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WO2009075344A1 - M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用 - Google Patents

M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用 Download PDF

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Publication number
WO2009075344A1
WO2009075344A1 PCT/JP2008/072609 JP2008072609W WO2009075344A1 WO 2009075344 A1 WO2009075344 A1 WO 2009075344A1 JP 2008072609 W JP2008072609 W JP 2008072609W WO 2009075344 A1 WO2009075344 A1 WO 2009075344A1
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Prior art keywords
leukemia
csf receptor
moz
mll
therapeutic agent
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PCT/JP2008/072609
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English (en)
French (fr)
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Issay Kitabayashi
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Japan As Represented By Director General Of Agency Of National Cancer Center
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Application filed by Japan As Represented By Director General Of Agency Of National Cancer Center filed Critical Japan As Represented By Director General Of Agency Of National Cancer Center
Priority to US12/747,848 priority Critical patent/US20110262425A1/en
Priority to JP2009545453A priority patent/JPWO2009075344A1/ja
Priority to EP08860018A priority patent/EP2241333A1/en
Publication of WO2009075344A1 publication Critical patent/WO2009075344A1/ja

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Abstract

　本発明の目的は、M-CSF受容体阻害剤を有効成分として含有するMLL白血病及びMOZ白血病治療剤を提供することにある。また、M-CSF受容体の発現または活性を抑制し、白血病を治療または予防する医薬組成物のスクリーニング方法の提供も課題とする。さらにM-CSF受容体の発現量を測定する工程を含む、白血病の検査方法の提供も課題とする。本発明者らは、上記の課題を解決するために、鋭意検討を行い、難治性急性白血病であるMLL白血病及びMOZ白血病を誘導する活性のある細胞（白血病幹細胞）において、M-CSF受容体（M-CSFR、CSF1R、c-FMS、CD115）の発現が高いこと、すなわちM-CSF受容体シグナルが白血病の発症に密接に結びついていることを見出した。
PCT/JP2008/072609 2007-12-12 2008-12-12 M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用 WO2009075344A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/747,848 US20110262425A1 (en) 2007-12-12 2008-12-12 Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
JP2009545453A JPWO2009075344A1 (ja) 2007-12-12 2008-12-12 Ｍ−ｃｓｆ受容体を分子標的とするｍｌｌ白血病及びｍｏｚ白血病治療剤、およびその利用
EP08860018A EP2241333A1 (en) 2007-12-12 2008-12-12 Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-321256 2007-12-12
JP2007321256 2007-12-12

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WO2009075344A1 true WO2009075344A1 (ja) 2009-06-18

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US (1) US20110262425A1 (ja)
EP (1) EP2241333A1 (ja)
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8747845B2 (en) 2010-05-04 2014-06-10 Five Prime Therapeutics, Inc. Methods of treatment by administering antibodies that bind colony stimulating factor 1 receptor (CSF1R)
US9243066B2 (en) 2011-07-18 2016-01-26 University Of Melbourne Use of M-CSF antibodies in the treatment of osteoarthritis or pain
JP2016529265A (ja) * 2013-08-30 2016-09-23 ユーシービー バイオファルマ エスピーアールエル 線維性疾患の処置のための方法
US9765147B2 (en) 2014-10-29 2017-09-19 Five Prime Therapeutics, Inc. Anti-CSFR1 antibody and anti PD-1 antibody combination therapy for cancer
US9856316B2 (en) 2013-04-12 2018-01-02 Morphosys Ag Antibodies targeting M-CSF
US10040858B2 (en) 2014-12-22 2018-08-07 Five Prime Therapeutics, Inc. Anti-CSF1R antibodies for treating PVNS
US10221243B2 (en) 2012-08-31 2019-03-05 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)
WO2020033791A1 (en) 2018-08-09 2020-02-13 Verseau Therapeutics, Inc. Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
WO2020203950A1 (ja) 2019-03-29 2020-10-08 興和株式会社 新規アザインドール誘導体
US10975153B2 (en) 2014-06-23 2021-04-13 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)
US10982001B2 (en) 2012-05-11 2021-04-20 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)
US11421034B2 (en) 2017-09-13 2022-08-23 Five Prime Therapeutics, Inc. Combination anti-CSF1R and anti-PD-1 antibody combination therapy for pancreatic cancer
US11559583B2 (en) 2015-04-13 2023-01-24 Five Prime Therapeutics, Inc. Anti-CSF1R antibody and agonistic anti-CD40 antibody combination therapy for cancer

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062399A2 (en) 2008-11-26 2010-06-03 Five Prime Therapeutics, Inc. Csf1r extracellular domain fusion molecules and treatments using same
US8183207B2 (en) 2008-11-26 2012-05-22 Five Prime Therapeutics, Inc. Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules

Citations (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0058481A1 (en) 1981-02-16 1982-08-25 Zeneca Limited Continuous release pharmaceutical compositions
EP0125023A1 (en) 1983-04-08 1984-11-14 Genentech, Inc. Recombinant immunoglobulin preparations, methods for their preparation, DNA sequences, expression vectors and recombinant host cells therefor
EP0133988A2 (de) 1983-08-02 1985-03-13 Hoechst Aktiengesellschaft Regulatorische Peptide enthaltende pharmazeutische Präparate mit protrahierter Freisetzung und Verfahren zu deren Herstellung
EP0239400A2 (en) 1986-03-27 1987-09-30 Medical Research Council Recombinant antibodies and methods for their production
JPH0159878B2 (ja) 1982-05-21 1989-12-20 Yunibaashitei Obu Karifuorunia
WO1992001047A1 (en) 1990-07-10 1992-01-23 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1992019759A1 (en) 1991-04-25 1992-11-12 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
WO1992020791A1 (en) 1990-07-10 1992-11-26 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993019172A1 (en) 1992-03-24 1993-09-30 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
WO1994011523A2 (en) 1992-11-13 1994-05-26 Idec Pharmaceuticals Corporation Fully impaired consensus kozac sequences for mammalian expression
WO1994025585A1 (en) 1993-04-26 1994-11-10 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1995001438A1 (en) 1993-06-30 1995-01-12 Medical Research Council Sbp members with a chemical moiety covalently bound within the binding site; production and selection thereof
WO1995015388A1 (en) 1993-12-03 1995-06-08 Medical Research Council Recombinant binding proteins and peptides
WO1996030394A1 (en) 1995-03-31 1996-10-03 Jakob Bohr Method for protein folding
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice

Patent Citations (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0058481A1 (en) 1981-02-16 1982-08-25 Zeneca Limited Continuous release pharmaceutical compositions
JPH0159878B2 (ja) 1982-05-21 1989-12-20 Yunibaashitei Obu Karifuorunia
EP0125023A1 (en) 1983-04-08 1984-11-14 Genentech, Inc. Recombinant immunoglobulin preparations, methods for their preparation, DNA sequences, expression vectors and recombinant host cells therefor
EP0133988A2 (de) 1983-08-02 1985-03-13 Hoechst Aktiengesellschaft Regulatorische Peptide enthaltende pharmazeutische Präparate mit protrahierter Freisetzung und Verfahren zu deren Herstellung
EP0239400A2 (en) 1986-03-27 1987-09-30 Medical Research Council Recombinant antibodies and methods for their production
WO1992001047A1 (en) 1990-07-10 1992-01-23 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1992020791A1 (en) 1990-07-10 1992-11-26 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1992019759A1 (en) 1991-04-25 1992-11-12 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993019172A1 (en) 1992-03-24 1993-09-30 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
WO1994011523A2 (en) 1992-11-13 1994-05-26 Idec Pharmaceuticals Corporation Fully impaired consensus kozac sequences for mammalian expression
WO1994025585A1 (en) 1993-04-26 1994-11-10 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1995001438A1 (en) 1993-06-30 1995-01-12 Medical Research Council Sbp members with a chemical moiety covalently bound within the binding site; production and selection thereof
WO1995015388A1 (en) 1993-12-03 1995-06-08 Medical Research Council Recombinant binding proteins and peptides
WO1996030394A1 (en) 1995-03-31 1996-10-03 Jakob Bohr Method for protein folding
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice

Non-Patent Citations (72)

* Cited by examiner, † Cited by third party
Title
AIKAWA, Y., EMBO J, vol. 25, 2006, pages 3955 - 65
ALTSCHUL SF ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
ASHMUN,RA ET AL.: "Monoclonal Antibodies to the Human CSF-1 Receptor (c-fms Proto-Oncogene Product) Detect Epitopes on Normal Mononuclear Phagocytes and on Human Myeloid Leukemic Blast Cells", BLOOD, vol. 73, no. 3, 15 February 1989 (1989-02-15), pages 827 - 837, XP002505053 *
BELYAVSKY, A. ET AL., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
BETTER, M. ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
BORROW, J. ET AL., NAT. GENET., vol. 14, 1996, pages 33 - 4
BURNETT, S. H. ET AL., J LEUKOC BIOL, vol. 75, 2004, pages 612 - 23
CAMOS, M. ET AL., CANCER RES, vol. 66, 2006, pages 6947 - 54
CARAPETI, M. ET AL., BLOOD, vol. 91, 1998, pages 3127 - 3133
CHAFFANET, M. ET AL., GENES CHROMOSOMES CANCER, vol. 28, 2000, pages 138 - 144
CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294 - 5299
CHOMCZYNSKI, P. ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
CORRAL, J. ET AL., CELL, vol. 85, 1996, pages 853 - 61
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
DE ST. GROTH, S. F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
DEGUCHI, K. ET AL., CANCER CELL, vol. 3, 2003, pages 259 - 271
DEGUCHI, K. ET AL., CANCER CELL, vol. 3, 2003, pages 259 - 71
DEWAR, A. L. ET AL., BLOOD, vol. 105, 2005, pages 3127 - 32
DEWAR, A. L. ET AL., CELL CYCLE, vol. 4, 2005, pages 851 - 3
DEWAR,AL ET AL.: "Inhibition of c-fms by Imatinib", CELL CYCLE, vol. 4, no. 7, July 2005 (2005-07-01), pages 851 - 853, XP009093634 *
DEWAR,AL ET AL.: "Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib", BLOOD, vol. 105, no. 8, 15 April 2005 (2005-04-15), pages 3127 - 3132, XP008092299 *
DIMARTINO, J. F. ET AL., BLOOD, vol. 99, 2002, pages 3780 - 5
DIMARTINO, J. F. ET AL., BLOOD, vol. 99, 2002, pages 3780 - 59
DOU, Y.; HESS, J. L., INT J HEMATOL, vol. 87, 2008, pages 10 - 8
DRUKER, BJ. ET AL., NAT. MED., vol. 2, 1996, pages 561 - 566
DUBREULI,P ET AL.: "c-fms Expression Is a Molecular Marker of Human Acute Myeloid Leukemias", BLOOD, vol. 72, no. 3, 1 September 1988 (1988-09-01), pages 1081 - 1085, XP008137446 *
EBERT, K.M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
FADERL, S. ET AL., N ENGL J MED, vol. 341, 1999, pages 164 - 172
FORSTER, A. ET AL., CELL, vol. 3, 2003, pages 449 - 58
FROHMAN, M. A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
GALFRE, G ET AL., NATURE, vol. 277, 1979, pages 131 - 133
GILLILAND, D. G., SEMIN HEMATOL, vol. 39, 2002, pages 6 - 11
HUNTLY, B. J. ET AL., CANCER CELL, vol. 6, 2004, pages 587 - 96
HURET, J. L. ET AL., LEUKEMIA, vol. 15, 2001, pages 987 - 989
JIN, G. ET AL., BLOOD, vol. 109, 2007, pages 3998 - 4005
JULIAN K.-C. MA ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 131 - 138
KARIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
KATSUMOTO, T. ET AL., GENES DEV, vol. 20, 2006, pages 1321 - 30
KEARNEY, J. F. ET AL., J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
KITABAYASHI, I. ET AL., EMBO J, vol. 20, 2001, pages 7184 - 96
KITABAYASHI, I. ET AL., LEUKEMIA, vol. 15, 2001, pages 89 - 94
KOHLER. G; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
KOHLER. G; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
LAVAU, C. ET AL., EMBO J, vol. 16, 1997, pages 4226 - 37
LEI, S. P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379 - 4383
LIANG, J. ET AL., BLOOD, vol. 92, 1998, pages 2118 - 2122
LOOK, A.T., SCIENCE, vol. 278, 1997, pages 1059 - 1064
MAEDA, S. ET AL., NATURE, vol. 315, 1985, pages 592 - 594
MARGULIES. D. H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
MEYER, C. ET AL., LEUKEMIA, vol. 20, 2006, pages 777 - 784
MIZUSHIMA, S.; NAGATA, S., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
MULLIGAN, R. C. ET AL., NATURE, vol. 277, 1979, pages 108 - 114
ODERO, M. D. ET AL., GENES CHROMOSOMES CANCER, vol. 29, 2000, pages 333 - 8
PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
SATO, K. ET AL., CANCER RES., vol. 53, 1993, pages 851 - 856
SAWYERS, CL. ET AL., N ENGL J MED, vol. 340, 1999, pages 1330 - 1340
SCAPPINI,B ET AL.: "Effects of Signal Transduction Inhibitor 571 in Acute Myelogenous Leukemia Cells", CLIN. CANCER RES, vol. 7, no. 12, December 2001 (2001-12-01), pages 3884 - 3893, XP008137445 *
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
TAYLOR, J. R. ET AL., ONCOGENE, vol. 25, 2006, pages 147 - 51
TROWBRIDGE, I. S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
TSUCHIYA, S. ET AL., INT J CANCER, vol. 26, 1980, pages 171 - 6
TUERK, C.; GOLD, L., SCIENCE, vol. 249, 1990, pages 505 - 510
VICKI GLASER, SPECTRUM BIOTECHNOLOGY APPLICATIONS, 1993
WALSH, J. C. ET AL., IMMUNITY, vol. 17, 2002, pages 665 - 76
WARD, E. S. ET AL., FASEB J., vol. 6, 1992, pages 2422 - 2427
WARD, E. S. ET AL., NATURE, vol. 341, 1989, pages 544 - 546
YOKOYAMA, A. ET AL., CELL, vol. 123, 2005, pages 207 - 18
ZHANG, D. E. ET AL., MOL CELL BIOL, vol. 14, 1994, pages 373 - 81
ZHANG, D. E. ET AL., MOL CELL BIOL, vol. 16, 1996, pages 1231 - 40

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