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WO2005013945A3 - Medicaments for inhalation comprising steroids and a betamimetic - Google Patents

Medicaments for inhalation comprising steroids and a betamimetic Download PDF

Info

Publication number
WO2005013945A3
WO2005013945A3 PCT/EP2004/008023 EP2004008023W WO2005013945A3 WO 2005013945 A3 WO2005013945 A3 WO 2005013945A3 EP 2004008023 W EP2004008023 W EP 2004008023W WO 2005013945 A3 WO2005013945 A3 WO 2005013945A3
Authority
WO
WIPO (PCT)
Prior art keywords
betamimetic
steroids
medicaments
inhalation
steroid
Prior art date
Application number
PCT/EP2004/008023
Other languages
French (fr)
Other versions
WO2005013945A2 (en
Inventor
Christopher John Montagu Meade
Michel Pairet
Michael P Pieper
Ingo Konetzki
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Christopher John Montagu Meade
Michel Pairet
Michael P Pieper
Ingo Konetzki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Christopher John Montagu Meade, Michel Pairet, Michael P Pieper, Ingo Konetzki filed Critical Boehringer Ingelheim Int
Priority to JP2006522264A priority Critical patent/JP2007501194A/en
Priority to EP04741127A priority patent/EP1654001A2/en
Priority to CA002534693A priority patent/CA2534693A1/en
Publication of WO2005013945A2 publication Critical patent/WO2005013945A2/en
Publication of WO2005013945A3 publication Critical patent/WO2005013945A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel pharmaceutical compositions comprising one or more, preferably one steroid 1 and a betamimetic of Formula (2) processes for preparing them and their use in the treatment of respiratory complaints.
PCT/EP2004/008023 2003-08-05 2004-07-17 Medicaments for inhalation comprising steroids and a betamimetic WO2005013945A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006522264A JP2007501194A (en) 2003-08-05 2004-07-17 Inhalable drugs including steroids and beta mimetics
EP04741127A EP1654001A2 (en) 2003-08-05 2004-07-17 Medicaments for inhalation comprising steroids and a betamimetic
CA002534693A CA2534693A1 (en) 2003-08-05 2004-07-17 Medicaments for inhalation comprising steroids and a betamimetic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03017814 2003-08-05
EP03017814.9 2003-08-05

Publications (2)

Publication Number Publication Date
WO2005013945A2 WO2005013945A2 (en) 2005-02-17
WO2005013945A3 true WO2005013945A3 (en) 2005-06-23

Family

ID=34130070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/008023 WO2005013945A2 (en) 2003-08-05 2004-07-17 Medicaments for inhalation comprising steroids and a betamimetic

Country Status (4)

Country Link
EP (1) EP1654001A2 (en)
JP (1) JP2007501194A (en)
CA (1) CA2534693A1 (en)
WO (1) WO2005013945A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR048339A1 (en) * 2004-03-24 2006-04-19 Chiesi Farma Spa 8- HYDROXI-5 MONOCLORHYDRATE - ((1R)) -1- HYDROXI-2- (((1R) -2 (4-METOXIFENIL) -1- METHYLETYL) AMINO) ETI L) -2 (1H) - QUINOLINONE EN ACRISTALINE FORM AND THE PROCESS FOR PREPARATION
DE102005007654A1 (en) * 2005-02-19 2006-08-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg New long-acting betamimetics for the treatment of respiratory diseases
DE102005030733A1 (en) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
EP2327403A3 (en) * 2007-02-19 2011-08-31 Cipla Limited Pharmaceutical combinations of at least two bronchodilators

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147719A2 (en) * 1983-12-24 1985-07-10 Tanabe Seiyaku Co., Ltd. Novel carbostyril derivative and process for preparing same
WO1998041193A1 (en) * 1997-03-20 1998-09-24 Schering Corporation Preparation of powder agglomerates
WO2001089480A1 (en) * 2000-05-22 2001-11-29 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurised metered dose inhalers
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
WO2004028545A1 (en) * 2002-09-25 2004-04-08 Astrazeneca Ab A COMBINATION OF A LONG-ACTING β2-AGONIST AND A GLUCOCORTICOSTEROID IN THE TREATMENT OF FIBROTIC DISEASES
EP1452179A1 (en) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804001D0 (en) * 1998-11-23 1998-11-23 Astra Ab New process
GB0123951D0 (en) * 2001-10-05 2001-11-28 Glaxo Group Ltd Therapies for treating respiratory diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147719A2 (en) * 1983-12-24 1985-07-10 Tanabe Seiyaku Co., Ltd. Novel carbostyril derivative and process for preparing same
WO1998041193A1 (en) * 1997-03-20 1998-09-24 Schering Corporation Preparation of powder agglomerates
WO2001089480A1 (en) * 2000-05-22 2001-11-29 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurised metered dose inhalers
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
WO2004028545A1 (en) * 2002-09-25 2004-04-08 Astrazeneca Ab A COMBINATION OF A LONG-ACTING β2-AGONIST AND A GLUCOCORTICOSTEROID IN THE TREATMENT OF FIBROTIC DISEASES
EP1452179A1 (en) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IZEBOUD, C. A. ET AL: "Stereoselectivity at the .beta.2-adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of .beta.2-agonists", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY , 362(2), 184-189 CODEN: NSAPCC; ISSN: 0028-1298, 2000, XP002300185 *
KIKKAWA, HIDEO ET AL: "Tracheal relaxing effects and .beta.2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues", JAPANESE JOURNAL OF PHARMACOLOGY , 57(2), 175-85 CODEN: JJPAAZ; ISSN: 0021-5198, 1991, XP008045059 *

Also Published As

Publication number Publication date
EP1654001A2 (en) 2006-05-10
JP2007501194A (en) 2007-01-25
WO2005013945A2 (en) 2005-02-17
CA2534693A1 (en) 2005-02-17

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