WO2006035300A3 - A process for the preparation of meropenem - Google Patents
A process for the preparation of meropenem Download PDFInfo
- Publication number
- WO2006035300A3 WO2006035300A3 PCT/IB2005/002889 IB2005002889W WO2006035300A3 WO 2006035300 A3 WO2006035300 A3 WO 2006035300A3 IB 2005002889 W IB2005002889 W IB 2005002889W WO 2006035300 A3 WO2006035300 A3 WO 2006035300A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- meropenem
- present
- provides
- invention further
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1896/DEL/2004 | 2004-09-30 | ||
IN1895/DEL/2004 | 2004-09-30 | ||
IN1896DE2004 | 2004-09-30 | ||
IN1895DE2004 | 2004-09-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006035300A2 WO2006035300A2 (en) | 2006-04-06 |
WO2006035300A3 true WO2006035300A3 (en) | 2006-08-31 |
Family
ID=35510909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/002889 WO2006035300A2 (en) | 2004-09-30 | 2005-09-28 | A process for the preparation of meropenem |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006035300A2 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5247449B2 (en) * | 2005-09-15 | 2013-07-24 | オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド | Improved process for preparing β-lactam antibiotics |
US20100240886A1 (en) * | 2006-03-28 | 2010-09-23 | Kaneka Corporation | Process for producing carbapenem compound |
KR100869165B1 (en) | 2007-09-13 | 2008-11-19 | 조동옥 | Process for preparing meropenem |
EP2098525A1 (en) * | 2008-02-26 | 2009-09-09 | Savior Lifetec Corporation | Crystalline carbapenem compound and produced method thereof |
US8097719B2 (en) | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
CN101348486B (en) * | 2008-08-29 | 2010-09-29 | 深圳市海滨制药有限公司 | Preparation of meropenem |
ES2477290T3 (en) | 2009-03-13 | 2014-07-16 | Daewoong Pharmaceutical Co., Ltd. | Improved method to prepare meropenem using zinc powder |
JP2012525339A (en) * | 2009-04-30 | 2012-10-22 | 石葯集団中奇制葯技▲術▼(石家庄)有限公司 | ELTAPENEM INTERMEDIATE, ELTAPENEM COMPOSITION, AND METHOD FOR PREPARING THEM |
KR101142757B1 (en) * | 2009-12-03 | 2012-05-08 | (주)하이텍팜 | Process for preparing meropenem trihydrate |
US8318716B2 (en) | 2009-12-31 | 2012-11-27 | Kbp Biosciences Co., Ltd. | Carbapenem derivatives |
CN101891742B (en) * | 2010-07-20 | 2012-06-27 | 深圳市海滨制药有限公司 | Preparation method of meropenem trihydrate crystal |
CN101914098B (en) * | 2010-07-20 | 2012-08-15 | 深圳市海滨制药有限公司 | Preparation method of Meropenem trihydrate crystals |
CN102153554A (en) * | 2010-09-21 | 2011-08-17 | 重庆天地药业有限责任公司 | Method for preparing meropenem |
WO2012052978A1 (en) | 2010-10-22 | 2012-04-26 | Ranbaxy Laboratories Limited | A process for the preparation of pure meropenem trihydrate |
CN102532140B (en) * | 2010-12-21 | 2015-03-11 | 北大方正集团有限公司 | Method for preparing meropenem trihydrate |
CN102250096B (en) * | 2011-09-05 | 2016-04-06 | 江西华邦药业有限公司 | A kind of preparation method of meropenem |
CN102372715A (en) * | 2011-12-07 | 2012-03-14 | 凯莱英医药集团(天津)股份有限公司 | Method for preparing meropenem |
KR102144777B1 (en) | 2013-06-19 | 2020-08-18 | 제이더블유중외제약 주식회사 | A process for the preparation of crystalline Meropenem trihydrate |
CN105194436A (en) * | 2015-10-26 | 2015-12-30 | 张刚 | Topical application medicine for eliminating appendicular abscess |
CN111992205B (en) * | 2020-09-07 | 2023-06-16 | 西安凯立新材料股份有限公司 | Method for preparing catalyst for meropenem by one-pot method |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0169410A1 (en) * | 1984-07-02 | 1986-01-29 | Merck & Co. Inc. | Carbapenems having a 2-quaternary pyridine altylthio or pyridine alkenylthio substituent, compositions containing the same and combinations with DHP inhibitors |
US4888344A (en) * | 1986-07-30 | 1989-12-19 | Sumitomo Pharmaceuticals Company, Limited | Carbapenem compound in crystalline form, and its production and use |
US5122604A (en) * | 1983-05-09 | 1992-06-16 | Sumitomo Pharmaceuticals Co., Ltd. | β-lactam compounds |
US5140030A (en) * | 1985-06-10 | 1992-08-18 | Merck | 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids |
US20020128283A1 (en) * | 2000-07-13 | 2002-09-12 | American Home Products Corporation | Process improvement in the preparation of (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
WO2002094828A1 (en) * | 2001-05-18 | 2002-11-28 | Ranbaxy Laboratories Limited | Process for the preparation of imipenem |
WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
-
2005
- 2005-09-28 WO PCT/IB2005/002889 patent/WO2006035300A2/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5122604A (en) * | 1983-05-09 | 1992-06-16 | Sumitomo Pharmaceuticals Co., Ltd. | β-lactam compounds |
EP0169410A1 (en) * | 1984-07-02 | 1986-01-29 | Merck & Co. Inc. | Carbapenems having a 2-quaternary pyridine altylthio or pyridine alkenylthio substituent, compositions containing the same and combinations with DHP inhibitors |
US5140030A (en) * | 1985-06-10 | 1992-08-18 | Merck | 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids |
US4888344A (en) * | 1986-07-30 | 1989-12-19 | Sumitomo Pharmaceuticals Company, Limited | Carbapenem compound in crystalline form, and its production and use |
US20020128283A1 (en) * | 2000-07-13 | 2002-09-12 | American Home Products Corporation | Process improvement in the preparation of (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
WO2002094828A1 (en) * | 2001-05-18 | 2002-11-28 | Ranbaxy Laboratories Limited | Process for the preparation of imipenem |
WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
Also Published As
Publication number | Publication date |
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WO2006035300A2 (en) | 2006-04-06 |
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