383464 RT1-Aw2 RTl class Ib, locus Aw2

BM387946 Zap70 zeta-chain (TCR) associated protein kinase 70

BM389005 Gpr68_predicted G protein-coupled receptor 68 (predicted) RTl class II, locus Bb similar to RTl class II histocompatibility antigen, B-I beta chain precursor

BM389513 LOC688090 RTl-Bb (RTl .B-beta(l))

D13555 Cd3z CD3 antigen, zeta polypeptide

UDP glycosyltransferase 1 family, polypeptide Al UDP glycosyltransferase 1 family, polypeptide A6 UDP

Ugtlal UgtlalO Ugtla2 glycosyltransferase 1 family, polypeptide A7 UDP

Ugtla3 Ugtla5 Ugtla6 glycosyltransferase 1 family, polypeptide A8 UDP

J02612 Ugtla7 Ugtlaδ glycosyltransferase 1 family polypeptide A2 UDP glycosy

M 10072 Ptprc protein tyrosine phosphatase, receptor type, C

M 13706 Prkcbl protein kinase C, beta 1

M17153 Fcerla Fc receptor, IgE, high affinity I, alpha polypeptide

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NM_012488 A2m alpha-2-macroglobulin v-ets erythroblastosis virus E26 oncogene homolog 1

NM_012555 Etsl (avian)

NM_012559 Fgg fibrinogen, gamma polypeptide

NM_012938 Ctse cathepsin E

NM 013169 Cd3d CD3 antigen delta polypeptide

NM_017028 Mx2 myxovirus (influenza virus) resistance 2

NMJM9175 Klk6 kallikrein 6

NM O 19295 Cd5 CD5 antigen

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM_030853 Lat linker for activation of T cells

NM_030863 Msn moesin glycine amidinotransferase (L-arginine:glycine

NM_031031 Gatm amidinotransferase)

NM_031538 Cd8a CD8 antigen, alpha chain

NM_053587 S100a9 SlOO calcium binding protein A9 (calgranulin B) adaptor protein with pleckstrin homology and src

NM_053669 Aps homology 2 domains

NM 053822 SlOOaδ SlOO calcium binding protein A8 (calgranulin A)

NM 053887 Map3kl mitogen activated protein kinase kinase kinase 1 protein phosphatase 2 (formerly 2A), regulatory subunit B

NM 053999 Ppp2r2a (PR 52), alpha isoform

NM_130429 Lefl lymphoid enhancer binding factor 1

NM_133424 Actn3 actinin alpha 3

NM_133533 Cd79b CD79B antigen

U13253 Fabp5 fatty acid binding protein 5, epidermal

U35025 Acvrlc activin A receptor, type IC

U54791 Cxcr4 chemokine (C-X-C motif) receptor 4

Multicellular Organismal Development

Public ID Gene Symbol Gene Title protein tyrosine phosphatase, non-receptor type 22

AI 176755 Ptpn22_predicted (lymphoid) (predicted)

AI179988 Encl ectodermal-neural cortex 1

AI502837 — Transcribed locus

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma sema domain, immunoglobulin domain (Ig), short basic

AW532165 Sema3d domain, secreted, (semaphorin) 3D

BE097933 Mitf microphthalmia-associated transcription factor

BE 126475 Prrx 1 paired related homeobox 1

BF283556 Plxncl_predicted plexin Cl (predicted)

BF417479 Dhcr24 24-dehydrocholesterol reductase

LOC685707 /// neuron navigator 1 (predicted) /// similar to neuron

BF547251 Navl_predicted navigator 1

BF553172 — Transcribed locus

BG662519 Ank Progressive ankylosis homolog (mouse)

BI285064 — Transcribed locus

BI290551 Fnbpl Formin binding protein 1 gremlin 1 homolog, cysteine knot superfamily (Xenopus

NM_019282 Greml laevis)

NM 019334 Pitx2 paired-like homeodomain transcription factor 2 glycine amidinotransferase (L-arginine: glycine

NM_031031 Gatm amidinotransferase)

U23407 Crabp2 cellular retinoic acid binding protein 2

Regulation of Apoptosis

Public ID Gene Symbol Gene Title caspase recruitment domain family, member 11

AA945727 Card 11 predicted (predicted)

AI044631 Cd3g CD3 antigen, gamma polypeptide

AW251860 Tcf7_predicted transcription factor 7, T-cell specific (predicted)

AW915948 Cd3e_predicted CD3 antigen, epsilon polypeptide (predicted)

BE097933 Mitf microphthalmia-associated transcription factor

BEl 12895 Pea 15 phosphoprotein enriched in astrocytes 15

BEl 17736 Tgfb2 Transforming growth factor, beta 2

BF417479 Dhcr24 24-dehydrocholesterol reductase

NM_012594 Lalba lactalbumin, alpha

NM O 13041 Sycp3 synaptonemal complex protein 3

NM_023987 Birc3 baculoviral IAP repeat-containing 3

NM_133424 Actn3 actinin alpha 3

U35025 Acvrlc activin A receptor, type IC

Table 8: Biochemical Pathways Associated with Genes Differentially Expressed in Liver Tissue as a Result of CLA

Supplementation, High Protein Diet and Increased Exercise PPAR Signaling Pathway

Public ID Gene Symbol Gene Title

NM_013068 Fabp2 fatty acid binding protein 2, intestinal

NM_012600 Mel malic enzyme 1

M30596 Mel malic enzyme 1

Fatty Acid Metabolism

Public ID Gene Symbol Gene Title

ELOVL family member 6, elongation of long chain fatty

BE116152 Elovl6 acids (yeast)

ELOVL family member 6, elongation of long chain fatty

BF396857 Elovlό acids (yeast)

NM_013068 Fabp2 fatty acid binding protein 2, intestinal

NM 031561 RGDl 562323 ϊdicted similar to fatty acid translocase/CD36 (predicted)

Table 9: Biochemical Pathways Associated with Genes Differentially Expressed In Muscle Tissue as a Result of CLA Supplementation, High Protein Diet and Increased Exercise

Lipid Metabolism

Public ID Gene Symbol Gene Title

AI 169092 Thrsp thyroid hormone responsive protein

J02585 Scdl stearoyl-Coenzyme A desaturase 1

NM 012703 Thrsp thyroid hormone responsive protein

Example 4

[00105] This example sets forth the further analysis of gene expression profiles in liver, muscle and/or adipose of the control and test animals comprising the high protein treatment described in Example 1 at day 60 and initially analyzed in Example 2.

[00106] Table 10 sets forth database identifiers and the names of the genes found to be differentially expressed in the high protein treatment.

Table 10: Genes Differentially Expressed in Three Tissues Indidually, or in Two or More Tissues, or in all Three

Tissues as a Result of a High Protein Diet

A. Adipose

Public ID Gene Symbol Gene Title

AA799328 RGDl 560913_predicted similar to expressed sequence AW413625 (predicted)

AA799400 B3galt3 UDP-Gal:betaGlcNAc beta 1 ,3-galactosyltransferase, polypeptide 3

AA799471 LOC688173 similar to Telethonin (Titin cap protein)

AA799557 ... Transcribed locus, strongly similar to XP 424899.1

PREDICTED: similar to Creatine kinase, sarcomeric mitochondrial precursor (S-MtCK) (Mib-CK) (Basic-type mitochondrial creatine kinase) [Gallus gallus]

AA799981 Prkch protein kinase C, eta

AA799996 GnglO guanine nucleotide binding protein (G protein), gamma 10

AA800004 Sept4 septin 4

AA800031 Fhl2 four and a half LIM domains 2

AA800240 Hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-

Coenzyme A thiolase/enoyl-Coenzyme A hydratase

(trifunctional protein), alpha subunit

AA800245 Trim54 tripartite motif-containing 54

AA800249 Mypn_predicted myopalladin (predicted)

AA800587 Gpx2 glutathione peroxidase 2

AA800701 LOC683626 similar to limb-bud and heart AA80071 1 AA800750 AA800892 RGD1563599_predicted similar to putative SH3BGR protein (predicted) AA801220 Transcribed locus AA817708 LOC310190 similar to hypothetical protein FLJl 1127 AA817742 Ms4al_predicted membrane-spanning 4-domains, subfamily A, member 1

(predicted)

AA817907 RGD1566355_predicted similar to cell division cycle 2-like 1 (predicted) AA817956 Grem2_predicted gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) (predicted)

AA818020 RGD 1309660_predicted similar to hypothetical protein MGC33214 (predicted) AA818055 Transcribed locus AA818098 Transcribed locus AA818143 Transcribed locus AA818262 AngptW angiopoietin-like 4 AA818334 Srpx2_predicted sushi-repeat-containing protein, X-linked 2 (predicted) AA818521 Thbd Thrombomodulin AA818664 Transcribed locus AA818807 Emp2 epithelial membrane protein 2 AA818849 RGD1310093_predicted similar to hypothetical protein FLJl 1354 (predicted) AA818954 Transcribed locus AA819034 isgl2(b) putative ISG12(b) protein AA819134 Dappl_predicted dual adaptor for phosphotyrosine and 3-phosphoinositides 1

(predicted)

AA819268 Transcribed locus AA819776 Hspca /// LOC498264 /// heat shock protein 1, alpha /// similar to heat shock protein 1 ,

LOC500299 /// alpha

LOC691091

AA819788 Rtp4_predicted receptor transporter protein 4 (predicted) AA819804 Zfp91 zinc finger protein 91 AA848738 LOC362792 similar to phospholipase D family, member 4 AA848820 Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) AA848821 LOC684681 similar to Histone H 1.2 (Hl VAR.1) (HIc) AA848944 Transcribed locus AA848980 LOC498205 similar to DnaJ (Hsp40) homolog, subfamily C, member 14 AA849552 LOC683381 similar to Paired amphipathic helix protein Sin3b

(Transcriptional corepressor Sin3b) (Histone deacetylase complex subunit Sin3b)

AA849706 Transcribed locus AA849719 Transcribed locus AA850195 Pankl_predicted pantothenate kinase 1 (predicted) AA850618 Sorll sortilin-related receptor, LDLR class A repeats-containing AA850773 AA850780 RGD 1564560_predicted similar to RCK (predicted) AA851046 AA851282 Ss 18 synovial sarcoma translocation, Chromosome 18 AA851313 AA851345 Transcribed locus AA858521 Transcribed locus AA858591 Transcribed locus, strongly similar to XP 996369.1

PREDICTED: similar to 40S ribosomal protein S27-like protein [Mus musculus]

AA858815 Transcribed locus AA859029 Transcribed locus AA859235 Cdca7 cell division cycle associated 7 AA859277 Transcribed locus AA859508 RGDl 564315_predicted similar to RIKEN cDNA 9330161 F08 (predicted) AA859545 RGD 1305455 similar to hypothetical protein FLJ 10925 AA859652 Transcribed locus

AA859902 — Transcribed locus

AA859919 Churcl_predicted churchill domain containing 1 (predicted)

AA859982 Dhx36_predicted DEAH (Asp-Glu-Ala-His) box polypeptide 36 (predicted)

AA866419 — Transcribed locus

AA874782 RGD1566234_predicted similar to GrblO protein (predicted)

AA875002 Lrrcδ leucine-rich repeat-containing 8

AA875123 — Transcribed locus

AA875132 — Transcribed locus

AA875143 LOC368062 similar to Ankyrin repeat and IBR domain-containing protein 1

AA875261 Fbliml filamin binding LIM protein 1

AA875438 RGDl 309414_predicted similar to KIAA0913 protein (predicted)

AA875609 Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

AA875647 ... Transcribed locus

AA891634 — Transcribed locus, weakly similar to XP_343521.3

PREDICTED: similar to Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg) [Rattus norvegicus]

AA891664 Mfng manic fringe homolog (Drosophila)

AA891826 Tacstd2 tumor-associated calcium signal transducer 2

AA892234 Mgst3_predicted microsomal glutathione S-transferase 3 (predicted)

AA892765 — —

AA892778 — Transcribed locus

AA893004 — Transcribed locus

AA893192 — Transcribed locus

AA893195 — Transcribed locus

AA893384 IrO interferon regulatory factor 3

AA893670 — Transcribed locus

AA893871 — Transcribed locus

AA894233 Amid_predicted apoptosis-inducing factor (AIF)-like mitochondrion- associated inducer of death (predicted)

AA894262 Septl septin 1

AA894336 Ly96 lymphocyte antigen 96

AA899923 Eml4_predicted echinoderm microtubule associated protein like 4 (predicted)

AA900322 — Transcribed locus

AA900477 Vav2_predicted Vav2 oncogene (predicted)

AA901088 RGD1561302_predicted similar to Hypothetical protein A030013D21 (predicted)

AA901290 — Transcribed locus

AA901341 Slc2a3 Solute carrier family 2 (facilitated glucose transporter), member 3

AA923988 — Transcribed locus

AA924312 — Transcribed locus

AA924350 LOC686634 /// hypothetical protein LOC686634 /// hypothetical protein

LOC690768 LOC690768

AA924459 RGD1560293_predicted similar to RIKEN cDNA 1200013 B08 (predicted)

AA925303 — —

AA925583 Blnk B-cell linker

AA925804 Pmpcb peptidase (mitochondrial processing) beta

AA925924 Crlfl_predicted cytokine receptor-like factor 1 (predicted)

AA926072 — Transcribed locus

AA926082 LOC500046 similar to hypothetical protein FLJ21986

AA926180 LOC684489 similar to angiopoietin-like 1

AA926313 ... Transcribed locus

AA943056 RGD1562563_predicted similar to RIKEN cDNA G430041M01 (predicted)

AA943147 Hercό potential ubiquitin ligase

AA943808 Transcribed locus AA944073 Rpl41 ribosomal protein L41

AA944162 Olfrnl2a_predicted olfactomedin-like 2A (predicted)

AA944304 Tpd52_predicted rumor protein D52 (predicted)

AA944325 Itgb5 Integrin, beta 5

AA944380 Nudt7_predicted nudix (nucleoside diphosphate linked moiety X)-type motif 7

(predicted)

AA944574 Transcribed locus

AA944588 — Transcribed locus

AA944812 HsG Heat shock factor 2

AA945568 RGD1565360_predicted similar to homolog of Human holocarboxylase synthetase gene HLCS (predicted)

AA945727 Cardl l_predicted caspase recruitment domain family, member 1 1 (predicted)

AA945737 Cxcr4 chemokine (C-X-C motif) receptor 4

AA945909 Cd3e_predicted CD3 antigen, epsilon polypeptide (predicted)

AA945955 Ogn_predicted osteoglycin (predicted)

AA946353 Satbl Special AT-rich sequence binding protein 1

AA946430 Syvnl synovial apoptosis inhibitor 1 , synoviolin

AA955213 RGD 1309362 similar to interferon-inducible GTPase

AA955354 Stat4 signal transducer and activator of transcription 4

AA955494 — Transcribed locus

AA955691 — Transcribed locus

AA955771 ...

AA956317 — Transcribed locus, strongly similar to XP 982636.1

PREDICTED: similar to stromal membrane-associated protein 1 isoform 5 [Mus musculus]

AA956714 Aridla_predicted AT rich interactive domain IA (Swil like) (predicted)

AA957260 Rrm2 ribonucleotide reductase M2

AA957585 Ehd3 EH-domain containing 3

AA95781 1 — Transcribed locus

AA958001 Cthrcl collagen triple helix repeat containing 1

AA963069 — Transcribed locus

AA963276 Etvl_predicted ets variant gene 1 (predicted)

AA963364 LOC680419 Similar to Ras suppressor protein 1

AA963477 — Transcribed locus

AA963975 — Transcribed locus

AA9641 14 Kiel kinesin light chain 1

AA964146 LOC498662 similar to RIKEN cDNA 2610019F03

AA964219 Lipg lipase, endothelial

AA964419 Capzb Capping protein (actin filament) muscle Z-line, beta

AA964492 — Transcribed locus

AA965084 Tnn_predicted tenascin N (predicted)

AA965147 — Transcribed locus

AA965250 LOC314964 similar to PHD finger protein 20-like 1 isoform 1

AA996417 —

AA996557 LOC678701 /// similar to immunoglobulin heavy chain 6 (Igh-6) ///

RGD 1359202 hypothetical protein LOC678701

AA996717 RGD1307583_predicted LOC361 1 1 1 (predicted)

AA996804 — Transcribed locus

AA996869 — Transcribed locus

AA996885 Ccll9_predicted chemokine (C-C motif) ligand 19 (predicted)

AA996921 — Transcribed locus

AA996927 LOC690795 similar to H2A histone family, member J

AA996943 Phactrl phosphatase and actin regulator 1

AA997187 — Transcribed locus

AA997710 Pcdhl9_predicted protocadherin 19 (predicted)

AA997873 — Transcribed locus

AA997880 Transcribed locus AA998001 Transcribed locus AA998043 LOC314964 similar to PHD finger protein 20-like 1 isoform 1 AA998516 Ccna2 cyclin A2 AA998540 LOC313934 similar to Intersectin-2 (SH3 domain-containing protein IB)

(SH3P18) (SH3P18-like WASP-associated protein)

AA998903 CDNA clone IMAGE:7374368 AA998979 LOC684857 /// similar to Autophagy-specific gene 2 CG 1241 -PA LOC689688

AA998997 Transcribed locus AB012232 Nfib nuclear factor I/B ABO 13454 Slc34al solute carrier family 34 (sodium phosphate), member 1 AB020615 Prkci protein kinase C, iota AB025017 Zφ36 zinc finger protein 36 AB035507 Mcam melanoma cell adhesion molecule AB039823 LOC259244 /// alpha-2u globulin PGCL3 /// alpha-2u globulin PGCL5 ///

LOC259245 /// alpha-2u globulin PGCLl /// alpha-2u globulin PGCL4 ///

LOC259246 /// major urinary protein 5 /// alpha-2u globulin PGCL2 ///

LOC298109 /// alpha2u globulin /// alpha-2u-globulin (L type) /// major

LOC29811 1 /// urinary protein 4 /// alpha 2U globulin /// similar to alpha-2u

LOC298116 /// globulin PGCL2 /// similar to alpha-2u-globulin (L type) ///

LOC366380 /// similar to alpha-2u globulin PGCL4 isoform 1 /// similar to

LOC500473 /// major urinary protein 5 /// similar to alpha2u globulin ///

LOC502954 /// similar to Major urinary protein precursor (MUP) (Alpha-2u-

LOC681426 /// globulin) (Alpha(2)-euglobulin) (Allergen Rat n 1) (Rat n I)

LOC682731 /// /// similar to major urinary protein 4

LOC685482 ///

LOC685577 ///

LOC688457 ///

LOC688547 /// Mup4 ///

Mup5 /// Obp3

AB039826 LOC259245 /// Mup5 alpha-2u globulin PGCL5 /// major urinary protein 5 AB039828 LOC259244 /// alpha-2u globulin PGCL3 /// alpha-2u globulin PGCL5 ///

LOC259245 /// alpha-2u globulin PGCLl /// alpha-2u globulin PGCL4 ///

LOC259246 /// major urinary protein 5 /// alpha-2u globulin PGCL2 ///

LOC298109 /// alpha2u globulin /// alpha-2u-globulin (L type) /// major

LOC2981 1 1 /// urinary protein 4 /// alpha 2U globulin /// similar to alpha-2u

LOC298116 /// globulin PGCL2 /// similar to alpha-2u-globulin (L type) ///

LOC366380 /// similar to alpha-2u globulin PGCL4 isoform 1 /// similar to

LOC500473 /// major urinary protein 5 /// similar to alpha2u globulin ///

LOC502954 /// similar to Major urinary protein precursor (MUP) (Alpha-2u-

LOC681426 /// globulin) (Alpha(2)-euglobulin) (Allergen Rat n 1) (Rat n I)

LOC682731 /// /// similar to major urinary protein 4

LOC685482 ///

LOC685577 ///

LOC688457 ///

LOC688547 /// Mup4 ///

Mup5 /// Obp3

AB048730 Ptges prostaglandin E synthase AB052846 Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)

AB060652 Nfia nuclear factor I/A AB070350 Chp /// calcium binding protein p22 /// similar to calcium binding

RGD1564956_predicted protein P22 (predicted)

///

RGD1565588_predicted

AF002251 Rassf5 Ras association (RalGDS/AF-6) domain family 5 AF002281 Pdlim3 PDZ and LIM domain 3 AF022247 Cubn cubilin (intrinsic factor-cobalamin receptor) AF035963 Haver 1 kidney injury molecule 1 AF040750 Gprkό G protein-coupled receptor kinase 6 AF057025 Tlr4 toll-like receptor 4

AF062594 Napl ll nucleosome assembly protein 1-like 1

AF065147 Cd44 CD44 antigen

AF065438 Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein

AF068860 Defbl defensin beta 1

AF077354 Hspa4 heat shock protein 4

AF081 196 Rasgφl RAS guanyl releasing protein 1

AF093139 Nxfl nuclear RNA export factor 1

AF095585 Pdlim7 PDZ and LIM domain 7

AF104399 Cited 1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

AF129400 Fxyd2 FXYD domain-containing ion transport regulator 2

AF159103 Tnfaipό tumor necrosis factor alpha induced protein 6

AF169637 Lilrb3 /// LOC683446 /// leukocyte immunoglobulin-like receptor, subfamily B (with

LOC683463 /// TM and ITIM domains), member 3 /// similar to killer

LOC690948 /// activatory receptor-like protein p91D (predicted) /// similar

LOC690955 /// to paired-Ig-like receptor Al l /// similar to paired-Ig-like

RGD1562625_predicted receptor B

AF201331 Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

AF220558 Trdn Triadin

AF228917 Zdhhc2 zinc finger, DHHC domain containing 2

AF245172 Gda guanine deaminase

AF253064 CkIf chemokine-like factor

AF254801 Ngef neuronal guanine nucleotide exchange factor

AF255614 Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3

AF260582 LOC257650 Hippyragranin

AF283276 Gabbrl gamma-aminobutyric acid (GABA) B receptor 1

AF321837 Rgs2 regulator of G-protein signaling 2

AF335571 Eml2 echinoderm microtubule associated protein like 2

AF370889 Tpml Tropomyosin 1 , alpha

AF372216 Tpml tropomyosin 1 , alpha

AF399874 Tnntl troponin Tl, skeletal, slow

AF400662 Cacna2dl calcium channel, voltage-dependent, alpha2/delta subunit 1

AF41 1318 MtIa metallothionein Ia

AI007639 — Transcribed locus

AI008151 Dcpla_predicted DCPl decapping enzyme homolog A (S. cerevisiae)

(predicted)

AI008369 Coro7 coronin 7

AI008409 — CDNA clone IMAGE:7321089

AI008646 —

AI008792 — Transcribed locus

AI009074 Ogt O-linked N-acetylglucosamine (GIcNAc) transferase (UDP-

N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

AI009657 Cs Citrate synthase

AI009791 — Transcribed locus

AI009823 Sectmlb secreted and transmembrane 1 B

AI009944 Txk TXK tyrosine kinase

AI010107 — Transcribed locus

AI010237 — Transcribed locus

AIO 10427 Cdknla cyclin-dependent kinase inhibitor IA

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2

AIOl I lOl RGD 1560320_predicted similar to brain specific protein 4 (predicted)

AI011713 — CDNA clone IMAGE:7320582

AIOl 1757 Fcgr3a Fc fragment of IgG, low affinity Ilia, receptor

AIOl 1920 Rcsdl_predicted RCSD domain containing 1 (predicted)

AI012081 Rhoh ras homolog gene family, member H AIO 12247 — Transcribed locus, strongly similar to XP 892770.1 PREDICTED: similar to Tyrosine-protein kinase FLK [Mus musculus]

AI012250 Transcribed locus

AI012518 — Transcribed locus

AIO 12520 —

AI012590 — Transcribed locus

AIO 12603 — Transcribed locus

AI012884 — Transcribed locus

AIOl 3044 — Transcribed locus

AI0291 13 Apeg3 antisense paternally expressed gene 3

AI029445 —

AI029460 — Transcribed locus

AI029631 Igl@ Immunoglobulin light chain, lambda gene cluster

AI029798 — Transcribed locus

AI029975 — Transcribed locus, strongly similar to NP 038482.3 ATP- binding cassette 1 , sub-family A, member 1 [Mus musculus]

AI030021 Transcribed locus

AI030120 LOC499094 similar to zinc finger protein 61

AI030203 Irx3_predicted Iroquois related homeobox 3 (Drosophila) (predicted)

AI030349 — CDNA clone IMAGE:7379585

AI030465 —

AI030701 Sox4_predicted SRY -box containing gene 4 (predicted)

AI030853 Calml3 calmodulin-like 3

AI031033 RGD131 1447_predicted LOC363276 (predicted)

AI043579 — Transcribed locus

AI043752 — Transcribed locus

AI043753 — Transcribed locus

AI043800 LOC31 1078 Similar to T-Brain-1

AI043817 RGD1565884_predicted Similar to Pellino protein homolog 2 (Pellino 2) (predicted)

AI044125 Dpep2 dipeptidase 2

AI044222 Cxcl9 chemokine (C-X-C motif) ligand 9

AI044316 — Transcribed locus

AI044494 — Transcribed locus

AI044500 Ctdspl_predicted CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (predicted)

AI044622 MGC 125004 similar to T cell receptor interacting molecule

AI044631 Cd3g CD3 antigen, gamma polypeptide

AI044632 —

AI044651 Loxl2_predicted lysyl oxidase-like 2 (predicted)

AI044661 Pil6_predicted protease inhibitor 16 (predicted)

AI044784 — Transcribed locus

AI044859 RGD131 1732 similar to hypothetical protein MGC 15407

AI044869 Pla2g2d phospholipase A2, group HD

AI045021 — Transcribed locus, strongly similar to XP OO 1061227.1

PREDICTED: similar to interleukin 17D precursor [Rattus norvegicus]

AI045116 ... Transcribed locus

AI045155 Ccr6 chemokine (C-C motif) receptor 6

AI045201 Tnfrsf21_predicted rumor necrosis factor receptor superfamily, member 21

(predicted)

AI045228 Apls2_predicted adaptor-related protein complex 1 , sigma 2 subunit

(predicted)

AI04531 1 Bin2a beta-galactosidase-like protein

AI045321 — Transcribed locus

AI045459 Ccnt2_predicted Cyclin T2 (predicted)

AI045904 —

AI045965 RGDl 31 1456 predicted AI058292 Sox7_predicted SRY-box containing gene 7 (predicted)

AI058307 Phemx pan hematopoietic expression

AI059078 RGD 1309969 similar to RIKEN cDNA 260001 OEOl

AI059204 Cpne8_predicted copine VIII (predicted)

AI059295 RGD1561653_predicted similar to HECT domain containing 1 (predicted)

AI059468 LOC308990 hypothetical protein LOC308990

AI059486 Dennd2d_predicted DENN/MADD domain containing 2D (predicted)

AI059850 LOC681012 similar to Estlp-like protein B

AI059914 Etvl_predicted ets variant gene 1 (predicted)

AI060043 — Transcribed locus

AI0601 17 ... Transcribed locus

AI060225 RGD1306534_predicted similar to P-Rexl (predicted)

AI060231 Fkbp7_predicted FK506 binding protein 7 (predicted)

AI070061 RGD1304626_predicted similar to KIAAl 128 protein (predicted)

AI070558 —

AI070944 Foxql Forkhead box Ql

AI070976 Lrp4 low density lipoprotein receptor-related protein 4

AI070991 — Transcribed locus

AI071 148 Tns Tensin

AI071227 RGD1563603_predicted similar to DNA repair protein RAD51 homolog 1 (predicted)

AI071253 — Transcribed locus

AI071395 — Transcribed locus

AI071569 I17r_predicted interleukin 7 receptor (predicted)

AI071649 — Transcribed locus

AI071674 — Transcribed locus

AI071686 — Transcribed locus

AI071722 Mφs 18c_predicted mitochondrial ribosomal protein S18C (predicted)

AI072042 —

AI072252 RGD 1565169_predicted similar to apolipoprotein B48 receptor (predicted)

AI072663 — Transcribed locus

AI072892 Frzb frizzled-related protein

AI073001 — Transcribed locus

AI073064 — Transcribed locus

AI073219 — Transcribed locus

AI073272 Torlb torsin family 1, member B

AI100827 — Transcribed locus

AI101388 GalNAc4S6ST N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase

AI101416 Cpm_predicted carboxypeptidase M (predicted)

AI 101440 Usp38_predicted . ubiquitin specific protease 38 (predicted)

AI101583 — Transcribed locus, strongly similar to NP 071858.2 transient receptor potential cation channel, subfamily V, member 6

[Mus musculus]

AI101659

AI 101886 Hnrph3_predicted heterogeneous nuclear ribonucleoprotein H3 (2H9)

(predicted)

AI 101952 MGC125215 multiple coiled-coil GABABRl -binding protein

AI 102061 Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3)

AI 102073 Mal2 mal, T-cell differentiation protein 2

AI102190 — Transcribed locus

AI 102248 Plxndl_predicted plexin Dl (predicted)

AI 102482 RGD1561521_predicted similar to 1 1 10014F24Rik protein (predicted)

AI102517 — Transcribed locus

AI 102519 Tyrobp Tyro protein tyrosine kinase binding protein

AI102530 Nab2 Ngfi-A binding protein 2

AI 102627 LOC681849 similar to Protein C6orfl42 homolog

AI102732 MGC 109340 similar to Microsomal signal peptidase 23 kDa subunit

(SPase 22 kDa subunit) (SPC22/23) AI 102760 ...

AI 102790 Bcatl branched chain aminotransferase 1, cytosolic

AI102833 — Transcribed locus

AI102838 Ivd isovaleryl coenzyme A dehydrogenase

AI 102906 — Transcribed locus

AI 103040 — Transcribed locus

AI 103218 LOC688228 similar to Myosin light polypeptide 4 (Myosin light chain 1 , atrial isoform)

AI103408 Transcribed locus

AI103918 Hdac7a histone deacetylase 7A

AI103939 LOC363091 similar to hypothetical protein FLJ30973

AI 104238 Gzma granzyme A

AI 104326 —

AI 104533 Ttn titin

AI104913 Tmodl tropomodulin 1

AI 104922 — Transcribed locus

AI 105042 Cabcl chaperone, ABCl activity of bcl complex like (S. pombe)

AI1051 17 Ubtf upstream binding transcription factor, RNA polymerase I

AI 105369 LOC691455 similar to calmodulin-like 4

All 1 1965 — Transcribed locus

AI1 12158 B3gntl_predicted UDP-GlcNAc:betaGal beta-l,3-N- acerylglucosaminyltransferase 1 (predicted)

All 12986 Josd3 Josephin domain containing 3

AI136136 LOC689364 Similar to chromatin modifying protein IB

AI136314 RGD131 1086 similar to RIKEN cDNA 2610029K21

AI136525 Degs2 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase

AI136555 Ciparl castration induced prostatic apoptosis-related protein 1

AI 137045 — Transcribed locus

AI1371 13 Tmed5 transmembrane emp24 protein transport domain containing 5

AI137137 Lck lymphocyte protein tyrosine kinase

AI137157 LOC500592 similar to tumor necrosis factor receptor superfamily, member 25

AI137163 1116 interleukin 16

AI137506 LOC362774 similar to serine proteinase inhibitor Al 1 gene

(SERPINAI l)

AI 137602 CDNA clone IMAGE:7383152

AI 137640 Cldnl claudin 1

AI 137672 Cd69 CD69 antigen

AI137791 — Transcribed locus

AI 137898 LOC685742 Hypothetical protein LOC685742

Al 137931 Itgaό integrin, alpha 6

AI 144822 Rcorl_predicted REST corepressor 1 (predicted)

AI 144946 Dynlrb2_predicted dynein light chain roadblock-type 2 (predicted)

AI 144948 — Transcribed locus

AI145081 Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae)

AI145398 Transcribed locus

AI 145497 — Transcribed locus

AI145562 RGD1310384_predicted hypothetical LOC289530 (predicted)

AI145951 — Transcribed locus

AI146037 Map3k7_predicted Mitogen activated protein kinase kinase kinase 7 (predicted)

AI146108 — Transcribed locus

AI146147 RGD131 1723_predicted similar to KIAA 1731 protein (predicted)

AI 169104 Cxcl4 chemokine (C-X-C motif) ligand 4

AI 169367 RGD 1309676 similar to RIKEN cDNA 5730469M10

AI 169601 Tnfrsπ4 tumor necrosis factor receptor superfamily, member 14

(herpesvirus entry mediator) AI 170002 LOC689134 similar to Protein transport protein SEC61 gamma subunit

AI170193 Dscrl Down syndrome critical region homolog 1 (human)

AI170356 —

AI 170362 Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in

B-cells 2, p49/plOO

AI170387 Cxcl9 chemokine (C-X-C motif) ligand 9

AI170535 Tp53il l_predicted tumor protein p53 inducible protein 1 1 (predicted)

AI 170541 — Transcribed locus

AI 170755 LOC682245 similar to Acylphosphatase, muscle type isozyme

(Acylphosphate phosphohydrolase)

AI 170987 Transcribed locus

AI 171093 Prkcq protein kinase C, theta

AI 171288 RGD1306739_predicted similar to RIKEN cDNA 1700040L02 (predicted)

AI171327 RGDl 563438_predicted similar to novel protein of unknown function (DUF423) family member (predicted)

AI 171553 RGD1307396_predicted similar to RIKEN cDNA 6330406115 (predicted)

AI 171653 — Transcribed locus, moderately similar to XP_342453.2

PREDICTED: titin [Rattus norvegicus]

AI 171654 Tφ53inp2 tumor protein p53 inducible nuclear protein 2

AI171856 — Transcribed locus

AI 171994 RGD 13069 l l_predicted similar to CG 10671 -like (predicted)

AI 172033 Rere arginine-glutamic acid dipeptide (RE) repeats

AI1721 10 —

AI172141 Ankl ankyrin 1 , erythroid

AI 172263 Rnpcl_predicted RNA-binding region (RNPl, RRM) containing 1 (predicted)

AI 175346 — Transcribed locus

AI175539 Pvalb Parvalbumin

AI 175668 —

AI175728 —

AI175732 Vegfa Vascular endothelial growth factor A

AI175779 — Transcribed locus, weakly similar to XP 984565.1

PREDICTED: hypothetical protein LOC66961 [Mus musculus]

AI175908 Transcribed locus

AI176129 LOC68661 1 similar to Protein FAM60A (Tera protein)

AI176172 — Transcribed locus

AI 176327 RGD 1562408_predicted similar to SH2 domain protein IA (Signaling lymphocyte activation molecule-associated protein) (predicted)

AI 176393 CoWaI procollagen, type IV, alpha 1

AI 176540 RGD 1307844_predicted Similar to 106 kDa O-GlcNAc transferase-interacting protein

(predicted)

AI 176565 Acssl_predicted acyl-CoA synthetase short-chain family member 1

(predicted)

Al l 76646 ... Transcribed locus

AI 176677 — Transcribed locus

AI 176732 Trem2_predicted triggering receptor expressed on myeloid cells 2 (predicted)

AI176755 Ptpn22_predicted protein tyrosine phosphatase, non-receptor type 22

(lymphoid) (predicted)

AI176913 Pgm2 phosphoglucomutase 2

AI177083 Pcqap_predicted positive cofactor 2, multiprotein complex, glutamine/Q-rich- associated protein (predicted)

AI177099 Prss23 protease, serine, 23

AI177373 Cr2_predicted Complement receptor 2 (predicted)

AI 177403 LOC497796 /// Ly49 inhibitory receptor 9 /// immunoreceptor Ly49si 1 ///

LOC502907 /// immunoreceptor Ly49si2 /// immunoreceptor Ly49si3 ///

LOC690045 /// Ly49 inhibitory receptor 5 /// hypothetical protein

LOC690097 /// Ly49i5 LOC497796 /// similar to immunoreceptor Ly49si3

/// Ly49i9 /// Ly49sil /// (predicted) /// similar to immunoreceptor Ly49sil /// similar

Ly49si2 /// Ly49si3 /// to immunoreceptor Ly49si3 RGD1561306_predicted

///

RGD15631 10_predicted

AI 177484 Rps24 ribosomal protein S24

AI177589 Sorll sortilin-related receptor, LDLR class A repeats-containing

AI 177645 RGD1310168_predicted similar to cDNA sequence BC032204 (predicted)

AI177743 — Transcribed locus, strongly similar to XP 573486.1

PREDICTED: hypothetical protein XP 573486 [Rattus norvegicus]

AI 177746 Transcribed locus

AI177934 LOC474169 pre-eosinophil-associated ribonuclease-2

AI178160 Myo9b myosin IXb

AI178214 Rassf3_predicted Ras association (RalGDS/AF-6) domain family 3 (predicted)

AI 178222 — Transcribed locus

AI 178243 Donson downstream neighbor of SON

AI178339 Cytor4 similar to cytokine receptor related protein 4

AI 178384 Klhl6_predicted kelch-like 6 (Drosophila) (predicted)

AI 178618 —

AI 178689 LOC691898 hypothetical protein LOC691898

AI178693 RGD1305754_predicted similar to 31 10080A02Rik protein (predicted)

AI 178784 RGD1310174_predicted hypothetical LOC298504 (predicted)

AI 178808 I12rg interleukin 2 receptor, gamma (severe combined immunodeficiency)

AI178914 AA926063 AA926063gene

AI 179227 Cybasc3 cytochrome b, ascorbate dependent 3

AI179334 Fasn fatty acid synthase

AI 179609 RGD1561062_predicted similar to RIKEN cDNA 5730593F17 (predicted)

AI 179665 RGD1305755 Similar to RIKEN cDNA 5033406L14

AI179886 RGD1310352 similar to HTGN29 protein; keratinocytes associated transmembrane protein 2

AI179988 End ectodermal-neural cortex 1

AI180300 LOC499331 similar to hypothetical protein D030056L22

All 80352 Hercl_predicted hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCCl (CHCl)-like domain (RLD) 1

(predicted)

AI 180370 RGD1304592_predicted similar to KIAA0528 protein (predicted)

AI227638 Satbl special AT-rich sequence binding protein 1

AI227800 Kifap3_predicted kinesin-associated protein 3 (predicted)

AI227930 Wdr48_predicted WD repeat domain 48 (predicted)

AI228039 —

AI228076 — Transcribed locus

AI228417 Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin)

4A

AI228630 Wdr23 WD repeat domain 23

AI229167 Hip2_predicted huntingtin interacting protein 2 (predicted)

AI229409 — Transcribed locus

AI229612 LOC686980 similar to arsenate resistance protein 2

AI229699 RGD1561665_predicted similar to spatial-delta (predicted)

AI230334 Tceal8 transcription elongation factor A (SΙI)-like 8

AI230466 —

AI230554 — Transcribed locus

AI230591 RGD1565540_predicted similar to ctla-2-beta protein (141 AA) (predicted)

AI230669 — Transcribed locus

AI230766 RGDl 310423 similar to hypothetical protein FLJ31737

AI231223 Cldndl Claudin domain containing 1

AI231438 Cndpl carnosine dipeptidase 1 (metal lopeptidase M20 family)

AI231787 — - Transcribed locus AI231826 ... Transcribed locus

AI232289 RGD1307812 similar to transcription factor (p38 interacting protein)

AI232407 —

AI232414 Pxmp4 peroxisomal membrane protein 4

AI232716 LOC368066 similar to indolethylamine N-methyltransferase

AI233143 Rab21 RAB2, member RAS oncogene family-like

AI233243 Rhot2 ras homolog gene family, member T2

AI233361 —

AI233902 — Transcribed locus

AI234022 GtOcI general transcription factor III C 1

AI234095 Smapl l stromal membrane-associated protein 1-like

AI234943 SObI Splicing factor 3b, subunit 1

AI235220 LOC498178 /// similar to SET domain-containing protein

LOC687538 ///

LOC689820

AI235414 —

AI235431 Tnpo2_predicted transportin 2 (importin 3, karyopherin beta 2b) (predicted)

AI235468 Dst_predicted dystonin (predicted)

AI235474 Prkwnkl Protein kinase, lysine deficient 1

AI235528 — Transcribed locus

AI235774 Mcm3ap_predicted minichromosome maintenance deficient 3 (S. cerevisiae) associated protein (predicted)

AI236141 LOC686590 similar to IQ motif and Sec7 domain 1

AI236229 LOC681858 /// similar to RNA binding motif protein 24

LOC690139

AI236455 Anxal annexin Al

AI236521 LOC691849 hypothetical protein LOC691849

AI237082 Hivepl human immunodeficiency virus type I enhancer binding protein 1

AI237098 Uxt ubiquitously expressed transcript

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)

AI237192 Fut4 fucosyltransferase 4

AI237227 — Transcribed locus

AI237640 LOC683446 /// similar to killer activatory receptor-like protein p91D

RGD1562625_predicted (predicted) /// similar to paired-Ig-like receptor Al 1

AI237698 — Transcribed locus

AI385291 BIk B lymphoid kinase

AI406275 Cbx7 chromobox homolog 7

AI406386 Lmo4 LIM domain only 4

AI406565 Smpx small muscle protein, X-linked

AI406660 —

AI406775 — Transcribed locus

AI406854 ... Transcribed locus

AI406967 — Transcribed locus

AI407107 Rnf44 Ring finger protein 44

AI407163 ... Transcribed locus

AI407239 — Transcribed locus

AI407261 Ubpl_predicted upstream binding protein 1 (predicted)

AI407418 RGD1562596_predicted similar to mKIAA0159 protein (predicted)

AI407458 Aldhόal aldehyde dehydrogenase family 6, subfamily Al

AI407487 — Transcribed locus

AI407688 Ubtf upstream binding transcription factor, RNA polymerase I

AI407827 Pik3cd_predicted phosphatidylinositol 3-kinase catalytic delta polypeptide

(predicted)

AI407985 RGD1561797_predicted RGD 1561797 (predicted)

AI407992 — Transcribed locus

AI408081 RGD1307597_predicted similar to mKIAA0317 protein (predicted)

AI408164 RGD 1306176 similar to FCRL AI408286 Ms4a7_predicted membrane-spanning 4-domains, subfamily A, member 7

(predicted)

AI408289 Cd22_predicted CD22 antigen (predicted)

AI408306 Slc44a2_predicted Solute carrier family 44, member 2 (predicted)

AI408343 RGD1562552_predicted similar to hypothetical protein LOC340061 (predicted)

AI408425 Tlr7_predicted toll-like receptor 7 (predicted)

AI408440 MGC 108823 /// similar to interferon-inducible GTPase /// similar to

RGDl 559715_predicted MGC 108823 protein (predicted)

AI408443 Psrc2 proline/serine-rich coiled-coil 2

AI408597 — Transcribed locus

AI408598 Git2 G protein-coupled receptor kinase-interactor 2

AI408613 —

AI408674 LOC688261 similar to 5(3)-deoxyribonucleotidase, cytosolic type

(Cytosolic 5,3-pyrimidine nucleotidase) (Deoxy-5- nucleotidase l) (dNT-l)

AI408827 LOC300191 similar to RIKEN cDNA 4930570C03

AI408833 Hnrpal heterogeneous nuclear ribonucleoprotein Al

AI408839 Rwdd2_predicted RWD domain containing 2 (predicted)

AI408948 Ca2 carbonic anhydrase 2

AI409142 LOC67981 1 similar to RIKEN cDNA D930015E06

AI409173 — Transcribed locus

AI409180 Mrpl52_predicted mitochondrial ribosomal protein L52 (predicted)

AI409262 Rhebll Ras homolog enriched in brain like 1

AI409460 RGD1561781_predicted similar to RIKEN cDNA 2600017H02 (predicted)

AI409545 LOC689938 similar to NADH dehydrogenase (ubiquinone) 1 , subcomplex unknown, 1

AI409634 Best5 Best5 protein

AI409635 — Transcribed locus

AI409904 — Transcribed locus

AI410068 Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide

AI410861 — Transcribed locus

AI41 1 149 — Transcribed locus

AI41 1 185 — Transcribed locus

AI41 1227 RGD1563485_predicted similar to mKIAA0534 protein (predicted)

AI41 1326 LOC303057 /// Slu7 similar to step II splicing factor SLU7; DNA segment, Chr

11, ERATO Doi 730, expressed; DNA segment, Chr 3,

Brigham & Womens Genetics 0878 expressed /// step II splicing factor SLU7 (S. cerevisiae)

AI411413 LOC685778 /// Pdhal pyruvate dehydrogenase El alpha 1 /// pyruvate dehydrogenase El alpha 1 pseudogene

AI41 1425 Esd esterase D/formylglutathione hydrolase

AI41 1436 Gadd45gipl growth arrest and DNA-damage-inducible, gamma interacting protein 1

AI41 1527 Wfdc2 WAP four-disulfide core domain 2

AI411563 Fgd2_predicted FYVE, RhoGEF and PH domain containing 2 (predicted)

AI411693 LOC299458 /// similar to immunoglobulin heavy chain 6 (Igh-6) /// similar

LOC366747 /// to Ig H-chain V-region precursor /// similar to Ig heavy chain

LOC678701 /// V region MClOl precursor /// hypothetical protein

RGD 1359202 LOC678701

AI41 1747 Art2b ADP-ribosyltransferase 2b

AI41 1753 — Transcribed locus

AI41 1774 LOC68061 1 /// similar to B-cell leukemia/lymphoma 3

LOC686871

AI41 1809 — Transcribed locus

AI412136 Tmprss2 transmembrane protease, serine 2

AI412155 Cryl cryptochrome 1 (photolyase-like)

AI412189 Igha mapped /// immunoglobulin heavy chain (alpha polypeptide) (mapped)

LOC366772 /// similar to immunoglobulin heavy chain

AI412244 Tbcldl4 TBCl domain family, member 14 AI412322 Acat2 acetyl-Coenzyme A acetyltransferase 2

AI412781 LOC680281 /// similar to RIKEN cDNA 4930555G01 (predicted) /// similar

LOC685769 /// to Discs large homolog 5 (Placenta and prostate DLG)

LOC690576 /// (Discs large protein P-dlg) /// hypothetical protein

LOC691414 /// LOC691414

RGDl 563862_predicted

AI412813 — Transcribed locus

AI412866 RGDl 306100_predicted similar to RRP22 (predicted)

AI412969 RGD 1307215 similar to protein phosphatase 1, regulatory (inhibitory) subunit 1C; thymocyte ARPP; DNA segment, Chr 9,

Brigham & Womens Genetics 1012 expressed

AI453967 RGD 1306176 similar to FCRL

AI454224 — Transcribed locus

AI454790 — Transcribed locus

AI454905 Tusc3 tumor suppressor candidate 3

AI45491 1 Scyel small inducible cytokine subfamily E, member 1

AI500952 SIa Src-like adaptor

AI501 127 —

AI501 187 Dsglc_predicted /// desmoglein 1 gamma (predicted) /// similar to Desmoglein-1

LOC679010 alpha precursor (Dsgl -alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DGl) (DGI)

AI501709 Clqtnf7_predicted CIq and tumor necrosis factor related protein 7 (predicted)

AI501853 Ptplad2_predicted protein tyrosine phosphatase-like A domain containing 2

(predicted)

AI502114 Abcal ATP-binding cassette, sub-family A (ABCl), member 1

AI502349 — Transcribed locus

AI502443 LOC680726 Similar to RNA binding motif, single stranded interacting protein 3 isoform 1

AI502459

AI502837 — Transcribed locus

AI502930 Eif3s8 eukaryotic translation initiation factor 3, subunit 8, 11OkDa

AI51 1408 —

AI535104 Plxncl_predicted plexin Cl (predicted)

AI5351 13 — Transcribed locus

AI547876 — Transcribed locus

AI547937 — Transcribed locus

AI5481 17 —

AI548667 — Transcribed locus

AI548779 RGDl 56225 l_predicted similar to DNA segment, Chr 1 1, ERATO Doi 461 , expressed (predicted)

AI548897 Soatl Sterol O-acyltransferase 1

AI548940 RGD1561963_predicted similar to Dedicator of cytokinesis protein 10 (Protein zizimin 3) (predicted)

AI549009 Prkag3_predicted protein kinase, AMP-activated, gamma 3 non-catatlytic subunit (predicted)

AI549199 Ptger4 Prostaglandin E receptor 4 (subtype EP4)

AI549209 — Transcribed locus

AI549335 Dock 1 1 dedicator of cytokinesis 1 1

AI549393 — Transcribed locus

AI549450 Cd209b CD209b antigen

AI549469 Ptk7_predicted PTK7 protein tyrosine kinase 7 (predicted)

AI555257 RGD1562305_predicted similar to suprabasal-specific protein suprabasin (predicted)

A1555336 Mllt6_predicted myeloid/lymphoid or mixed lineage-leukemia translocation to 6 homolog (Drosophila) (predicted)

AI555447 RGD1565975_predicted RGD 1565975 (predicted)

AI555526 — Transcribed locus

AI555855 — Transcribed locus

AI556056 Cr2_predicted complement receptor 2 (predicted)

AI556235 RGD1310061 similar to hypothetical protein FLJlOl 54 AI556333 RGD1564257_predicted similar to hypothetical protein FLJ32825 (predicted)

AI556638 —

AI556940 Tmc4 transmembrane channel-like gene family 4

AI556957 Aff4_predicted AF4/FMR2 family, member 4 (predicted)

AI575072 Strn4_predicted striatin, calmodulin binding protein 4 (predicted)

AI575255 — Transcribed locus

AI575264 Ddx58_predicted DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (predicted)

AI575442 Ryrl ryanodine receptor 1, skeletal muscle

AI575608 LOC297481 similar to eukaryotic translation initiation factor 4E member

3

AI576002 Transcribed locus

AI576009 Higdlb_predicted HIGl domain family, member IB (predicted)

AI576184 — Transcribed locus

AI576518 — Transcribed locus

AI577508 LOC684425 similar to Adenylosuccinate synthetase isozyme 1

(Adenylosuccinate synthetase, muscle isozyme) (IMP-- aspartate ligase 1) (AdSS 1) (AMPSase 1)

AI577567 Rasal2_predicted RAS protein activator like 2 (predicted)

AI577848 Trio Triple functional domain (PTPRF interacting)

AI578087 Tm4sfl _predicted transmembrane 4 superfamily member 1 (predicted)

AI578098 LOC683220 /// similar to CD209 antigen

LOC688750

AI578268 Ssh3 slingshot homolog 3 (Drosophila)

AI578566 Ubnl_predicted ubinuclein 1 (predicted)

AI579376 RGD 1309220 similar to RIKEN cDNA 463241 IB 12

AI598307 Slc45a3_predicted solute carrier family 45, member 3 (predicted)

AI598971 Perp_predicted PERP, TP53 apoptosis effector (predicted)

AI599048 — Transcribed locus

AI599133 LOC363060 similar to RIKEN cDNA 1600029D21

AI599232 — Transcribed locus

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI599794 — Transcribed locus, moderately similar to XP_580071.1

PREDICTED: hypothetical protein XP 580071 [Rattus norvegicus]

AI600030 RGD1306494_predicted similar to Expressed sequence AW 146242 (predicted)

AI600061 Addl adducin 1 (alpha)

AI638971 OcIn Occluding

AI638986 Neb_predicted nebulin (predicted)

AI639108 —

AI6391 17 Cfb complement factor B

AI639241 LOC684318 /// ubiquitin specific protease 12 (predicted) /// similar to

RGD1561481_predicted ubiquitin specific protease 12 (predicted) /// similar to

/// Uspl2_predicted ubiquitin specific protease 12

AI639268 Dhrs7c_predicted dehydrogenase/reductase (SDR family) member 7C

(predicted)

AI639331

AI639401 Thh_predicted Trichohyalin (predicted)

AI639412 LOC306805 similar to asporin precursor

AI639521 — Transcribed locus

AI706508 Pprcl_predicted peroxisome proliferative activated receptor, gamma, coactivator-related 1 (predicted)

AI706673 Wasl Wiskott-Aldrich syndrome-like (human)

AI709455 — Transcribed locus

AI709793 — Transcribed locus

AI710051 Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)

AI710604 Transcribed locus AI710682 Tnncl troponin C type 1 (slow)

AI712791 Slc6al7 solute carrier family 6 (neurotransmitter transporter), member 17

AI713204 MgIl Monoglyceride lipase

AI713965 Irx3_predicted Iroquois related homeobox 3 (Drosophila) (predicted)

AI713966 Igfbp3 insulin-like growth factor binding protein 3

AI714002 Mki67_predicted antigen identified by monoclonal antibody Ki-67 (predicted)

AI715202 RTl-Bb RTl class II, locus Bb

AI71541 1 MGC 108778 Similar to RIKEN cDNA 1810057C19

AI715999 LOC688864 similar to transmembrane protein 61

AI716125 C2 complement component 2

AI716456 Tiaml T-cell lymphoma invasion and metastasis 1

AI716887 RGD1561064_predicted similar to myozenin 1 (predicted)

AI716969 RGD1305774_predicted hypothetical LOC287353 (predicted)

AI716980 Capn9 calpain 9 (nCL-4)

AI716987 Dsglc_predicted /// desmoglein 1 gamma (predicted) /// similar to Desmoglein-1

LOC679010 alpha precursor (Dsgl -alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DGl) (DGI)

AI717047 Cml5 camello-like 5

AI717081 — Transcribed locus

AI717163 — Transcribed locus

AI717186 RGD1306300_predicted similar to CG9643-PA (predicted)

AI717476 Pygm muscle glycogen phosphorylase

AI717644 RGD1563764_predicted similar to PHD finger protein 14 isoform 1 (predicted)

AI717736 LOC503164 hypothetical protein LOC503164

AI764088 Myolf_predicted myosin IF (predicted)

AI948410 —

AJOl 1 1 16 Nos3 nitric oxide synthase 3, endothelial cell

AJOl 181 1 Cldn7 claudin 7

AJ243304 Trdn triadin

AJ243338 RT1-CE5 RTl class I, CE5

AJ243973 RTl -S3 RTl class Ib, locus S3

AJ243974 RTl -S3 RTl class Ib, locus S3

AJ245707 Phyh2 phytanoyl-CoA 2-hydroxylase 2

AW141642 RGD1306067 similar to chromosome 20 open reading frame 6

AW142500 Sept6_predicted septin 6 (predicted)

AW142773 — Transcribed locus

AW142796 RGD1566282_predicted similar to RIKEN cDNA D330045A20 (predicted)

AW 142978 Traf3ip3 TRAF3 interacting protein 3

AW143154 Mkll_predicted megakaryoblastic leukemia (translocation) 1 (predicted)

AW144132 — Transcribed locus

AW144193 — Transcribed locus

AW144216 Enpep glutamyl aminopeptidase

AW 144509 Dsp desmoplakin

AW 144823 Sorll sortilin-related receptor, LDLR class A repeats-containing

AW251280 —

AW251324 LOC680308 similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor

AW251647 Transcribed locus

AW251860 Tcf7_predicted transcription factor 7, T-cell specific (predicted)

AW2521 15 RGDl 562105_predicted similar to Rho-GTPase-activating protein 25 (predicted)

AW252232 — Transcribed locus

AW252401 LOC362564 hypothetical LOC362564

AW252428 — Transcribed locus

AW25251 1 Ddx24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24

AW254450 RGD 1310433_predicted similar to mKIAA1757 protein (predicted)

AW433901 Celsrl cadherin EGF LAG seven-pass G-type receptor 1 AW433947 Tnfrsf5 tumor necrosis factor receptor superfamily, member 5 AW434166 Nicnl nicolin 1 AW434961 Hfe2 hemochromatosis type 2 (juvenile) homolog (human) AW434972 Rbm25_predicted /// RNA binding motif protein 25 (predicted) /// similar to RNA

RGD 1565486_predicted binding motif protein 25 (predicted)

AW43521 1 Transcribed locus AW435343 Tm4sfl_predicted transmembrane 4 superfamily member 1 (predicted) AW435407 Transcribed locus AW435415 Transcribed locus AW435479 RGDl 5612 l l_predicted similar to Amyloid beta (A4) precursor-like protein 1

(predicted)

AW522166 Transcribed locus AW522341 Transcribed locus AW522357 Transcribed locus AW522661 Lnxl_predicted ligand of numb-protein X 1 (predicted) AW522944 Ndph_predicted Norrie disease homolog (human) (predicted) AW523423 AW523620 Transcribed locus, moderately similar to XP 418639.1

PREDICTED: similar to metalloprotease-disintegrin [Gallus gallus]

AW523955 Transcribed locus AW523958 Transcribed locus AW524037 Transcribed locus AW524146 Pcdh20_predicted protocadherin 20 (predicted) AW524173 Transcribed locus AW524239 Transcribed locus AW524359 Transcribed locus AW524694 LOC500591 similar to calmodulin-binding transcription activator 1 AW525235 Suv420h2_predicted suppressor of variegation 4-20 homolog 2 (Drosophila)

(predicted)

AW525288 Transcribed locus AW525315 AW525662 Cdc27 cell division cycle 27 homolog (S. cerevisiae) AW525862 AW526014 Transcribed locus AW526015 RGDl 56424 l_predicted similar to zinc finger protein 426 (predicted) AW526072 Transcribed locus AW526087 LOC680047 /// similar to protocadherin beta 9

LOC683183

AW526268 RGD1561817_predicted Similar to Traf2 and NCK interacting kinase, splice variant 4

(predicted)

AW526551 RGD1307724_predicted similar to NCAGl (predicted) AW526631 Sorll sortilin-related receptor, LDLR class A repeats-containing AW526714 Transcribed locus AW526982 Tlr2 toll-like receptor 2 AW527159 Transcribed locus AW527270 RGD1309360 hypothetical LOC294715 AW527313 Rdx radixin AW527403 Sh3yll_predicted Sh3 domain YSC-like 1 (predicted) AW528106 Transcribed locus AW528353 Transcribed locus, strongly similar to XP_579759.1

PREDICTED: hypothetical protein XP 579759 [Rattus norvegicus]

AW528448 Transcribed locus AW528482 Transcribed locus AW528765 Transcribed locus, strongly similar to XP_341205.2

PREDICTED: similar to LNXpδO [Rattus norvegicus]

AW528853 RGD1309403_predicted similar to hypothetical protein FLJ 12661 (predicted) AW529415 ... Transcribed locus

AW529736 Wfdc5_predicted WAP four-disulfide core domain 5 (predicted)

AW530415 — Transcribed locus

AW530423 — Transcribed locus

AW530507 — Transcribed locus

AW530769 Fdftl farnesyl diphosphate farnesyl transferase 1

AW530812 RGD131 1224_predicted similar to fatty acid desaturase 2; linoleoyl-CoA desaturase

(delta-6-desaturase)-like 2; delta-6 fatty acid desaturase

(predicted)

AW531135 ... Transcribed locus

AW531805 Ifit3 interferon-induced protein with tetratricopeptide repeats 3

AW531880 — Transcribed locus

AW531902 Zfhx4_predicted zinc finger homeodomain 4 (predicted)

AW532114 Rasgrp2_predicted RAS guanyl releasing protein 2 (calcium and DAG- regulated) (predicted)

AW532165 Sema3d sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D

AW532179 LOC500449 similar to SHP2-interacting transmembrane adaptor protein

AW532214 — Transcribed locus

AW532414 RGD1565549_predicted similar to polybromo-1 (predicted)

AW532525 Srrm2_predicted serine/arginine repetitive matrix 2 (predicted)

AW532618 — Transcribed locus

AW532634 — Transcribed locus

AW533203 Agpat3_predicted l-acylglycerol-3 -phosphate O-acyltransferase 3 (predicted)

AW533234 LOC688915 similar to cardiomyopathy associated 5

AW533569 Clca2_predicted chloride channel, calcium activated, family member 2

(predicted)

AW533848 Mybpc2_predicted myosin binding protein C, fast-type (predicted)

AW533923 LOC500015 similar to mKIAA2005 protein

AW533998 — Transcribed locus

AW534046 —

AW534142 — Transcribed locus, strongly similar to NP 075544.1 leucine zipper- and sterile alpha motif-containing kinase isoform 1 [Mus musculus]

AW534148

AW534218 RGD 1310722_predicted similar to RIKEN cDNA D130059P03 gene (predicted)

AW534277 Atp2bl ATPase, Ca++ transporting, plasma membrane 1

AW534554 ...

AW534561 — Transcribed locus

AW534728 Ewsrl Ewing sarcoma breakpoint region 1

AW534807 Elk4_predicted ELK4, member of ETS oncogene family (predicted)

AW534965 RGD 1560358_predicted similar to cell division cycle and apoptosis regulator 1

(predicted)

AW535052 Smc211_predicted SMC2 structural maintenance of chromosomes 2-like 1

(yeast) (predicted)

AW535067 Ephbl Eph receptor B 1

AW535122 LOC679020 /// similar to nucleoredoxin

LOC689232

AW535232 RGD1561 145_predicted similar to novel protein (predicted)

AW5353O5 RGD1305145 similar to CG6796-PA

AW915049 ... Transcribed locus

AW915083 — Transcribed locus, strongly similar to XP 996556.1

PREDICTED: similar to Dual specificity protein phosphatase CDC14A (CDC14 cell division cycle 14 homolog A) isoform 1 [Mus musculus]

AW915152 Echdcl enoyl Coenzyme A hydratase domain containing 1

AW915157 LOC685462 similar to EMI domain containing 1

AW915435 —

AW915948 Cd3e predicted CD3 antigen, epsilon polypeptide (predicted) AW916093 ... Transcribed locus

AW916957 ... Transcribed locus, strongly similar to XP 579758.1

PREDICTED: hypothetical protein XP 579758 [Rattus norvegicus]

AW917731 Tbcldl_predicted TBCl domain family, member 1 (predicted)

AW917933 — Transcribed locus

AW918029 Gimapl /// Gimap5 GTPase, IMAP family member 5 /// GTPase, IMAP family member 1

AW918387 Abcal ATP-binding cassette, sub- family A (ABCl), member 1

AW918480 — Transcribed locus

AW918614 Spnb2 spectrin beta 2

AW918981 — Transcribed locus

AW919180 Pygm muscle glycogen phosphorylase

AW919569 MGC156825 similar to MIR-interacting saposin-like protein precursor

(Transmembrane protein 4) (Putative secreted protein

ZSIG9)

AW919577 Tcrb T-cell receptor beta chain

AW920000 LOC362587 similar to microfilament and actin filament cross-linker protein isoform b

AW920026 LOC364393 /// PHD finger protein 11 /// similar to RIKEN cDNA

LOC684778 /// Phfl 1 4933417L10 /// hypothetical protein LOC684778

AW920039 RGD1311584 similar to stem cell adaptor protein STAP-I

AW920881 Actr2 /// LOC301861 ARP2 actin-related protein 2 homolog (yeast) /// similar to

ARP2 actin-related protein 2 homolog (yeast) (predicted)

AW920944 Transcribed locus

AW921 158 —

AW921279 LOC683839 /// hypothetical protein LOC683839 /// hypothetical protein

LOC688495 LOC688495

AW921478 Ms4al l_predicted membrane-spanning 4-domains, subfamily A, member 11

(predicted)

AY082657 Kcnipl Kv channel-interacting protein 1

BE095824 Ccl6 chemokine (C-C motif) ligand 6

BE096367 — Transcribed locus

BE096453 Ubel l_predicted ubiquitin-activating enzyme E 1 -like (predicted)

BE096523 Glp2_predicted interferon, alpha-inducible protein (clone IFI- 15K)

(predicted)

BE096652 Ly6g6c lymphocyte antigen 6 complex, locus G6C

BE096750 RGD1305928_predicted hypothetical LOC300207 (predicted)

BE096812 — Transcribed locus

BE097574 Kcnabl potassium voltage-gated channel, shaker-related subfamily, beta member 1

BE097933 Mitf microphthalmia-associated transcription factor

BE097945 — Transcribed locus

BE098153 Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

BE098186 Anksl_predicted ankyrin repeat and SAM domain containing 1 (predicted)

BE098532 LOC303057 similar to step II splicing factor SLU7; DNA segment, Chr

11, ERATO Doi 730, expressed; DNA segment, Chr 3,

Brigham & Womens Genetics 0878 expressed

BE098713 Igsf3_predicted immunoglobulin superfamily, member 3 (predicted)

BE098726 — Transcribed locus

BE098732 Uhrfl ubiquitin-like, containing PHD and RING finger domains, 1

BE099038 —

BE099050 Nfib nuclear factor I/B

BE099838 — Non-coding RNA expressed in the brain, repeat sequence, clone 12

BE100015 Arhgap27 Rho GTPase activating protein 27

BE 100543 Ncorl nuclear receptor co-repressor 1

BE10081 1 Epb4.114a_predicted erythrocyte protein band 4.1 -like 4a (predicted) BE1O1 133 ...

BE 102265 —

BE 102340 —

BE102358 — Transcribed locus, moderately similar to XP 237998.3

PREDICTED: similar to mKIAA0183 protein [Rattus norvegicus]

BE102861 Transcribed locus

BE103057 — Transcribed locus

BE103561 Ccnj_predicted cyclin J (predicted)

BE103689 Zfhx4_predicted zinc finger homeodomain 4 (predicted)

BE103745 Sortl Sortilin 1

BE103975 — Transcribed locus, strongly similar to NP_001035488.1 SET domain containing 1 B [Mus musculus]

BE104164 Transcribed locus

BE104167 — Transcribed locus

BE 104421 — Transcribed locus

BE 104506 RGD 1307284_predicted similar to protein kinase, lysine deficient 1 ; kinase deficient protein (predicted)

BE104517 Transcribed locus

BE 104676 — Transcribed locus, strongly similar to NP 001029332.1 hypothetical protein LOC619476 [Rattus norvegicus]

BE 104961 Cenpj_predicted centromere protein J (predicted)

BE105050 — Transcribed locus

BE105268 Pcnxl3 pecanex-like 3 (Drosophila)

BEl 05494 LOC294762 similar to poly (ADP-ribose) polymerase family, member 8

BE 105498 — Transcribed locus

BE105565 Rbaf600 ZUBRl

BE105705 LOC688144 /// similar to ankyrin repeat domain 40

LOC690586

BE105855 Cyb5r2 cytochrome b5 reductase 2

BE106199 Rora_predicted RAR-related orphan receptor alpha (predicted)

BEl 06353 Tsga2 testis specific gene A2

BE 106791 — Transcribed locus

BEl 06891 — Transcribed locus

BE 107024 — Transcribed locus

BE107173 —

BE 107282 Vofl6 ischemia related factor vof-16

BE 107346 Eif5 eukaryotic translation initiation factor 5

BE107351 — Transcribed locus

BEl 07400 LOC690606 similar to MANSC domain containing 1

BE107859 RGD131 1595 similar to KIAA2026 protein

BEl 08006 Aebp2_predicted AE binding protein 2 (predicted)

BE108131 Wdfyl WD repeat and FYVE domain containing 1

BE108135 ... Transcribed locus

BE108165 Cepl_predicted centrosomal protein 1 (predicted)

BE 108221 Corolc_predicted coronin, actin binding protein 1C (predicted)

BE 108294 — Transcribed locus

BE108367 RGDl 560834 jredicted similar to FRBZl protein (FRBZl) (predicted)

BE 108409 — Transcribed locus

BE108587 Nisch nischarin

BE108716 — Transcribed locus

BE108758 — Transcribed locus

BE108849 — Transcribed locus

BE108893 — Transcribed locus

BE 108905 Naplll Nucleosome assembly protein 1 -like 1

BE 109260 — Transcribed locus

BE 109322 Plk4_predicted polo-like kinase 4 (Drosophila) (predicted)

BE 109605 SfI splicing factor 1 BE 109730 Transcribed locus

BE 109926 Pik3cd_predicted phosphatidylinositol 3-kinase catalytic delta polypeptide

(predicted)

BEl 10067 Transcribed locus

BEl 10332 RGD1307829_predicted similar to chromosome 14 open reading frame 6 (predicted)

/// Rnasel l /// ribonuclease 1 1

BEl 10369 Arhgefl 8_predicted rho/rac guanine nucleotide exchange factor (GEF) 18

(predicted)

BEl 10674 LOC686259 /// hypothetical protein LOC686259 /// hypothetical protein

LOC690243 LOC690243

BEl 10723 Mphosph 1 _predicted M-phase phosphoprotein 1 (predicted)

BE1 1 1310 Ky_predicted kyphoscoliosis (predicted)

BEl 1 1378 Rpl31_predicted ribosomal protein L3-like (predicted)

BEl 1 1631 Zfp91 zinc finger protein 91

BEl 11669 Gcnlll_predicted /// GCNl general control of amino-acid synthesis 1-like 1

LOC690632 (yeast) (predicted) /// similar to GCNl general control of amino-acid synthesis 1-like 1

BEl 1 1692 Transcribed locus

BEl 1 1706 Marcks myristoylated alanine rich protein kinase C substrate

BEl 1 1722 LOC498279 similar to NADH dehydrogenase (ubiquinone) Fe-S protein

2

BEl 12093 Zfp91 zinc finger protein 91

BEl 12202 Arrdcl arrestin domain containing 1

BEl 12261 Ctdspl_predicted CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (predicted)

BEl 12453

BEl 12895 Pea 15 phosphoprotein enriched in astrocytes 15

BEl 12927 Cyfip2_predicted cytoplasmic FMRl interacting protein 2 (predicted)

BEl 12948 RGD 1566282_predicted similar to RIKEN cDNA D330045A20 (predicted)

BEl 13005 — Transcribed locus, moderately similar to NP OO 1028560.1 hypothetical protein LOC320003 [Mus musculus]

BEl 13144 — Transcribed locus, strongly similar to XP 579782.1 PREDICTED: hypothetical protein XP_579782 [Rattus norvegicus]

BEl 13247

BEl 13263 Mppel_predicted metallophosphoesterase 1 (predicted)

BEl 13270 Igfbp5 insulin-like growth factor binding protein 5

BE1 13419 Srpk2_predicted serine/arginine-rich protein specific kinase 2 (predicted)

BE1 13571 — Transcribed locus

BEl 13753 RGD 1562949_predicted similar to mKIAA0259 protein (predicted)

BEl 13958 Nr2O Nuclear receptor subfamily 2, group F, member 2

BEl 13961 — Transcribed locus

BEl 14751 —

BEl 15061 Lefl Lymphoid enhancer binding factor 1

BE1 15155 Rhpn2_predicted rhophilin, Rho GTPase binding protein 2 (predicted)

BE 1 15262 — Transcribed locus

BEl 15432 Utrn Utrophin

BE 1 15465 SObI splicing factor 3b, subunit 1

BE1 15521 RGD1310433_predicted similar to mKIAA1757 protein (predicted)

BEl 15594 Rfx5_predicted regulatory factor X, 5 (influences HLA class II expression)

(predicted)

BEl 15612 LOC679629 /// similar to smoothelin, like

LOC687788

BEl 15641 —

BEl 16021 Slc5a3 solute carrier family 5 (inositol transporters), member 3

BEl 16084 Xlkdl_predicted extracellular link domain-containing 1 (predicted)

BEl 161 1 1 — Transcribed locus

BEl 16127 —

BEl 16140 Transcribed locus BE l 16152 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast)

BE l 16383 Transcribed locus

BEl 16698 RGD 1564964_predicted similar to WD repeat domain 1 1 protein (predicted)

BEl 16750 Arhgap9 Rho GTPase activating protein 9

BEl 16774 —

BEl 16855 — CDNA clone IMAGE:7384525

BEl 17044 Cd8a CD8 antigen, alpha chain

BE1 17215 Nek7_predicted NIMA (never in mitosis gene a)-related expressed kinase 7

(predicted)

BEl 17217 Transcribed locus

BEl 17361 LOC681423 /// NIPBL Nipped-B homolog (Drosophila) /// similar to delangin isoform A

BEl 17736 Tgfb2 Transforming growth factor, beta 2

BE l 17773 Eif5b /// LOC689581 eukaryotic translation initiation factor 5B /// similar to

Eukaryotic translation initiation factor 5B (eIF-5B)

(Translation initiation factor IF-2)

BEl 17804 Cbfa2tl_predicted CBFA2T1 identified gene homolog (human) (predicted)

BEl 17891 M115 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)

BE 1 18096 Transcribed locus

BE1 18102 RGD 1307055_predicted similar to hypothetical protein FLJ22490 (predicted)

BEl 18107 —

BE1 181 16 — Transcribed locus

BE1 18197 — Transcribed locus

BE l 18548 Gtpbp3 GTP binding protein 3

BEl 18580 ... Transcribed locus

BEl 18651 Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase)

BE 1 18704 Transcribed locus

BEl 18866 LOC363849 similar to histone cell cycle regulation defective homolog A isoform 1

BE l 18901 Gata3 GATA binding protein 3

BEl 18929 — Transcribed locus

BEl 19167 — Transcribed locus

BEl 19699 — Transcribed locus

BE 120370 — Transcribed locus

BE120415 — Transcribed locus

BE 120660 — Transcribed locus

BE120816 — Transcribed locus

BE120823 Smc411 SMC4 structural maintenance of chromosomes 4-like 1

(yeast)

BE120852 Transcribed locus

BE 120904 — Transcribed locus

BE 126475 Prrxl paired related homeobox 1

BE328934 RGD1310958_predicted similar to RIKEN cDNA C 130090K23 (predicted)

BE328951 Cldn4 claudin 4

BE329013 Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

BE329196 Transcribed locus

BE329244 —

BE349699 Tspanl tetraspanin 1

BF281337 Krt2-8 keratin complex 2, basic, gene 8

BF281697 LOC681 190 similar to potassium voltage-gated channel, Isk-related family, member 1-like

BF281701 Transcribed locus

BF281987 Cxcl l l chemokine (C-X-C motif) ligand 1 1

BF282187 Transcribed locus BF282190 I122ra2 interleukin 22 receptor, alpha 2

BF282228 Ltb lymphotoxin B

BF282471 Lcp2 lymphocyte cytosolic protein 2

BF282632 Tspan4 tetraspanin 4

BF282978 RGD1307222_predicted similar to mKIAA0664 protein (predicted)

BF283053 Atp6vlc2 ATPase, H+ transporting, Vl subunit C, isoform 2

BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

BF283079 SfI splicing factor 1

BF283238 RGD1307506_predicted similar to RIKEN cDN A 2310016C 16 (predicted)

BF283341 — Transcribed locus

BF283556 Plxncl_predicted plexin Cl (predicted)

BF283610 — Transcribed locus

BF283642 LOC363060 similar to RIKEN cDNA 1600029D21

BF283675 — Transcribed locus

BF283692 Krt2-5 keratin complex 2, basic, gene 5

BF283779 RGD1565496_predicted similar to Butyrate-induced transcript 1 (predicted)

BF283797 MGCl 16327 similar to MK-5 type 2

BF283924 Lamp3 lysosomal-associated membrane protein 3

BF284168 — CDNA clone IMAGE:7460165

BF284224 LOC365842 similar to CDC-like kinase 2

BF284262 IrfS Interferon regulatory factor 8

BF284295 Tor3a torsin family 3, member A

BF284523 Abcal ATP-binding cassette, sub-family A (ABCl), member 1

BF284716 Ankrdl5 ankyrin repeat domain 15

BF284889 Actn2_predicted actinin alpha 2 (predicted)

BF285345 Arrb2 arrestin, beta 2

BF285350 Apobec2_predicted apolipoprotein B editing complex 2 (predicted)

BF285466 LOC680259 Hypothetical protein LOC680259

BF285731 — Transcribed locus

BF285996 LOC301334 similar to Rho guanine nucleotide exchange factor 4 isoform a

BF287135 Brd4 bromodomain containing 4

BF287629 I127ra_predicted interleukin 27 receptor, alpha (predicted)

BF288000 —

BF288101 Snn stannin

BF288109 — Transcribed locus

BF288130 Ptprc protein tyrosine phosphatase, receptor type, C

BF288177 Csnk2al casein kinase II, alpha 1 polypeptide

BF288243 Klf2_predicted Kruppel-like factor 2 (lung) (predicted)

BF288361 —

BF288533 — Transcribed locus

BF289020 Rab24 RAB24, member RAS oncogene family

BF289150 — Transcribed locus

BF289368 Lbp lipopolysaccharide binding protein

BF290109 —

BF2901 13 RGD131 1584 similar to stem cell adaptor protein STAP-I

BF290181 —

BF290301 LOC498662 similar to RIKEN cDNA 2610019F03

BF290410 — Transcribed locus

BF290784 —

BF386238 — Transcribed locus

BF386742 — Transcribed locus

BF387238 RGD131 11 17_predicted similar to KIAA 1409 protein (predicted)

BF387865 — Transcribed locus

BF388220 RGDl 30825 l_predicted similar to RIKEN cDNA 2810405K02 (predicted)

BF388585 Znf292 zinc finger protein 292

BF389056 ... Transcribed locus BF389793 Crabpl cellular retinoic acid binding protein 1 BF389889 Transcribed locus BF390077 Transcribed locus BF390257 RGD 1309863 similar to hypothetical protein DKFZp434K1421 BF390510 RGD131 1155 similar to RIKEN cDNA 9230117N10 BF390952 Transcribed locus BF391127 Arid4a_predicted AT rich interactive domain 4 A (Rbpl like) (predicted) BF392234 Bbx_predicted bobby sox homolog (Drosophila) (predicted) BF392577 Akap81 A kinase (PRKA) anchor protein 8-like BF393607 LOC689147 hypothetical protein LOC689147 BF393825 Dcir3 dendritic cell inhibitory receptor 3 BF393994 Transcribed locus BF394055 Depdc2_predicted DEP domain containing 2 (predicted) BF394095 Transcribed locus BF395095 RGD 1564875_predicted similar to mKIAA0613 protein (predicted) BF395171 Ehd4 EH-domain containing 4 BF395317 Ms4al l_predicted membrane-spanning 4-domains, subfamily A, member 1 1

(predicted)

BF395615 Atgl611_predicted ATG16 autophagy related 16-like 1 (S. cerevisiae)

(predicted)

BF396210 Trim59_predicted tripartite motif-containing 59 (predicted) BF396282 Kifl5 kinesin family member 15 BF396303 Transcribed locus BF396316 Transcribed locus BF396319 Transcribed locus BF396350 Irakl_predicted interleukin-1 receptor-associated kinase 1 (predicted) BF396495 Transcribed locus BF396501 Transcribed locus BF396623 Transcribed locus, strongly similar to XP_346904.2

PREDICTED: hypothetical protein XP 346903 [Rattus norvegicus]

BF396633 Transcribed locus BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF397627 Transcribed locus BF397719 Plekhg2_predicted pleckstrin homology domain containing, family G (with

RhoGef domain) member 2 (predicted)

BF397766 BF397936 RGD 1307526 similar to modulator of estrogen induced transcription BF398050 Chd6_predicted chromodomain helicase DNA binding protein 6 (predicted) BF398091 CDNA clone IMAGE:7374368 BF398122 Synaptogenesis-related mRNA sequence 6 BF398168 Transcribed locus BF398245 Tφsl_predicted trichorhinophalangeal syndrome I (predicted) BF398408 Transcribed locus BF398435 Transcribed locus BF398454 BF398513 RGDl 563803_predicted Similar to Lmnb2 protein (predicted) BF398614 Transcribed locus BF399329 BF399517 Transcribed locus BF399587 Transcribed locus BF399855 SeψinblO serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10

BF400995 RGDl 308019_predicted similar to hypothetical protein FLJ20245 (predicted) BF401109 Transcribed locus BF401586 Transcribed locus BF402012 Zbtb20_predicted zinc finger and BTB domain containing 20 (predicted) BF402387 Transcribed locus BF403434 Transcribed locus BF404261 RGD1561602_predicted similar to nemo like kinase (predicted) BF404462 Transcribed locus BF404935 Transcribed locus BF405339 Transcribed locus BF405616 Transcribed locus BF405906 BF406562 Tmem 1 _predicted transmembrane protein 1 (predicted) BF406973 RGD131 1490_predicted similar to DKFZP434P1750 protein (predicted) BF407551 BF407782 Transcribed locus BF408105 BF408445 Gpx7_predicted glutathione peroxidase 7 (predicted) BF408465 Myctl_predicted myc target 1 (predicted) BF408757 Transcribed locus BF408881 RGDl 30798 l_predicted similar to cisplatin resistance-associated overexpressed protein (predicted)

BF408990 Srrm2_predicted serine/arginine repetitive matrix 2 (predicted) BF409007 Transcribed locus BF409092 Transcribed locus BF409213 Transcribed locus BF409820 Transcribed locus BF410101 Transcribed locus BF410240 BF410366 Transcribed locus BF410504 GPR34_predicted G-protein-coupled receptor GPR34 (predicted) BF410953 BF411017 LOC304000 cell adhesion molecule JCAM BF411036 Irf7 interferon regulatory factor 7 BF411402 RGD131 1662_predicted similar to open reading frame 9 BF411408 BF411859 Transcribed locus BF412954 Transcribed locus BF413246 Transcribed locus, weakly similar to XP 990808.1

PREDICTED: hypothetical protein [Mus musculus]

BF413374 Transcribed locus BF414000 Transcribed locus BF414018 Tmem97 transmembrane protein 97 BF414285 Transcribed locus BF414649 Mrpl52_predicted mitochondrial ribosomal protein L52 (predicted) BF415030 Pigp_predicted phosphatidylinositol glycan, class P (predicted) BF415080 RGD1305202_predicted similar to Protein C20orfl 60 (predicted) BF415114 Zbtb20_predicted zinc finger and BTB domain containing 20 (predicted) BF415195 Gcn512_predicted GCN5 general control of amino acid synthesis-like 2 (yeast)

(predicted)

BF415512 Transcribed locus BF415825 Transcribed locus BF415852 LOC299907 similar to Extl BF416214 Transcribed locus BF416343 LOC681423 /// NIPBL Nipped-B homolog (Drosophila) /// similar to delangin isoform A

BF416764 LOC363326 hypothetical LOC363326 BF416786 Fmnll_predicted formin-like 1 (predicted) BF416979 Spsbl_predicted splA/ryanodine receptor domain and SOCS box containing 1

(predicted)

BF417048 LOC499300 similar to protein tyrosine phosphatase, receptor type, C polypeptide-associated protein BF417079 ... Transcribed locus

BF417216 LOC686132 similar to hemicentin 1

BF417252 RGD1305350_predicted similar to RIKEN cDNA 2510039018 (predicted)

BF417363 Hmhal_predicted histocompatibility (minor) HA-I (predicted)

BF417385 MGC109519 similar to tropomyosin 1, embryonic fibroblast - rat

BF417479 Dhcr24 24-dehydrocholesterol reductase

BF417582 Myolg myosin IG

BF417625 — Transcribed locus

BF417784 — Transcribed locus

BF418025 Grap GRB2-related adaptor protein

BF418487 Med31_predicted mediator of RNA polymerase II transcription, subunit 31 homolog (yeast) (predicted)

BF418522 Transcribed locus

BF418596 Ssl8 synovial sarcoma translocation, Chromosome 18

BF418649 RGD1305645_predicted similar to RIKEN cDNA 1500015010 (predicted)

BF418812 Tceall transcription elongation factor A (SΙI)-like 1

BF418957 Clqa complement component 1 , q subcomponent, alpha polypeptide

BF419134 Acbd3 acyl-Coenzyme A binding domain containing 3

BF419319 Oasll 2'-5' oligoadenylate synthetase-like 1

BF419899 Ccl7 chemokine (C-C motif) ligand 7

BF419995 Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow

BF420720 RGD1563128_predicted similar to ADP-ribosylation-like factor 12 protein (predicted)

BF420722 Nfix nuclear factor I/X

BF420803 — Transcribed locus

BF420807 —

BF420810 Hrc histidine rich calcium binding protein

BF521859 Tnnt3 troponin T3, skeletal, fast

BF522317 — Transcribed locus

BF522436 RGD 1306067 similar to chromosome 20 open reading frame 6

BF522954 I118rl_predicted interleukin 18 receptor 1 (predicted)

BF523248 Ankrdl l_predicted ankyrin repeat domain 1 1 (predicted)

BF524010 —

BF525282 Hsphl heat shock 105kDa/l 1OkDa protein 1

BF542615 Ptplad2_predicted protein tyrosine phosphatase-like A domain containing 2

(predicted)

BF543289 RGD1304592_predicted similar to KIAA0528 protein (predicted)

BF544982 Gmip_predicted Gem-interacting protein (predicted)

BF545080 Cox6b2 cytochrome c oxidase subunit VIb testes-specific isoform precursor

BF545268 Cr2_predicted complement receptor 2 (predicted)

BF545930 — Transcribed locus

BF545988 Tmc4 transmembrane channel-like gene family 4

BF546899 RGD1307396_predicted similar to RIKEN cDNA 6330406115 (predicted)

BF547251 LOC685707 /// neuron navigator 1 (predicted) /// similar to neuron navigator

Navl_predicted 1

BF548081 —

BF549535 — Transcribed locus, weakly similar to XP 999107.1

PREDICTED: similar to zinc finger protein 700 [Mus musculus]

BF550315 Tφsl_predicted trichorhinophalangeal syndrome I (predicted)

BF550555 Lig4_predicted Ligase IV, DNA, ATP-dependent (predicted)

BF551 187 — Transcribed locus

BF551457 LOC501619 similar to 4OS ribosomal protein S29

BF551686 Apls2_predicted adaptor-related protein complex 1 , sigma 2 subunit

(predicted)

BF552772 LOC499094 similar to zinc finger protein 61

BF552973 Myot_predicted myotilin (predicted) BF553172 Transcribed locus

BF553613 Txndc4 thioredoxin domain containing 4 (endoplasmic reticulum)

BF554283 Ogfrll opioid growth factor receptor-like 1

BF554746 Rtn4rll reticulon 4 receptor-like 1

BF555727 Efha3 ephrin A3

BF555968 Nedd9 neural precursor cell expressed, developmentally down- regulated gene 9

BF555972 RGD1359529 similar to chromosome 1 open reading frame 63

BF555973 — Transcribed locus

BF556622 —

BF556812 — Transcribed locus

BF557813 — Transcribed locus

BF558056 —

BF558075 RGDl 305464 similar to DKFZP434H132 protein

BF558512 — Transcribed locus

BF558732 Bazlb bromodomain adjacent to zinc finger domain protein IB

BF558946 LOC688717 similar to CG33714-PB, isoform B

BF560693 —

BF560932 Sox4_predicted SRY-box containing gene 4 (predicted)

BF560938 Zfp503_predicted zinc finger protein 503 (predicted)

BF561077 — Transcribed locus

BF561454 Fgl2 fibrinogen-like 2

BF561717 Pdhal pyruvate dehydrogenase El alpha 1

BF562507 Sorll sortilin-related receptor, LDLR class A repeats-containing

BF564217 Angl angiogenin, ribonuclease A family, member 1

BF565167 Rdx radixin

BF565675 Arsa arylsulfatase A

BF565718 — Transcribed locus

BF565756 — Transcribed locus

BF565850 — Transcribed locus

BF566051 — Transcribed locus

BF567833 Tmod2 tropomodulin 2

BG057565 Bat Ia HLA-B-associated transcript 1 A

BG371544 — Transcribed locus

BG371683 — Transcribed locus, moderately similar to NP 598678.1 mondoA isoform 2 [Mus musculus]

BG371843 Pkpl_predicted plakophilin 1 (predicted)

BG372056 — Transcribed locus

BG372184 — Transcribed locus

BG372243 — Transcribed locus

BG372342 RGD131 1019_predicted similar to hypothetical protein DKFZp434H2010 (predicted)

BG372602 RGD1306601_predicted similar to cDNA sequence BC019755 (predicted)

BG372703 Fnbp4 formin binding protein 4

BG372891 — Transcribed locus

BG372903 Rnpc2 RNA-binding region (RNPl , RRM) containing 2

BG372987 —

BG373000 — Transcribed locus

BG373166 Elf5_predicted E74-like factor 5 (predicted)

BG373352 B3gntl_predicted UDP-GIcNAc :betaGal beta-l,3-N- acetylglucosaminyltransferase 1 (predicted)

BG373576 Prmt6_predicted protein arginine N-methyltransferase 6 (predicted)

BG373580 Chchdl_predicted coiled-coil-helix-coiled-coil-helix domain containing 1

(predicted)

BG373799 Transcribed locus

BG374483 Per3 period homolog 3 (Drosophila)

BG374493 Cyp2j lO_predicted cytochrome P450, family 2, subfamily j, polypeptide 10

(predicted)

BG374639 Transcribed locus BG375315 Sdcl syndecan 1

BG375352 Ca5b carbonic anhydrase VB, mitochondrial

BG375362 Ltbp4 latent transforming growth factor beta binding protein 4

BG375798 — Transcribed locus

BG376030 RGDl 306107_predicted similar to chromosome 1 open reading frame 2 (predicted)

BG376644 Rsbnl l_predicted round spermatid basic protein 1-like (predicted)

BG3771 16 Atp6v0a4_predicted ATPase, H+ transporting, lysosomal VO subunit A isoform 4

(predicted)

BG377332

BG377504 Foxil_predicted forkhead box Il (predicted)

BG377979 LOC690528 similar to POU domain class 2, associating factor 1 (B-cell- specific coactivator OBF-I) (OCT binding factor 1) (BOB-I)

(BOBl) (OCA-B)

BG378166 Map4k2_predicted mitogen activated protein kinase kinase kinase kinase 2

(predicted)

BG378238 Transcribed locus

BG378310 Scel_predicted sciellin (predicted)

BG378463 RGD1563547_predicted RGD 1563547 (predicted)

BG378588 Mybpc2_predicted myosin binding protein C, fast-type (predicted)

BG378607 LOC362350 /// Tcrb T-cell receptor beta chain /// similar to T-cell receptor beta-2 chain C region

BG378613 Agpat3_predicted l-acylglycerol-3-phosphate O-acyltransferase 3 (predicted)

BG378630 Plac8_predicted placenta-specific 8 (predicted)

BG378709 —

BG378709 —

BG378760 Srpkl Serine/arginine-rich protein specific kinase 1

BG378874 Wbp5_predicted WW domain binding protein 5 (predicted)

BG378885 Hmgal high mobility group AT-hook 1

BG378912 Wdr47 WD repeat domain 47

BG379188 S iglec5_predicted sialic acid binding Ig-like lectin 5 (predicted)

BG379338 Rrm2 ribonucleotide reductase M2

BG379358 Xpc_predicted xeroderma pigmentosum, complementation group C

(predicted)

BG379394 Transcribed locus

BG380122 Seψinbόb serine (or cysteine) proteinase inhibitor, clade B, member 6b

BG380534 Tlel_predicted transducin-like enhancer of split 1, homolog of Drosophila

E(spl) (predicted)

BG380672 LOC682058 similar to nucleolar protein with MIF4G domain 1

BG380684 Rtn2 reticulon 2 (Z-band associated protein)

BG380735 — Transcribed locus

BG380816 LOC29141 1 similar to Potential phospholipid-transporting ATPase HB

BG381555 — CDNA clone IMAGE:7388962

BG381583 RGD 15651 18_predicted similar to mKIAA0843 protein (predicted)

BG662519 Ank Progressive ankylosis homolog (mouse)

BG662875 Pea 15 phosphoprotein enriched in astrocytes 15

BG663128 Tnnc2 troponin C type 2 (fast)

BG663208 Jakl Janus kinase 1

BG663284 Fgl2 fibrinogen-like 2

BG663444 Wbp4 WW domain binding protein 4

BG663460 Pafahlbl platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa

BG663483 Pcdhal /Z/ PcdhalO /// protocadherin alpha 4 /// protocadherin alpha 13 ///

Pcdhal l /// Pcdhal2 /// protocadherin alpha 10 /// protocadherin alpha 12 ///

Pcdhal3 /// Pcdha2 /// protocadherin alpha 3 /// protocadherin alpha 8 ///

Pcdha3 /// Pcdha4 /// protocadherin alpha 1 /// protocadherin alpha 2 ///

Pcdha5 /// Pcdhaό /// protocadherin alpha 5 /// protocadherin alpha 6 ///

Pcdha7 /// Pcdhaδ /// protocadherin alpha 7 /// protocadherin alpha 9 ///

Pcdha9 /// Pcdhacl /// protocadherin alpha subfamily C, 1 /// protocadherin alpha

Pcdhac2 subfamily C, 2 /// protocadherin alpha 1 1 BG663870 RGD1310061 similar to hypothetical protein FLJlO 154

BG66401 1 Pxmp4 peroxisomal membrane protein 4

BG664123 Cyp51 cytochrome P450, subfamily 51

BG664221 Ogn_predicted osteoglycin (predicted)

BG664660 Tnfaipό tumor necrosis factor alpha induced protein 6

BG665051 —

BG665568 — Transcribed locus

BG665934 Oact2 O-acyltransferase (membrane bound) domain containing 2

BG666095 RGD1306274 similar to hypothetical protein BC002942

BG666306 Thbd thrombomodulin

BG666882 — Transcribed locus

BG666933 Cst3 cystatin C

BG668062 RGD 1566320_predicted RGDl 566320 (predicted)

BG668493 Stmn2 stathmin-like 2

BG668724 Ncoa5_predicted nuclear receptor coactivator 5 (predicted)

BG668816 Etnk 1 _predicted ethanolamine kinase 1 (predicted)

BG668988 Elovl4_predicted elongation of very long chain fatty acids (FEN1/Elo2,

SUR4/Elo3, yeast)-like 4 (predicted)

BG669096 Mpz myelin protein zero

BG669749 — Transcribed locus

BG670310 Tgfa transforming growth factor alpha

BG670822 ... Non-coding RNA expressed in the brain, repeat sequence, clone 2 /// Non-coding RNA expressed in the brain, repeat sequence, clone 7 /// Non-coding RNA expressed in the brain, repeat sequence, clone 3 /// Non-coding RNA expressed in the brain, repeat sequence, clone 12

BG671050 —

BG671521 Hspca heat shock protein 1 , alpha

BG671686 —

BG671734 — Transcribed locus, strongly similar to XP 927381.1

PREDICTED: hypothetical protein LOC69784 [Mus musculus]

BG672259 LOC691397 /// similar to PI-3-kinase-related kinase SMG-I isoform 2

RGD1563508_predicted (predicted) /// similar to PI-3-kinase-related kinase SMG-I

BG672517 RGDl 308373 similar to DKFZP566K1924 protein

BG672572 — Transcribed locus

BG673248 — Transcribed locus

BG673380 Ppp2r5 a_predicted protein phosphatase 2, regulatory subunit B (B56), alpha isoform (predicted)

BI273721 Transcribed locus

BI273815 RGD1309747_predicted similar to KIAA0947 protein (predicted)

BI273908 — Transcribed locus

BI273954 — Transcribed locus

BI274054 Folr2_predicted folate receptor 2 (fetal) (predicted)

BI274094 LOC313641 perlecan

BI274189 Rxrb retinoid X receptor beta

BI274216 — Transcribed locus

BI274308 Ttc7b_predicted tetratricopeptide repeat domain 7B (predicted)

BI274326 Mucl mucin 1, transmembrane

BI274438 Fam38a_predicted family with sequence similarity 38, member A (predicted)

BI274471 — Transcribed locus

BI274480 Fnbp4 formin binding protein 4

BI274481 Fnbpl Formin binding protein 1

BI274516 LOC304396 similar to hypothetical protein DKFZp434K1815

BI274533 RGD1309534 similar to RIKEN cDNA 4931406C07

BI274548 Rtell regulator of telomere elongation helicase 1

BI274615 —

BI274778 Transcribed locus BI2751 19 L3 mbtl3_predicted l(3)mbt-like 3 (Drosophila) (predicted)

BI275261 —

BI275485 Sema3b_predicted sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B (predicted)

BI275633 Pygm muscle glycogen phosphorylase

BI275677 —

BI275765 Uhrf2_predicted ubiquitin-like, containing PHD and RING finger domains 2

(predicted)

BI275827 Transcribed locus

BI275873 Centbl_predicted centaurin, beta 1 (predicted)

BI275966 Sipal signal-induced proliferation-associated gene 1

BI276075 — Transcribed locus

BI276216 Tyki_predicted thymidylate kinase family LPS-inducible member

(predicted)

BI276252 Micall_predicted microtubule associated monoxygenase, calponin and LIM domain containing 1 (predicted)

BI276959 LOC679341 /// similar to Calsequestrin- 1 precursor (Calsequestrin, skeletal

LOC686019 muscle isoform)

BI276972 Heatrl_predicted HEAT repeat containing 1 (predicted)

BI276974 Vars21 valyl-tRNA synthetase 2-like

BI277513 LOC360975 similar to oxoglutarate dehydrogenase (lipoamide)

BI277545 Myhl /// Myh2 myosin, heavy polypeptide 1 , skeletal muscle, adult /// myosin, heavy polypeptide 2, skeletal muscle, adult

BI277586 Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult

BI277805 RGD1562335_predicted similar to mKIAA1931 protein (predicted)

BI278180 — Transcribed locus

BI278186 Crctl_predicted cysteine-rich C-terminal 1 (predicted)

BI278333 — Transcribed locus, weakly similar to NP 742040.1 mannan- binding lectin serine protease 2 [Rattus norvegicus]

BI278404 RGD1562885_predicted similar to RIKEN cDNA 2300002M23 (predicted)

BI278423 Nbeal2_predicted neurobeachin-like 2 (predicted)

BI278559 Clec4al C-type lectin domain family 4, member al

BI278590 — Transcribed locus

BI278614 Bmpl bone morphogenetic protein 1

BI278687 Pltp_predicted phospholipid transfer protein (predicted)

BI278721 Calm4_predicted calmodulin 4 (predicted)

BI278952 —

BI279191 Lengδ leukocyte receptor cluster (LRC) member 8

BI279216 Ube216 ubiquitin-conjugating enzyme E2L 6

BI279384 — Transcribed locus

BI279486 LOC494538 ABP beta

BI279526 RTl-DbI RTl class II, locus DbI

BI279562 Baiap2 brain-specific angiogenesis inhibitor 1 -associated protein 2

BI279605 Krtl-19 keratin complex 1, acidic, gene 19

BI279646 Krtl-14 keratin complex 1, acidic, gene 14

BI279663 Dsc2 desmocollin 2

BI279680 LOC684050 similar to procollagen C-endopeptidase enhancer 2

BI279694 Trim29_predicted tripartite motif protein 29 (predicted)

BI279760 Pgkl phosphoglycerate kinase 1

BI279786 Myold myosin ID

BI280124 RGDl 565500_predicted RGDl 565500 (predicted)

BI281680 Cldn5 claudin 5

BI282076 Prdx4 peroxiredoxin 4

BI282114 — Endogenous retrovirus mRNA, partial sequence

BI282130 LOC687682 /// similar to Disco-interacting protein 2 homolog

LOC690211

BI282164 Cyb561_predicted cytochrome b-561 (predicted)

BI282272 RGDl 304587 similar to RIKEN cDNA 2310033P09 BI282281 LOC500372 similar to Stress-70 protein, mitochondrial precursor (75 kDa glucose regulated protein) (GRP 75) (Peptide-binding protein 74) (PBP74) (MTHSP70) (Mortalin)

BI282513 Stfa3_predicted stefin A3 (predicted)

BI282567 Klk8 kallikrein 8 (neuropsin/ovasin)

BI282568 Krtdap keratinocyte differentiation associated protein

BI282576 RGD1310935_predicted similar to Dermal papilla derived protein 7 (predicted)

BI282584 RGD1560328_predicted similar to UPFO 197 protein Cl lorflO homolog (predicted)

BI282694 RGD1565037_predicted similar to selenoprotein SeIM (predicted)

BI282719 RGD1565055_predicted similar to PDZ-domain protein scribble (predicted)

BI282755 — Transcribed locus

BI282819 — Transcribed locus

BI282860 LOC685652 similar to keratin 6L

BI282883 LOC312678 similar to Retinoblastoma-binding protein 2 (RBBP-2)

BI282914 Kctdl4_predicted potassium channel tetramerisation domain containing 14 (predicted)

BI282920 Ccl21b chemokine (C-C motif) ligand 21b (serine)

BI282944 LOC301 126 similar to scaffold attachment factor B2

BI282960 Gpsn2 glycoprotein, synaptic 2

BI283060 Flna_predicted filamin, alpha (predicted)

BI283128 LOC682360 hypothetical protein LOC682360

BI283139 LOC679693 similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator- recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein)

BI283346 KIk 10 kallikrein 10

BI283648 — Transcribed locus, moderately similar to XP_919392.1 PREDICTED: hypothetical protein XP 914299 [Mus musculus]

BI283695 ... Transcribed locus

BI283728 — Transcribed locus

BI283851 Ppill peptidylprolyl isomerase (cyclophilin)-like 1

BI284430 Tmed3 transmembrane emp24 domain containing 3

BI285064 — Transcribed locus

BI285065 — Transcribed locus

BI285092 LOC682044 /// hypothetical protein LOC682044 /// hypothetical protein

LOC684972 LOC684972

BI285329 LOC498178 /// similar to SET domain-containing protein

LOC687538 ///

LOC689820

BI285346 Ppp4rl protein phosphatase 4, regulatory subunit 1

BI285402 Ddx 17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

BI285443 RGDl 560859_predicted similar to 2300003P22Rik protein (predicted)

BI285494 Ifϊtm3 interferon induced transmembrane protein 3

BI285676 — Transcribed locus

BI285700 Hspcb heat shock 9OkDa protein 1 , beta

BI285902 RGD 1308696 similar to hypothetical protein Dl lErtd497e

BI285941 — Transcribed locus

BI285951 RGD1308734 similar to RIKEN cDNA 1 100001 H23

BI285965 Usp48 ubiquitin specific protease 48

BI286012 Krtl-18 keratin complex 1 , acidic, gene 18

BI286166 LOC298795 /// similar to 14-3-3 protein sigma /// stratifin (predicted)

Sfh_predicted

BI286340 RGD1305779_predicted similar to NSEl (predicted)

BI286364 — Transcribed locus

BI286387 LOC499660 similar to Cornifin A (Small proline-rich protein IA)

(SPR1A) (SPRR1)

BI286389 KaI 7 type I keratin KA 17 B 1286396 Perp_predicted PERP, TP53 apoptosis effector (predicted)

BI2864U — Ultraviolet B radiation-activated UV 103 mRNA, partial sequence

BI286411 LOC683295 similar to keratin complex 2, basic, gene 6a

BI286421 — Transcribed locus, strongly similar to NP OO 1007709.1 hypothetical protein LOC315126 [Rattus norvegicus]

BI287007 RGD 1560606_predicted similar to down-regulated in metastasis (predicted)

BI287330 RGD1561312_predicted similar to type 1 protein phosphatase targeting subunit

RGL/GM (predicted)

B 1287702 Usp28_predicted ubiquitin specific protease 28 (predicted)

BI288055 — Transcribed locus, moderately similar to NP 036691.2 fibrinogen, gamma polypeptide [Rattus norvegicus]

BI288162 Transcribed locus

BI288619 Jun Jun oncogene

B 1288833 Dact2_predicted dapper homo log 2, antagonist of beta-catenin (xenopus)

(predicted)

BI288898 LOC680692 /// similar to Golgi phosphoprotein 2 (Golgi membrane protein

LOC682869 GP73)

BI289103 Slc44a4 solute carrier family 44, member 4

B 12891 10 — Transcribed locus

BI289371 Rhbdl6_predicted rhomboid, veinlet-like 6 (Drosophila) (predicted)

BI289386 Bcor_predicted Bcl6 interacting corepressor (predicted)

BI289517 RGD 1562778_predicted similar to tripartite motif protein 50 (predicted)

BI289527 Tmod4_predicted tropomodulin 4 (predicted)

BI289641 RGD 1566064_predicted similar to KIAA 1096 protein (predicted)

BI289662 LOC690326 hypothetical protein LOC690326

BI289840 — Transcribed locus

BI289867 Slcl6a6 solute carrier family 16 (monocarboxylic acid transporters), member 6

BI290053 Transcribed locus

B 1290161 Agpat3_predicted l-acylglycerol-3-phosphate O-acyltransferase 3 (predicted)

BI290551 Fnbpl Formin binding protein 1

BI290633 LOC306805 Similar to asporin precursor

B1290737 ... Transcribed locus

BI290787 —

BI290909 Scapl src family associated phosphoprotein 1

BI291212 — Transcribed locus

BI291230 —

BI291434 Pfkm phosphofructokinase, muscle

BI291600 RGD 1309450_predicted similar to KIAA2010 protein (predicted)

BI291604 LOC687609 similar to ras homolog gene family, member f

BI291798 — Immunoglobulin delta heavy chain transmembrane form

(IgD)

BI291804 Transcribed locus

BI291875 Clca3_predicted chloride channel calcium activated 3 (predicted)

BI291927 RT1-A2 /// RT1-A3 RTl class Ia, locus A2 /// RTl class I, A3

BI292034 —

BI292036 LOC683839 /// hypothetical protein LOC683839 /// hypothetical protein

LOC688495 LOC688495

BI292056 — Transcribed locus

BI292067 — Transcribed locus

BI292090 Cldn8 claudin 8

BI292231 Lpo_predicted lactoperoxidase (predicted)

BI292687 — Transcribed locus

BI292758 — Transcribed locus

BI293047 Bmper_predicted BMP-binding endothelial regulator (predicted)

BI293248 — Transcribed locus

BI293796 Nckap 1 l_predicted NCK associated protein 1 like (predicted) BI293987 Rbm5 RNA binding motif protein 5

BI294084 Ccl24 chemokine (C-C motif) ligand 24

BI294122 Gpr23_predicted G protein-coupled receptor 23 (predicted)

BI294141 Angpt4_predicted angiopoietin 4 (predicted)

BI294158 — Transcribed locus

BI294178 — Transcribed locus

BI294556 Stkl7b serine/threonine kinase 17b (apoptosis-inducing)

BI294721 RGDl 562617_predicted similar to RAB7-like protein (predicted)

BI294722 — Transcribed locus, weakly similar to XP 487464.2

PREDICTED: similar to zinc finger protein 85, related sequence 1 [Mus musculus]

BI294737

BI294787 Mamll_predicted mastermind like 1 (Drosophila) (predicted)

BI294788 — Transcribed locus

BI294789 RGD 130833 l_predicted similar to Trithorax homolog 2 (Mixed lineage leukemia gene homolog 2 protein) (predicted)

BI294811 RGD131 1381_predicted similar to hypothetical protein FLJ20037 (predicted)

BI294855 Limd2 LIM domain containing 2

BI294907 Ncoa3 nuclear receptor coactivator 3

BI294910 Car8 carbonic anhydrase 8

BI294976 — Transcribed locus

BI295047 RGD1309550 similar to hypothetical protein D12Ertd771e

BI295614 — Transcribed locus, strongly similar to NP OO 1041317.1

BCL2 -associated transcription factor 1 [Rattus norvegicus]

BI295700 Mil myeloid/lymphoid or mixed-lineage leukemia

BI295832 Crebll cAMP responsive element binding protein-like 1

BI295864 Tmeffl transmembrane protein with EGF-like and two follistatin- like domains 1

BI295900 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

BI295930 Clecl4a C-type lectin domain family 14, member a

BI295947 RGD 1564924_predicted similar to leiomodin 3 (fetal) (predicted)

BI295964 Slamf9_predicted SLAM family member 9 (predicted)

BI296029 Camta2_predicted calmodulin binding transcription activator 2 (predicted)

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

BI296353 LOC501039 similar to solute carrier family 25, member 36

BI296499 —

BI296577 Pex5_predicted peroxisome biogenesis factor 5 (predicted)

BI296579 — Transcribed locus

BI296586 LOC499014 similar to zinc finger, DHHC domain containing 14

BI296626 LOC679725 /// similar to MASK-4E-BP3 protein

LOC682955

BI296641 — Transcribed locus

BI296696 Cables l_predicted Cdk5 and AbI enzyme substrate 1 (predicted)

BI296717 — Transcribed locus

BI296754 Ddxl7 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

BI296868 RGDl 56640 l_predicted similar to GTL2, imprinted maternally expressed untranslated (predicted)

BI296989 CdklO cyclin-dependent kinase (CDC2-like) 10

BI296990 — Transcribed locus

BI297744 RGDl 310507 similar to RIKEN cDNA 1300017J02

BI298306 — Transcribed locus

BI299761 — Transcribed locus

BI300393 — Transcribed locus, strongly similar to NP_848878.1 hypothetical protein LOC319530 [Mus musculus]

BI300470 Transcribed locus

BI300502 — Transcribed locus

BI300794 Transcribed locus BI301 1 17 ... Transcribed locus

BI301 125 LOC682926 /// similar to chromatin modifying protein 1 B

LOC689364

BI301280 RGD1561004_predicted similar to AMME syndrome candidate gene 1 protein homolog (predicted)

BI301453 Ckmtl creatine kinase, mitochondrial 1 , ubiquitous

BI301465 — Transcribed locus

BI301467 LOC363009 similar to CG31653-PA

BI301495 LOC688276 similar to epidermodysplasia verruciformis 2

BI302005 Mlfl_predicted myeloid leukemia factor 1 (predicted)

BI302669 Stno_predicted strawberry notch homolog (Drosophila) (predicted)

BI302694 RGD1561555_predicted similar to CDNA sequence BC022692 (predicted)

BI303078 — Transcribed locus

BI303106 TraO_predicted Tnf receptor-associated factor 3 (predicted)

BI303187 Sc65 Synaptonemal complex protein SC65

BI303187 Sc65 synaptonemal complex protein SC65

BI303253 — CDNA clone IMAGE:7365313

BI303636 — Transcribed locus

BI304009 Lox lysyl oxidase

BI304019 — Transcribed locus

BI389176 Lnx2_predicted ligand of numb-protein X 2 (predicted)

BI395810 Npylr neuropeptide Y receptor Yl

BI395849 —

BM382988 — Transcribed locus

BM383065 RGD1310587 similar to hypothetical protein FLJ 14146

BM383395 Mknk2 MAP kinase-interacting serine/threonine kinase 2

BM383423 Ehf_predicted ets homologous factor (predicted)

BM383428 LOC367976 /// minichromosome maintenance deficient 3 (S. cerevisiae)

Mcm3_predicted (predicted) /// similar to DNA replication licensing factor

MCM3 (DNA polymerase alpha holoenzyme-associated protein Pl) (P1-MCM3)

BM383442 LOC363009 similar to CG31653-PA

BM383464 — Transcribed locus

BM383531 LOC682651 /// similar to Metallothionein-2 (MT-2) (Metallothionein-II)

LOC689415 (MT-II)

BM383809 Mlstd2 male sterility domain containing 2

BM383953 LOC367171 microtubule-associated protein 4

BM383972 — Transcribed locus

BM383995 — Transcribed locus

BM384008 Arhgap5 Rho GTPase activating protein 5

BM384116 LOC691397 /// similar to PI-3-kinase-related kinase SMG-I isoform 2

RGD1563508_predicted (predicted) /// similar to PI-3-kinase-related kinase SMG-I

BM384446 Aofl_predicted amine oxidase, flavin containing 1 (predicted)

BM384731 RGD1309944_predicted similar to RIKEN cDNA 0610009K11 (predicted)

BM384872 Usp48 ubiquitin specific protease 48

BM384937 MGC 108776 Snf7 homologue associated with AHx 3

BM385061 ... Transcribed locus

BM385071 RGDl 563060_predicted similar to AVLV472 (predicted)

BM3851 17 — Transcribed locus

BM385221 Ddx 17 DEAD (Asp-Glu- Ala-Asp) box polypeptide 17

BM385244 — Transcribed locus

BM385286 Lpinl lipin 1

BM385476 Bst2 bone marrow stromal cell antigen 2

BM385502 Kal5 type I keratin KA 15

BM385735 Stac3_predicted SH3 and cysteine rich domain 3 (predicted)

BM385779 RGD131 1307 similar to 1300014I06Rik protein

BM385790 Klf2_predicted Kruppel-like factor 2 (lung) (predicted)

BM385804 LOC360910 /// similar to ATP-binding cassette transporter ABCG3 /// LOC360997 similar to ATP-binding cassette, sub-family G (WHITE), member 3

BM385870 ... Transcribed locus

BM385950 Sbfl_predicted SET binding factor 1 (predicted)

BM385951 — Transcribed locus

BM386010 RGD1359684 similar to T-cell receptor alpha chain precursor V and C regions (TRA29)

BM386036 — Transcribed locus, strongly similar to XP 345296.2 PREDICTED: similar to AVIEF [Rattus norvegicus]

BM3861 19 Galnt3 UDP-N-acetyl-alpha-D-galactosamineipolypeptide N- acetylgalactosaminyltransferase 3

BM386334 Ankrd23_predicted ankyrin repeat domain 23 (predicted)

BM386413 Trim2 tripartite motif protein 2

BM386789 Rgsl regulator of G-protein signaling 1

BM387006 Scamp2 secretory carrier membrane protein 2

BM387106 Amid_predicted Apoptosis-inducing factor (AIF)-like mitochondrion- associated inducer of death (predicted)

BM3871 12 Transcribed locus

BM387125 — Transcribed locus

BM387133 —

BM387197 —

BM387384 Bazla_predicted bromodomain adjacent to zinc finger domain, IA (predicted)

BM387419 —

BM387754 — Transcribed locus

BM387797 LOC360619 similar to gasdermin 1

BM387813 — Transcribed locus

BM387863 Itgb3bp integrin beta 3 binding protein (beta3-endonexin)

BM387914 Krt25A keratin 25A

BM387946 Zap70 zeta-chain (TCR) associated protein kinase 70

BM388077 RGD 1562629_predicted similar to neurobeachin (predicted)

BM388319 Gimap7 GTPase, IMAP family member 7

BM388328 RGD1311 126_predicted similar to RIKEN cDNA 4922503N01 (predicted)

BM388334 Spink5_predicted serine protease inhibitor, Kazal type 5 (predicted)

BM388416 RGD 130462 l_predicted similar to Hypothetical protein KIAA0539 (predicted)

BM388525 F13al coagulation factor XIII, Al subunit

BM388719 Rpl7 Ribosomal protein L7

BM388725 — Transcribed locus

BM388738 —

BM388814 LOC313707 similar to exosome component 10

BM388975 Nfrkb_predicted nuclear factor related to kappa B binding protein (predicted)

BM389001 Col9a3_predicted procollagen, type IX, alpha 3 (predicted)

BM389005 Gpr68_predicted G protein-coupled receptor 68 (predicted)

BM389207 Brd4 bromodomain containing 4

BM389208 Gimap4 GTPase, IMAP family member 4

BM389214 RGD1559565_predicted similar to EF hand domain containing 1 (predicted)

BM389223 Pdhb pyruvate dehydrogenase (lipoamide) beta

BM389240 RGDl 564142_predicted similar to chromosome 10 open reading frame 64 (predicted)

BM389254 Anxa8 annexin A8

BM389426 Pdgfrb platelet derived growth factor receptor, beta polypeptide

BM389444 — Transcribed locus

BM389513 LOC688090 /// RTl-Bb RTl class II, locus Bb /// similar to RTl class II histocompatibility antigen, B-I beta chain precursor (RT 1.B- beta(l))

BM389585 Capnl3 calpain 13

BM389644 Rhoj ras homolog gene family, member J

BM389813 —

BM389831 Seroinb 1 1 Dredicted serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 1 1 (predicted) BM389967 RGD1308398 similar to hypothetical protein MGC37548

BM390000 Sema3f_predicted sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3 F (predicted)

BM390176 Spink5_predicted serine protease inhibitor, Kazal type 5 (predicted)

BM390226 — Transcribed locus

BM390227 Bcll lb_predicted B-cell leukemia/lymphoma 1 1 B (predicted)

BM390320 — Transcribed locus, strongly similar to XP 580137.1

PREDICTED: hypothetical protein XP 580137 [Rattus norvegicus]

BM390324 Eppb9_predicted endothelial precursor protein B9 (predicted)

BM390325 RGD1562868_predicted similar to squamous cell carcinoma antigen 2 (predicted)

BM390378 RGD1562732_predicted similar to Glutathione S-transferase, theta 3 (predicted)

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

BM390440 — Transcribed locus

BM390571 Sult2bl_predicted sulfotransferase family, cytosolic, 2B, member 1 (predicted)

BM390574 Lss Lanosterol synthase

BM390774 Peci /// RGDl 310224 peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase /// similar to RIKEN cDNA 1810022C23

BM390827 Ppplr3c protein phosphatase 1, regulatory (inhibitor) subunit 3C

BM390872 RGD 1560293_predicted similar to RIKEN cDNA 1200013B08 (predicted)

BM390965 RGD 1305592 similar to RIKEN cDNA 2900092E17

BM391096 — Transcribed locus

BM391 100 Muc4 mucin 4

BM391 1 19 Chd3 chromodomain helicase DNA binding protein 3

BM391169 Myh4 myosin, heavy polypeptide 4

BM391278 — CDNA clone IMAGE:7930328

BM391283 Etnkl_predicted Ethanolamine kinase 1 (predicted)

BM391302 Kdelr3_predicted KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 (predicted)

BM391303

BM391354 LOC287274 sedlin-like

BM391471 Atf5 activating transcription factor 5

BM391538 Frzb frizzled-related protein

BM391631 Fcgrl Fc receptor, IgG, high affinity I

BM391750 Usp40 ubiquitin specific protease 40

BM391823 RGD1563309_predicted similar to diacylglycerol kinase, delta 13OkDa isoform 1

(predicted)

BM391896 Transcribed locus

BM392106 CaId 1 caldesmon 1

BM392203 Dapk2 death-associated kinase 2

BM392321 Hipk2_predicted homeodomain interacting protein kinase 2 (predicted)

D10831 Sell selectin, lymphocyte

D13555 Cd3z CD3 antigen, zeta polypeptide

D29960 Hspbό heat shock protein, alpha-crystallin-related, B6

D50306 Slcl5al solute carrier family 15 (oligopeptide transporter), member 1

D83948 RbmlO RNA binding motif protein 10

D86817 Vamp4_predicted vesicle-associated membrane protein 4 (predicted)

D87927 Gm 1960 gene model 1960, (NCBI)

D88586 Earl l eosinophil-associated, ribonuclease A family, member 1 1

D88672 Pld2 phospholipase D2

H31078 —

H33235 Cs citrate synthase

H34497 LOC684513 /// similar to SWI/SNF-related matrix-associated actin-

LOC685179 dependent regulator of chromatin c2 isoform b /// similar to

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c2

H34775 Riok3_predicted RIO kinase 3 (yeast) (predicted)

J00710 Csnlsl casein alpha si J00741 LOC641523 immunoglobulin delta heavy chain constant region J02585 Scdl stearoyl-Coenzyme A desaturase 1 J02612 Ugtlal /// UgtlalO /// UDP glycosyltransferase 1 family, polypeptide Al /// UDP

Ugtla2 /// Ugtla3 /// glycosyltransferase 1 family, polypeptide A6 /// UDP Ugtla5 /// Ugtla6 /// glycosyltransferase 1 family, polypeptide A7 /// UDP Ugtla7 /// Ugtla8 glycosyltransferase 1 family, polypeptide A8 /// UDP glycosyltransferase 1 family polypeptide A2 /// UDP glycosyltransferase 1 family polypeptide A3 /// UDP glycosyltransferase 1 family polypeptide AlO /// UDP glycosyltransferase 1 family, polypeptide A5

J02705 Ocm oncomodulin

J02811 Ampdl adenosine monophosphate deaminase 1 (isoform M)

J03867 Cyb5r3 cytochrome b5 reductase 3

J04035 EIn elastin

L07316 Dpepl dipeptidase 1 (renal)

L08447 Cd3z CD3 antigen, zeta polypeptide

L14782 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homo log

L17138 Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6

L19933 Ptprd protein tyrosine phosphatase, receptor type, D

L22654 IgG-2a gamma-2a immunoglobulin heavy chain

L25527 SeIe selectin, endothelial cell

L81 169 Oxtr oxytocin receptor

M 10072 Ptprc protein tyrosine phosphatase, receptor type, C

M13706 Prkcbl protein kinase C, beta 1

M15481 Igfl insulin-like growth factor 1

M17153 Fcerla Fc receptor, IgE, high affinity I, alpha polypeptide

M24024 RT1-Aw2 RTl class Ib, locus Aw2

M25804 Nrldl nuclear receptor subfamily 1 , group D, member 1

M30596 Mel malic enzyme 1

M37568 Hoxcό /// Hoxc8 homeo box C6 /// homeo box C8

M57668 PrIr prolactin receptor

M61 142 Thopl thimet oligopeptidase 1

M83681 Rab3d RAB3D, member RAS oncogene family

M85035 Gria2 glutamate receptor, ionotropic, AMPA2

M88469 Sponl spondin 1

M94288 NoIc 1 nucleolar and coiled-body phosphoprotein 1

NM_012488 A2m alpha-2-macroglobulin

NM_012493 Afp alpha-fetoprotein

NM_012497 Aldoc aldolase C

NM_012502 Ar androgen receptor

NM_012516 C4bpa complement component 4 binding protein, alpha

NM_012524 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha

NM_012530 Ckm creatine kinase, muscle

NM_012531 Comt catechol-O-methyltransferase

NM_012532 Cp ceruloplasmin

NM_012554 Enol enolase 1 , alpha

NM_012555 Etsl v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

NMJ) 12559 Fgg fibrinogen, gamma polypeptide

NM_012561 Fst follistatin

NM_012594 Lalba lactalbumin, alpha

NM O 12600 Mel malic enzyme 1

NM O 12605 Mylpf myosin light chain, phosphorylatable, fast skeletal muscle

NM_012606 Myl3 myosin, light polypeptide 3

NM_012640 Rbp2 retinol binding protein 2, cellular

NM O 12646 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl class

RT1-N3 Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene,

H2-TL-like, grc region(N2) NM_012652 Slc9al solute carrier family 9, member 1

NM_012660 Eefla2 eukaryotic translation elongation factor 1 alpha 2

NM_012663 Vamp2 vesicle-associated membrane protein 2

NM_012684 Vcsal /// Vcsa2 variable coding sequence Al /// variable coding sequence A2

NM_012703 Thrsp thyroid hormone responsive protein

NM_012733 Rbpl retinol binding protein 1 , cellular

NMJ 12744 Pc Pyruvate carboxylase

NM_012745 Klrdl killer cell lectin-like receptor, subfamily D, member 1

NM_012755 Fyn fyn proto-oncogene

NM_012760 Plagll pleomorphic adenoma gene-like 1

NM_012777 Apod apolipoprotein D

NM_012779 Aqp5 aquaporin 5

NMJ) 12786 Cox8h Cytochrom c oxidase subunit VIII-H (heart/muscle)

NMJ) 12794 Glycaml glycosylation dependent cell adhesion molecule 1

NMJH2812 Cox6a2 cytochrome c oxidase, subunit Via, polypeptide 2

NM O 12824 Apocl apolipoprotein C-I

NMJ) 12836 Cpd carboxypeptidase D

NMJ) 12851 Hsdl7bl hydroxysteroid (17-beta) dehydrogenase 1

NMJ) 12855 Jak3 Janus kinase 3

NMJ) 12888 Tshr thyroid stimulating hormone receptor

NMJH2893 Actg2 actin, gamma 2

NMJ) 12914 Atp2a3 ATPase, Ca++ transporting, ubiquitous

NMJ) 12915 Atpifl ATPase inhibitory factor 1

NMJ) 12925 Cd59 CD59 antigen

NMJ) 12938 Ctse cathepsin E

NMJ) 12941 Cyp51 cytochrome P450, subfamily 51

NMJ) 12949 Eno3 enolase 3, beta

NMJ) 12993 Nrdl nardilysin, N-arginine dibasic convertase 1

NMJ) 13002 Pcp4 Purkinje cell protein 4

NMJ) 13020 Rabggta Rab geranylgeranyl transferase, a subunit

NM O 13026 Sdc 1 syndecan 1

NMJ) 13028 Shox2 short stature homeobox 2

NMJ) 13041 Sycp3 synaptonemal complex protein 3

NMJ) 13060 Id2 inhibitor of DNA binding 2

NMJ) 13085 Plau plasminogen activator, urokinase

NMJ) 13092 Cmal chymase 1, mast cell

NMJ)13127 Cd38 CD38 antigen

NMJ)13134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NMJH3169 Cd3d CD3 antigen delta polypeptide

NMJH3172 Myf6 myogenic factor 6

NMJ)13186 Kcnbl potassium voltage gated channel, Shab-related subfamily, member 1

NMJ)13187 Plcgl phospholipase C, gamma 1

NMJ) 13194 Myh9 myosin, heavy polypeptide 9, non-muscle

NMJ) 13200 Cptlb carnitine palmitoyltransferase Ib, muscle

NM O 16986 Acadm acetyl-Coenzyme A dehydrogenase, medium chain

NM O 16987 AcIy ATP citrate lyase

NMJ) 16998 Cpal carboxypeptidase Al

NMJ) 17006 G6pdx glucose-6-phosphate dehydrogenase X-linked

NMJ) 17015 Gusb glucuronidase, beta

NMJ) 17028 Mx2 myxovirus (influenza virus) resistance 2

NMJ) 17048 Slc4a2 solute carrier family 4, member 2

NMJ) 17066 Ptn pleiotrophin

NMJ) 17120 Csn2 casein beta

NM_017124 Cd37 CD37 antigen

NMJH7130 Neu2 neuraminidase 2

NM 017156 Cyp2bl5 cytochrome P450, family 2, subfamily b, polypeptide 15 NMJ) 17174 Pla2g5 phospholipase A2, group V

NM_017185 Tnni2 troponin I type 2 (skeletal, fast)

NM_017200 Tfpi tissue factor pathway inhibitor

NM_017206 Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6

NM_017225 Pctp phosphatidylcholine transfer protein

NM_017240 Myh6 /// Myh7 myosin, heavy polypeptide 6, cardiac muscle, alpha /// myosin, heavy polypeptide 7, cardiac muscle, beta

NM_017240 Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta

NM_017249 Mbc2 membrane bound C2 domain containing protein

NM_017259 Btg2 B-cell translocation gene 2, anti-proliferative

NM_017260 Alox5ap arachidonate 5-lipoxygenase activating protein

NM O 17261 Gria2 glutamate receptor, ionotropic, AMPA2

NM_017268 Hmgcsl 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

NM_017307 Slc25al solute carrier family 25, member 1

NM 017311 Atp5gl ATP synthase, H+ transporting, mitochondrial FO complex, subunit c (subunit 9), isoform 1

NMJ)17313 Rab3ip RAB3A interacting protein

NM_017320 Ctss cathepsin S

NM_017328 Pgam2 phosphoglycerate mutase 2

NMJ 17332 Fasn fatty acid synthase

NM 019131 Tpml tropomyosin 1 , alpha

NM_019161 RGD 1566401 _predicted similar to GTL2, imprinted maternally expressed untranslated (predicted)

NM_019171 LOC685608 /// salivary protein 1 /// hypothetical protein LOC685608 ///

LOC688807 /// Sptl hypothetical protein LOC688807

NM 019175 Klk6 kallikrein 6

NM 019193 Sox 10 SRY -box containing gene 10

NM_019205 Ccll l chemokine (C-C motif) ligand 11

NM_019206 StklO serine/threonine kinase 10

NM 019212 Actal actin, alpha 1 , skeletal muscle

NM O 19221 Trp63 transformation related protein 63

NM_019225 SIc Ia3 solute carrier family 1 (glial high affinity glutamate transporter), member 3

NMJ)19238 Fdftl farnesyl diphosphate farnesyl transferase 1

NMJ) 19240 Gjb3 gap junction membrane channel protein beta 3

NMJ) 19241 Gjb5 gap junction membrane channel protein beta 5

NMJ) 19282 Greml gremlin 1 homolog, cysteine knot superfamily (Xenopus laevis)

NM O 19291 Ca2 carbonic anhydrase 2

NMJ) 19295 Cd5 CD5 antigen

NMJ) 19311 Inpp5d inositol polyphosphate-5-phosphatase D

NMJ) 19334 Pitx2 paired-like homeodomain transcription factor 2

NMJ) 19370 Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3

NMJ) 19371 Egln3 EGL nine homolog 3 (C. elegans)

NMJ) 19384 Scafl SR-related CTD-associated factor 1

NMJ)20072 Acpp acid phosphatase, prostate

NMJ)20099 Leprot leptin receptor overlapping transcript

NMJ)20104 MyIl myosin, light polypeptide 1

NMJ)20542 Ccrl chemokine (C-C motif) receptor 1

NMJ)21581 Sc65 synaptonemal complex protein SC65

NMJ)21588 Mb myoglobin

NMJ)21694 Arhgefl Rho guanine nucleotide exchange factor (GEF) 1

NMJ)21698 F13al coagulation factor XIII, Al subunit

NM 021744 Cdl4 CD14 antigen

NM 021759 Lypd3 Ly6/Plaur domain containing 3

NMJ)21760 Col5a3 procollagen, type V, alpha 3

NM 021769 Suit IdI sulfotransferase family 1 D, member 1 NM_021866 Ccr2 chemokine (C-C motif) receptor 2

NM_022193 Acaca acetyl-coenzyme A carboxylase alpha

NM_022229 Hspdl heat shock protein 1 (chaperonin)

NM_022268 Pygl liver glycogen phosphorylase

NM_022282 Dlgh2 discs, large homolog 2 (Drosophila)

NM_022389 Dhcr7 7-dehydrocholesterol reductase

NM_022392 Insigl insulin induced gene 1

NM_022396 Gngl l guanine nucleotide binding protein (G protein), gamma 1 1

NM_022582 Lgals7 lectin, galactose binding, soluble 7

NM_022592 Tkt transketolase

NM 022596 Golga2 cis-Golgi matrix protein GM130

NM_022603 Fgfbpl fibroblast growth factor binding protein 1

NM_022610 Icos inducible T-cell co-stimulator

NM_022628 Nphsl nephrosis 1 homolog, nephrin (human)

NM_022676 Ppplrla protein phosphatase 1, regulatory (inhibitor) subunit IA

NM_022681 Adnp activity-dependent neuroprotective protein

NM_022686 LOC680097 /// similar to germinal histone H4 gene

LOC684887

NM_022705 Thedcl thioesterase domain containing 1

NM_022799 Nucks nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate

NM_022860 B4galntl beta-l^-N-acetyl-galactosaminyl transferase 1

NM_022935 Abpl amiloride binding protein 1 (amine oxidase, copper- containing)

NM_022952 Ap2sl adaptor-related protein complex 2, sigma 1 subunit

NM_023021 Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

NM_023025 Cyp2j3 /// Cyp2j4 cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome P450, family 2, subfamily j, polypeptide 3

NM_023092 Myolc myosin IC

NM_023987 Birc3 baculoviral IAP repeat-containing 3

NM_024002 Secisbp2 SECIS binding protein 2

NM 024131 Ddt D-dopachrome tautomerase

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM_024162 Fabp3 fatty acid binding protein 3

NM_024364 Hr hairless homolog (mouse)

NM 024390 Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD)

NM 024398 Aco2 aconitase 2, mitochondrial

NM_030585 Rabep2 rabaptin, RAB GTPase binding effector protein 2

NM_030836 Artsl type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

NM_030852 Mial melanoma inhibitory activity 1

NM 030853 Lat linker for activation of T cells

NM_030863 Msn moesin

NM_030865 Myoc myocilin

NM_030989 Tp53 tumor protein p53

NM_030994 Itgal integrin alpha 1

NM_031020 Mapkl4 mitogen activated protein kinase 14

NM_031031 Gatm glycine amidinotransferase (L-arginine: glycine amidinotransferase)

NM_031051 Mif macrophage migration inhibitory factor

NM_031085 Prkch protein kinase C, eta

NM_031 1 16 Ccl5 chemokine (C-C motif) ligand 5

NM_031143 Dgkz diacylglycerol kinase zeta

NM_031 144 Actb actin, beta

NM_031327 Cyrόl cysteine rich protein 61

NM_031337 St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5

NM 031360 Smpd2 sphingomyelin phosphodiesterase 2, neutral NM_031530 Ccl2 chemokine (C-C motif) ligand 2

NM_031538 Cd8a CD8 antigen, alpha chain

NM_031544 Ampd3 adenosine monophosphate deaminase 3

NM_031559 Cptla carnitine palmitoyltransferase Ia, liver

NM_031562 CsnlO casein kappa

NM_031598 Pla2g2a phospholipase A2, group HA (platelets, synovial fluid)

NM 031646 Ramp2 receptor (calcitonin) activity modifying protein 2

NM_031699 Cldnl claudin 1

NM 031700 Cldn3 claudin 3

NM_031715 Pfkm phosphofructokinase, muscle

NM_031766 Cpz carboxypeptidase Z

NM_031771 Thbd thrombomodulin

NM_031778 Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3

NM 031781 Apba3 amyloid beta (A4) precursor protein-binding, family A, member 3

NM_031786 Trim3 tripartite motif protein 3

NM_031801 Deafl deformed epidermal autoregulatory factor 1 (Drosophila)

NM_031817 Omd osteomodulin

NM_031827 Vamp8 vesicle-associated membrane protein 8

NM_031837 Sept9 septin 9

NM_031840 Fdps farnesyl diphosphate synthase

NM_031841 Scd2 stearoyl-Coenzyme A desaturase 2

NM_031971 Hspala /// Hspalb heat shock 7OkD protein IA /// heat shock 7OkD protein IB

(mapped)

NM_033230 Aktl thymoma viral proto-oncogene 1

NM_053322 Pom210 nuclear pore membrane glycoprotein 210

NM_053328 Bhlhb2 basic helix-loop-helix domain containing, class B2

NM_053339 Acox3 acyl-Coenzyme A oxidase 3, pristanoyl

NM_053355 Ikbkb inhibitor of kappaB kinase beta

NM_053372 RGD 1563818_predicted secretory leukocyte peptidase inhibitor /// similar to

/// Slpi secretory leukocyte protease inhibitor (predicted)

NM_053388 Gjb6 gap junction membrane channel protein beta 6

NM_053433 Fmo3 flavin containing monooxygenase 3

NM_O53535 Enppl ectonucleotide pyrophosphatase/phosphodiesterase 1

NM_053539 Idil isopentenyl-diphosphate delta isomerase

NM_053540 Cox 17 cytochrome c oxidase, subunit XVII assembly protein homolog (yeast)

NM 053584 ...

NM_053587 S100a9 SlOO calcium binding protein A9 (calgranulin B)

NM_053591 Dpepl dipeptidase 1 (renal)

NM_053618 Bbs2 Bardet-Biedl syndrome 2 homolog (human)

NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4

NM_053633 Egr2 early growth response 2

NM_053639 Ltc4s leukotriene C4 synthase

NM_053669 Aps adaptor protein with pleckstrin homology and src homology

2 domains

NM_053674 Phyh phytanoyl-CoA hydroxylase

NM_053688 Pdeόh phosphodiesterase 6H, cGMP-specific, cone, gamma

NM_053714 Ank progressive ankylosis homolog (mouse)

NM_053747 Ubqlnl ubiquilin 1

NM_053751 Wap whey acidic protein

NM_053806 Kcnk6 /// LOC501662 potassium channel, subfamily K, member 6 /// similar to potassium channel, subfamily K, member 6

NM_053819 Timpl tissue inhibitor of metallopeptidase 1

NM_053822 S100a8 SlOO calcium binding protein A8 (calgranulin A)

NM_053826 Pdkl pyruvate dehydrogenase kinase, isoenzyme 1

NM 053827 Plodl procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 NM_053843 Fcgr3 Fc receptor, IgG, low affinity III

NM_053847 Map3k8 mitogen-activated protein kinase kinase kinase 8

NM 053864 Vcp valosin-containing protein

NM_053883 Duspό dual specificity phosphatase 6

NM 053885 Rere arginine-glutamic acid dipeptide (RE) repeats

NM_053887 Map3kl mitogen activated protein kinase kinase kinase 1

NM_053904 Oplah 5-oxoprolinase (ATP-hydrolysing)

NM_053953 Illr2 interleukin 1 receptor, type II

NM_053960 Ccr5 chemokine (C-C motif) receptor 5

NM_053999 Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform

NM_057144 Csφ3 cysteine and glycine-rich protein 3

NM_057151 CcI 17 chemokine (C-C motif) ligand 17

NM_057187 Grifin galectin-related inter-fiber protein

NM 057191 KbtbdlO kelch repeat and BTB (POZ) domain containing 10

NM 057208 Tpm3 tropomyosin 3, gamma

NM_058213 Atp2al ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

NM_080399 Ddit41 DNA-damage-inducible transcript 4-like

NM_080770 Scgb2al /// Scgb2a2 secretoglobin, family 2A, member 1 /// secretoglobin, family 2A, member 2

NM_080787 Dgka diacylglycerol kinase, alpha

NM_080906 Ddit4 DNA-damage-inducible transcript 4

NM_130399 Ada adenosine deaminase

NM l 30409 Cfh complement component factor H

NM_13041 1 Corola coronin, actin binding protein 1 A

NM_130421 Lcp2 lymphocyte cytosolic protein 2

NM_130429 LeH lymphoid enhancer binding factor 1

NM_130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3- oxoacyl-Coenzyme A thiolase)

NM_130741 Lcn2 lipocalin 2

NM_130744 Cygb cytoglobin

NM_130755 Cs citrate synthase

NM_133303 Bhlhb3 basic helix-loop-helix domain containing, class B3

NM_133320 Ndell nudE nuclear distribution gene E homolog like 1 (A. nidulans)

NM_133392 Stkl7b serine/threonine kinase 17b (apoptosis- inducing)

NM_133416 Bcl2al B-cell leukemia/lymphoma 2 related protein Al

NM_133418 Slc25alO solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

NM_133421 Lkap limkain bl

NM_133424 Actn3 actinin alpha 3

NM_133513 MuclO mucin 10, submandibular gland salivary mucin

NM_133522 Sstr3 somatostatin receptor 3

NM_133524 Tcfe2a transcription factor E2a

NM_133533 Cd79b CD79B antigen

NM_133542 Igsfδ immunoglobulin superfamily, member 6

NM_133551 Pla2g4a phospholipase A2, group IVA (cytosolic, calcium- dependent)

NM 133561 Brp441 brain protein 44-like

NM 133566 Cst6 cystatin E/M

NM_133572 Cdc25b cell division cycle 25 homolog B (S. pombe)

NM l 33600 Slc31al solute carrier family 31 (copper transporters), member 1

NM_ 134326 Alb albumin

NMJ 34334 Ctsd cathepsin D

NM_134351 Mat2a methionine adenosyltransferase II, alpha

NM_134361 XcIl chemokine (C motif) ligand 1

NM 134382 Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) NM_134389 Acsbgl acyl-CoA synthetase bubblegum family member 1

NM_138850 Fap fibroblast activation protein

S75280 Hspa9a_predicted heat shock 7OkDa protein 9A (predicted)

U13253 Fabp5 fatty acid binding protein 5, epidermal

U17565 Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog,

S. pombe) (S. cerevisiae)

U22520 CxcllO chemokine (C-X-C motif) ligand 10

U23056 Ceacaml /// CeacamlO CEA-related cell adhesion molecule 1 /// CEA-related cell adhesion molecule 10

U23407 Crabp2 cellular retinoic acid binding protein 2

U24150 Tsc2 tuberous sclerosis 2

U25684 Tmsbll thymosin beta-like protein 1

U25746 Ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

U28830 Ralbpl ralA binding protein 1

U35025 Acvrlc activin A receptor, type IC

U44948 Csrp2 cysteine and glycine-rich protein 2

U50449 RT1-CE16 RTl class I, CE 16

U53475 Rab8b RAB8B, member RAS oncogene family

U54791 Cxcr4 chemokine (C-X-C motif) receptor 4

U56824 Klra5 /// Ly49s7 killer cell lectin-like receptor, subfamily A, member 5 ///

Ly49 stimulatory receptor 7

U67914 Cpa3 carboxypeptidase A3

U67915 Mcptl mast cell protease 1

U78857 Dclkl doublecortin-like kinase 1

U86635 Gstm5 glutathione S-transferase, mu 5

X04440 Prkcbl protein kinase C, beta 1

X 16262 RGDl 564935_predicted similar to Myhl 1 protein (predicted)

X57764 Ednrb endothelin receptor type B

X63744 SIc Ia3 solute carrier family 1 (glial high affinity glutamate transporter), member 3

X74293 Itga7 integrin alpha 7

X74294 Itga7 integrin alpha 7

X77815 Vcsa2 variable coding sequence A2

X77818 —

X83537 Mmpl4 matrix metal lopeptidase 14 (membrane-inserted)

X97445 Slcl6a7 solute carrier family 16 (monocarboxylic acid transporters), member 7

Z18877 Oasl 2',5'-oligoadenylate synthetase 1, 40/46kDa

B. Liver

Public ID Gene Symbol Gene Title

AA799328 RGD 1560913_predicted similar to expressed sequence AW413625 (predicted)

AA799700 Sephs2 selenophosphate synthetase 2

AA800212 Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

AA817761 Adhl alcohol dehydrogenase 1 (class I)

AA818262 Angpttø angiopoietin-like 4

AA818759 RGD1560745_predicted similar to OTTHUMPOOOOOO 18508 (predicted)

AA818819 — Transcribed locus

AA818900 LOC304138 similar to cysteine and tyrosine-rich protein 1

AA819250 RGDl 560915_predicted similar to Hypothetical protein MGC30714 (predicted)

AA849966 —

AA850751 —

AA858645 Chdll_predicted chromodomain helicase DNA binding protein 1-like

(predicted)

AA858930 Pde4b Phosphodiesterase 4B, cAMP specific

AA858993 Ugt2b UDP glycosyltransferase 2 family, polypeptide B

AA859029 — Transcribed locus

AA859049 Es2 esterase 2 AA859496 Gch GTP cyclohydrolase 1

AA859663 LOC301 1 13 similar to solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

AA874941 Adfp Adipose differentiation related protein

AA891362 Hadhsc L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain

AA891834 Col4a5_predicted collagen, type IV, alpha 5 (predicted)

AA892813 LOC680445 Similar to muscleblind-like 2 isoform 1

AA892845 Hexb hexosaminidase B

AA893169 Timp3 tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)

AA893192 Transcribed locus

AA893529 —

AA899326 — Transcribed locus

AA899371 Pwpl_predicted PWPl homolog (S. cerevisiae) (predicted)

AA899481 — Transcribed locus

AA899721 Mtel mitochondrial acyl-CoA thioesterase 1

AA900547 Nfxl Nuclear transcription factor, X-box binding 1

AA900645 — Transcribed locus

AA901337 Spic_predicted Spi-C transcription factor (Spi-1/PU. l related) (predicted)

AA924350 LOC686634 /// hypothetical protein LOC686634 /// hypothetical protein

LOC690768 LOC690768

AA924380 Zφl31 zinc finger protein 131

AA924588 RGD 1304748 similar to cDNA sequence BC006662

AA924620 Rab40b_predicted Rab40b, member RAS oncogene family (predicted)

AA926109 — Transcribed locus

AA926305 — Transcribed locus

AA945268 — Transcribed locus

AA945604 — Transcribed locus

AA945955 Ogn_predicted osteoglycin (predicted)

AA946294 —

AA955091 Itga6 integrin, alpha 6

AA955771 —

AA955879 — Transcribed locus

AA957585 Ehd3 EH-domain containing 3

AA957990 — Transcribed locus

AA963524 Slc35c2 solute carrier family 35, member C2

AA963797 SuIO sulfatase 2

AA9971 15 RGD131 1859_predicted similar to hypothetical protein DKFZp434H01 15 (predicted)

AA997683 Aldhlbl aldehyde dehydrogenase 1 family, member B 1

AA997980 — Transcribed locus

AA998264 LOC307495 similar to biliverdin reductase B (flavin reductase (NADPH))

AA998903 — CDNA clone IMAGE:7374368

ABO 13454 Slc34al solute carrier family 34 (sodium phosphate), member 1

ABO 19693 Kegl kidney expressed gene 1

AB020967 Trib3 tribbles homolog 3 (Drosophila)

AB030829 Ca3 carbonic anhydrase 3

AB047324 SlclόalO solute carrier family 16 (monocarboxylic acid transporters), member 10

AB052294 Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member

8

AF065161 Cish cytokine inducible SH2 -containing protein

AF072411 Cd36 /// LOC685953 /// cd36 antigen /// similar to fatty acid translocase/CD36

RGD1562323_predicted (predicted) /// similar to CD36 antigen

AF079864 Olr59 olfactory receptor 59

AF090134 Lin7a lin-7 homolog a (C. elegans)

AFl 1 1099 Lphnl latrophilin 1

AF202733 Pde4b phosphodiesterase 4B, cAMP specific

AF311886 LOC266761 cytochrome P450-like protein AF335281 Steap3 STEAP family member 3

AF41 1318 MtIa metallothionein Ia

AI008441 Pgd phosphogluconate dehydrogenase (mapped)

AIO 10322 Mbnl3_predicted muscleblind-like 3 (Drosophila) (predicted)

AI010839 Kcnmal potassium large conductance calcium-activated channel, subfamily M, alpha member 1

AIO 13299 RGDl 565184_predicted ventricular zone expressed PH domain homolog 1

/// Vephl (zebrafish) /// similar to VEPH isoform A (predicted)

AI013567 Glt25dl_predicted glycosyltransferase 25 domain containing 1 (predicted)

AI044253 — Transcribed locus

AI044343 RGDl 560170_predicted similar to cofactor required for SpI transcriptional activation, subunit 2, 15OkDa (predicted)

AI045015 RGDl 560736_predicted similar to solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 (predicted)

AI045116 Transcribed locus

AI045533 LOC679725 Similar to MASK-4E-BP3 protein

AI045767 Ank progressive ankylosis homolog (mouse)

AI058895 — Transcribed locus

AI059204 Cpne8_predicted copine VIII (predicted)

AI060043 — Transcribed locus

AI060139 Atxn2_predicted Ataxin 2 (predicted)

AI060227 Rnd3 Rho family GTPase 3

AI071547 RGD1308329_predicted Similar to KIAA0869 protein (predicted)

AI072107 Akrlcό aldo-keto reductase family 1 , member C6

AI072892 Frzb frizzled-related protein

AI073272 Tor Ib torsin family 1, member B

AI101330 Ncald neurocalcin delta

AI101727 — Transcribed locus

AI 102035 — Transcribed locus

AI 102061 Gria3 glutamate receptor, ionotropic, AMP A3 (alpha 3)

AI102258 — Transcribed locus

AI103389 —

AI 104238 Gzma granzyme A

All 10520 — Transcribed locus

AI 1 11413 Spsb4_predicted splA/ryanodine receptor domain and SOCS box containing 4

(predicted)

Al l 13090 Transcribed locus

All 13261 LOC687696 similar to AMSH-family protein

AI 136684 siat7D alpha-2,6-sialyltransferase ST6GalNAc IV

AI 137045 — Transcribed locus

AI137310 — Transcribed locus

AI137640 Cldnl claudin 1

AI 138048 Dscrlll Down syndrome critical region gene 1 -like 1

AI 146237 — Transcribed locus

AI 168953 Sultlc2a sulfotransferase family, cytosolic, 1C, member 2a

AI169331 Gstm2 glutathione S-transferase, mu 2

AI 170076 RGD1562829_predicted similar to RAS-like, estrogen-regulated, growth-inhibitor

(predicted)

AI171727 Nnmt_predicted nicotinamide N-methyltransferase (predicted)

AI 176041 Pir Pirin

AI176172 — Transcribed locus

AI 176481 LOC684841 similar to CG31613-PA

AI176583 Mrvldcl MARVEL (membrane-associating) domain containing 1

AI177143 — Transcribed locus

AI 177358 Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

AI178784 RGD1310174_predicted hypothetical LOC298504 (predicted)

AI 179334 Fasn fatty acid synthase AI179886 RGD1310352 similar to HTGN29 protein, keratinocytes associated transmembrane protein 2

AI 180253 RGD1563825_predicted similar to ENSANGP00000020885 (predicted)

AI 180398 — Transcribed locus

AI228307 Mlcl_predicted megalencephalic leukoencephalopathy with subcortical cysts

1 homolog (human) (predicted)

AI229240 Transcribed locus

AI230709 Igf2bp3 insulin-like growth factor 2, binding protein 3

AI231218 — Transcribed locus

AI231999 LOC689256 similar to Tumor protein D53 (mD53) (Tumor protein D52- hke 1)

AI232036 Atplbl ATPase, Na+/K+ transporting, beta 1 polypeptide

AI232328 Hgd homogentisate 1 , 2-dioxygenase

AI232414 Pxmp4 peroxisomal membrane protein 4

AI232716 LOC368066 similar to indolethylamine N-methyltransferase

AI232723 —

AI232806 — Transcribed locus

AI233769 — Transcribed locus

AI234919 Eprs glutamyl-prolyl-tRNA synthetase

AI235527 — Transcribed locus

AI236188 — Transcribed locus

AI237079 — Transcribed locus

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S cerevisiae)

AI385229 —

AI406386 Lmo4 LIM domain only 4

AI406660 —

AI406662 Sec63_predicted SEC63-hke (S cerevisiae) (predicted)

AI407074 LOC690634 similar to F-box only protein 3 isoform 1

AI407487 — Transcribed locus

AI408556 Fdx 1 Ferredoxin 1

AI408557 — Transcribed locus

AI408948 Ca2 carbonic anhydrase 2

AI409048 — Transcribed locus

AI410221 Sat2_predicted spermidine/spermine Nl -acetyl transferase 2 (predicted)

AI410749 — Transcribed locus

AI411141 —

AI411227 RGD1563485_predicted similar to mKIAA0534 protein (predicted)

AI411294 — Transcribed locus

AI41 1345 LOC680409 /// similar to Proline oxidase, mitochondrial precursor (Proline

LOC682565 dehydrogenase)

AI41 1693 LOC299458 /// similar to immunoglobulin heavy chain 6 (Igh-6) /// similar

LOC366747 /// to Ig H-cham V-region precursor /// similar to Ig heavy chain

LOC678701 /// V region MClOl precursor /// hypothetical protein

RGD 1359202 LOC678701

AI41 1947 Igh-la immunoglobulin heavy chain 1 a (serum IgG2a)

AI412161 — Transcribed locus

AI412189 Igha mapped /// immunoglobulin heavy chain (alpha polypeptide) (mapped)

LOC366772 /// similar to immunoglobulin heavy chain

AI45461 1 Fmo5 flavin containing monooxygenase 5

AI500781 — Transcribed locus

AI535089 Zfpl31 zinc finger protein 131

AI547468 — Transcribed locus

AI547628 LOC367485 /// similar to spermatogenesis associated glutamate (E)-πch

LOC501235 /// protein 4d /// similar to RIKEN cDNA 5031410106

LOC501339 ///

LOC688687 ///

LOC689870 ///

LOC690439 /// LOC690577 ///

LOC691712

AI548117 —

AI548708 — Transcribed locus, strongly similar to XP 696468.1

PREDICTED: similar to related RAS viral (r-ras) oncogene homolog 2 (predicted) [Danio rerio]

AI555855 Transcribed locus

AI556333 RGD1564257_predicted similar to hypothetical protein FLJ32825 (predicted)

AI556941 Slc39a4_predicted solute carrier family 39 (zinc transporter), member 4

(predicted)

AI575616 ... Transcribed locus

AI577508 LOC684425 similar to Adenylosuccinate synthetase isozyme 1

(Adenylosuccinate synthetase, muscle isozyme) (IMP— aspartate ligase 1) (AdSS 1) (AMPSase 1)

AI598315 Slc39alO_predicted solute carrier family 39 (zinc transporter), member 10

(predicted)

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI600057 Criml_predicted cysteine-rich motor neuron 1 (predicted)

AI603217 Gnb5 guanine nucleotide binding protein, beta 5

AI639108 —

AI639241 LOC684318 /// ubiquitin specific protease 12 (predicted) /// similar to

RGD1561481_predicted ubiquitin specific protease 12 (predicted) /// similar to

/// Uspl2_predicted ubiquitin specific protease 12

AI639457 — Transcribed locus

AI703807 Criml_predicted cysteine-rich motor neuron 1 (predicted)

AI715156 — Transcribed locus

AI715202 RTl-Bb RTl class II, locus Bb

AI715484 — Transcribed locus

AI716248 RGD131 1 155 similar to RIKEN cDNA 92301 17N10

AI716500 — Transcribed locus

AJ243338 RT1-CE5 RTl class I, CE5

AJ249701 RT1-A2 /// RT1-A3 /// RTl class Ib, locus Aw2 /// RTl class Ia, locus A2 /// RTl

RT1-Aw2 class I, A3

AW143798 Ccndl Cyclin Dl

AW144193 — Transcribed locus

AW251313 RGD1559797_predicted similar to CDNA sequence BCO 14699 (predicted)

AW251647 — Transcribed locus

AW252232 — Transcribed locus

AW434782 RGD1305020_predicted similar to Hepatocellular carcinoma-associated antigen 58 homolog (predicted)

AW435376 Lφ5_predicted low density lipoprotein receptor-related protein 5 (predicted)

AW521621 — Transcribed locus

AW522341 — Transcribed locus

AW524532 — Transcribed locus

AW525342 Uspl ubiquitin specific peptdiase 1

AW525662 Cdc27 cell division cycle 27 homolog (S. cerevisiae)

AW526014 — Transcribed locus

AW526910 — Transcribed locus

AW527403 Sh3yl l_predicted Sh3 domain YSC-like 1 (predicted)

AW528213 Gdpdl_predicted glycerophosphodiester phosphodiesterase domain containing

1 (predicted)

AW530264 Transcribed locus

AW530361 Ppplr3c protein phosphatase 1, regulatory (inhibitor) subunit 3C

AW530647 Slc25a30 solute carrier family 25, member 30

AW533234 LOC688915 similar to cardiomyopathy associated 5

AW533569 Clca2_predicted chloride channel, calcium activated, family member 2

(predicted)

AW533965 Nars Asparaginyl-tRNA synthetase AW916358 Sptlc 1 _predicted serine palmitoyltransferase, long chain base subunit 1

(predicted) AW916957 Transcribed locus, strongly similar to XP 579758.1

PREDICTED: hypothetical protein XP 579758 [Rattus norvegicus]

AW920026 LOC364393 /// PHD finger protein 1 1 /// similar to RIKEN cDNA LOC684778 /// Phfl 1 4933417L10 /// hypothetical protein LOC684778 AW920487 Casrll /// LOC365807 calcium-sensing receptor like 1 /// similar to putative pheromone receptor V2R2

AY044251 I113ral interleukin 13 receptor, alpha 1 AY082609 Abcbla /// Abcblb ATP-binding cassette, sub-family B (MDR/TAP), member

IB /// ATP-binding cassette, sub-family B (MDR/TAP), member IA

BE096457 Transcribed locus BE097095 Transcribed locus BE097185 Transcribed locus BE097702 BE097947 Transcribed locus BE098143 Transcribed locus BE098160 Transcribed locus, weakly similar to XP_001158686.1 PREDICTED: SA hypertension-associated homolog isoform 3 [Pan troglodytes]

BE098827 Transcribed locus BE100625 Emrl EGF-like module containing, mucin-like, hormone receptor- like sequence 1

BE101298 Transcribed locus BE102861 Transcribed locus BE104060 Igfbp5 insulin-like growth factor binding protein 5 BE104552 Elavil _predicted ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (predicted)

BE104961 Cenpj_predicted centromere protein J (predicted) BE105916 BE106199 Rora_predicted RAR-related orphan receptor alpha (predicted) BE106376 LOC687219 /// similar to zinc finger protein 84 (HPF2) LOC691 170

BE106921 Transcribed locus BE107075 Transcribed locus, strongly similar to NP 056335.1 membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform a [Homo sapiens]

BE107313 RGD1310271_predicted similar to hypothetical protein MGC45873 (predicted) BE107450 Nrep Neuronal regeneration related protein BE108158 Unc5d_predicted unc-5 homolog D (C. elegans) (predicted) BE108176 BE108354 Transcribed locus BE108376 Transcribed locus, strongly similar to NP 795961.2 hypothetical protein LOC319719 [Mus musculus]

BE108648 Transcribed locus BE108745 LOC680182 /// nucleosome binding protein 1 (predicted) /// similar to LOC681284 /// Nucleosome binding protein 1 (Nucleosome binding protein Nsbpl_predicted 45) (NBP-45) (GARP45 protein)

BE109520 LOC619558 hypothetical protein LOC619558 BE109875 Transcribed locus BE110171 LOC368158 /// similar to Nuclear receptor ROR-gamma (Nuclear receptor

RGDl 562025_predicted RZR-gamma) (Thymus orphan receptor) (TOR) /// similar to leucine rich repeat neuronal 6D (predicted)

BEl 10921 Transcribed locus BEl 11310 Ky_predicted kyphoscoliosis (predicted)

BEl 13268 Pkp2 plakophilin 2 BE113419 Srpk2_predicted serine/arginine-rich protein specific kinase 2 (predicted) BEl 14005 RGD 1564024_predicted similar to KIAA1913 (predicted)

BEl 14778 Cgn_predicted cingulin (predicted)

BEl 15309 Gldc_predicted glycine decarboxylase (predicted)

BEl 15481 Cbfa2t3_predicted core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (predicted)

BEl 15496 Transcribed locus

BEl 15823 —

BE1 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BEl 16364 Bmp5_predicted bone morphogenetic protein 5 (predicted)

BEl 16408 — Transcribed locus

BEl 18653 — Transcribed locus

BEl 19164 —

BE120352 — Transcribed locus

BE 120522 — Transcribed locus

BE120930 — Transcribed locus

BE121026 — Transcribed locus

BE121383 Ncam2 neural cell adhesion molecule 2

BE121400 LOC681284 similar to Nucleosome binding protein 1 (Nucleosome binding protein 45) (NBP-45) (GARP45 protein)

BE329244

BE349658 —

BE349669 Cav2 caveolin 2

BE349670 — Transcribed locus

BE349751 —

BF282112 — Transcribed locus

BF282228 Ltb lymphotoxin B

BF282495 Enpp6_predicted Ectonucleotide pyrophosphatase/phosphodiesterase 6

(predicted)

BF282636 RGD 1305457 similar to RIKEN cDNA 1700023 M03

BF282722 — Transcribed locus

BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

BF283779 RGD1565496_predicted similar to Butyrate-induced transcript 1 (predicted)

BF284175 Pla2gl2a_predicted phospholipase A2, group XIIA (predicted)

BF284288 — Transcribed locus

BF284700 — Transcribed locus

BF287122 — Transcribed locus

BF287593 Coch_predicted coagulation factor C homolog (Limulus polyphemus)

(predicted)

BF288218 RGD 1309007_predicted similar to RIKEN cDNA 2610034E18 gene (predicted)

BF288295 — Transcribed locus

BF288361 —

BF289154 — Transcribed locus

BF290890 RGD 1310769_predicted similar to HSPC288 (predicted)

BF291026 — Transcribed locus, strongly similar to XP_577836.1

PREDICTED: similar to RIKEN cDNA 4933424N09

[Rattus norvegicus]

BF386242 Paqr9_predicted progestin and adipoQ receptor family member IX (predicted)

BF386770 — Transcribed locus

BF386852 Abca8b_predicted ATP-binding cassette, sub-family A (ABCl), member 8b

(predicted)

BF389489 Tbcldl2_predicted TBC1D12: TBCl domain family, member 12 (predicted)

BF390510 RGD131 1 155 similar to RIKEN cDNA 92301 17N 10

BF391 129 — Transcribed locus

BF391308 — Transcribed locus

BF391556 RGD1310710_predicted similar to RIKEN cDNA 2700091N06 (predicted)

BF391820 — Transcribed locus

BF392285 Transcribed locus BF392577 Akap81 A kinase (PRKA) anchor protein 8-like BF393056 Transcribed locus BF393945 Transcribed locus BF394158 Transcribed locus BF394166 Gpmόa glycoprotein m6a BF394600 Transcribed locus BF395791 Transcribed locus BF396135 Stard4_predicted StAR-related lipid transfer (START) domain containing 4

(predicted)

BF396622 Transcribed locus, strongly similar to XP 982134.1

PREDICTED: similar to SET binding factor 2 [Mus musculus]

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF397095 LOC681234 similar to debranching enzyme homolog 1

BF397926 Gmps guanine monphosphate synthetase

BF398091 — CDNA clone IMAGE:7374368

BF398168 — Transcribed locus

BF398558 — Transcribed locus

BF400594 Odz2 Odd Oz/ten-m homolog 2 (Drosophila)

BF400669 — Transcribed locus

BF401 106 — Transcribed locus

BF401529 — Transcribed locus

BF401705 — Transcribed locus

BF403483 ... Transcribed locus, moderately similar to NP 997413.2 oxysterol binding protein-like 1 [Mus musculus]

BF403998 Cib2 calcium and integrin binding family member 2

BF404957 — Transcribed locus

BF406487 LOC684448 /// similar to transmembrane 6 superfamily member 2

LOC689029

BF408099 Pcdhl 8_predicted protocadherin 18 (predicted)

BF408445 Gpx7_predicted glutathione peroxidase 7 (predicted)

BF41 1794 — Transcribed locus

BF412036 — Transcribed locus

BF413105 — Transcribed locus

BF413433 Mil myeloid/lymphoid or mixed-lineage leukemia

BF414160 Igf2bp3 Insulin-like growth factor 2, binding protein 3

BF414655 Maoa Monoamine oxidase A

BF414677 Znf213_predicted zinc finger protein 213 (predicted)

BF414998 RGDl 306105_predicted similar to RIKEN cDNA 2610318G 18 (predicted)

BF416266 RGD 1309948 similar to CG 1 1737-PA

BF416465 — Transcribed locus

BF417289 — Transcribed locus

BF417649 —

BF418138 — Transcribed locus

BF419663 ... Transcribed locus

BF420260 —

BF420465 Kifl6b_predicted kinesin family member 16B (predicted)

BF543574 Irxl_predicted /// Iroquois related homeobox 1 (Drosophila) (predicted) ///

LOC501463 similar to Iroquois-class homeodomain protein IRX-I

(Iroquois homeobox protein 1) (Homeodomain protein

IRXAl)

BF545930 Transcribed locus

BF549748 LOC498796 hypothetical protein LOC498796

BF553076 — Transcribed locus

BF554138 RGDl 563179_predicted similar to BAZF (predicted)

BF555448 Mtel Mitochondrial acyl-CoA thioesterase 1

BF555947 Transcribed locus BF557891 Irf6_predicted interferon regulatory factor 6 (predicted)

BF56341 1 — Transcribed locus

BF565675 Arsa arylsulfatase A

BG371721 — Transcribed locus

BG372602 RGDl 30660 l_predicted similar to cDNA sequence BC019755 (predicted)

BG372643 RGD1308967_predicted similar to hypothetical protein MGC 16491 (predicted)

BG374683 — Ig active Iambda2-like chain mRNA, 3' end

BG375362 Ltbp4 latent transforming growth factor beta binding protein 4

BG375383 RGD13081 16_predicted similar to hypothetical protein MGC42105 (predicted)

BG376410 Tacstdl tumor-associated calcium signal transducer 1

BG376813 —

BG377595 LOC367746 similar to Spindlin-like protein 2 (SPIN-2)

BG377996 LOC680248 /// similar to Diphosphoinositol polyphosphate

LOC683238 phosphohydrolase 3 alpha (DIPP-3 alpha) (DIPP3 alpha)

(Diadenosine 5,5-Pl,P6-hexaphosphate hydrolase 3 alpha)

(Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10)

BG378056 Transcribed locus

BG378637 Hrasls3 HRAS like suppressor 3

BG379394 — Transcribed locus

BG380581 — Transcribed locus

BG380860 — Transcribed locus

BG38131 1 Slcl3a5 solute carrier family 13 (sodium-dependent citrate transporter), member 5

BG662490 Abhd3_predicted abhydrolase domain containing 3 (predicted)

BG662519 Ank Progressive ankylosis homolog (mouse)

BG66401 1 Pxmp4 peroxisomal membrane protein 4

BG664221 Ogπ_predicted osteoglycin (predicted)

BG666635 — Transcribed locus

BG666735 Elovl2_predicted /// elongation of very long chain fatty acids (FEN1/Elo2,

LOC682492 SUR4/Elo3, yeast)-like 2 (predicted) /// similar to Elongation of very long chain fatty acids protein 2

BG669396 LOC680201 /// similar to zinc finger protein 322a

LOC684943

BG670960 MGC95152 similar to B230212L03Rik protein

BG673602 —

BI273908 — Transcribed locus

BI274408 Dscrlll Down syndrome critical region gene 1-like 1

BI275030 RGD 1308694_predicted similar to hypothetical protein MGC47256 (predicted)

BI275467 —

BI275560 — Transcribed locus

BI275815 Tmem 106a transmembrane protein 106 A

BI275894 — Transcribed locus

BI276183 — Transcribed locus

BI277482 MGCl 12775 similar to map kinase interacting kinase

BI277527 Bckdk branched chain ketoacid dehydrogenase kinase

BI277600 LOC362972 similar to adiponutrin

BI278180 — Transcribed locus

BI279030 — Transcribed locus

BI279202 RGD1565709_predicted similar to ovostatin-2 (predicted)

BI279384 — Transcribed locus

BI281668 — Transcribed locus

BI281738 TspyW TSPY-like 4

BI282024 LOC690845 similar to 4OS ribosomal protein S4, X isoform

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

BI28221 1 Acsm3 acyl-CoA synthetase medium-chain family member 3

BI282488 Acaa2 Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3- oxoacyl-Coenzyme A thiolase) BI283159 Scpepl serine carboxypeptidase 1

BI283223 RGD 1562168_predicted similar to retinoid binding protein 7 (predicted)

BI283882 Gpi glucose phosphate isomerase

BI284363 Vcpipl valosin containing protein (p97)/p47 complex interacting protein 1

BI285494 Ifitm3 interferon induced transmembrane protein 3

BI285576 Gsn Gelsolin

BI285616 Adfp adipose differentiation related protein

BI285941 — Transcribed locus

BI288517 Hnf4a hepatocyte nuclear factor 4, alpha

BI288540 Plxnbl_predicted plexin B 1 (predicted)

BI288580 rCG_34031 similar to kynurenine formamidase

BI288945 RGD1305713 similar to RIKEN cDNA 31 10040N1 1

BI289032 —

BI289085 Vnnl vanin 1

BI289506 — Transcribed locus

BI289620 Criml_predicted cysteine-rich motor neuron 1 (predicted)

BI289723 LOC310721 similar to 493043 lB09Rik protein

BI290154 RGD1309578 similar to Aa2- 174

BI290769 RGD1309634_predicted hypothetical LOC305452 (predicted)

BI290794 — Transcribed locus, strongly similar to XP 347073.1

PREDICTED: hypothetical protein XP 347072 [Rattus norvegicus]

BI291842 Transcribed locus

B 1292055 — Transcribed locus

BI292056 — Transcribed locus

BI293584 Tmem55a transmembrane protein 55 A

BI295569 RGD1564089_predicted similar to peroxisomal long chain acyl-CoA thioesterase Ia

(predicted)

BI295739 — Transcribed locus, moderately similar to NP 005132.2 fibrinogen, beta chain preproprotein [Homo sapiens]

BI295961 Tjp3_predicted tight junction protein 3 (predicted)

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

BI296275 Mmd2_predicted monocyte to macrophage differentiation-associated 2

(predicted)

BI296384 Transcribed locus

BI296388 — Transcribed locus, strongly similar to XP_574380.1

PREDICTED: poliovirus receptor-related 2 (herpesvirus entry mediator B) (predicted) [Rattus norvegicus]

BI296463 Tpcn2_predicted two pore segment channel 2 (predicted)

BI296494 — Transcribed locus

BI296524 — Transcribed locus

BI297291 — Transcribed locus

BI300997 Sultlc2 /// Sultlc2a sulfotransferase family, cytosolic, 1C, member 2 /// sulfotransferase family, cytosolic, 1C, member 2a

BI301687 Transcribed locus

BI395849 —

BM382879 Pura_predicted Purine rich element binding protein A (predicted)

BM383209 RGD1561 153_predicted similar to myosin-VIIb (predicted)

BM383212 — Transcribed locus

BM383531 LOC682651 /// similar to Metallothionein-2 (MT-2) (Metallothionein-II)

LOC689415 (MT-II)

BM383683 RGD1310710_predicted similar to RIKEN cDNA 2700091N06 (predicted)

BM384088 — Transcribed locus

BM384752 Kdelc2 KDEL (Lys-Asp-Glu-Leu) containing 2

BM384823 — Transcribed locus

BM385772 ... Transcribed locus

BM386280 ___ BM386775 Aiml l_predicted absent in melanoma 1-like (predicted)

BM387172 — Transcribed locus, strongly similar to XP 233470.2

PREDICTED: similar to 6330530A05Rik protein [Rattus norvegicus]

BM387283 Triml4_predicted tripartite motif protein 14 (predicted)

BM387449 — Transcribed locus

BM387813 — Transcribed locus

BM388141 —

BM388719 Rpl7 Ribosomal protein L7

BM389786 — Transcribed locus

BM390238 — Transcribed locus

BM390378 RGD1562732_predicted similar to Glutathione S-transferase, theta 3 (predicted)

BM390571 Sult2bl_predicted sulfotransferase family, cytosolic, 2B, member 1 (predicted)

BM391206 Histlh2bh histone cluster 1 , H2bh

BM391471 Atf5 activating transcription factor 5

BM391823 RGD1563309_predicted similar to diacylglycerol kinase, delta 13OkDa isoform 1

(predicted)

BM986536 Histlh4b histone cluster 1 , H4b

D00252 Gotl glutamate oxaloacetate transaminase 1

H33577 — Transcribed locus

H33845 — Transcribed locus

H35736 Slc25a30 Solute carrier family 25, member 30

J02585 Scdl stearoyl-Coenzyme A desaturase 1

J05499 Gls2 glutaminase 2 (liver, mitochondrial)

K.02422 Cypl a2 cytochrome P450, family 1, subfamily a, polypeptide 2

L06804 Lhx2_predicted LIM homeobox protein 2 (predicted)

L12458 Lyz Lysozyme

L19180 Ptprd protein tyrosine phosphatase, receptor type, D

L19181 Ptprd protein tyrosine phosphatase, receptor type, D

L19933 Ptprd protein tyrosine phosphatase, receptor type, D

L22655 LOC500180 similar to IG KAPPA CHAIN V-V REGION K2

PRECURSOR

L26525 —

L46791 Ces3 /// LOC291863 carboxylesterase 3 /// carboxylesterase-like

L48060 PrIr prolactin receptor

M 10094 RT1-Aw2 RTl class Ib, locus Aw2

M13506 Udpgtr2 liver UDP-glucuronosyltransferase, phenobarbital-inducible form

M14137 Atplbl ATPase, Na+/K+ transporting, beta 1 polypeptide

M17685 PkIr pyruvate kinase, liver and red blood cell

M 18340 Tat tyrosine aminotransferase

M24024 RT1-Aw2 RTl class Ib, locus Aw2

M24327 MtIa metallothionein Ia

M25804 Nrldl nuclear receptor subfamily 1, group D, member 1

M27882 Spinkl serine protease inhibitor, Kazal type 1

M27883 Spink3 serine protease inhibitor, Kazal type 3

M30596 Mel malic enzyme 1

M57668 PrIr prolactin receptor

M63991 Seφina7 serine (or cysteine) peptidase inhibitor, clade A (alpha- 1 antipeptidase, antitrypsin), member 7

M64755 Csad cysteine sulfinic acid decarboxylase

NM_012522 Cbs cystathionine beta synthase

NM_012524 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha

NM_012531 Comt catechol-O-methyltransferase

NM_012552 Elal elastase 1 , pancreatic

NM_012600 Mel malic enzyme 1

NM_012603 Myc Myelocytomatosis viral oncogene homolog (avian)

NM 012624 PkIr pyruvate kinase, liver and red blood cell NM O 12645 RT1-Aw2 RTl class Ib, locus Aw2

NM_012646 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl class

RT1-N3 Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene,

H2-TL-like, grc region(N2)

NM_012674 Spinkl serine protease inhibitor, Kazal type 1

NM_012695 Smp2a rat senescence marker protein 2A gene, exons 1 and 2

NM_012737 Apoa4 apolipoprotein A-IV

NM_012742 Foxal forkhead box A 1

NM_012744 Pc Pyruvate carboxylase

NM_012753 Cypl7al cytochrome P450, family 17, subfamily a, polypeptide 1

NM_012798 MaI myelin and lymphocyte protein, T-cell differentiation protein

NM_012816 Amacr alpha-methylacyl-CoA racemase

NM_012907 Apobecl apolipoprotein B editing complex 1

NMJ 13027 Sepwl selenoprotein W, muscle 1

NM O 13068 Fabp2 fatty acid binding protein 2, intestinal

NM O 13084 Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain

NM O 13095 Smad3 MAD homolog 3 (Drosophila)

NM 013144 Igfbpl insulin-like growth factor binding protein 1

NM_016987 AcIy ATP citrate lyase

NM_017019 Ilia interleukin 1 alpha

NM_017025 Ldha lactate dehydrogenase A

NM_017077 Foxa3 forkhead box A3

NM_017106 Clcn5 chloride channel 5

NM_01711 1 Slcolal solute carrier organic anion transporter family, member IaI

NM_017125 Cd63 CD63 antigen

NMJ) 17128 Inhba inhibin beta-A

NMJ)17149 Meox2 mesenchyme homeobox 2

NMJM7159 Hal histidine ammonia lyase

NM_017161 Adora2b adenosine A2B receptor

NM O 17206 Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6

NMJ) 17229 Pde3b phosphodiesterase 3B

NMJ) 17235 Hsdl7b7 hydroxysteroid (17-beta) dehydrogenase 7

NMJ) 17245 EeO eukaryotic translation elongation factor 2

NMJ) 17332 Fasn fatty acid synthase

NMJ) 17357 HpcaW hippocalcin-like 4

NMJ) 19203 Tsx testis specific X-linked gene

NMJ) 19216 Gdfl5 growth differentiation factor 15

NM O 19291 Ca2 carbonic anhydrase 2

NM O 19292 Ca3 carbonic anhydrase 3

NMJ) 19314 Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

NMJ) 19323 McptlO /// Mcpt8 /// mast cell protease 8 /// mast cell protease 10 /// mast cell

Mcpt812 /// Mcpt9 protease 9 /// mast cell protease 8-like 2

NM_020072 Acpp acid phosphatase, prostate

NMJ)20540 Gstm4 glutathione S-transferase M4

NMJ)21577 AsI Argininosuccinate lyase

NMJ)21653 Dio 1 deiodinase, iodothyronine, type I

NMJ)21664 Dnase2b deoxyribonuclease II beta

NMJ)21744 Cdl4 CD 14 antigen

NMJ)22224 Pter phosphodiesterase related

NMJ)22280 Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-

O-acyltransferase)

NMJ)22407 Aldhlal aldehyde dehydrogenase family 1, member Al

NMJ)22521 Oat ornithine aminotransferase

NMJ)22542 Rhob ras homolog gene family, member B

NM_022617 Mpegl macrophage expressed gene 1

NM 022686 LOC680097 /// similar to germinal histone H4 gene LOC684887

NM_023025 Cyp2j3 /// Cyp2j4 cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome P450, family 2, subfamily j, polypeptide 3

NM 023951 Og9x OG9 homeobox gene

NM_023969 Edg7 putative G protein-coupled receptor snGPCR32

NM_024127 Gadd45a growth arrest and DNA-damage-inducible 45 alpha

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM 024381 Gyk glycerol kinase

NM_030994 Itgal integrin alpha 1

NM_031039 Gptl glutamic pyruvic transaminase 1 , soluble

NM_031073 Ntf3 neurotrophin 3

NM 031074 Nup98 nucleoporin 98

NM_031 154 Gstm3 glutathione S-transferase, mu type 3

NM_031330 AsI Argininosuccinate lyase

NM_031533 Ugt2b UDP glycosyltransferase 2 family, polypeptide B

NM 031543 Cyp2el cytochrome P450, family 2, subfamily e, polypeptide 1

NM 031548 Scnnla sodium channel, nonvoltage-gated 1 alpha

NM_031559 Cptla carnitine palmitoyltransferase Ia, liver

NM 031561 RGD1562323_predicted similar to fatty acid translocase/CD36 (predicted)

NM_031605 Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8

NM_031641 Sult4al sulfotransferase family 4A, member 1

NM_031741 Slc2a5 solute carrier family 2, member 5

NM_031841 Scd2 stearoyl-Coenzyme A desaturase 2

NM_031970 Hspbl heat shock 27kDa protein 1

NM_031971 Hspala /// Hspalb heat shock 7OkD protein 1 A /// heat shock 7OkD protein I B

(mapped)

NM_053299 Ubd ubiquitin D

NM_053328 Bhlhb2 basic helix-loop-helix domain containing, class B2

NM_053380 Slc34a2 solute carrier family 34 (sodium phosphate), member 2

NM_053584 —

NM_053587 S100a9 SlOO calcium binding protein A9 (calgranulin B)

NM 053639 Ltc4s leukotriene C4 synthase

NM_053714 Ank progressive ankylosis homolog (mouse)

NM_053754 Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5

NM 053962 Sds serine dehydratase

NM_053977 Cdhl7 cadherin 17

NM_053999 Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B

(PR 52), alpha isoform

NM_057133 Nr0b2 nuclear receptor subfamily 0, group B, member 2

NM_057208 Tpm3 tropomyosin 3, gamma

NM_080773 Chrml cholinergic receptor, muscarinic 1

NM_130422 Caspl2 caspase 12

NM_130430 Psmd9 proteasome (prosome, macropain) 26S subunit, non-ATPase,

9

NM_130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3- oxoacyl-Coenzyme A thiolase)

NM_130752 FgOl fibroblast growth factor 21

NM_133413 Cysltr2 cysteinyl leukotriene receptor 2

NM_133525 RGD620382 Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382

NM_133526 Tspanδ tetraspanin 8

NM 133538 I113ra2 interleukin 13 receptor, alpha 2

NM_133547 Sultlc2 /// Sultlc2a sulfotransferase family, cytosolic, 1C, member 2 /// sulfotransferase family, cytosolic, 1C, member 2a

NM_133586 Ces2 carboxylesterase 2 (intestine, liver)

NM_133614 Slc25a21 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

NM 134372 Acmsd 2-amino-3 -carboxymuconate-6-semialdehyde decarboxylase NM_134379 UST4r integral membrane transport protein UST4r

NMJ 39255 LOC246120 RDCR-0918-3 protein

NM_139258 Bmf Bcl2 modifying factor

U36476 Mmp9 matrix metallopeptidase 9

U46118 Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9

U88294 Cptla carnitine palmitoyltransferase 1 a, liver

Y09333 Mtel mitochondrial acyl-CoA thioesterase 1

Y09945 Slc22a9 solute carrier family 22 (organic anion/cation transporter), member 9

Z78279 Collal procollagen, type 1, alpha 1

C. Quadricep

Public ID Gene Symbol Gene Title

AA799328 RGDl 560913_predicted similar to expressed sequence AW413625 (predicted)

AA800285 — Transcribed locus

AA800750 —

AA818732 — Transcribed locus

AA819034 isgl2(b) putative ISG12(b) protein

AA849966 —

AA850780 RGD1564560_predicted similar to RCK (predicted)

AA866223 —

AA875438 RGD1309414_predicted similar to KIAA0913 protein (predicted)

AA892854 LOC498335 similar to Small inducible cytokine B 13 precursor

(CXCL 13) (B lymphocyte chemoattractant) (CXC chemokine BLC)

AA900536 Transcribed locus

AA901 178 RGD1304595_predicted similar to RIKEN cDNA 6330416G13 gene (predicted)

AA901290 — Transcribed locus

AA946467 — Transcribed locus

AA965076 RGDl 305179_predicted similar to Nedd4 binding protein 1 (predicted)

AA998276 — Transcribed locus

ABOO 1382 Sppl secreted phosphoprotein 1

AB035650 UsG upstream transcription factor 2

AF065161 Cish cytokine inducible SH2-containing protein

AFl 98441 Rup2 urinary protein 2

AF220558 Trdn triadin

AF368860 LOC680367 similar to Urinary protein 3 precursor (RUP-3)

AI008409 — CDNA clone IMAGE:7321089

AI009530 MGC72614 hypothetical LOC310540

AIO 10831 RGD1561425_predicted similar to RIKEN cDNA 4832428D23 gene (predicted)

AI012630 Smarcad l_predicted SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box I' (predicted)

AI013568 RGD131 1 123 Similar to 1300013J15Rik protein

AI029745 Chodl_predicted chondrolectin (predicted)

AI030168 LOC367902 similar to ALEX3 protein

AI030203 Irx3_predicted Iroquois related homeobox 3 (Drosophila) (predicted)

AI044273 — Transcribed locus

AI044549 — Transcribed locus

AI044784 — Transcribed locus

AI045857 RGD1565099_predicted similar to BTEB3 protein (predicted)

AI045904 —

AI059437 —

AI070365 — Transcribed locus

AI071674 — Transcribed locus

AI 102732 MGC 109340 similar to Microsomal signal peptidase 23 kDa subunit

(SPase 22 kDa subunit) (SPC22/23)

AI 104783 Transcribed locus AI105018 Cmyal_predicted cardiomyopathy associated 1 (predicted)

AI137988 — Transcribed locus

AI145077 — Transcribed locus

AI 145240 Akap9 A kinase (PRKA) anchor protein (yotiao) 9

AI 169080 LOC690040 /// protein tyrosine phosphatase-like (proline instead of catalytic

Ptplb_predicted arginine), member b (predicted) /// similar to protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b

AI 169092 Thrsp thyroid hormone responsive protein

AI169331 Gstm2 glutathione S-transferase, mu 2

AI170377 — Transcribed locus

AI 170665 Chacl_predicted ChaC, cation transport regulator-like 1 (E. coli) (predicted)

AI 170690 LOC501126 similar to hypothetical protein MGC26733

AI1721 10 —

AI172311 RGDl 310022 similar to RIKEN cDNA 2610204K14

AI172334 —

AI 175045 — Transcribed locus

AI177358 Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

AI177934 LOC474169 pre-eosinophil-associated ribonuclease-2

AI179334 Fasn fatty acid synthase

AI179886 RGD1310352 similar to HTGN29 protein; keratinocytes associated transmembrane protein 2

AI 179988 Encl ectodermal-neural cortex 1

AI 180253 RGDl 563825_predicted similar to ENSANGP00000020885 (predicted)

AI230048 Dbp D site albumin promoter binding protein

AI231999 LOC689256 similar to Tumor protein D53 (mD53) (Tumor protein D52- like 1)

AI232414 Pxmp4 peroxisomal membrane protein 4

AI233530 —

AI235468 Dst_predicted dystonin (predicted)

AI236142 HdaclO histone deacetylase 10

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)

AI237251 —

AI406386 Lmo4 LIM domain only 4

AI406684 RGD 1562672_predicted similar to Arx homeoprotein (predicted)

AI406939 G0s2 G0/G1 switch gene 2

AI407339 Irgm immunity-related GTPase family, M

AI408099 AkrlblO aldo-keto reductase family 1 , member B lO (aldose reductase)

AI408498 Col7al_predicted procollagen, type VII, alpha 1 (predicted)

AI412065 Grhpr_predicted glyoxylate reductase/hydroxypyruvate reductase (predicted)

AI412218 Slc6a8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8

AI501537 Transcribed locus

A1501693 — Transcribed locus

AI502757 Cst7_predicted cystatin F (leukocystatin) (predicted)

AI535506 Smtnll_predicted smoothelin-like 1 (predicted)

AI548667 — Transcribed locus

AI555855 — Transcribed locus

AI574994 — Transcribed locus

AI57861 1 — Transcribed locus

AI579422 Bexl brain expressed X-linked 1

AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI638990 — Transcribed locus

AI639318 Ret ret proto-oncogene

AI710284 —

AI713274 Svt7 synaptotagmin VII AI715202 RTl-Bb RTl class II, locus Bb

AJ249701 RT1-A2 /// RT1 -A3 /// RTl class Ib, locus Aw2 /// RTl class Ia, locus A2 /// RTl

RT1-Aw2 class I, A3

AW251280 —

AW433899 Rbml 7 RNA binding motif protein 17

AW520914 Casq2 calsequestrin 2

AW521704 RGD1308371_predicted hypothetical LOC2931 14 (predicted)

AW521752 — Transcribed locus

AW522341 ... Transcribed locus

AW525342 Uspl ubiquitin specific peptdiase 1

AW527159 — Transcribed locus

AW530219 Ryrl ryanodine receptor 1 , skeletal muscle

AW530361 Ppplr3c protein phosphatase 1 , regulatory (inhibitor) subunit 3C

AW533490 —

AW534218 RGD1310722_predicted similar to RIKEN cDNA D130059P03 gene (predicted)

AW534519 — Transcribed locus

AW535196 RGD1310383_predicted similar to T-cell activation protein phosphatase 2C

(predicted)

AW535541 Svil_predicted Supervillin (predicted)

AW535897 — Transcribed locus

AW536022 — Transcribed locus

AW918670 Flnc_predicted filamin C, gamma (actin binding protein 280) (predicted)

AW920063 Kcne2 Potassium voltage-gated channel, Isk-related family, member 2

BE096522

BE097574 Kcnabl potassium voltage-gated channel, shaker-related subfamily, beta member 1

BE097672 LOC679974 /// similar to transcription elongation factor A (SΙI)-like 3

RGD1562504_predicted (predicted) /// similar to transcription elongation factor A

(SΙI)-like 3

BE098532 LOC303057 similar to step II splicing factor SLU7; DNA segment, Chr

1 1 , ERATO Doi 730, expressed; DNA segment, Chr 3,

Brigham & Womens Genetics 0878 expressed

BE100840 Gngl l guanine nucleotide binding protein (G protein), gamma 1 1

BE100915 Tmem42_predicted Transmembrane protein 42 (predicted)

BE100932 — Transcribed locus

BE102861 — Transcribed locus

BE104375 LOC499745 Similar to Notch-regulated ankyrin repeat protein

BE104457 — Transcribed locus

BE 106279 — Transcribed locus

BE107587 RGD1562949_predicted similar to mKIAA0259 protein (predicted)

BE 108208 — Transcribed locus

BE108716 — Transcribed locus

BE 109369 Plekhcl Pleckstrin homology domain containing, family C (with

FERM domain) member 1

BE 109675 Transcribed locus

BEl 1 1349 —

BEl 12451 RGD1561027_predicted

BEl 13460 — Transcribed locus

BEl 14634 Mocs3_predicted Molybdenum cofactor synthesis 3 (predicted)

BEl 15520 —

BEl 16867 — Transcribed locus

BEl 17891 M115 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)

BEl 18330 RGD1560397_predicted similar to RNA-binding protein Musashi2-S (predicted)

BEl 18382 Nek9_predicted NIMA (never in mitosis gene a)- related kinase 9 (predicted)

BEl 18557 —

BEl 18639 Tpr translocated promoter region BE 126475 Prrxl paired related homeobox 1

BE329244 —

BE349751 —

BE349808 Zdhhc9 zinc finger, DHHC domain containing 9

BF281984 LOC360570 similar to myosin XVIIIa

BF282876 RGD1308952 similar to mKIAA0665 protein

BF283384 — Transcribed locus

BF283420 — Transcribed locus, moderately similar to XP OO 1000045.1

PREDICTED: similar to WD repeat domain 66 [Mus musculus]

BF284035

BF284535 — Transcribed locus

BF284876 — Transcribed locus

BF288243 Klf2_predicted Kruppel-like factor 2 (lung) (predicted)

BF288683 Adhfel alcohol dehydrogenase, iron containing, 1

BF289725 Lφprc leucine-rich PPR-motif containing

BF290088 Nkx2-3_predicted NK2 transcription factor related, locus 3 (Drosophila) (predicted)

BF386502 Transcribed locus

BF386877 — Transcribed locus

BF387694 — Transcribed locus

BF387767 — Transcribed locus

BF388757 RGD 1309104_predicted similar to RIKEN cDNA 1700025G04 gene (predicted)

BF393261 LOC246295 glycine-, glutamate-, thienylcyclohexylpiperidine-binding protein

BF397936 RGD1307526 similar to modulator of estrogen induced transcription

BF398031 — Transcribed locus

BF398435 — Transcribed locus

BF401902 Rsn restin (Reed-Steinberg cell-expressed intermediate filament- associated protein)

BF404113 — Transcribed locus

BF405468 LOC311548 similar to RIKEN cDNA 4930509020

BF408444 RGD 1564043_predicted Similar to RIKEN cDNA E430021N18 (predicted)

BF40861 1 SIn sarcolipin

BF409078 — Transcribed locus

BF409456 LOC688018 similar to SH3-domain binding protein 3

BF409997 — Transcribed locus

BF410146 Hspa2 heat shock 7OkDa protein 2

BF410555 —

BF412297 LOC686226 similar to TSC22 domain family protein 4 (TSC22-related- inducible leucine zipper protein 2)

BF415479 RGD1306148_predicted similar to KIAA0368 (predicted)

BF416871 AbcblO ATP-binding cassette, sub-family B (MDR/TAP), member

10

BF417216 LOC686132 similar to hemicentin 1

BF419602 RGD1307729_predicted similar to KIAA0853 protein (predicted)

BF522436 RGD 1306067 similar to chromosome 20 open reading frame 6

BF524010 —

BF542281 LOC681012 similar to Estlp-like protein B

BF546659 Syncrip Synaptotagmin binding, cytoplasmic RNA interacting protein

BF55321 1 Eprs glutamyl-prolyl-tRNA synthetase

BF559640 — Transcribed locus

BF559746 Dyrk2_predicted dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (predicted)

BF561222 Transcribed locus

BF564825 LOC500591 similar to calmodulin-binding transcription activator 1

BF565278 Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 BF566724 RGD1305235 similar to RIKEN cDNA 1700052N19

BF568007 LOC501069 similar to golgi autoantigen golgin subtype a4; tGolgin-1

BG371544 — Transcribed locus

BG373455 — Transcribed locus

BG375165 ...

BG375279 RGD1565787_predicted similar to RIKEN cDNA 1810065E05 (predicted)

BG375352 Ca5b carbonic anhydrase VB, mitochondrial

BG375480 Iqub IQ motif and ubiquitin domain containing

BG375603 Asph_predicted aspartate-beta-hydroxylase (predicted)

BG377396 Slc22al2 solute carrier family 22 (organic anion/cation transporter), member 12

BG378837 Transcribed locus

BG380430 RGD 1564105 predicted similar to RIKEN cDNA B130052G07 (predicted)

BI273836 — Transcribed locus

B 1274605 Ucp3 uncoupling protein 3 (mitochondrial, proton carrier)

B 1275261 —

BI275292 Angpt2 angiopoietin 2

BI275763 Phyhdl phytanoyl-CoA dioxygenase domain containing 1

BI277460 Pckl phosphoenolpyruvate carboxykinase 1

BI278180 — Transcribed locus

B 1278550 Npas2_predicted neuronal PAS domain protein 2 (predicted)

BI278813 Ckap4_predicted cytoskeleton-associated protein 4 (predicted)

BI279347 — Transcribed locus

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

BI282920 Ccl21b chemokine (C-C motif) ligand 21b (serine)

BI288579 —

BI288589 RGD1561597_predicted similar to mKI AA0518 protein (predicted)

BI288619 Jun Jun oncogene

BI289559 Sox6 SRY-box containing gene 6

BI291842 — Transcribed locus

BI294465 — Transcribed locus

BI295878 Kat3 kynurenine aminotransferase III

BI297744 RGD 1310507 similar to RIKEN cDNA 1300017J02

BI300470 — Transcribed locus

BI300794 — Transcribed locus

BI302283 LOC690745 MOCO sulphurase C-terminal domain containing-like

BI303199 — Transcribed locus

BM382843 RGD1559885_predicted similar to hypothetical gene supported by BC063892

(predicted)

BM383683 RGD1310710_predicted similar to RIKEN cDNA 2700091N06 (predicted)

BM383757 MGC105830 /// similar to Ras-related protein Rab-1B /// RABlB, member rCG 48149 RAS oncogene family

BM385476 Bst2 bone marrow stromal cell antigen 2

BM388738 —

BM389513 LOC688090 /// RTl-Bb RTl class II, locus Bb /// similar to RTl class II histocompatibility antigen, B-I beta chain precursor (RT 1.B- beta(l))

BM391248 MGC 108778 similar to RIKEN cDNA 1810057C19

BM391779 — Transcribed locus

H31 1 12 Sucla2_predicted Succinate-Coenzyme A ligase, ADP-forming, beta subunit

(predicted)

H31802

J00710 Csnlsl casein alpha si

J02585 Scdl stearoyl-Coenzyme A desaturase 1

L35572 Lhx5 LIM homeobox protein 5

L81174 Ankrdl ankyrin repeat domain 1 (cardiac muscle)

M24024 RT1-Aw2 RTl class Ib, locus Aw2

M91450 Cdx 1 caudal type homeo box 1 NM_012531 Comt catechol-O-methyltransferase

NM O 12594 Lalba lactalbumin, alpha

NM_012646 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl class

RT1-N3 Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene,

H2-TL-like, grc region(N2)

NMJ 12703 Thrsp thyroid hormone responsive protein

NM O 12870 Tnfrsfl lb tumor necrosis factor receptor superfamily, member 1 Ib

(osteoprotegerin)

NM_013220 Ankrdl ankyrin repeat domain 1 (cardiac muscle)

NM_017332 Fasn fatty acid synthase

NM_019161 RGDl 56640 l_predicted similar to GTL2, imprinted maternally expressed untranslated (predicted)

NM_019205 Ccll l chemokine (C-C motif) ligand 1 1

NM_022392 Insigl insulin induced gene 1

NM_022400 Bcat2 branched chain aminotransferase 2, mitochondrial

NM_022643 Histlh2ba histone cluster 1 , H2ba

NM_023025 Cyp2j3 /// Cyp2j4 cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome P450, family 2, subfamily j, polypeptide 3

NM_024131 Ddt D-dopachrome tautomerase

NM_024486 Acvrl activin A receptor, type 1

NM 030994 Itgal integrin alpha 1

NM_031327 Cyr61 cysteine rich protein 61

NM_031598 Pla2g2a phospholipase A2, group HA (platelets, synovial fluid)

NM_031971 Hspala /// Hspalb heat shock 7OkD protein 1 A /// heat shock 7OkD protein IB

(mapped)

NM_053299 Ubd ubiquitin D

NM_053355 Ikbkb inhibitor of kappaB kinase beta

NM_053381 Atplb4 ATPase, (Na+)/K+ transporting, beta 4 polypeptide

NM_053551 Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4

NM_053665 Akapl A kinase (PRKA) anchor protein 1

NM_053750 Nppc natriuretic peptide precursor type C

NM_053885 Rere arginine-glutamic acid dipeptide (RE) repeats

NM_057187 Grifin galectin-related inter-fiber protein

NM_057208 Tpm3 tropomyosin 3, gamma

NM_133298 Gpnmb glycoprotein (transmembrane) nmb

NM_134326 Alb albumin

NM_134387 Dcxr dicarbonyl L-xylulose reductase

U56241 Mafb v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)

U86635 Gstm5 glutathione S-transferase, mu 5

U92069 Ucp3 uncoupling protein 3 (mitochondrial, proton carrier)

X67108 Bdnf brain derived neurotrophic factor

D. Adipose + Liver*

Public ID Gene Symbol Gene Title

AA799328 RGDl 560913_predicted similar to expressed sequence AW413625 (predicted)

AA818262 Angptl4 angiopoietin-like 4

AA859029 — Transcribed locus

AA893192 — Transcribed locus

AA924350 LOC686634 /// hypothetical protein LOC686634 /// hypothetical protein

LOC690768 LOC690768

AA945955 Ogn_predicted osteoglycin (predicted)

AA955771 —

AA957585 Ehd3 EH-domain containing 3

AA998903 — CDNA clone IMAGE:7374368

ABO 13454 Slc34al solute carrier family 34 (sodium phosphate), member 1

AF41 1318 MtIa metallothionein Ia

AI0451 16 — Transcribed locus

AI059204 Cpneδ predicted copine VIII (predicted) AI060043 ... Transcribed locus

AI072892 Frzb frizzled-related protein

AI073272 Tor Ib torsin family 1, member B

AI 102061 Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3)

AI 104238 Gzma granzyme A

AI 137045 — Transcribed locus

AI 137640 Cldnl claudin 1

AI176172 — Transcribed locus

AI178784 RGD1310174_predicted hypothetical LOC298504 (predicted)

AI 179334 Fasn fatty acid synthase

AI179886 RGD1310352 similar to HTGN29 protein; keratinocytes associated transmembrane protein 2

AI232414 Pxmp4 peroxisomal membrane protein 4

AI232716 LOC368066 similar to indolethylamine N-methyltransferase

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)

AI406386 Lmo4 LIM domain only 4

AI406660 —

AI407487 — Transcribed locus

AI408948 Ca2 carbonic anhydrase 2

AI41 1227 RGD1563485_predicted similar to mKIAA0534 protein (predicted)

AI41 1693 LOC299458 /// similar to immunoglobulin heavy chain 6 (Igh-6) /// similar

LOC366747 /// to Ig H-chain V-region precursor /// similar to Ig heavy chain

LOC678701 /// V region MClOl precursor /// hypothetical protein

RGD 1359202 LOC678701

AI412189 Igha mapped /// immunoglobulin heavy chain (alpha polypeptide) (mapped)

LOC366772 /// similar to immunoglobulin heavy chain

AI5481 17 —

AI555855 — Transcribed locus

AI556333 RGD1564257_predicted similar to hypothetical protein FLJ32825 (predicted)

AI577508 LOC684425 similar to Adenylosuccinate synthetase isozyme 1

(Adenylosuccinate synthetase, muscle isozyme) (IMP— aspartate ligase 1) (AdSS 1) (AMPSase 1)

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI639108 —

AI639241 LOC684318 /// ubiquitin specific protease 12 (predicted) /// similar to

RGD1561481_predicted ubiquitin specific protease 12 (predicted) /// similar to

/// Uspl2_predicted ubiquitin specific protease 12

AI715202 RTl-Bb RTl class II, locus Bb

AJ243338 RT1-CE5 RTl class I, CE5

AW144193 — Transcribed locus

AW251647 — Transcribed locus

AW252232 — Transcribed locus

AW522341 — Transcribed locus

AW525662 Cdc27 cell division cycle 27 homolog (S. cerevisiae)

AW526014 — Transcribed locus

AW527403 Sh3yll_predicted Sh3 domain YSC-like 1 (predicted)

AW533234 LOC688915 similar to cardiomyopathy associated 5

AW533569 Clca2_predicted chloride channel, calcium activated, family member 2

(predicted)

AW916957 — Transcribed locus, strongly similar to XP 579758.1

PREDICTED: hypothetical protein XP 579758 [Rattus norvegicus]

AW920026 LOC364393 /// PHD finger protein 11 /// similar to RIKEN cDNA

LOC684778 /// Phfl 1 4933417L10 /// hypothetical protein LOC684778

BE102861 — Transcribed locus

BE 104961 Cenpj_predicted centromere protein J (predicted)

BE106199 Rora predicted RAR-related orphan receptor alpha (predicted) BE1 11310 Ky_predicted kyphoscoliosis (predicted)

BE1 13419 Srpk2_predicted serine/arginine-rich protein specific kinase 2 (predicted)

BE1 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BE329244 — -

BF282228 Ltb lymphotoxin B

BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

BF283779 RGD1565496_predicted similar to Butyrate-induced transcript 1 (predicted)

BF288361 —

BF390510 RGD131 1 155 similar to RIKEN cDNA 92301 17N10

BF392577 Akapδl A kinase (PRKA) anchor protein 8-like

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF398091 CDNA clone IMAGE:7374368

BF398168 — Transcribed locus

BF408445 Gpx7_predicted glutathione peroxidase 7 (predicted)

BF545930 — Transcribed locus

BF565675 Arsa arylsulfatase A

BG372602 RGDl 30660 l_predicted similar to cDNA sequence BC019755 (predicted)

BG375362 Ltbp4 latent transforming growth factor beta binding protein 4

BG379394 — Transcribed locus

BG662519 Ank Progressive ankylosis homolog (mouse)

BG664011 Pxmp4 peroxisomal membrane protein 4

BG664221 Ogn_predicted osteoglycin (predicted)

BI273908 — Transcribed locus

BI278180 — Transcribed locus

BI279384 — Transcribed locus

BI282114 — Endogenous retrovirus mRNA, partial sequence

BI285494 Ifitm3 interferon induced transmembrane protein 3

BI285941 — Transcribed locus

BI292056 — Transcribed locus

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

BI395849 —

BM383531 LOC682651 /// similar to Metallothionein-2 (MT-2) (Metallothionein-II)

LOC689415 (MT-II)

BM387813 — Transcribed locus

BM388719 Rpl7 Ribosomal protein L7

BM390378 RGD 1562732 predicted similar to Glutathione S-transferase, theta 3 (predicted)

BM390571 Sult2bl predicted sulfotransferase family, cytosolic, 2B, member 1 (predicted)

BM391471 Atf5 activating transcription factor 5

BM391823 RGD1563309_predicted similar to diacylglycerol kinase, delta 13OkDa isoform 1

(predicted)

J02585 Scdl stearoyl-Coenzyme A desaturase 1

L19933 Ptprd protein tyrosine phosphatase, receptor type, D

M24024 RT1-Aw2 RTl class Ib, locus Aw2

M25804 Nrldl nuclear receptor subfamily 1, group D, member 1

M30596 Mel malic enzyme 1

M57668 PrIr prolactin receptor

NM_012524 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha

NM_012531 Comt catechol-O-methyltransferase

NM_012600 Mel malic enzyme 1

NM_012646 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl class

RT1-N3 Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene,

H2-TL-like, grc region(N2)

NM_012744 Pc Pyruvate carboxylase

NM_016987 AcIy ATP citrate lyase

NM 017206 Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 NM_017332 Fasn fatty acid synthase

NM_019291 Ca2 carbonic anhydrase 2

NM_020072 Acpp acid phosphatase, prostate

NM_021744 CdH CD 14 antigen

NM_022686 LOC680097 /// similar to germinal histone H4 gene

LOC684887

NM_023025 Cyp2j3 /// Cyp2j4 cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome P450, family 2, subfamily j, polypeptide 3

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM 030994 Itgal integrin alpha 1

NM_031559 Cptla carnitine palmitoyltransferase Ia, liver

NM_031841 Scd2 stearoyl-Coenzyme A desaturase 2

NM_031971 Hspala /// Hspalb heat shock 7OkD protein 1 A /// heat shock 7OkD protein IB

(mapped)

NM_053328 Bhlhb2 basic helix-loop-helix domain containing, class B2

NM_053584 —

NM_053587 S100a9 SlOO calcium binding protein A9 (calgranulin B)

NM_053639 Ltc4s leukotriene C4 synthase

NM_053714 Ank progressive ankylosis homolog (mouse)

NM_053999 Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B

(PR 52), alpha isoform

NM_057208 Tpm3 tropomyosin 3, gamma

NM_130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3- oxoacyl-Coenzyme A thiolase)

I. Adipose + Quadricep*

Public ID Gene Symbol Gene Title

AA799328 RGDl 560913_predicted similar to expressed sequence AW413625 (predicted)

AA800750 —

AA819034 isgl2(b) putative ISG12(b) protein

AA850780 RGD1564560_predicted similar to RCK (predicted)

AA875438 RGDl 309414_predicted similar to KIAA0913 protein (predicted)

AA901290 — Transcribed locus

AI008409 — CDNA clone IMAGE:7321089

AI030203 Irx3_predicted Iroquois related homeobox 3 (Drosophila) (predicted)

AI044784 — Transcribed locus

AI045904 —

AI071674 — Transcribed locus

AI102732 MGC 109340 similar to Microsomal signal peptidase 23 kDa subunit

(SPase 22 kDa subunit) (SPC22/23)

AI1721 10

AI177934 LOC474169 pre-eosinophil-associated ribonuclease-2

AI 179334 Fasn fatty acid synthase

AI 179886 RGD 1310352 similar to HTGN29 protein; keratinocytes associated transmembrane protein 2

AI 179988 End ectodermal-neural cortex 1

AI232414 Pxmp4 peroxisomal membrane protein 4

AI235468 Dst_predicted dystonin (predicted)

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)

AI406386 Lmo4 LIM domain only 4

AI548667 — Transcribed locus

AI555855 — Transcribed locus

AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI715202 RTl-Bb RTl class II, locus Bb

AW251280 —

AW522341 — Transcribed locus

AW527159 — Transcribed locus

AW534218 RGD1310722_predicted similar to RIKEN cDNA D130059P03 gene (predicted)

BE097574 Kcnab 1 potassium voltage-gated channel, shaker-related subfamily, beta member 1

BE098532 LOC303057 similar to step II splicing factor SLU7; DNA segment, Chr

1 1, ERATO Doi 730, expressed; DNA segment, Chr 3,

Brigham & Womens Genetics 0878 expressed

BE 102861 Transcribed locus

BE108716 — Transcribed locus

BEl 17891 M115 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)

BE 126475 Prrxl paired related homeobox 1

BE329244 —

BF288243 Klf2_predicted Kruppel-like factor 2 (lung) (predicted)

BF397936 RGD 1307526 similar to modulator of estrogen induced transcription

BF398435 — Transcribed locus

BF417216 LOC686132 similar to hemicentin 1

BF522436 RGD 1306067 similar to chromosome 20 open reading frame 6

BF524010 —

BG371544 — Transcribed locus

BG375352 Ca5b carbonic anhydrase VB, mitochondrial

BI275261 —

BI278180 — Transcribed locus

BI2821 14 — Endogenous retrovirus mRNA, partial sequence

B 1282920 Ccl21b chemokine (C-C motif) ligand 21b (serine)

BI288619 Jun Jun oncogene

BI297744 RGDl 310507 similar to RIKEN cDNA 1300017J02

BI300470 ... Transcribed locus

BI300794 — Transcribed locus

BM385476 Bst2 bone marrow stromal cell antigen 2

BM388738 —

BM389513 LOC688090 /// RTl-Bb RTl class II, locus Bb /// similar to RTl class II histocompatibility antigen, B-I beta chain precursor (RTl . B- beta(l))

J00710 Csnlsl casein alpha s 1

J02585 Scdl stearoyl-Coenzyme A desaturase 1

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NM_012531 Comt catechol-O-methyltransferase

NM_012594 Lalba lactalbumin, alpha

NMJ) 12646 RTl-N l /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl class

RT1-N3 Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene,

H2-TL-like, grc region(N2)

NM_012703 Thrsp thyroid hormone responsive protein

NM_017332 Fasn fatty acid synthase

NMJH9161 RGD 156640 l_predicted similar to GTL2, imprinted maternally expressed untranslated (predicted)

NM_019205 Ccll l chemokine (C-C motif) ligand 11

NM_022392 Insigl insulin induced gene 1

NM_023025 Cyp2j3 /// Cyp2j4 cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome P450, family 2, subfamily j, polypeptide 3

NM_024131 Ddt D-dopachrome tautomerase

NM_030994 Itgal integrin alpha 1

NM_031327 Cyrόl cysteine rich protein 61

NM_031598 Pla2g2a phospholipase A2, group HA (platelets, synovial fluid)

NM_031971 Hspala /// Hspalb heat shock 7OkD protein IA /// heat shock 7OkD protein IB

(mapped)

NM_053355 Ikbkb inhibitor of kappaB kinase beta

NM_053885 Rere arginine-glutamic acid dipeptide (RE) repeats

NM_057187 Grifin galectin-related inter-fiber protein

NM_057208 Tpm3 tropomyosin 3, gamma

NM 134326 Alb albumin U86635 Gstm5 glutathione S-transferase, mu 5

F. Liver + Quadricep*

Public ID Gene Symbol Gene Title

AA799328 RGD 1560913_predicted similar to expressed sequence AW413625 (predicted)

AA849966 —

AF065161 Cish cytokine inducible SH2-containing protein

AI 169331 Gstm2 glutathione S-transferase, mu 2

AI177358 Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

AI 179334 Fasn fatty acid synthase

AI 179886 RGD1310352 similar to HTGN29 protein; keratinocytes associated transmembrane protein 2

AI 180253 RGD1563825_predicted similar to ENSANGP00000020885 (predicted)

AI231999 LOC689256 similar to Tumor protein D53 (mD53) (Tumor protein D52- like 1)

AI232414 Pxmp4 peroxisomal membrane protein 4

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)

AI406386 Lmo4 LIM domain only 4

AI555855 — Transcribed locus

AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI715202 RTl-Bb RTl class II, locus Bb

AJ249701 RT1-A2 /// RT1-A3 /// RTl class Ib, locus Aw2 /// RTl class Ia, locus A2 /// RTl

RT1-Aw2 class I, A3

AW522341 — Transcribed locus

AW525342 Uspl ubiquitin specific peptdiase 1

AW530361 Ppplr3c protein phosphatase 1, regulatory (inhibitor) subunit 3C

BE 102861 — Transcribed locus

BE329244 —

BE349751 —

BI278180 — Transcribed locus

BI2821 14 ... Endogenous retrovirus mRNA, partial sequence

BI291842 ... Transcribed locus

BM383683 RGD1310710_predicted similar to RIKEN cDNA 2700091N06 (predicted)

J02585 Scdl stearoyl-Coenzyme A desaturase 1

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NM_012531 Comt catechol-O-methyltransferase

NM O 12646 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl class

RT1-N3 Ib gene, H2-TL-like, grc region (N3) /// RTl class Ib gene,

H2-TL-like, grc region(N2)

NMJ) 17332 Fasn fatty acid synthase

NM_023025 Cyp2j3 /// Cyp2j4 cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome P450, family 2, subfamily j, polypeptide 3

NM 030994 Itgal integrin alpha 1

NM 031971 Hspala /// Hspalb heat shock 7OkD protein IA /// heat shock 7OkD protein IB

(mapped)

NM_053299 Ubd ubiquitin D

NM 057208 Tpm3 tropomyosin 3, gamma

G. Adipose + Liver + Quadricep*

Public ID Gene Symbol Gene Title

AA799328 RGDl 560913_predicted similar to expressed sequence AW413625 (predicted)

AI 179334 Fasn fatty acid synthase

AI179886 RGD1310352 similar to HTGN29 protein; keratinocytes associated transmembrane protein 2

AI232414 Pxmp4 peroxisomal membrane protein 4

AI237143 Rexo4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)

AI406386 Lmo4 LIM domain only 4

AI555855 Transcribed locus AI599463 Dguok_predicted deoxyguanosine kinase (predicted)

AI715202 RTl-Bb RTl class II, locus Bb

AW522341 Transcribed locus

BE102861 Transcribed locus

BE329244

BI278180 Transcribed locus

BI2821 14 Endogenous retrovirus mRNA, partial sequence

J02585 Scdl stearoyl-Coenzyme A desaturase 1

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NM_012531 Comt catechol-O-methyltransferase

NM 012646 RTl-Nl /// RT 1-N2 /// RTl class Ib gene, H2-TL-like, grc region (Nl) /// RTl class Ib

RT1-N3 gene, H2-TL-like, grc region (N3) /// RTl class Ib gene, H2-

TL-like, grc region(N2)

NM_017332 Fasn fatty acid synthase NM_023025 Cyp2j3 /// Cyp2j4 cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome P450, family 2, subfamily j, polypeptide 3

NM_030994 Itgal integrin alpha 1 NM 031971 Hspala /// Hspalb heat shock 7OkD protein 1 A /// heat shock 7OkD protein IB

(mapped)

NM 057208 Tpm3 tropomyosin 3, gamma

* "Adipose + Liver", for example refers to genes that are differentially expressed in both adipose and liver tissue in response to high protein treatments as compared with the control. "Adipose + Quadricep," "Liver + Quadricep," and "Adipose + Liver + Quadricep" are defined analogously.

[00107] Biological pathway analysis was conducted using commercially available mapping programs and public databases. The major pathways represented by the differentially expressed genes in adipose, liver, and muscle are set forth below in Tables 1 1, 12 and 13. As stated above, these genes were found to be differentially expressed as a result of the high protein diet treatment.

Table 1 1 : Biochemical Pathways Associated with Genes Differentially Expressed in Adipose Tissue as a Result of

High Protein Diet

Immune Response

Public ID Gene Symbol Gene Title membrane-spanning 4-domains, subfamily A, member 1

AA817742 Ms4al_predicted (predicted)

AA858815 — Transcribed locus

AA996885 Ccll9_predicted chemokine (C-C motif) ligand 19 (predicted)

AF057025 Tlr4 toll-like receptor 4

AI009823 Sectmlb secreted and transmembrane 1 B

AIOl 1757 Fcgr3a Fc fragment of IgG, low affinity IHa, receptor

AIO 12250 — Transcribed locus

AI029460 — Transcribed locus

AI044222 Cxcl9 chemokine (C-X-C motif) ligand 9

AI 104238 Gzma granzyme A

AI 169104 Cxcl4 chemokine (C-X-C motif) ligand 4 tumor necrosis factor receptor superfamily, member 14

AI 169601 Tnfrsfl4 (herpesvirus entry mediator)

AI 170387 Cxcl9 chemokine (C-X-C motif) ligand 9

LOC497796 ///

LOC502907 ///

LOC690045 ///

LOC690097 /// Ly49i5 Ly49 inhibitory receptor 9 /// immunoreceptor Ly49sil ///

/// Ly49i9 /// Ly49sil /// immunoreceptor Ly49si2 /// immunoreceptor Ly49si3 /// Ly49

Ly49si2 /// Ly49si3 /// inhibitory receptor 5 /// hypothetical protein LOC497796 ///

RGD 1561306_predicted similar to immunoreceptor Ly49si3 (predicted) /// similar to

/// immunoreceptor Ly49sil /// similar to immunoreceptor

AI 177403 RGD 15631 10 predicted Ly49si3 interleukin 2 receptor, gamma (severe combined

AI178808 H2rg immunodefic iency)

LOC681858 ///

AI236229 LOC690139 similar to RNA binding motif protein 24

AI549199 Ptger4 Prostaglandin E receptor 4 (subtype EP4)

AI599423 Gadd45g growth arrest and DNA-damage- inducible 45 gamma

AI715202 RTl-Bb RTl class II, locus Bb

AJ243338 RT1-CE5 RTl class I, CE5

AJ243973 RTl -S3 RTl class Ib, locus S3

AJ243974 RTl -S3 RTl class Ib, locus S3

AW433947 Tnfrsf5 tumor necrosis factor receptor superfamily, member 5

AW526982 Tlr2 toll-like receptor 2

AW532179 LOC500449 similar to SHP2-interacting transmembrane adaptor protein

BE095824 Ccl6 chemokine (C-C motif) ligand 6

BE096652 Ly6g6c lymphocyte antigen 6 complex, locus G6C

BE109730 — Transcribed locus

BEl 17044 Cd8a CD8 antigen, alpha chain

BF281987 Cxcll l chemokine (C-X-C motif) ligand 11

BF282228 Ltb lymphotoxin B

BF282471 Lcp2 lymphocyte cytosolic protein 2

BF288109 — Transcribed locus

BF418957 Clqa complement component 1 , q subcomponent, alpha polypeptide

BF419319 Oasll 2'-5' oligoadenylate synthetase-like 1

BF419899 Ccl7 chemokine (C-C motif) ligand 7

BG057565 Bat Ia HLA -B-associated transcript IA mitogen activated protein kinase kinase kinase kinase 2

BG378166 Map4k2_predicted (predicted)

BI279526 RTl-DbI RTl class II, locus DbI

BI282920 Ccl21b chemokine (C-C motif) ligand 21b (serine)

BI285494 Ifitm3 interferon induced transmembrane protein 3

BI290909 Scapl src family associated phosphoprotein 1

BI291927 RT1-A2 /// RT1-A3 RTl class Ia, locus A2 /// RTl class I, A3

BI294084 Ccl24 chemokine (C-C motif) ligand 24

BM383464 — Transcribed locus

BM386789 Rgsl regulator of G-protein signaling 1

BM387813 — Transcribed locus

RTl class II, locus Bb /// similar to RTl class II histocompatibility antigen, B-I beta chain precursor (RT 1.B-

BM389513 LOC688090 /// RTl-Bb beta(l))

BM391631 Fcgrl Fc receptor, IgG, high affinity I

D87927 Gm 1960 gene model 1960, (NCBI)

M17153 Fcerla Fc receptor, IgE, high affinity I, alpha polypeptide

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NM O 12493 Aφ alpha-fetoprotein

NMJ)12516 C4bpa complement component 4 binding protein, alpha

NM_012555 Etsl v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

NMJH2755 Fyn fyn proto-oncogene

NM_012925 Cd59 CD59 antigen

NM_017028 Mx2 myxovirus (influenza virus) resistance 2

NM_017320 Ctss cathepsin S

NM_019205 Cell 1 chemokine (C-C motif) ligand 1 1

NM_021744 Cdl4 CD 14 antigen

NM_021866 Ccr2 chemokine (C-C motif) receptor 2

NM_030853 Lat linker for activation of T cells

NM 031 116 Ccl5 chemokine (C-C motif) ligand 5

NM_031530 Ccl2 chemokine (C-C motif) ligand 2

NM 031538 Cd8a CD8 antigen, alpha chain NM_053843 Fcgr3 Fc receptor, IgG, low affinity III

NM_057151 CcI 17 chemokine (C-C motif) ligand 17

NM_130399 Ada adenosine deaminase

NM_130421 Lcp2 lymphocyte cytosolic protein 2

NM_133533 Cd79b CD79B antigen

NM_133542 Igsfδ immunoglobulin superfamily, member 6

NM_134361 XcIl chemokine (C motif) ligand 1

U22520 CxcllO chemokine (C-X-C motif) ligand 10

U50449 RT1-CE16 RTl class I, CE 16

Z18877 Oasl 2',5'-oligoadenylate synthetase 1, 40/46kDa

Inflammatory response

Public ID Gene Symbol Gene Title

AF057025 Tlr4 toll-like receptor 4

AI044869 Pla2g2d phospholipase A2, group HD

AI103918 Hdac7a histone deacetylase 7A

AI236229 LOC681858 /// similar to RNA binding motif protein 24

LOC690139

AI236455 Anxal annexin Al

AI45491 1 Scyel small inducible cytokine subfamily E, member 1

AW433947 Tnfrsf5 Tumor necrosis factor receptor superfamily, member 5

AW526982 Tlr2 toll-like receptor 2

BEl 17044 Cd8a CD8 antigen, alpha chain

BF282228 Ltb lymphotoxin B

BF419899 Ccl7 chemokine (C-C motif) ligand 7

BI282920 Ccl21b chemokine (C-C motif) ligand 21b (serine)

BI294084 Ccl24 chemokine (C-C motif) ligand 24

BM383464 — Transcribed locus

BM389005 Gpr68_predict G protein-coupled receptor 68 (predicted) ed

BM391303 —

D87927 Gm 1960 gene model 1960, (NCBI)

L25527 SeIe selectin, endothelial cell

NM_012488 A2m Alpha-2-macroglobulin

NMJ) 12559 Fgg fibrinogen, gamma polypeptide

NMJ) 17260 Alox5ap arachidonate 5-lipoxygenase activating protein

NMJ) 19205 Ccll l chemokine (C-C motif) ligand 1 1

NM_020542 Ccrl chemokine (C-C motif) receptor 1

NM_021744 Cdl4 CD 14 antigen

NM 021866 Ccr2 chemokine (C-C motif) receptor 2

NM_024131 Ddt D-dopachrome tautomerase

NM 031051 Mif macrophage migration inhibitory factor

NM_031116 Ccl5 chemokine (C-C motif) ligand 5

NMJ)31530 Ccl2 chemokine (C-C motif) ligand 2

NMJ)31538 Cd8a CD8 antigen, alpha chain

NM_033230 Aktl thymoma viral proto-oncogene 1

NM_053587 S100a9 SlOO calcium binding protein A9 (calgranulin B)

NM_053822 SlOOaδ SlOO calcium binding protein A8 (calgranulin A)

NM_053843 Fcgr3 Fc receptor, IgG, low affinity III

U22520 CxcllO chemokine (C-X-C motif) ligand 10

Response to Stress

Public ID Gene Symbol Gene Title

AA819776 Hspca /// heat shock protein 1 , alpha /// similar to heat shock protein 1 , alpha

LOC498264 ///

LOC500299 ///

LOC691091

AI170535 Tp53il l_predi Tumor protein p53 inducible protein 1 1 (predicted) cted AI236229 LOC681858 /// similar to RNA binding motif protein 24

LOC690139

AI408948 Ca2 carbonic anhydrase 2

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

BF288101 Snn stannin

BF417479 Dhcr24 24-dehydrocholesterol reductase

BG378166 Map4k2_predi mitogen activated protein kinase kinase kinase kinase 2 (predicted) cted

J02612 Ugtlal /// UDP glycosyltransferase 1 family, polypeptide Al /// UDP

UgtlalO /// glycosyltransferase 1 family, polypeptide A6 /// UDP

Ugtla2 /// glycosyltransferase 1 family, polypeptide A7 /// UDP

Ugtla3 /// glycosyltransferase 1 family, polypeptide A8 /// UDP

Ugtla5 /// glycosyltransferase 1 family polypeptide A2 /// UDP

Ugtlaό /// glycosyltransferase 1 family polypeptide A3 /// UDP

Ugtla7 /// glycosyltransferase 1 family polypeptide AlO /// UDP

Ugtlaδ glycosyltransferase 1 family, polypeptide A5

NM_019291 Ca2 carbonic anhydrase 2

NM 031020 Mapkl4 mitogen activated protein kinase 14

NM_031031 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase)

NM_031971 Hspala /// heat shock 7OkD protein 1 A /// heat shock 7OkD protein IB (mapped)

Hspalb

NM_053843 Fcgr3 Fc receptor, IgG, low affinity III

NM_053887 Map3kl mitogen activated protein kinase kinase kinase 1

NM_ 134326 Alb albumin

Chemotaxis

Public ID Gene Symbol Gene Title

AA996885 CcI 19_predicte chemokine (C-C motif) ligand 19 (predicted) d

AF253064 CkIf chemokine-like factor

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2

AI045155 Ccr6 chemokine (C-C motif) receptor 6

AI169104 Cxcl4 chemokine (C-X-C motif) ligand 4

BE095824 Ccl6 chemokine (C-C motif) ligand 6

BF414285 — Transcribed locus

BF419899 Ccl7 chemokine (C-C motif) ligand 7

BI282920 Ccl21b chemokine (C-C motif) ligand 21b (serine)

BI294084 Ccl24 chemokine (C-C motif) ligand 24

D87927 Gm 1960 gene model I960, (NCBI)

NM_013085 Plau plasminogen activator, urokinase

NM_019205 Ccll l chemokine (C-C motif) ligand 1 1

NM 031020 Mapkl4 Mitogen activated protein kinase 14

NM 031 1 16 Ccl5 chemokine (C-C motif) ligand 5

NM_031327 Cyr61 Cysteine rich protein 61

NM 031530 Ccl2 chemokine (C-C motif) ligand 2

NM 053822 S100a8 SlOO calcium binding protein A8 (calgranulin A)

NM 053843 Fcgr3 Fc receptor, IgG, low affinity III

NM_057151 CcI 17 chemokine (C-C motif) ligand 17

NM l 34361 XcIl chemokine (C motif) ligand 1

U22520 CxcllO chemokine (C-X-C motif) ligand 10

U28830 Ralbpl ralA binding protein 1

Response to Unfolded Protein

Public ID Gene Symbol Gene Title

AA819776 Hspca /// heat shock protein 1, alpha /// similar to heat shock protein 1, alpha

LOC498264 ///

LOC500299 ///

LOC691091

AF077354 Hspa4 heat shock protein 4

AI073272 Torlb torsin family 1, member B AI6391 17 Cfb complement factor B

AI716125 C2 complement component 2

BF525282 Hsphl heat shock 105kDa/l 1OkDa protein 1

BF553613 Txndc4 thioredoxin domain containing 4 (endoplasmic reticulum)

BI285700 Hspcb heat shock 9OkDa protein 1, beta

BI289103 Slc44a4 solute carrier family 44, member 4

BM383464 — Transcribed locus

NM_022229 Hspdl heat shock protein 1 (chaperonin)

NM_031971 Hspala /// heat shock 7OkD protein 1 A /// heat shock 7OkD protein 1 B (mapped)

Hspalb

Defense Response

Public ID Gene Symbol Gene Title

AF068860 Defbl defensin beta 1

AI236229 LOC681858 /// similar to RNA binding motif protein 24

LOC690139

AI6391 17 Cfb complement factor B

AI716125 C2 complement component 2

BEl 18901 Gata3 GATA binding protein 3

BI289103 Slc44a4 solute carrier family 44, member 4

BM383464 — Transcribed locus

NM_012594 Lalba lactalbumin, alpha

NM_017028 Mx2 myxovirus (influenza virus) resistance 2

NM_023021 Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

NM_031971 Hspala /// heat shock 7OkD protein IA /// heat shock 7OkD protein IB (mapped)

Hspalb

NM_053843 Fcgr3 Fc receptor, IgG, low affinity III

NM 053960 Ccr5 chemokine (C-C motif) receptor 5

Cell activation

Public ID Gene Symbol Gene Title

AI044631 Cd3g CD3 antigen, gamma polypeptide

BF282228 Ltb lymphotoxin B

BM383464 — Transcribed locus

NM_053819 Timpl tissue inhibitor of metallopeptidase 1

NM_053843 Fcgr3 Fc receptor, IgG, low affinity III

U56824 Klra5 /// killer cell lectin-like receptor, subfamily A, member 5 /// Ly49 stimulatory

Ly49s7 receptor 7

Lymphocyte Activation

Public ID Gene Symbol Gene Title

AA945909 Cd3e_predicte CD3 antigen, epsilon polypeptide (predicted)

AI044631 Cd3g CD3 antigen, gamma polypeptide

AW915948 Cd3e_predicte CD3 antigen, epsilon polypeptide (predicted)

U56824 Klra5 /// killer cell lectin-like receptor, subfamily A, member 5 /// Ly49 stimulatory

Ly49s7 receptor 7

Locomotory Behavior

Public ID Gene Symbol Gene Title

AA926313 — Transcribed locus

BF389056 — Transcribed locus

BG662519 Ank Progressive ankylosis homolog (mouse)

BI395810 Npylr neuropeptide Y receptor Yl

NM_053714 Ank progressive ankylosis homolog (mouse)

NM 053843 Fcgr3 Fc receptor, IgG, low affinity IN

Lipid Metabolic I ³rocess

Public ID Gene Symbol Gene Title AA800240 Hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

AA848820 Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD)

AA892234 Mgst3_predicted microsomal glutathione S-transferase 3 (predicted)

AF022247 Cubn cubilin (intrinsic factor-cobalamin receptor)

AIO 13044 — Transcribed locus

AI136525 Degs2 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase

AI236455 Anxal annexin Al

AI548897 Soatl Sterol O-acyltransferase 1

AJ245707 Phyh2 phytanoyl-CoA 2-hydroxylase 2

AW530812 RGDl 31 1224 _pr similar to fatty acid desaturase 2; linoleoyl-CoA desaturase (delta-6- edicted desaturase)-like 2; delta-6 fatty acid desaturase (predicted)

BEl 13958 Nr2f2 Nuclear receptor subfamily 2, group F, member 2

BE116152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF417479 Dhcr24 24-dehydrocholesterol reductase

BG671686

BI278687 Pltp_predicted phospholipid transfer protein (predicted)

BM383809 Mlstd2 male sterility domain containing 2

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

BM390571 Sult2bl_predicte sulfotransferase family, cytosolic, 2B, member 1 (predicted)

U A

BM390774 Peci /// peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase /// similar to RIKEN

RGDl 310224 cDNA 1810022C23

J02585 Scdl stearoyl-Coenzyme A desaturase 1

NM_012703 Thrsp thyroid hormone responsive protein

NM_012777 Apod apolipoprotein D

NM_012824 Apocl apolipoprotein C-I

NMJH3134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NM_013187 Plcgl phospholipase C, gamma 1

NM_013200 Cptlb carnitine palmitoyltransferase Ib, muscle

NM_016986 Acadm acetyl-Coenzyme A dehydrogenase, medium chain

NM O 16987 AcIy ATP citrate lyase

NM O 17268 Hmgcsl 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

NM_022392 Insigl insulin induced gene 1

NM_024390 Hpgd hydroxyprostaglandin dehydrogenase 15 (N AD)

NM_031559 Cptla carnitine palmitoyltransferase 1 a, liver

NM 031841 Scd2 stearoyl-Coenzyme A desaturase 2

NM_053339 Acox3 acyl-Coenzyme A oxidase 3, pristanoyl

NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4

NM_053674 Phyh phytanoyl-CoA hydroxylase

NM_130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)

NMJ 34382 Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast)

U13253 Fabp5 fatty acid binding protein 5, epidermal

Lipid Biosynthetic Process

Public ID Gene Symbol Gene Title

AI 179334 Fasn fatty acid synthase

AW530769 Fdftl farnesyl diphosphate farnesyl transferase 1

BE105855 Cyb5r2 cytochrome b5 reductase 2

BE1 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF417479 Dhcr24 24-dehydrocholesterol reductase

BF419134 Acbd3 acyl-Coenzyme A binding domain containing 3

BG664123 Cyp51 cytochrome P450, subfamily 51

BM383809 Mlstd2 male sterility domain containing 2 BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

BM390574 Lss Lanosterol synthase

J02585 Scdl stearoyl-Coenzyme A desaturase 1

J03867 Cyb5r3 cytochrome b5 reductase 3

NM O 12744 Pc Pyruvate carboxylase

NM_012851 Hsdl7bl hydroxysteroid (17-beta) dehydrogenase 1

NM_012941 Cyp51 cytochrome P450, subfamily 51

NM_013134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NM_016987 AcIy ATP citrate lyase

NM_017268 Hmgcsl 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

NM_017332 Fasn fatty acid synthase

NM_019238 Fdftl famesyl diphosphate farnesyl transferase 1

NM_022193 Acaca acetyl-coenzyme A carboxylase alpha

NM_022389 Dhcr7 7-dehydrocholesterol reductase

NM_022705 Thedcl thioesterase domain containing 1

NM_031840 Fdps farnesyl diphosphate synthase

NM 031841 Scd2 stearoyl-Coenzyme A desaturase 2

NM_053539 Idil isopentenyl-diphosphate delta isomerase

NM_134382 Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast)

Steroid Biosynthetic Process

Public ID Gene Symbol Gene Title

AI407163 — Transcribed locus

AW530769 Fdftl farnesyl diphosphate farnesyl transferase 1

BE105855 Cyb5r2 cytochrome b5 reductase 2

BF417479 Dhcr24 24-dehydrocholesterol reductase

BF419134 Acbd3 acyl-Coenzyme A binding domain containing 3

BG664123 Cyp51 cytochrome P450, subfamily 51

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

BM390574 Lss Lanosterol synthase

J03867 Cyb5r3 cytochrome b5 reductase 3

L17138 Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta- isomerase 6

M57668 PrIr prolactin receptor

NM_012851 Hsdl7bl hydroxysteroid (17-beta) dehydrogenase 1

NM_012941 Cyp51 cytochrome P450, subfamily 51

NM_013134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NM_017268 Hmgcsl 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

NM_019238 Fdftl farnesyl diphosphate famesyl transferase 1

NM_022389 Dhcr7 7-dehydrocholesterol reductase

NM_031840 Fdps farnesyl diphosphate synthase

NM_053539 Idil isopentenyl-diphosphate delta isomerase

Cholesterol Metabolic Process

Public ID Gene Symbol Gene Title

AF022247 Cubn cubilin (intrinsic factor-cobalamin receptor)

AI412322 Acat2 acetyl-Coenzyme A acetyltransferase 2

AI502114 Abcal ATP-binding cassette, sub-family A (ABCl), member 1

AI548897 Soatl Sterol O-acyltransferase 1

AW918387 Abcal ATP-binding cassette, sub- family A (ABCl), member 1

BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

BF284523 Abcal ATP-binding cassette, sub- family A (ABCl), member 1

BF417479 Dhcr24 24-dehydrocholesterol reductase

NM_017225 Pctp phosphatidylcholine transfer protein

NM_022392 Insigl insulin induced gene 1

Steroid Metabolic Process

Public ID Gene Symbol Gene Title

AF022247 Cubn cubilin (intrinsic factor-cobalamin receptor) AI548897 Soatl Sterol O-acyltransferase 1

BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

BF417479 Dhcr24 24-dehydrocholesterol reductase

BM390571 Sult2bl_predic sulfotransferase family, cytosolic, 2B, member 1 (predicted) ted

NM_022392 Insigl insulin induced gene 1

Glycolysis

Public ID Gene Symbol Gene Title

AI41 1413 LOC685778 /// pyruvate dehydrogenase El alpha 1 /// pyruvate dehydrogenase El alpha 1

Pdhal pseudogene

AI41 1413 LOC685778 /// pyruvate dehydrogenase El alpha 1 /// pyruvate dehydrogenase El alpha 1

Pdhal pseudogene

BF561717 Pdhal pyruvate dehydrogenase El alpha 1

BI279760 Pgkl phosphoglycerate kinase 1

BI291434 Pfkm phosphofructokinase, muscle

BI295900 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

BM389223 Pdhb pyruvate dehydrogenase (lipoamide) beta

NMJ 12497 Aldoc aldolase C

NM_012554 Enol enolase 1, alpha

NM 012949 Eno3 enolase 3, beta

NM_017328 Pgam2 phosphoglycerate mutase 2

NM_031715 Pfkm phosphofructokinase, muscle

Glucose Metabolic Process

Public ID Gene Symbol Gene Title

AI41 1413 LOC685778 /// pyruvate dehydrogenase El alpha 1 /// pyruvate dehydrogenase El alpha 1

Pdhal pseudogene

BE108587 Nisch nischarin

BI295900 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

BI395810 Npylr neuropeptide Y receptor Yl

NM_017006 G6pdx glucose-6-phosphate dehydrogenase X-linked

NM_031020 Mapkl4 mitogen activated protein kinase 14

NM_031559 Cptla carnitine palmitoyltransferase Ia, liver

NM_033230 Aktl thymoma viral proto-oncogene 1

NM_053826 Pdkl pyruvate dehydrogenase kinase, isoenzyme 1

U13253 Fabp5 fatty acid binding protein 5, epidermal

Organ Development

Public ID Gene Symbol Gene Title

AA800004 Sept4 septin 4

AI713966 Igfbρ3 insulin-like growth factor binding protein 3

AW144216 Enpep glutamyl aminopeptidase

BF417479 Dhcr24 24-dehydrocholesterol reductase

BG662519 Ank Progressive ankylosis homolog (mouse)

BG663483 Pcdhal /// protocadherin alpha 4 /// protocadherin alpha 13 /// protocadherin alpha 10

PcdhalO /// /// protocadherin alpha 12 /// protocadherin alpha 3 /// protocadherin alpha

Pcdhal 1 /// 8 /// protocadherin alpha 1 /// protocadherin alpha 2 /// protocadherin alpha

Pcdhal 2 /// 5 /// protocadherin alpha 6 /// protocadherin alpha 7 /// protocadherin alpha

Pcdhal 3 /// 9 /// protocadherin alpha subfamily C, 1 /// protocadherin alpha subfamily

Pcdha2 /// C, 2 /// protocadherin alpha 11

Pcdha3 ///

Pcdha4 ///

Pcdha5 ///

Pcdhaό ///

Pcdha7 ///

Pcdhaδ ///

Pcdha9 ///

Pcdhacl /// Pcdhac2

NM_012755 Fyn fyn proto-oncogene NM_017240 Myh6 /// Myh7 myosin, heavy polypeptide 6, cardiac muscle, alpha /// myosin, heavy polypeptide 7, cardiac muscle, beta

NM 019161 RGDl 566401_ similar to GTL2, imprinted maternally expressed untranslated (predicted) predicted

NM_031031 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) NM_053714 Ank progressive ankylosis homolog (mouse) NM_133303 Bhlhb3 basic helix-loop-helix domain containing, class B3 U23056 Ceacaml /// CEA-related cell adhesion molecule 1 /// CEA-related cell adhesion

CeacamlO molecule 10

U23407 Crabp2 cellular retinoic acid binding protein 2 Muscle Development Public ID Gene Symbol Gene Title

AA963276 Etvl_predicted ets variant gene 1 (predicted) AA964492 Transcribed locus AI059914 Etvl_predicted ets variant gene 1 (predicted) AI713966 Igfbp3 insulin-like growth factor binding protein 3

BI277545 Myhl /// Myh2 myosin, heavy polypeptide 1, skeletal muscle, adult /// myosin, heavy polypeptide 2, skeletal muscle, adult

M15481 Igfl insulin-like growth factor 1 NM_012893 Actg2 actin, gamma 2 NMJ)13172 Myf6 myogenic factor 6 NM 017240 Myh6 /// Myh7 myosin, heavy polypeptide 6, cardiac muscle, alpha /// myosin, heavy polypeptide 7, cardiac muscle, beta

NM_019212 Actal aaccttiinn,, aallpphhaa 11 , skeletal muscle

U22520 CxcllO cchheemmookkiinnee (((C-X-C motif) ligand 10

U44948 Csrp2 ccyysstteeiinnee aanndd g : lycine-rich protein 2

X74293 Itga7 iinntteeggrriinn aallpplhua 7

X74294 Itga7 iinntteeggrriinn aallpphh∑a 7

Positive Regulation of Cell Proliferation

Public ID Gene Symbol Gene Title

AAFF006622559944 Naplll nnuucclleeoossoomme assembly protein 1-like 1

AI 144948 Transcribed locus

BE108905 Naplll Nucleosome assembly protein 1-like 1

BEl 17736 Tgfb2 Transforming growth factor, beta 2

BF553172 Transcribed locus

BG670310 Tgfa transforming growth factor alpha

BM392321 Hipk2_predicted homeodomain interacting protein kinase 2 (predicted)

L14782 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

M15481 Igfl insulin-like growth factor 1

NM_012559 Fgg fibrinogen, gamma polypeptide

NM O 12888 Tshr thyroid stimulating hormone receptor

NM_013060 Id2 inhibitor of DNA binding 2

NM_017066 Ptn pleiotrophin

NM_053819 Timpl tissue inhibitor of metallopeptidase 1

U22520 CxcllO chemokine (C-X-C motif) ligand 10

Angiogenesis Public ID Gene Symbol Gene Title AA818262 Angptl4 angiopoietin-like 4 AI 146037 Map3k7_predicted Mitogen activated protein kinase kinase kinase 7 (predicted) AW144216 Enpep glutamyl aminopeptidase BEl 17736 Tgfb2 Transforming growth factor, beta 2 BF553172 Transcribed locus BF564217 Angl angiogenin, ribonuclease A family, member 1 BG670310 Tgfa transforming growth factor alpha BI285064 -— Transcribed locus

NM_013085 Plau plasminogen activator, urokinase

NM_013194 Myh9 myosin, heavy polypeptide 9, non-muscle

NM 031020 Mapkl4 mitogen activated protein kinase 14

U23056 Ceacaml /// CEA-related cell adhesion molecule 1 /// CEA-related cell adhesion

CeacamlO molecule 10

X83537 Mmpl4 matrix metallopeptidase 14 (membrane-inserted)

Blood Vessel Morphogenesis

Public ID Gene Symbol Gene Title

AI45491 1 Scyel small inducible cytokine subfamily E, member 1

AW144216 Enpep glutamyl aminopeptidase

BEl 13958 Nr2f2 Nuclear receptor subfamily 2, group F, member 2

NM_013085 Plau plasminogen activator, urokinase

U23056 Ceacaml /// CEA-related cell adhesion molecule 1 /// CEA-related cell adhesion

CeacamlO molecule 10

X74293 Itga7 integrin alpha 7

X74294 Itga7 integrin alpha 7

Anti-apoptosis

Public ID Gene Symbol Gene Title

AA819804 Zφ91 zinc finger protein 91

AA946430 Syvnl synovial apoptosis inhibitor 1 , synoviolin

AI236455 Anxal annexin Al

AI407163 — Transcribed locus

AW143154 Mkll_predicte megakaryoblastic leukemia (translocation) 1 (predicted) d

BEl 1 1631 Zfp91 zinc finger protein 91

BEl 12093 Zfp91 zinc finger protein 91

BEl 12895 Pea 15 phosphoprotein enriched in astrocytes 15

BF399517 — Transcribed locus

BF417479 Dhcr24 24-dehydrocholesterol reductase

BG662875 Pea 15 phosphoprotein enriched in astrocytes 15

BG670310 Tgfa transforming growth factor alpha

BI282281 LOC500372 similar to Stress-70 protein, mitochondrial precursor (75 kDa glucose regulated protein) (GRP 75) (Peptide-binding protein 74) (PBP74)

(MTHSP70) (Mortalin)

BM391471 Atf5 activating transcription factor 5

M15481 Igfl insulin-like growth factor 1

M57668 PrIr prolactin receptor

NM_012555 Etsl v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

NM_012660 Eefla2 eukaryotic translation elongation factor 1 alpha 2

NMJ 12925 Cd59 CD59 antigen

NM_023987 Birc3 baculoviral IAP repeat-containing 3

NM_031530 Ccl2 chemokine (C-C motif) ligand 2

NM_031971 Hspala /// heat shock 7OkD protein 1 A /// heat shock 7OkD protein 1 B (mapped)

Hspalb

NM 033230 Aktl thymoma viral proto-oncogene 1

NM 133416 Bcl2al B-cell leukemia/lymphoma 2 related protein Al

S75280 Hspa9a_predic heat shock 7OkDa protein 9A (predicted) ted

Muscle Contraction

Public ID Gene Symbol Gene Title

AA875132 — Transcribed locus

AF220558 Trdn triadin

AF370889 Tpml Tropomyosin 1 , alpha

AF372216 Tpml tropomyosin 1, alpha

AJ243304 Trdn triadin

AW533848 Mybpc2_predi myosin binding protein C, fast-type (predicted) cted

BF284889 Actn2_predict actinin alpha 2 (predicted) ed

BF521859 Tnnt3 troponin T3, skeletal, fast

BF555973 — Transcribed locus

BG378588 Mybpc2_predi myosin binding protein C, fast-type (predicted) cted

BI277545 Myhl /// Myh2 myosin, heavy polypeptide 1, skeletal muscle, adult /// myosin, heavy polypeptide 2, skeletal muscle, adult

BI289527 Tmod4_predic tropomodulin 4 (predicted) ted

BM391169 Myh4 myosin, heavy polypeptide 4

BM392106 CaId 1 caldesmon 1

L81 169 Oxtr oxytocin receptor

NM O 12605 Mylpf myosin light chain, phosphorylatable, fast skeletal muscle

NM O 12606 Myl3 myosin, light polypeptide 3

NM_017240 Myh6 /// Myh7 myosin, heavy polypeptide 6, cardiac muscle, alpha /// myosin, heavy polypeptide 7, cardiac muscle, beta

NM_019131 Tpml tropomyosin 1 , alpha

NM_019212 Actal actin, alpha 1, skeletal muscle

NM_133424 Actn3 actinin alpha 3

Phosphate Transport

Public ID Gene Symbol Gene Title

AA958001 Cthrcl collagen triple helix repeat containing 1

AB013454 Slc34al solute carrier family 34 (sodium phosphate), member 1

AI030021 — Transcribed locus

AI 176393 Col4al procollagen, type IV, alpha 1

AI501709 Clqtnf7_predi CIq and tumor necrosis factor related protein 7 (predicted) cted

AJ245707 Phyh2 phytanoyl-CoA 2-hydroxylase 2

BF418957 Clqa complement component 1 , q subcomponent, alpha polypeptide

BG662519 Ank Progressive ankylosis homolog (mouse)

BM389001 Col9a3_predic procollagen, type IX, alpha 3 (predicted) ted

NM_021760 Col5a3 procollagen, type V, alpha 3

NM_053714 Ank progressive ankylosis homolog (mouse)

NM_133418 Slc25alO solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

Protein Complex Assembly

Public ID Gene Symbol Gene Title

AA945909 Cd3e_predicte CD3 antigen, epsilon polypeptide (predicted) d

AI044631 Cd3g CD3 antigen, gamma polypeptide

AI227800 Kifap3_predict kinesin-associated protein 3 (predicted) ed

AW915948 Cd3e_predicte CD3 antigen, epsilon polypeptide (predicted) d

BF282632 Tspan4 tetraspanin 4

BF410366 — Transcribed locus

BI277545 Myhl /// Myh2 myosin, heavy polypeptide 1, skeletal muscle, adult /// myosin, heavy polypeptide 2, skeletal muscle, adult

NM_013169 Cd3d CD3 antigen delta polypeptide

NM_022952 Ap2sl adaptor-related protein complex 2, sigma 1 subunit

NM_030989 Tp53 tumor protein p53

NM_031827 Vamp8 vesicle-associated membrane protein 8

Calcium-mediated Signaling

Public ID Gene Symbol Gene Title AB070350 Chp /// calcium binding protein p22 /// similar to calcium binding protein P22

RGDl 564956 (predicted) predicted ///

RGD1565588 predicted

AI170193 Dscrl Down syndrome critical region homolog 1 (human)

BF282228 Ltb lymphotoxin B

BM383464 — Transcribed locus

Regulation of GTPase Activity

Public ID Gene Symbol Gene Title

AAII223344009955 Smapl l stromal membrane-associated protein 1-like

AAII440088559988 Git2 G protein-coupled receptor kinase-interactor 2 BG378709 BI275873 Centbl_predic centaurin, beta 1 (predicted) ted U28830 Ralbpl ralA binding protein 1

Protein Amino Acid Glycosylation Public ID Gene Symbol Gene Title

AAAA779999440000 B3galt3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 AAII11 1122115588 B3gntl_predic UDP-GlcNAc:betaGal beta-l,3-N-acetylglucosaminyltransferase 1 ted (predicted)

AI237192 Fut4 fucosyltransferase 4

BG373352 B3gntl_predic UDP-GlcNAc:betaGal beta-l,3-N-acetylglucosaminyltransferase 1 ted (predicted)

NM_031337 St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5

Regulation of Cell Shape

Public ID Gene Symbol Gene Title

BEl 10369 Arhgefl8_pred rho/rac guanine nucleotide exchange factor (GEF) 18 (predicted) icted

BM389644 Rhoj ras homolog gene family, member J

NMJH2755 Fyn fyn proto-oncogene

NM_013194 Myh9 myosin, heavy polypeptide 9, non-muscle

X74293 Itga7 integrin alpha 7

X74294 Itga7 integrin alpha 7

Rn B Cell Receptor NetPath 12

Public ID Gene Symbol Gene Title

AA900477 Vav2_predicted Vav2 oncogene (predicted)

AA925583 Blnk B-cell linker

AA998516 Ccna2 cyclin A2

AI101388 GalNAc4S6ST N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase

AI103918 Hdac7a histone deacetylase 7A

AI137137 Lck lymphocyte protein tyrosine kinase

AI146037 Map3k7_predicted Mitogen activated protein kinase kinase kinase 7 (predicted)

AI171093 Prkcq protein kinase C, theta

AI 177373 Cr2_predicted Complement receptor 2 (predicted)

AI385291 BIk B lymphoid kinase

AI408289 Cd22_predicted CD22 antigen (predicted)

AI556056 Cr2_predicted complement receptor 2 (predicted)

AW920039 RGD1311584 similar to stem cell adaptor protein STAP-I

Actr2 /// ARP2 actin-related protein 2 homolog (yeast) /// similar to ARP2

AW920881 LOC301861 actin-related protein 2 homolog (yeast) (predicted)

BF282471 Lcp2 lymphocyte cytosolic protein 2

BF288130 Ptprc protein tyrosine phosphatase, receptor type, C

BF290113 RGD1311584 similar to stem cell adaptor protein STAP-I

BF401586 Transcribed locus

BF545268 Cr2_predicted complement receptor 2 (predicted) neural precursor cell expressed, developmentally down-regulated

BF555968 Nedd9 gene 9 BI288619 Jun Jun oncogene BI301465 Transcribed locus BM387946 Zap70 zeta-chain (TCR) associated protein kinase 70 L14782 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog M 10072 Ptprc protein tyrosine phosphatase, receptor type, C M 13706 Prkcbl protein kinase C, beta 1 NM_012755 Fyn fyn proto-oncogene NM_013187 Plcgl phospholipase C, gamma 1 NM O 19295 Cd5 CD5 antigen NM 01931 1 Inpp5d inositol polyphosphate-5-phosphatase D NM_031020 Mapkl4 mitogen activated protein kinase 14 NM_033230 Aktl thymoma viral proto-oncogene 1 NM 053355 Ikbkb inhibitor of kappaB kinase beta adaptor protein with pleckstrin homology and src homology 2

NM_053669 Aps domains

NM_053883 Dusp6 dual specificity phosphatase 6

NM_130421 Lcp2 lymphocyte cytosolic protein 2

NM_133533 Cd79b CD79B antigen

X04440 Prkcbl protein kinase C, beta 1

Rn T-CeIl Receptor NetPath 11

Public ID Gene Symbol Gene Title

AA900477 Vav2_predicte Vav2 oncogene (predicted) d

AA945909 Cd3e_predicte CD3 antigen, epsilon polypeptide (predicted) d

AI009944 Txk TXK tyrosine kinase

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2

AI044622 MGC 125004 similar to T cell receptor interacting molecule

AI044631 Cd3g CD3 antigen, gamma polypeptide

AI103918 Hdac7a histone deacetylase 7A

AI137137 Lck lymphocyte protein tyrosine kinase

AI171093 Prkcq protein kinase C, theta

AI 176755 Ptpn22_predict protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ed (predicted)

AI408598 Git2 G protein-coupled receptor kinase-interactor 2

AI500952 SIa Src-like adaptor

AW532114 Rasgrp2_predi RAS guanyl releasing protein 2 (calcium and DAG-regulated) (predicted) cted

AW532179 LOC500449 similar to SHP2-interacting transmembrane adaptor protein

AW915948 Cd3e_predicte CD3 antigen, epsilon polypeptide (predicted) d

BBEEll 1177004444 Cd8a CD8 antigen, alpha chain

BBFF228822447711 Lcp2 lymphocyte cytosolic protein 2

BBFF228888113300 Ptprc protein tyrosine phosphatase, receptor type, C

BBFF441188002255 Grap GRB2-related adaptor protein

BBFF555555996688 Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9

BBII227744332266 Mucl mucin 1 , transmembrane

BBII228888661199 Jun Jun oncogene

BBII229900990099 Scapl src family associated phosphoprotein 1

BBMM338877994466 Zap70 zeta-chain (TCR) associated protein kinase 70

DD1133555555 Cd3z CD3 antigen, zeta polypeptide

LL0088444477 Cd3z CD3 antigen, zeta polypeptide

L14782 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

M 10072 Ptprc protein tyrosine phosphatase, receptor type, C

NM 012755 Fyn fyn proto-oncogene NM_012855 Jak3 Janus kinase 3

NM_013169 Cd3d CD3 antigen delta polypeptide

NM_013187 Plcgl phospholipase C, gamma 1

NM_019295 Cd5 CD5 antigen

NM_024147 EvI Ena-vasodilator stimulated phosphoprotein

NM 030853 Lat linker for activation of T cells

NM_031538 Cd8a CD8 antigen, alpha chain

NM_033230 Aktl thymoma viral proto-oncogene 1

NM_130421 Lcp2 lymphocyte cytosolic protein 2

Rn IL-4 NetPath 16

Public ID Gene Symbol Gene Title

AA945737 Cxcr4 chemokine (C-X-C motif) receptor 4

AB020615 Prkci protein kinase C, iota

AI137137 Lck lymphocyte protein tyrosine kinase

AI 178808 I12rg interleukin 2 receptor, gamma (severe combined immunodeficiency)

BE 109926 Pik3cd_predict phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) ed

BG378885 Hmgal high mobility group AT-hook 1

BG663208 Jakl Janus kinase 1

NM O 12555 Etsl v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

NM_012755 Fyn fyn proto-oncogene

NM_012855 Jak3 Janus kinase 3

NM Ol 3187 Plcgl phospholipase C, gamma 1

NM 01931 1 Inpp5d inositol polyphosphate-5-phosphatase D

NM_031020 Mapkl4 mitogen activated protein kinase 14

NM_033230 Aktl thymoma viral proto-oncogene 1

U54791 Cxcr4 chemokine (C-X-C motif) receptor 4

Rn IL-7 NetPath 19

Public ID Gene Symbol Gene Title

AA998516 Ccna2 cyclin A2

AI178808 I12rg interleukin 2 receptor, gamma (severe combined immunodeficiency)

AI385291 BIk B lymphoid kinase

BF397766 —

BG663208 Jakl Janus kinase 1

BI274326 Mucl mucin ^ transmembrane

L14782 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

NM_012755 Fyn fyn proto-oncogene

NM_012855 Jak3 Janus kinase 3

NM_033230 Aktl thymoma viral proto-oncogene 1

Rn Eicosanoid Synthesis

Public ID Gene Symbol Gene Title

AB048730 Ptges prostaglandin E synthase

L07316 Dpepl dipeptidase 1 (renal)

NM_017260 Alox5ap arachidonate 5-lipoxygenase activating protein

NM_031598 Pla2g2a phospholipase A2, group ILA (platelets, synovial fluid)

NM_053591 Dpepl dipeptidase 1 (renal)

NM_053639 Ltc4s leukotriene C4 synthase

Rn Insulin Signaling

Public ID Gene Symbol Gene Title

AA799981 Prkch protein kinase C, eta

AA957585 Ehd3 EH-domain containing 3

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2

AI146037 Map3k7_predi Mitogen activated protein kinase kinase kinase 7 (predicted) cted

AI171093 Prkcq protein kinase C, theta BE 109926 Pik3cd_predict phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) ed

BF401586 — Transcribed locus

BG378166 Map4k2_predi mitogen activated protein kinase kinase kinase kinase 2 (predicted) cted

BI279786 Myold myosin ID

BI288619 Jun Jun oncogene

BI291434 Pfkm phosphofructokinase, muscle

BM389644 Rhoj ras homolog gene family, member J

M13706 Prkcbl protein kinase C, beta 1

NM_012663 Vamp2 vesicle-associated membrane protein 2

NM_031020 Mapkl4 mitogen activated protein kinase 14

NM 031085 Prkch protein kinase C, eta

NM 031715 Pfkm phosphofructokinase, muscle

NM_033230 Aktl thymoma viral proto-oncogene 1

NM_053355 Ikbkb inhibitor of kappaB kinase beta

NM_O53535 Enppl ectonucleotide pyrophosphatase/phosphodiesterase 1

NM_053669 Aps adaptor protein with pleckstrin homology and src homology 2 domains

NM_053847 Map3k8 mitogen-activated protein kinase kinase kinase 8

NM_053887 Map3kl mitogen activated protein kinase kinase kinase 1

U24150 Tsc2 tuberous sclerosis 2

X04440 Prkcbl protein kinase C, beta 1

Rn Cholesterol 1 Biosynthesis

Public ID Gene Symbol Gene Title

AW530769 Fdftl farnesyl diphosphate farnesyl transferase 1

BG664123 Cyp51 cytochrome P450, subfamily 51

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

BM390574 Lss Lanosterol synthase

NM O 12941 Cyp51 cytochrome P450, subfamily 51

NM_013134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NM_017268 Hmgcsl 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

NM_019238 Fdftl farnesyl diphosphate farnesyl transferase 1

NM_022389 Dhcr7 7-dehydrocholesterol reductase

NM_031840 Fdps farnesyl diphosphate synthase

NM_053539 Idil isopentenyl-diphosphate delta isomerase

Rn Fatty Acid Synthesis BiGCaT

Public ID Gene Symbol Gene Title

AI179334 Fasn fatty acid synthase

AW915152 Echdcl enoyl Coenzyme A hydratase domain containing 1

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

J02585 Scdl stearoyl-Coenzyme A desaturase 1

NM_012744 Pc Pyruvate carboxylase

NM_016987 AcIy ATP citrate lyase

NM_017332 Fasn fatty acid synthase

NM 022193 Acaca acetyl-coenzyme A carboxylase alpha

NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4

NM_130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-

Coenzyme A thiolase)

Rn Krebs-TCA Cycle

Public ID Gene Symbol Gene Title

AI009657 Cs Citrate synthase

AI411413 LOC685778 /// pyruvate dehydrogenase El alpha 1 /// pyruvate dehydrogenase El alpha

Pdhal 1 pseudogene

BF561717 Pdhal pyruvate dehydrogenase El alpha 1

BI295900 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) NM O 12744 Pc Pyruvate carboxylase

NM 024398 Aco2 aconitase 2, mitochondrial

NM l 30755 Cs citrate synthase

Rn Mitochondrial Fatty Acid Betaoxidation

Public ID Gene Symbol Gene Title NM_013200 Cptlb carnitine palmitoyltransferase Ib, muscle NM_016986 Acadm acetyl-Coenzyme A dehydrogenase, medium chain NM_031559 Cptla carnitine palmitoyltransferase Ia, liver NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4 NM 130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-

Coenzyme A thiolase)

Rn Striated Muscle Contraction

Public ID Gene Symbol Gene Title

AA875132 Transcribed locus

AF370889 Tpml Tropomyosin 1 , alpha

AF372216 Tpml tropomyosin 1 , alpha

AF399874 Tnntl troponin Tl, skeletal, slow

AI 104533 Ttn titin

AI104913 Tmodl tropomodulin 1

AI710682 Tnncl troponin C type 1 (slow)

AW533848 Mybpc2_predi myosin binding protein C, fast-type (predicted) cted

BF284889 Actn2_predict actinin alpha 2 (predicted) ed

BF521859 Tnnt3 troponin T3, skeletal, fast BG378588 Mybpc2_predi myosin binding protein C, fast-type (predicted) cted

NM O 12605 Mylpf myosin light chain, phosphorylatable, fast skeletal muscle NM O 12606 Myl3 myosin, light polypeptide 3 NM_017185 Tnni2 troponin I type 2 (skeletal, fast) NM 017240 Myh6 /// Myh7 myosin, heavy polypeptide 6, cardiac muscle, alpha /// myosin, heavy polypeptide 7, cardiac muscle, beta

NM_019131 Tpm 1 ttrrooppoommyyoossiinn 1, alpha

NM_019212 Actal aaccttiinn,, aallpphhaa 1, skeletal muscle

NM_057208 Tpm3 ttrrooppoommyyoossiinn 3, gamma

NM_133424 Actn3 aaccttiinniinn aallpphhaa 3

Leukocyte Transendothelial Migration

Public ID Gene Symbol Gene Title

AA900477 Vav2_predicted VVaavv22 oonncceogene (predicted)

AA945737 Cxcr4 cchheemmookkiinnee (C-X-C motif) receptor 4

AF002251 Rassf5 RRaass aassssoocciiation (RalGDS/AF-6) domain family 5

AI009944 Txk TTXXKK ttyyrroossine kinase

AIO 10476 Rac2 RRAASS--rreellaattfed C3 botulinum substrate 2

AI012081 Rhoh rraass hhoommooklog gene family, member H

AI 137640 Cldnl ccllaauuddiinn 11

AI169104 Cxcl4 cchheemmookkiimne (C-X-C motif) ligand 4

Transcribed locus, moderately similar to XP 580071.1 PREDICTED:

AI599794 hypothetical protein XP_580071 [Rattus norvegicus] AI638971 OcIn occludin BE328951 Cldn4 claudin 4 BF284889 Actn2_predicted actinin alpha 2 (predicted) BF386742 Transcribed locus BF401586 Transcribed locus BI275966 Sipal signal-induced proliferation-associated gene 1 BI281680 Cldn5 claudin 5 BI292090 Cldn8 claudin 8 BM384008 Arhgap5 Rho GTPase activating protein 5

M13706 Prkcbl protein kinase C, beta 1

NM_013187 Plcgl phospholipase C, gamma 1

NM_030863 Msn moesin

NM_031020 Mapkl4 mitogen activated protein kinase 14

NM_031 144 Actb actin, beta

NM_031699 Cldnl claudin 1

NM_O3170O Cldn3 claudin 3

NM_133424 Actn3 actinin alpha 3

U54791 Cxcr4 chemokine (C-X-C motif) receptor 4

X04440 Prkcbl protein kinase C, beta 1

T Cell Receptor Signaling Pathway

Public ID Gene Symbol Gene Title

AA900477 Vav2_predicted Vav2 oncogene (predicted)

AA945727 Cardl l_predict caspase recruitment domain family, member 1 1 (predicted) ed

AA945909 Cd3e_predicted CD3 antigen, epsilon polypeptide (predicted)

AB070350 Chp /// calcium binding protein p22 /// similar to calcium binding protein P22

RGD1564956_ (predicted) predicted ///

RGD1565588_ predicted

AF081 196 Rasgrpl RAS guanyl releasing protein 1

AI044631 Cd3g CD3 antigen, gamma polypeptide

AI 137137 Lck lymphocyte protein tyrosine kinase

AI170362 Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/pl00

AW915948 Cd3e_predicted CD3 antigen, epsilon polypeptide (predicted)

BE099038 —

BEl 17044 Cd8a CD8 antigen, alpha chain

BF282471 Lcp2 lymphocyte cytosolic protein 2

BI288619 Jun Jun oncogene

BM387946 Zap70 zeta-chain (TCR) associated protein kinase 70

D13555 Cd3z CD3 antigen, zeta polypeptide

L08447 Cd3z CD3 antigen, zeta polypeptide

NM_012755 Fyn fyn proto-oncogene

NM 013169 Cd3d CD3 antigen delta polypeptide

NM_013187 Plcgl phospholipase C, gamma 1

NM_022610 Icos inducible T-cell co-stimulator

NM 030853 Lat linker for activation of T cells

NM 031538 Cd8a CD8 antigen, alpha chain

NM 033230 Aktl thymoma viral proto-oncogene 1

NM_053355 Ikbkb inhibitor of kappaB kinase beta

NM_053826 Pdkl pyruvate dehydrogenase kinase, isoenzyme 1

NM_053847 Map3k8 mitogen-activated protein kinase kinase kinase 8

NM_130421 Lcp2 lymphocyte cytosolic protein 2

Tight Junction

Public ID Gene Symbol Gene Title

AA799981 Prkch protein kinase C, eta

AB020615 Prkci protein kinase C, iota

AF255614 Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3

AI 137640 Cldnl claudin 1

AI 171093 Prkcq protein kinase C, theta

AI599794 — Transcribed locus, moderately similar to XP 580071.1 PREDICTED: hypothetical protein XP 580071 [Rattus norvegicus]

AI638971 OcIn Occluding AI717081 Transcribed locus BE328951 Cldn4 claudin 4 BF284889 Actn2_predicte actinin alpha 2 (predicted) d

BF288177 Csnk2al casein kinase II, alpha 1 polypeptide

BF386742 Transcribed locus

BF401586 Transcribed locus

BF411017 LOC304000 cell adhesion molecule JCAM

BI281680 Cldn5 claudin 5

BI292090 Cldn8 claudin 8

BI301465 Transcribed locus

M13706 Prkcbl protein kinase C, beta 1

NM_013194 Myh9 myosin, heavy polypeptide 9, non-muscle

NM_O31O85 Prkch protein kinase C, eta

NM_031 144 Actb actin, beta

NM 031699 Cldnl claudin 1

NM_031700 Cldn3 claudin 3

NM_033230 Aktl thymoma viral proto-oncogene 1

NM 053999 Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform

NM_133424 Actn3 actinin alpha 3 X04440 Prkcbl protein kinase C, beta 1

B Cell Receptor Signaling Pathway

Public ID Gene Symbol Gene Title AA900477 Vav2_predicted Vav2 oncogene (predicted) AA925583 Blnk B-cell linker AA945727 Cardl l_predict caspase recruitment domain family, member 1 1 (predicted) ed

AB070350 Chp /// calcium binding protein p22 /// similar to calcium binding protein P22

RGD1564956_ (predicted) predicted ///

RGD1565588_ predicted

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2 AI 170362 Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/pl00

AI177373 Cr2_predicted Complement receptor 2 (predicted)

AI408289 Cd22_predicted CD22 antigen (predicted)

AI556056 Cr2_predicted complement receptor 2 (predicted)

BF401586 Transcribed locus

BBFF554455226688 Cr2_predicted ccoommpplleemmeent receptor 2 (predicted)

BBII228888661199 Jun JJuunn oonnccooggiene

LL 1144778822 Lyn YYaammaagguucchhi sarcoma viral (v-yes-1) oncogene homolog

MM1133770066 Prkcbl pprrootteeiinn kkiinnase C, beta 1

NNMM__0011993311 11 Inpp5d iinnoossiittooll ppoolyphosphate-5-phosphatase D

NNMM__OO33332233OO Aktl tthhyymmoommaa i viral proto-oncogene 1

NNMM__005533335555 Ikbkb iinnhhiibbiittoorr oof kappaB kinase beta

NNMM 113333553333 Cd79b CCDD7799BB aanntigen

XX0044444400 Prkcbl pprrootteeiinn kkiinnase C, beta 1

Complement and Coagulation Cascades

Public ID Gene Symbol Gene Title

AA818521 Thbd TThhrroommbboormr odulin

AI177373 Cr2_predicted CCoommpplleemmeent receptor 2 (predicted)

AI556056 Cr2_predicted ccoommpplleemmee;nt receptor 2 (predicted)

AI6391 17 Cfb ccoommpplleemmeent factor B

AI716125 C2 ccoommpplleemmeent component 2

BF545268 Cr2_predicted ccoommpplleemmeent receptor 2 (predicted) BG666306 Thbd Thrombomodulin

BM388525 F13al coagulation factor XIII, Al subunit

NM_012488 A2m alpha-2-macroglobulin

NM_012516 C4bpa complement component 4 binding protein, alpha

NM_012559 Fgg fibrinogen, gamma polypeptide

NM_012925 Cd59 CD59 antigen

NM_013085 Plau plasminogen activator, urokinase

NM_017200 Tfpi tissue factor pathway inhibitor

NM 021698 F13al coagulation factor XIII, Al subunit

NM_031771 Thbd Thrombomodulin

NM_130409 Cfh complement component factor H

Fc epsilon RI Signaling Pathway

Public ID Gene Symbol Gene Title

AA900477 Vav2_predicted Vav2 oncogene (predicted)

AIO 10476 Rac2 RAS-related C3 botulinum substrate 2

BF282471 Lcp2 lymphocyte cytosolic protein 2

BI301465 — Transcribed locus

L14782 Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

M17153 Fcerla Fc receptor, IgE, high affinity I, alpha polypeptide

NM_012755 Fyn fyn proto-oncogene

NM_013187 Plcgl phospholipase C, gamma 1

NM_017174 Pla2g5 phospholipase A2, group V

NM 01931 1 Inpp5d inositol polyphosphate-5-phosphatase D

NM_030853 Lat linker for activation of T cells

NM_031020 Mapkl4 mitogen activated protein kinase 14

NM_031598 Pla2g2a phospholipase A2, group HA (platelets, synovial fluid)

NM_033230 Aktl thymoma viral proto-oncogene 1

NM_053826 Pdkl pyruvate dehydrogenase kinase, isoenzyme 1

NM_130421 Lcp2 lymphocyte cytosolic protein 2

NMJ33551 Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent)

Toll-like Receptor Signaling Pathi

Public ID Gene Symbol Gene Title

AA893384 IrG interferon regulatory factor 3

AF057025 Tlr4 toll-like receptor 4

AI170362 Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/pl00

AW526982 Tlr2 toll-like receptor 2

BF281987 Cxcll l chemokine (C-X-C motif) ligand 1 1

BF289368 Lbp lipopolysaccharide binding protein

BF396350 Irakl_predicted interleukin-1 receptor-associated kinase 1 (predicted)

BI288619 Jun Jun oncogene

NM_021744 Cdl4 CD 14 antigen

NM_031020 Mapkl4 mitogen activated protein kinase 14

NM_031 1 16 Ccl5 chemokine (C-C motif) ligand 5

NM_033230 Aktl thymoma viral proto-oncogene 1

NM_053355 Ikbkb inhibitor of kappaB kinase beta

U22520 CxcllO chemokine (C-X-C motif) ligand 10

PPAR Signaling Pathway

Public ID Gene Symbol Gene Title

AA818262 Angptl4 angiopoietin-like 4

AIO 13044 — Transcribed locus

BI274189 Rxrb retinoid X receptor beta

BI278687 Pltp_predicted phospholipid transfer protein (predicted)

J02585 Scdl stearoyl-Coenzyme A desaturase 1

M30596 Mel malic enzyme 1

NM 012600 Mel malic enzyme 1 NM_013200 Cptlb carnitine palmitoyltransferase Ib, muscle

NMJ) 16986 Acadm acetyl-Coenzyme A dehydrogenase, medium chain

NM_024162 Fabp3 fatty acid binding protein 3

NM_031559 Cptla carnitine palmitoyltransferase Ia, liver

NM_031841 Scd2 stearoyl-Coenzyme A desaturase 2

NM_053339 Acox3 acyl-Coenzyme A oxidase 3, pristanoyl

NM_053623 Acsl4 acyl-CoA synthetase long-chain family member 4

U 13253 Fabp5 fatty acid binding protein 5, epidermal

Biosynthesis of Steroids

Public ID Gene Symbol Gene Title

AB052846 Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)

AI710051 Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)

AW530769 Fdftl farnesyl diphosphate farnesyl transferase 1

BF417479 Dhcr24 24-dehydrocholesterol reductase

BG664123 Cyp51 cytochrome P450, subfamily 51

BM390399 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

BM390574 Lss Lanosterol synthase

NM_012941 Cyp51 cytochrome P450, subfamily 51

NM_013134 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NMJ)19238 Fdftl farnesyl diphosphate farnesyl transferase 1

NM 022389 Dhcr7 7-dehydrocholesterol reductase

NM 031840 Fdps farnesyl diphosphate synthase

NM_053539 Idil isopentenyl-diphosphate delta isomerase

Glycolysis/Gluconeogenesis

Public ID Gene Symbol Gene Title

BI279760 Pgkl phosphoglycerate kinase 1

BI291434 Pfkm phosphofructokinase, muscle

BI295900 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

BM389223 Pdhb pyruvate dehydrogenase (lipoamide) beta

NMJ) 12497 Aldoc aldolase C

NMJ) 12554 Enol enolase 1, alpha

NMJ) 12949 Eno3 enolase 3, beta

NMJ) 17328 Pgam2 phosphoglycerate mutase 2

NM_031715 Pfkm phosphofructokinase, muscle

Arachidonic Acid Metabolism

Public ID Gene Symbol Gene Title

AA800587 Gpx2 glutathione peroxidase 2

AB048730 Ptges prostaglandin E synthase

NM_017156 Cyp2bl5 cytochrome P450, family 2, subfamily b, polypeptide 15

NM_017174 Pla2g5 phospholipase A2, group V

NMJ323025 Cyp2j3 /// cytochrome P450, family 2, subfamily J, polypeptide 4 /// cytochrome

Cyp2j4 P450, family 2, subfamily j, polypeptide 3

NM_031598 Pla2g2a phospholipase A2, group HA (platelets, synovial fluid)

NM_053639 Ltc4s leukotriene C4 synthase

NM_133551 Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent)

Pyruvate Metabolism

Public ID Gene Symbol Gene Title

BI295900 Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

BM389223 Pdhb pyruvate dehydrogenase (lipoamide) beta

M30596 Mel malic enzyme 1

NM 012600 Mel malic enzyme 1 NM_012744 Pc Pyruvate carboxylase

NM_022193 Acaca acetyl-coenzyme A carboxylase alpha

Riboflavin Metabolism

Public ID Gene Symbol Gene Title

NM_019370 Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3

NM 020072 Acpp acid phosphatase, prostate

NM_053535 Enppl ectonucleotide pyrophosphatase/phosphodiesterase 1

Table 12: Biochemical Pathways Associated With Genes Differentially Expressed in Liver Tissue as a Result of

High Protein Diet

Lipid Metabolic Process

Public ID Gene Symbol Gene Title AA817761 Adhl alcohol dehydrogenase 1 (class I) AA891362 Hadhsc L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain AA899721 Mtel mitochondrial acyl-CoA thioesterase 1

Cd36 /// LOC685953 /// cd36 antigen /// similar to fatty acid translocase/CD36

AF07241 1 RGD1562323_predicted (predicted) /// similar to CD36 antigen AW435376 Lrp5_predicted low density lipoprotein receptor-related protein 5 (predicted)

ELOVL family member 6, elongation of long chain fatty

BEl 16152 Elovlό acids (yeast) BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

ELOVL family member 6, elongation of long chain fatty

BF396857 Elovl6 acids (yeast) BF555448 Mtel Mitochondrial acyl-CoA thioesterase 1 similar to peroxisomal long chain acyl-CoA thioesterase Ia

BI295569 RGD 1564089_predicted (predicted) BM390571 Sult2bl_predicted sulfotransferase family, cytosolic, 2B, member 1 (predicted) J02585 Scdl stearoyl-Coenzyme A desaturase 1 NM_012695 Smp2a rat senescence marker protein 2A gene, exons 1 and 2 NM_012737 Apoa4 apolipoprotein A-IV NM_012907 Apobecl apolipoprotein B editing complex 1 NM O 13084 Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain NM_016987 AcIy ATP citrate lyase NM_031559 Cptla carnitine palmitoyltransferase Ia, liver NM_031641 Sult4al sulfotransferase family 4A, member 1 NM 031841 Scd2 stearoyl-Coenzyme A desaturase 2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-

NM_130433 AAccaaaa22 oxoacyl-Coenzyme A thiolase)

U88294 CCppttllaa carnitine palmitoyltransferase Ia, liver

Y09333 MMtteell mitochondrial acyl-CoA thioesterase 1

Fatty Acid Metabolic Process

Public ID Gene Symbol Gene Title

AA891362 Hadhsc L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain

AF07241 1 Cd36 /// cd36 antigen /// similar to fatty acid translocase/CD36 (predicted) ///

LOC685953 /// similar to CD36 antigen

RGD1562323_ predicted

BEl 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

NM_013068 Fabp2 fatty acid binding protein 2, intestinal

NM_013084 Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain

NM_031559 Cptla carnitine palmitoyltransferase 1 a, liver

NM_031561 RGD1562323_ similar to fatty acid translocase/CD36 (predicted) predicted

NM_031605 Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8

NM 130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl- Coenzyme A thiolase) U88294 Cptla carnitine palmitoyltransferase Ia, liver

Lipid Biosynthetic Process

Public ID Gene Symbol Gene Title

AI 179334 Fasn fatty acid synthase

BE1 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

J02585 Scdl stearoyl-Coenzyme A desaturase 1

NM_012744 Pc Pyruvate carboxylase

NM_016987 AcIy ATP citrate lyase

NM_017235 Hsdl7b7 hydroxysteroid (17-beta) dehydrogenase 7

NMJ 17332 Fasn fatty acid synthase

NM_031841 Scd2 stearoyl-Coenzyme A desaturase 2

Fatty Acid Biosynthetic Process

Public ID Gene Symbol Gene Title

AI179334 Fasn fatty acid synthase

BE1 16152 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BF396857 Elovlό ELOVL family member 6, elongation of long chain fatty acids (yeast)

BI282211 Acsm3 acyl-CoA synthetase medium-chain family member 3

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

J02585 Scdl stearoyl-Coenzyme A desaturase 1

NM_017332 Fasn fatty acid synthase

NM 031841 Scd2 stearoyl-Coenzyme A desaturase 2

Steroid Metabolic Process Public ID Gene Symbol Gene Title

AI072107 Akrlcό aldo-keto reductase family 1, member C6

BF283070 Cyp7bl cytochrome P450, family 7, subfamily b, polypeptide 1

BF403483 Transcribed locus, moderately similar to NP 997413.2 oxysterol binding protein-like 1 [Mus musculus]

BBMM339900557711 Sult2bl_predic sulfotransferase family, cytosolic, 2B, member 1 (predicted) ted

NNMM OO 1122669955 Smp2a rat senescence marker protein 2A gene, exons 1 and 2 NNMM__003311664411 Sult4al sulfotransferase family 4A, member 1

P Prrootteeoollyyssiiss PPuubblliicc IIDD Gene Symbol Gene Title AAII110044223388 Gzma granzyme A AAII663399224411 LOC684318 /// ubiquitin specific protease 12 (predicted) /// similar to ubiquitin specific

RGD 1561481_ protease 12 (predicted) /// similar to ubiquitin specific protease 12 predicted ///

Uspl2_predict ed

B DFr3J975J7 I9y1 I Transcribed locus BBII228833115599 Scpepl serine carboxypeptidase 1 BBMM338833220099 RGD1561 153_ similar to myosin-VIIb (predicted) predicted

NNMM OO 1122555522 Elal elastase 1 , pancreatic NNMM_ 001199332233 McptlO /// mast cell protease 8 /// mast cell protease 10 /// mast cell protease 9 ///

Mcpt8 /// mast cell protease 8-like 2

Mcpt812 ///

Mcpt9

NM_053299 Ubd ubiquitin D

NM_130422 Caspl2 caspase 12

U36476 Mmp9 matrix metal lopeptidase 9

Carbohydrate Metabolic Process

Public ID Gene Symbol Gene Title

AA892845 Hexb hexosaminidase B

AA997683 Aldhlbl aldehyde dehydrogenase 1 family, member Bl AB052294 Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8

AW530361 Ppplr3c protein phosphatase 1, regulatory (inhibitor) subunit 3C

BEl 15496 — Transcribed locus

BI279202 RGD1565709_ similar to ovostatin-2 (predicted) predicted

BI283882 Gpi glucose phosphate isomerase

M17685 PkIr pyruvate kinase, liver and red blood cell

M30596 MeI malic enzyme 1

NM_012600 Mel malic enzyme 1

NM_012624 PkIr pyruvate kinase, liver and red blood cell

NM_013144 Igfbpl insulin-like growth factor binding protein 1

NM_017025 Ldha lactate dehydrogenase A

NM_024381 Gyk glycerol kinase

NM_031741 Slc2a5 solute carrier family 2, member 5

Glucose Metabolic Process

Public ID Gene Symbol Gene Title

NM_012603 Myc myelocytomatosis viral oncogene homolog (avian)

NM_013144 Igfbpl insulin-like growth factor binding protein 1

NM_017025 Ldha lactate dehydrogenase A

NM_031559 Cptla carnitine palmitoyltransferase 1 a, liver

U88294 Cptla carnitine palmitoyltransferase 1 a, liver

Gluconeogenesis

Public ID Gene Symbol Gene Title

BI283882 Gpi glucose phosphate isomerase

M18340 Tat tyrosine aminotransferase

NM_012744 Pc Pyruvate carboxylase

NM 031039 Gptl glutamic pyruvic transaminase 1 , soluble

NM_053962 Sds serine dehydratase

Amino Acid Metabolic Process

Public ID Gene Symbol Gene Title

AA799700 Sephs2 selenophosphate synthetase 2

AI41 1227 RGD1563485_ similar to mKIAA0534 protein (predicted) predicted

AI41 1345 LOC680409 /// similar to Proline oxidase, mitochondrial precursor (Proline

LOC682565 dehydrogenase)

D00252 Gotl glutamate oxaloacetate transaminase 1

M18340 Tat tyrosine aminotransferase

NM_012522 Cbs cystathionine beta synthase

NM_017206 Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6

NM_022521 Oat ornithine aminotransferase

NM_O3133O AsI argininosuccinate lyase

NM_053962 Sds serine dehydratase

Amine Metabolic Process

Public ID Gene Symbol Gene Title

AA799700 Sephs2 selenophosphate synthetase 2

AI168953 Sultlc2a sulfotransferase family, cytosolic, 1C, member 2a

AI41 1345 LOC680409 /// similar to Proline oxidase, mitochondrial precursor (Proline

LOC682565 dehydrogenase)

BI300997 Sultlc2 /// sulfotransferase family, cytosolic, 1C, member 2 /// sulfotransferase

Sultlc2a family, cytosolic, 1C, member 2a

NM 031330 AsI argininosuccinate lyase

NM_133547 Sultlc2 /// sulfotransferase family, cytosolic, 1C, member 2 /// sulfotransferase

Sultlc2a family, cytosolic, 1C, member 2a

Nitrogen Compound Metabolic Process Public ID Gene Symbol Gene Title

AA799700 Sephs2 selenophosphate synthetase 2 AI411345 LOC680409 /// similar to Proline oxidase, mitochondrial precursor (Proline

LOC682565 dehydrogenase)

BI289085 Vnnl vanin 1

NM_031039 Gptl glutamic pyruvic transaminase 1, soluble

NM_031330 AsI argininosuccinate lyase

One-carbon Compound Metabolic Process

Public ID Gene Symbol Gene Title

AABB003300882299 Ca3 ccaarrbboonniicc aannhhyyddrraassee 33

AAII440088994488 Ca2 ccaarrbboonniicc aannhhyyddrraassee 22 BI301687 Transcribed locus NM_019291 Ca2 carbonic anhydrase 2 NM 019292 Ca3 carbonic anhydrase 3

Xenobiotic Metabolic Process

Public ID Gene Symbol Gene Title

AI072107 Akrlcό aldo-keto reductase family 1 , member C6

AI 169331 Gstm2 glutathione S-transferase, mu 2

K02422 Cypla2 cytochrome P450, family 1, subfamily a, polypeptide 2

NM_031543 Cyp2el cytochrome P450, family 2, subfamily e, polypeptide 1

U461 18 Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9

Sodium Ion Transport

Public ID Gene Symbol Gene Title AB013454 Slc34al solute carrier family 34 (sodium phosphate), member 1 AI232036 Atplbl ATPase, Na+/K+ transporting, beta 1 polypeptide BG38131 1 Slcl3a5 solute carrier family 13 (sodium-dependent citrate transporter), member

5

M14137 Atplbl ATPase, Na+/K+ transporting, beta 1 polypeptide

NM 031548 Scnnla sodium channel, nonvoltage-gated 1 alpha

NM_053380 Slc34a2 solute carrier family 34 (sodium phosphate), member 2

Multicellular organismal development

Public ID Gene Symbol Gene Title

AA818262 Angptl4 angiopoietin-like 4

AA893169 Timp3 tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinfiammatory)

AI045767 Ank progressive ankylosis homolog (mouse) AI 180398 Transcribed locus AI41 1227 RGD1563485_ similar to mKIAA0534 protein (predicted) predicted

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma AY082609 Abcbla /// ATP-binding cassette, sub-family B (MDR/TAP), member IB /// ATP-

Abcblb binding cassette, sub-family B (MDR/TAP), member IA

BE104552 Elavil _predict ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu ed antigen R) (predicted)

BE121383 NNccaamm22 neural cell adhesion molecule 2

BF391129 — Transcribed locus

BF391308 — Transcribed locus

BG662519 Ank Progressive ankylosis homolog (mouse)

BM986536 Histlh4b histone cluster 1 , H4b

NMJ) 13144 Igfbpl insulin-like growth factor binding protein 1

NM_017025 Ldha lactate dehydrogenase A

NMJ⁾17149 Meox2 mesenchyme homeobox 2

NMJ)22542 Rhob ras homolog gene family, member B

NM_031330 AsI argininosuccinate lyase

NM_053714 Ank progressive ankylosis homolog (mouse)

Regulation of Cell Growth

Public ID Gene Symbol Gene Title

AF065161 Cish cytokine inducible SH2 -containing protein AI600057 Criml_predict cysteine-rich motor neuron 1 (predicted) ed

AI703807 Criml_predict cysteine-rich motor neuron 1 (predicted) ed

BE 104060 Igfbp5 insulin-like growth factor binding protein 5

BF386770 — Transcribed locus

BI289620 Criml_predict cysteine-rich motor neuron 1 (predicted) ed

BI291842 — Transcribed locus

NM_013144 Igfbpl insulin-like growth factor binding protein 1

Myelination

Public ID Gene Symbol Gene Title

AA892845 Hexb hexosaminidase B

AI 137640 Cldnl claudin 1

NM O 12798 MaI myelin and lymphocyte protein, T-cell differentiation protein

NM_031073 NtC neurotrophin 3

NM 031841 Scd2 stearoyl-Coenzyme A desaturase 2

Regulation of progression throug :ell cycle

Public ID Gene Symbol Gene Title

ABO 19693 Kegl kidney expressed gene 1

AI599423 Gadd45g growth arrest and DNA-damage-inducible 45 gamma

AW143798 Ccndl Cyclin Dl

BEl 18653 — Transcribed locus

NMJ) 17019 Ilia interleukin 1 alpha

NM_020072 Acpp acid phosphatase, prostate

NM_024127 Gadd45a growth arrest and DNA-damage-inducible 45 alpha

Antigen Processing and Presenta n

Public ID Gene Symbol Gene Title

AI715202 RTl-Bb RTl class II, locus Bb

AJ243338 RT1-CE5 RTl class I, CE5

AJ249701 RT1-A2 /// RTl class Ib, locus Aw2 /// RTl class Ia, locus A2 /// RTl class I, A3

RTl -A3 ///

RT1-Aw2

BI292055 — Transcribed locus

BM387813 — Transcribed locus

M 10094 RT1-Aw2 RTl class Ib, locus Aw2

M24024 RT1-Aw2 RTl class Ib, locus Aw2

NMJ) 12645 RT1-Aw2 RTl class Ib, locus Aw2

NM 053299 Ubd ubiquitin D

Rn Adipogenesis

Public ID Gene Symbol Gene Title

AA874941 Adfp Adipose differentiation related protein

AB020967 Trib3 tribbles homolog 3 (Drosophila)

AI072892 Frzb frizzled-related protein

BE106199 Rora_predicte RAR-related orphan receptor alpha (predicted) d

BF394158 — Transcribed locus

BI285616 Adfp adipose differentiation related protein

BI289506 — Transcribed locus

J02585 Scdl stearoyl-Coenzyme A desaturase 1

L48060 PrIr prolactin receptor

M57668 PrIr prolactin receptor

NM O 12524 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha

NM O 13095 Smad3 MAD homolog 3 (Drosophila)

NM 024127 Gadd45a growth arrest and DNA-damage-inducible 45 alpha Rn Fatty Acid Synthesis BiGCaT Public ID Gene Symbol Gene Title

AA891362 Hadhsc L-3 -hydroxy acyl-Coenzyme A dehydrogenase, short chain AI179334 Fasn fatty acid synthase BI296153 Acaca acetyl-coenzyme A carboxylase alpha J02585 Scdl stearoyl-Coenzyme A desaturase 1 NM_012744 Pc Pyruvate carboxylase NM O 16987 AcIy ATP citrate lyase NM_017332 Fasn fatty acid synthase NM 130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-

Coenzyme A thiolase)

Rn Glycolysis and Gluconeogenesis

Public ID Gene Symbol Gene Title

BI283882 Gpi glucose phosphate isomerase

D00252 Gotl glutamate oxaloacetate transaminase 1

M17685 PkIr pyruvate kinase, liver and red blood cell

NM_012624 PkIr pyruvate kinase, liver and red blood cell

NM_012744 Pc Pyruvate carboxylase

NM 017025 Ldha lactate dehydrogenase A

Rn Nuclear Receptors in Lipid Metabolism and Toxicity Public ID Gene Symbol Gene Title

AY082609 AAbbccbb 1I aa ////// ATP-binding cassette, sub-family B (MDR/TAP), member 1 B /// ATP-

Abcb Ib binding cassette, sub-family B (MDR/TAP), member IA

K02422 Cypla2 cytochrome P450, family 1 , subfamily a, polypeptide 2 NMJB l 543 Cyp2el cytochrome P450, family 2, subfamily e, polypeptide 1 NM_053754 Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 U461 18 Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9

Rn Fatty Acid Beta Oxidation 1 BiGCaT

Public ID Gene Symbol Gene Title

AA891362 Hadhsc L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain

NM_024381 Gyk glycerol kinase

NM 031559 Cptla carnitine palmitoyltransferase Ia, liver

U88294 Cptla carnitine palmitoyltransferase Ia, liver

Rn Fatty Acid Omega Oxidation BiGCaT

Public ID Gene Symbol Gene Title

AA817761 Adhl alcohol dehydrogenase 1 (class I)

K02422 Cypla2 cytochrome P450, family 1 , subfamily a, polypeptide 2

NM_022407 Aldhlal aldehyde dehydrogenase family 1, member Al

NM_031543 Cyp2el cytochrome P450, family 2, subfamily e, polypeptide 1

PPAR Signaling Pathway

Public ID Gene Symbol Gene Title AA818262 Angptl4 angiopoietin-like 4 AF072411 Cd36 /// cd36 antigen /// similar to fatty acid translocase/CD36 (predicted) /// LOC685953 /// similar to CD36 antigen RGD1562323_ predicted

BF398558 Transcribed locus J02585 Scdl stearoyl-Coenzyme A desaturase 1 M30596 Mel malic enzyme 1 NM_012600 Mel malic enzyme 1 NMJ 13068 Fabp2 fatty acid binding protein 2, intestinal NM_024381 Gyk glycerol kinase NM_031559 Cptla carnitine palmitoyltransferase Ia, liver NM 031605 Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 NM 031841 Scd2 stearoyl-Coenzyme A desaturase 2 U88294 Cptla carnitine palmitoyltransferase Ia, liver

Metabolism of Xenobiotics by Cytochrome P450

Public ID Gene Symbol Gene Title

AA817761 Adhl alcohol dehydrogenase 1 (class I)

AA858993 Ugt2b UDP glycosyltransferase 2 family, polypeptide B

AI 169331 Gstm2 glutathione S-transferase, mu 2

K02422 Cypla2 cytochrome P450, family 1 , subfamily a, polypeptide 2

M13506 Udpgtr2 liver UDP-glucuronosyltransferase, phenobarbital-inducible form

NM_020540 Gstm4 glutathione S-transferase M4

NM_031 154 Gstm3 glutathione S-transferase, mu type 3

NM_031533 Ugt2b UDP glycosyltransferase 2 family, polypeptide B

NM_031543 Cyp2el cytochrome P450, family 2, subfamily e, polypeptide 1

U461 18 Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9

Fatty Acid Metabolism

Public ID Gene Symbol Gene Title

AA817761 Adhl alcohol dehydrogenase 1 (class I)

AA891362 Hadhsc L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain

NM_013084 Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain

NM_031559 Cptla carnitine palmitoyltransferase Ia, liver

NM_031605 Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8

NM 130433 Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl- Coenzyme A thiolase) U88294 Cptla carnitine palmitoyltransferase Ia, liver

Alanine and Aspartate Metabolism Public ID Gene Symbol Gene Title

BF416465 — Transcribed locus

D00252 Gotl glutamate oxaloacetate transaminase 1

NM_012744 Pc Pyruvate carboxylase

NM_021577 AsI argininosuccinate lyase

NM_031039 Gptl glutamic pyruvic transaminase 1, soluble

NM_031330 AsI argininosuccinate lyase

Arginine and Proline Metabolism

Public ID Gene Symbol Gene Title

AI234919 Eprs glutamyl-prolyl-tRNA synthetase

AI41 1345 LOC680409 /// similar to Proline oxidase, mitochondrial precursor (Proline

LOC682565 dehydrogenase)

D00252 Gotl glutamate oxaloacetate transaminase 1

NM_021577 AsI argininosuccinate lyase

NM_022521 Oat ornithine aminotransferase

NM_031330 AsI argininosuccinate lyase

Pyruvate Metabolism

Public ID Gene Symbol Gene Title

BI296153 Acaca acetyl-coenzyme A carboxylase alpha

M17685 PkIr pyruvate kinase, liver and red blood cell

M30596 Mel malic enzyme 1

NM_012600 Mel malic enzyme 1

NM_012624 PkIr pyruvate kinase, liver and red blood cell

NM_012744 Pc Pyruvate carboxylase

NMJ 17025 Ldha lactate dehydrogenase A

Glutamate Metabolism

Public ID Gene Symbol Gene Title

AI234919 Eprs glutamyl-prolyl-tRNA synthetase

BF397926 Gmps guanine monphosphate synthetase

BF416465 — Transcribed locus

D00252 Gotl glutamate oxaloacetate transaminase 1 J05499 Gls2 glutaminase 2 (liver, mitochondrial)

NM_031039 Gptl glutamic pyruvic transaminase 1, soluble

Nitrogen Metabolism

Public ID Gene Symbol Gene Title

AB030829 Ca3 carbonic anhydrase 3

AI408948 Ca2 carbonic anhydrase 2

J05499 Gls2 glutaminase 2 (liver, mitochondrial)

NM_017159 Hal histidine ammonia lyase

NM_019291 Ca2 carbonic anhydrase 2

NM O 19292 Ca3 carbonic anhydrase 3

Cysteine Metabolism

Public ID Gene Symbol Gene Title

BI300997 Sultlc2 /// sulfotransferase family, cytosolic, 1C, member 2 /// sulfotransferase

Sultlc2a family, cytosolic, 1C, member 2a

D00252 Gotl glutamate oxaloacetate transaminase 1

NM_017025 Ldha lactate dehydrogenase A

NM_031641 Sult4al sulfotransferase family 4A, member 1

NM_053962 Sds serine dehydratase

NM_133547 Sultlc2 /// sulfotransferase family, cytosolic, 1C, member 2 /// sulfotransferase

Sultlc2a family, cytosolic, 1C, member 2a

Tyrosine Metabolism

Public ID Gene Symbol Gene Title

AA817761 Adhl alcohol dehydrogenase 1 (class I)

AI232328 Hgd homogentisate 1 , 2-dioxygenase

D00252 Gotl glutamate oxaloacetate transaminase 1

M 18340 Tat tyrosine aminotransferase

NM 012531 Comt catechol-O-methyltransferase

Table 13: Biochemical Pathways Associated with Genes Differentially Expressed in Muscle Tissue as a Result of High Protein Diet

Immune Response

Public ID Gene Symbol Gene Title AA892854 LOC498335 similar to Small inducible cytokine B 13 precursor (CXCL 13) (B lymphocyte chemoattractant) (CXC chemokine BLC)

AI502757 Cst7_predicted cystatin F (leukocystatin) (predicted) AI715202 RTl-Bb RTl class II, locus Bb AJ249701 RT1-A2 /// RTl class Ib, locus Aw2 /// RTl class Ia, locus A2 /// RTl class I, A3

RTl -A3 ///

RT1-Aw2

BF290088 Nkx2- NK2 transcription factor related, locus 3 (Drosophila) (predicted)

3_predicted

BI282920 Ccl21b chemokine (C-C motif) ligand 21b (serine) BM389513 LOC688090 /// RTl class II, locus Bb /// similar to RTl class II histocompatibility

RTl-Bb antigen, B-I beta chain precursor (RTl .B-beta(l))

M24024 RT1-Aw2 RTl class Ib, locus Aw2 NM_019205 Ccll l chemokine (C-C motif) ligand 1 1 NM_053299 Ubd ubiquitin D

Defense response Public ID Gene Symbol Gene Title AI407339 Irgm immunity-related GTPase family, M AJ249701 RT1-A2 /// RT1-A3 /// RTl class Ib, locus Aw2 /// RTl class Ia, locus A2 /// RTl class I, A3

RT1-Aw2

L81 174 Ankrdl ankyrin repeat domain 1 (cardiac muscle) NM_012594 Lalba lactalbumin, alpha NM_013220 Ankrdl ankyrin repeat domain 1 (cardiac muscle) NM 031971 Hspala /// Hspalb heat shock 7OkD protein IA /// heat shock 7OkD protein 1 B (mapped) Inflammatory Response

Public ID Gene Symbol Gene Title

ABOO 1382 Sppl secreted phosphoprotein 1

AJ249701 RT1-A2 /// RT1-A3 /// RTl class Ib, locus Aw2 /// RTl class Ia, locus A2 /// RTl class I,

RT1-Aw2 A3

BI282920 Ccl21b chemokine (C-C motif) ligand 21b (serine)

NMJ 19205 CcI 11 chemokine (C-C motif) ligand 11

NM_024131 Ddt D-dopachrome tautomerase

Rn Circadian Exercise

Public ID Gene Symbol Gene Title

AI406939 G0s2 G0/G1 switch gene 2

AW530361 Ppplr3c protein phosphatase 1, regulatory (inhibitor) subunit 3C

BI274605 Ucp3 uncoupling protein 3 (mitochondrial, proton carrier)

U86635 Gstm5 glutathione S-transferase, mu 5

U92069 Ucp3 uncoupling protein 3 (mitochondrial, proton carrier)

[00108] The specification has disclosed typical preferred embodiments of the invention. Although specific terms are employed, they are used in a generic and descriptive sense only and not for purposes of limitation, the scope of the invention being set forth in the claims. Clearly, many modifications and variations of the invention are possible in light of the above teachings. It is therefore to be understood that within the scope of the appended claims the invention may be practiced otherwise than as specifically described.

Claims

CLAIMS What is claimed is:

1. A combination comprising a plurality of polynucleotides that are differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of conjugated linoleic acid (CLA), (2) consumption of a high protein diet, and (3) increased exercise, wherein the polynucleotides are selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof.

2. The combination of claim 1 wherein the polynucleotides are differentially expressed in each of the lean phenotype promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, and the polynucleotides are selected from genes encoding proteins listed in Table 6, or fragments thereof.

3. The combination of claim 2 wherein the polynucleotides are selected from genes encoding proteins listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof.

4. The combination of claim 2 wherein the polynucleotides are differentially expressed in adipose tissue and encode proteins involved in functions selected from cholesterol biosynthetic pathway, statin pathway, adipogenesis, apoptosis, cell motility, mitochondrial fatty acid betaoxidation, fatty acid biosynthesis, fatty acid metabolism, glycolysis, regulation of cell proliferation, inflammation, immunity and stress response, multicellular organismal development, and regulation of apoptosis.

5. The combination of claim 2 wherein the polynucleotides are differentially expressed in liver and encode proteins involved in functions selected from PPAR signaling pathway and fatty acid metabolism.

6. The combination of claim 2 wherein the polynucleotides are differentially expressed in muscle and encode proteins involved in lipid metabolism.

7. The combination of claim 1 wherein the polynucleotides are differentially expressed in the lean phenotype promoting treatments comprising consumption of a high protein diet, and the polynucleotides are selected from genes encoding proteins listed in Table 10, or fragments thereof.

8. The combination of claim 7 wherein the polynucleotides are selected from genes encoding proteins listed in tissue-specific subsets of Table 10 selected from: Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof.

9. The combination of claim 7 wherein the polynucleotides are differentially expressed in adipose tissue and encode proteins involved in functions selected from immune response, inflammatory response, response to stress, chemotaxis, response to unfolded protein, defense response, cell activation, lymphocyte activation, locomotory behavior, lipid metabolic process, lipid biosynthetic process, steroid biosynthetic process, cholesterol metabolic process, steroid metabolic process, glycolysis, glucose metabolic process, organ development, muscle development, positive regulation of cell proliferation, angiogenesis, blood vessel morphogenesis, anti-apoptosis, muscle contraction, phosphate transport, protein complex assembly, calcium-mediated signaling, regulation of GTPase activity, protein amino acid glycosylation, regulation of cell shape, Rattus norvegicus (Rn) B cell receptor NetPath 12, Rn T-cell receptor NetPath 1 1, Rn IL-4 NetPath 16, Rn IL-7 NetPath 19, Rn eicosanoid synthesis, Rn insulin signaling, Rn cholesterol biosynthesis, Rn fatty acid synthesis BiGCaT, Rn Krebs-TCA cycle, Rn mitochondrial fatty acid betaoxidation, Rn striated muscle contraction, leukocyte transendothelial migration, T cell receptor signaling pathway, tight junction, B cell receptor signaling pathway, complement and coagulation cascades, Fc epsilon RI signaling pathway, toll-like receptor signaling pathway, PPAR signaling pathway, biosynthesis of steroids, glycolysis/gluconeogenesis, arachidonic acid metabolism, pyruvate metabolism, and riboflavin metabolism.

10. The combination of claim 7 wherein the polynucleotides are differentially expressed in liver and encode proteins involved in functions selected from lipid metabolic process, fatty acid metabolic process, lipid biosynthetic process, fatty acid biosynthetic process, steroid metabolic process, proteolysis, carbohydrate metabolic process, glucose metabolic process, gluconeogenesis, amino acid metabolic process, amine metabolic process, nitrogen compound metabolic process, one-carbon compound metabolic process, xenobiotic metabolic process, sodium ion transport, multicellular organismal development, regulation of cell growth, myelination, regulation of progression through cell cycle, antigen processing and presentation, Rn adipogenesis, Rn fatty acid synthesis BiGCaT, Rn glycolysis and gluconeogenesis, Rn nuclear receptors in lipid metabolism and toxicity, Rn fatty acid beta oxidation 1 BiGCaT, Rn fatty acid omega oxidation BiGCaT, PPAR signaling pathway, metabolism of xenobiotics by cytochrome P450, fatty acid metabolism, alanine and aspartate metabolism, arginine and proline metabolism, pyruvate metabolism, glutamate metabolism, nitrogen metabolism, cysteine metabolism, and tyrosine metabolism.

1 1. The combination of claim 7 wherein the polynucleotides are differentially expressed in muscle and encode proteins involved in functions selected from immune response, defense response, inflammatory response, and Rn circadian exercise.

12. The combination of claim 1 wherein the lean phenotype-promoting treatment is administered for at least one week.

13. The combination of claim 1 wherein the lean phenotype-promoting treatment is administered for at least four weeks.

14. The combination of claim 1 wherein the lean phenotype-promoting treatment is administered for at least eight weeks.

15. The combination of claim I wherein the polynucleotides are canine or feline polynucleotides.

16. A composition comprising two or more probes for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, wherein the probes comprise: a) polynucleotides that specifically hybridize to two or more genes encoding proteins listed in Table 6 or Table 10, or fragments thereof; or b) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins listed in Table 6 or Table 10, or fragments thereof.

17. The composition of claim 16 wherein the polypeptide binding agents are antibodies.

18. The composition of claim 16 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof.

19. The composition of claim 16 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 7, Table 8 or Table 9.

20. The composition of claim 16 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof.

21. The composition of claim 16 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 1 1, Table 12 or Table 13.

22. The composition of claim 16 wherein the probes specifically hybridize or bind to canine or feline polynucleotides or polypeptides.

23. A device comprising a solid support to which is affixed an array comprising a plurality of probes for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, wherein the probes comprise: a) polynucleotides that specifically hybridize to two or more genes encoding proteins listed in Table 6 or

Table 10, or fragments thereof; or b) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins listed in Table 6 or Table 10, or fragments thereof.

24. The device of claim 23 wherein the polypeptide binding agents are antibodies.

25. The device of claim 23 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof.

26. The device of claim 23 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 7, Table 8 or Table 9.

27. The device of claim 23 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof.

28. The device of claim 23 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 11, Table 12 or Table 13.

29. A method for detecting differential expression of one or more genes differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, as compared with normal animals, the method comprising: a) providing probes comprising (i) polynucleotides that specifically hybridize to two or more genes encoding proteins listed in Table 6 or Table 10, or fragments thereof; or (ii) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins listed in Table 6 or Table 10, or fragments thereof; b) adding the probes to a sample comprising mRNA or proteins from an animal exhibiting the lean phenotype, in a manner enabling hybridization or binding of the probes to the mRNA or proteins in the sample, thereby forming hybridization or binding complexes in the sample; c) optionally, adding the probes to another sample comprising mRNA or proteins from a normal animal, in a manner enabling hybridization or binding of the probes to the mRNA or proteins in the second sample, thereby forming hybridization or binding complexes in the other sample; d) detecting the hybridization complexes in the sample or samples; and e) comparing the hybridization or binding complexes from the first sample with the hybridization or binding complexes from a standard or, optionally, from the other sample, wherein at least one difference between the amount of hybridization or binding in the sample as compared with the standard or the optional other sample indicates differential expression of the one or more genes differentially expressed in animals exhibiting the lean phenotype.

30. The method of claim 29 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof.

31. The method of claim 29 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 7, Table 8 or Table 9.

32. The method of claim 29 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof.

33. The method of claim 29 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 1 1, Table 12 or Table 13.

34. The method of claim 29 wherein the probes specifically hybridize or bind to canine or feline polynucleotides or polypeptides.

35. The method of claim 29 wherein the probes are bound to a substrate.

36. The method of claim 35 wherein the probes are in an array.

37. The method of claim 29 wherein the detecting is performed at intervals and used to monitor an animal's progress when attempting to promote the lean phenotype in the animal.

38. A method of determining if a test substance is likely to be useful in promoting a lean phenotype when administered to an animal, the method comprising: a) determining a first gene expression profile by measuring the transcription or translation products of two or more polynucleotides selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, in a test system in the absence of the test substance; b) determining a second gene expression profile by measuring the transcription or translation products of two or more polynucleotides selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, in a test system in the presence of the test substance; and c) comparing the first gene expression profile with the second gene expression profile, wherein a change in the second gene expression profile as compared with the first gene expression profile indicates that the test substance is likely to be useful in promoting a lean phenotype when administered to an animal.

39. The method of claim 38 further comprising comparing at least the second gene expression profile with a reference gene expression profile obtained by measuring the transcription or translation products of two or more polynucleotides selected from genes encoding proteins listed in Table 6 or Table 10, or fragments thereof, in a test system in the presence of a reference substance known to promote a lean phenotype when administered to animals.

40. The method of claim 38 wherein the test system comprises a population of cultured cells.

41. The method of claim 38 wherein the test system comprises animals.

42. The method of claim 38 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6 A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 6 selected from Table 6A, Table 6B, Table 6C, Table 6D, Table 6E, Table 6F, and Table 6G, or fragments thereof.

43. The method of claim 38 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 7, Table 8 or Table 9.

44. The method of claim 38 wherein the probes specifically hybridize to genes encoding proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof, or specifically bind to polypeptides comprising proteins listed in listed in tissue-specific subsets of Table 10 selected from Table 1OA, Table 1OB, Table 1OC, Table 10D, Table 1OE, Table 1OF, and Table 1OG, or fragments thereof.

45. The method of claim 38 wherein the probes specifically hybridize to, or specifically bind to, polynucleotides encoding proteins, or polypeptides comprising proteins, listed in Table 11, Table 12 or Table 13.

46. The method of claim 38 wherein the probes are bound to a substrate.

47. The method of claim 46 wherein the probes are in an array.

48. The method of claim 38 wherein the sample contains mRNA or proteins from a canine or feline.

49. A substance identified by the method of claim 38 as likely to promote a lean phenotype when administered to an animal.

50. A computer system comprising a database containing information identifying expression levels of one or more polynucleotides that are differentially expressed in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, wherein the polynucleotides are selected from genes encoding proteins listed in any of Tables 6-13, or fragments thereof, and a user interface that enables a user to access or manipulate the information in the database.

51. A kit comprising, in separate containers in a single package, or in separate containers in a virtual package, two or more probes for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, wherein the probes comprise: (a) polynucleotides that specifically hybridize to two or more genes encoding proteins listed in any of Tables 6-13, or fragments thereof; or (b) polypeptide binding agents that specifically bind to two or more polypeptides selected from proteins listed in any of Tables 6-13, or fragments thereof; wherein the kit further comprises at least one of (1) instructions for how to use the probes in a gene expression assay for detecting differential gene expression in animals exhibiting a lean phenotype resulting from one or more lean phenotype-promoting treatments comprising (1) administration of CLA, (2) consumption of a high protein diet, and (3) increased exercise, (2) reagents and equipment for using the probes, and (3) a composition known to induce the lean phenotype upon regular ingestion.

52. The kit of claim 51 wherein the probes are affixed to a solid support at known locations.

53. The kit of claim 51 wherein the polypeptide binding agents are antibodies.

54. The kit of claim 51 wherein the substance known to induce the lean phenotype is CLA.

55. A means for communicating information about or instructions for one or more of (1) using polynucleotides encoding proteins listed in any of Tables 6-13, or the proteins encoded thereby, or fragments thereof, for detecting expression of genes differentially expressed in animals exhibiting a lean phenotype; (2) using polynucleotides encoding proteins listed in any of Tables 6-13, or the proteins encoded thereby, or fragments thereof, for measuring the effect of a test substance on expression of genes differentially expressed in animals exhibiting lean phenotype; (3) using polynucleotides encoding proteins listed in any of Tables 6-13, or the proteins encoded thereby, or fragments thereof, for screening a test substance to determine if it is likely to modulate expression of genes differentially expressed in animals exhibiting a lean phenotype; (4) using polynucleotides encoding proteins listed in any of Tables 6-13, or the proteins encoded thereby, or fragments thereof, for modulating expression of one or more genes differentially expressed in animals exhibiting a lean phenotype; (5) using a computer system comprising a database containing information identifying expression levels of one or more polynucleotides that are differentially expressed in animals exhibiting a lean phenotype, wherein the polynucleotides are selected from genes encoding proteins listed in any of Tables 6-13, or fragments thereof; and (6) administering substances identified through their ability to cause differential expression of one or more genes encoding proteins listed in any of Tables 6-13 as likely to be useful in promoting a lean phenotype when administered to an animal; wherein the means comprises one or more of a document, a digital storage medium, an optical storage medium, an audio presentation or a visual display containing the information or instructions.

56. The means of claim 55 selected from the group consisting of a displayed web site, a kiosk, brochure, product label, package insert, advertisement, handout, public announcement audiotape, videotape, DVD, CD, computer-readable chip, computer-readable card, computer-readable disk, computer memory, or combination thereof.