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WO2008142986A1 - Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する含窒素複素環誘導体 - Google Patents

Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する含窒素複素環誘導体 Download PDF

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Publication number
WO2008142986A1
WO2008142986A1 PCT/JP2008/058461 JP2008058461W WO2008142986A1 WO 2008142986 A1 WO2008142986 A1 WO 2008142986A1 JP 2008058461 W JP2008058461 W JP 2008058461W WO 2008142986 A1 WO2008142986 A1 WO 2008142986A1
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WO
WIPO (PCT)
Prior art keywords
optionally substituted
hydrogen
substituted alkyl
hydroxysteroid dehydrogenase
dehydrogenase type
Prior art date
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PCT/JP2008/058461
Other languages
English (en)
French (fr)
Inventor
Koji Masuda
Tomoyuki Ogawa
Takuji Nakatani
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009515137A priority Critical patent/JP4671369B2/ja
Priority to CA2689659A priority patent/CA2689659C/en
Priority to DK08764258T priority patent/DK2163543T3/en
Priority to CN200880025349.3A priority patent/CN101754954B/zh
Priority to MX2009012283A priority patent/MX2009012283A/es
Priority to BRPI0811191-0A2A priority patent/BRPI0811191A2/pt
Priority to PL08764258T priority patent/PL2163543T3/pl
Priority to EP08764258.3A priority patent/EP2163543B1/en
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Priority to KR1020127009630A priority patent/KR101376432B1/ko
Priority to US12/599,133 priority patent/US8383622B2/en
Priority to ES08764258.3T priority patent/ES2535317T3/es
Priority to AU2008252185A priority patent/AU2008252185B2/en
Publication of WO2008142986A1 publication Critical patent/WO2008142986A1/ja
Priority to HK10107274.0A priority patent/HK1140766A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Ｉ型１１βヒドロキシステロイド脱水素酵素阻害剤として有用な化合物を提供する。 式（Ⅰ）： （式中、 環Ａは、（ⅠⅠ） であり、 環Ｂは、置換されていてもよいヘテロアリール（ただし、置換されていてもよいイソキサゾールは除く。）または置換されていてもよいヘテロサイクルであり、 Ｒ１は水素または置換されていてもよいアルキルであり、 Ｒ２は－ＯＲ５、－ＳＲ５、ハロゲンまたはハロゲン化アルキル等であり、 Ｒ３は置換されていてもよいアルキル等であり、 Ｒ４は置換されていてもよいアルキル等あり、 Ｒ５は置換されていてもよいアルキル等であり、 Ｒ６は水素等であり、 Ｒ７およびＲ８は各々独立して水素等であり、 Ｒ１０およびＲ１１は各々独立して水素等であり、 Ｒ１２は置換されていてもよいアルキル等であり、 ｍおよびｐは各々独立して１～３の整数である。）で示される化合物、その製薬上許容される塩またはそれらの溶媒和物。
PCT/JP2008/058461 2007-05-18 2008-05-07 Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する含窒素複素環誘導体 WO2008142986A1 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
PL08764258T PL2163543T3 (pl) 2007-05-18 2008-05-07 Heterocykliczna pochodna zawierająca azot o aktywności hamującej dehydrogenazę 11-beta-hydroksysteroidową typu I
DK08764258T DK2163543T3 (en) 2007-05-18 2008-05-07 Nitrogenholdigt heterocyklisk derivat med 11beta-hydroxysteroiddehydrogenase-type 1-inhibitorisk aktivitet
CN200880025349.3A CN101754954B (zh) 2007-05-18 2008-05-07 具有11β-羟基类固醇脱氢酶Ⅰ型抑制活性的含氮杂环衍生物
MX2009012283A MX2009012283A (es) 2007-05-18 2008-05-07 Derivado heterociclico que contiene nitrogeno que tiene actividad inhibitoria de 11beta-hidroxiesteroide-deshidrogenasa tipo 1.
BRPI0811191-0A2A BRPI0811191A2 (pt) 2007-05-18 2008-05-07 Derivado heterocíclico contendo nitrogênio tendo atividade inibitória para 11beta-hidroxiesteroide deidrogenase tipo 1
JP2009515137A JP4671369B2 (ja) 2007-05-18 2008-05-07 Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する含窒素複素環誘導体
EP08764258.3A EP2163543B1 (en) 2007-05-18 2008-05-07 Nitrogen-containing heterocyclic derivative having 11 beta-hydroxysteroid dehydrogenase type i inhibitory activity
CA2689659A CA2689659C (en) 2007-05-18 2008-05-07 Nitrogen-containing heterocyclic derivative having 11.beta.-hydroxysteroid dehydrogenase type 1 inhibitory activity
KR1020127009630A KR101376432B1 (ko) 2007-05-18 2008-05-07 １１β-하이드록시스테로이드 탈수소효소 유형 １ 저해 활성을 갖는 질소-함유 헤테로환형 유도체
US12/599,133 US8383622B2 (en) 2007-05-18 2008-05-07 Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity
ES08764258.3T ES2535317T3 (es) 2007-05-18 2008-05-07 Derivado heterocíclico que contiene nitrógeno que tiene actividad inhibidora de la 11 beta-hidroxiesteroide deshidrogenasa de tipo 1
AU2008252185A AU2008252185B2 (en) 2007-05-18 2008-05-07 Nitrogen-containing heterocyclic derivative having 11 beta-hydroxysteroid dehydrogenase type I inhibitory activity
HK10107274.0A HK1140766A1 (en) 2007-05-18 2010-07-29 Nitrogen-containing heterocyclic derivative having 11 beta-hydroxysteroid dehydrogenase type i inhibitory activity 11- i

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007132259 2007-05-18
JP2007-132259 2007-05-18
JP2007327114 2007-12-19
JP2007-327114 2007-12-19

Publications (1)

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WO2008142986A1 true WO2008142986A1 (ja) 2008-11-27

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Country Status (16)

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US (1) US8383622B2 (ja)
EP (1) EP2163543B1 (ja)
JP (2) JP4671369B2 (ja)
KR (2) KR101376432B1 (ja)
CN (2) CN103288738B (ja)
AU (1) AU2008252185B2 (ja)
BR (1) BRPI0811191A2 (ja)
CA (1) CA2689659C (ja)
DK (1) DK2163543T3 (ja)
ES (1) ES2535317T3 (ja)
HK (1) HK1140766A1 (ja)
MX (1) MX2009012283A (ja)
PL (1) PL2163543T3 (ja)
RU (1) RU2455285C2 (ja)
TW (1) TWI426902B (ja)
WO (1) WO2008142986A1 (ja)

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EP2243479A2 (en) 2009-04-20 2010-10-27 Abbott Laboratories Novel amide and amidine derivates and uses thereof
US7951833B2 (en) 2008-02-04 2011-05-31 Astrazeneca Ab Crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic acid 471
US7964618B2 (en) 2006-11-03 2011-06-21 Astrazeneca Ab Chemical compounds
WO2011078101A1 (ja) 2009-12-22 2011-06-30 塩野義製薬株式会社 アダマンタンアミン誘導体
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011142359A1 (ja) * 2010-05-10 2011-11-17 日産化学工業株式会社 スピロ化合物及びアディポネクチン受容体活性化薬
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WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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WO2012020724A1 (ja) 2010-08-09 2012-02-16 塩野義製薬株式会社 アミノアダマンタンカルバメート誘導体の製造方法
WO2012124781A1 (ja) 2011-03-17 2012-09-20 塩野義製薬株式会社 ピラゾールカルボン酸誘導体の製造方法
US8324265B2 (en) 2005-11-21 2012-12-04 Shionogi & Co., Ltd. Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity
US8383381B2 (en) 2007-09-27 2013-02-26 Shjonogi & Co., Ltd. Method for producing hydroxylated adaivjantane using cytochrome P450
US8383622B2 (en) 2007-05-18 2013-02-26 Shionogi & Co., Ltd. Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP2014517013A (ja) * 2011-06-10 2014-07-17 エスケー バイオファーマシューティカルズ カンパニー リミテッド ５−カルバモイルアダマンタン−２−イルアミド誘導体、その薬学的に許容可能な塩およびその製造方法
WO2017094743A1 (ja) * 2015-11-30 2017-06-08 塩野義製薬株式会社 Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する医薬組成物

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US8871208B2 (en) * 2009-12-04 2014-10-28 Abbvie Inc. 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof
CA2809112A1 (en) * 2010-09-03 2012-03-08 Dainippon Sumitomo Pharma Co., Ltd. Cyclic amide derivative
RU2533558C1 (ru) * 2013-08-06 2014-11-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) Способ получения 1-(1-адамантил)-3,4-динитро-5-(o-r)-1h-пиразолов
RU2532268C1 (ru) * 2013-08-06 2014-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) Способ получения 1-(1-адамантил)-3,4-динитро-5(n-нитропиразолил)-1h-пиразолов
CN111423396B (zh) * 2020-04-30 2023-01-06 沈阳药科大学 一种sEH抑制剂及其制备方法和应用

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CA2689659C (en) 2012-10-23
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RU2455285C2 (ru) 2012-07-10
AU2008252185A1 (en) 2008-11-27
CN103288738B (zh) 2016-03-16
BRPI0811191A2 (pt) 2014-10-29
KR20140057689A (ko) 2014-05-13
CN101754954A (zh) 2010-06-23
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