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WO2006035300A3 - A process for the preparation of meropenem - Google Patents

A process for the preparation of meropenem Download PDF

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Publication number
WO2006035300A3
WO2006035300A3 PCT/IB2005/002889 IB2005002889W WO2006035300A3 WO 2006035300 A3 WO2006035300 A3 WO 2006035300A3 IB 2005002889 W IB2005002889 W IB 2005002889W WO 2006035300 A3 WO2006035300 A3 WO 2006035300A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
meropenem
present
provides
invention further
Prior art date
Application number
PCT/IB2005/002889
Other languages
French (fr)
Other versions
WO2006035300A2 (en
Inventor
Neera Tewari
Hashim Nizar Poovanathi Meeran
Bishwa Prakash Rai
Avinash Sheshrao Mane
Yatendra Kumar
Original Assignee
Ranbaxy Lab Ltd
Neera Tewari
Hashim Nizar Poovanathi Meeran
Bishwa Prakash Rai
Avinash Sheshrao Mane
Yatendra Kumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Neera Tewari, Hashim Nizar Poovanathi Meeran, Bishwa Prakash Rai, Avinash Sheshrao Mane, Yatendra Kumar filed Critical Ranbaxy Lab Ltd
Publication of WO2006035300A2 publication Critical patent/WO2006035300A2/en
Publication of WO2006035300A3 publication Critical patent/WO2006035300A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a one-pot process for the preparation of meropenem. The present invention further provides a process for the preparation of meropenem trihydrate.
PCT/IB2005/002889 2004-09-30 2005-09-28 A process for the preparation of meropenem WO2006035300A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1896/DEL/2004 2004-09-30
IN1895/DEL/2004 2004-09-30
IN1896DE2004 2004-09-30
IN1895DE2004 2004-09-30

Publications (2)

Publication Number Publication Date
WO2006035300A2 WO2006035300A2 (en) 2006-04-06
WO2006035300A3 true WO2006035300A3 (en) 2006-08-31

Family

ID=35510909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002889 WO2006035300A2 (en) 2004-09-30 2005-09-28 A process for the preparation of meropenem

Country Status (1)

Country Link
WO (1) WO2006035300A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5247449B2 (en) * 2005-09-15 2013-07-24 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド Improved process for preparing β-lactam antibiotics
US20100240886A1 (en) * 2006-03-28 2010-09-23 Kaneka Corporation Process for producing carbapenem compound
KR100869165B1 (en) 2007-09-13 2008-11-19 조동옥 Process for preparing meropenem
EP2098525A1 (en) * 2008-02-26 2009-09-09 Savior Lifetec Corporation Crystalline carbapenem compound and produced method thereof
US8097719B2 (en) 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
CN101348486B (en) * 2008-08-29 2010-09-29 深圳市海滨制药有限公司 Preparation of meropenem
ES2477290T3 (en) 2009-03-13 2014-07-16 Daewoong Pharmaceutical Co., Ltd. Improved method to prepare meropenem using zinc powder
JP2012525339A (en) * 2009-04-30 2012-10-22 石葯集団中奇制葯技▲術▼(石家庄)有限公司 ELTAPENEM INTERMEDIATE, ELTAPENEM COMPOSITION, AND METHOD FOR PREPARING THEM
KR101142757B1 (en) * 2009-12-03 2012-05-08 (주)하이텍팜 Process for preparing meropenem trihydrate
US8318716B2 (en) 2009-12-31 2012-11-27 Kbp Biosciences Co., Ltd. Carbapenem derivatives
CN101891742B (en) * 2010-07-20 2012-06-27 深圳市海滨制药有限公司 Preparation method of meropenem trihydrate crystal
CN101914098B (en) * 2010-07-20 2012-08-15 深圳市海滨制药有限公司 Preparation method of Meropenem trihydrate crystals
CN102153554A (en) * 2010-09-21 2011-08-17 重庆天地药业有限责任公司 Method for preparing meropenem
WO2012052978A1 (en) 2010-10-22 2012-04-26 Ranbaxy Laboratories Limited A process for the preparation of pure meropenem trihydrate
CN102532140B (en) * 2010-12-21 2015-03-11 北大方正集团有限公司 Method for preparing meropenem trihydrate
CN102250096B (en) * 2011-09-05 2016-04-06 江西华邦药业有限公司 A kind of preparation method of meropenem
CN102372715A (en) * 2011-12-07 2012-03-14 凯莱英医药集团(天津)股份有限公司 Method for preparing meropenem
KR102144777B1 (en) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 A process for the preparation of crystalline Meropenem trihydrate
CN105194436A (en) * 2015-10-26 2015-12-30 张刚 Topical application medicine for eliminating appendicular abscess
CN111992205B (en) * 2020-09-07 2023-06-16 西安凯立新材料股份有限公司 Method for preparing catalyst for meropenem by one-pot method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0169410A1 (en) * 1984-07-02 1986-01-29 Merck & Co. Inc. Carbapenems having a 2-quaternary pyridine altylthio or pyridine alkenylthio substituent, compositions containing the same and combinations with DHP inhibitors
US4888344A (en) * 1986-07-30 1989-12-19 Sumitomo Pharmaceuticals Company, Limited Carbapenem compound in crystalline form, and its production and use
US5122604A (en) * 1983-05-09 1992-06-16 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds
US5140030A (en) * 1985-06-10 1992-08-18 Merck 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US20020128283A1 (en) * 2000-07-13 2002-09-12 American Home Products Corporation Process improvement in the preparation of (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
WO2002094828A1 (en) * 2001-05-18 2002-11-28 Ranbaxy Laboratories Limited Process for the preparation of imipenem
WO2005118586A1 (en) * 2004-06-02 2005-12-15 Sandoz Ag Meropenem intermediate in crystalline form

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122604A (en) * 1983-05-09 1992-06-16 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds
EP0169410A1 (en) * 1984-07-02 1986-01-29 Merck & Co. Inc. Carbapenems having a 2-quaternary pyridine altylthio or pyridine alkenylthio substituent, compositions containing the same and combinations with DHP inhibitors
US5140030A (en) * 1985-06-10 1992-08-18 Merck 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US4888344A (en) * 1986-07-30 1989-12-19 Sumitomo Pharmaceuticals Company, Limited Carbapenem compound in crystalline form, and its production and use
US20020128283A1 (en) * 2000-07-13 2002-09-12 American Home Products Corporation Process improvement in the preparation of (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
WO2002094828A1 (en) * 2001-05-18 2002-11-28 Ranbaxy Laboratories Limited Process for the preparation of imipenem
WO2005118586A1 (en) * 2004-06-02 2005-12-15 Sandoz Ag Meropenem intermediate in crystalline form

Also Published As

Publication number Publication date
WO2006035300A2 (en) 2006-04-06

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