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WO2005043168A3 - Method for distinguishing aml-specific flt3 length mutations from tkd mutations - Google Patents

Method for distinguishing aml-specific flt3 length mutations from tkd mutations Download PDF

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Publication number
WO2005043168A3
WO2005043168A3 PCT/EP2004/012470 EP2004012470W WO2005043168A3 WO 2005043168 A3 WO2005043168 A3 WO 2005043168A3 EP 2004012470 W EP2004012470 W EP 2004012470W WO 2005043168 A3 WO2005043168 A3 WO 2005043168A3
Authority
WO
WIPO (PCT)
Prior art keywords
mutations
tkd
distinguishing aml
flt3 length
specific flt3
Prior art date
Application number
PCT/EP2004/012470
Other languages
French (fr)
Other versions
WO2005043168A2 (en
Inventor
Torsten Haferlach
Martin Dugas
Wolfgang Kern
Alexander Kohlmann
Susanne Schnittger
Claudia Schoch
Original Assignee
Roche Diagnostics Gmbh
Hoffmann La Roche
Torsten Haferlach
Martin Dugas
Wolfgang Kern
Alexander Kohlmann
Susanne Schnittger
Claudia Schoch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Hoffmann La Roche, Torsten Haferlach, Martin Dugas, Wolfgang Kern, Alexander Kohlmann, Susanne Schnittger, Claudia Schoch filed Critical Roche Diagnostics Gmbh
Priority to US10/575,600 priority Critical patent/US20070292970A1/en
Priority to EP04797597A priority patent/EP1682903A2/en
Publication of WO2005043168A2 publication Critical patent/WO2005043168A2/en
Publication of WO2005043168A3 publication Critical patent/WO2005043168A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medical Treatment And Welfare Office Work (AREA)

Abstract

Disclosed is a method for distinguishing AML-specific FLT3 length mutations from TKD mutations in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.
PCT/EP2004/012470 2003-11-04 2004-11-04 Method for distinguishing aml-specific flt3 length mutations from tkd mutations WO2005043168A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/575,600 US20070292970A1 (en) 2003-11-04 2004-11-04 Method for Distinguishing Aml-Specific Flt3 Length Mutations From Tkd Mutations
EP04797597A EP1682903A2 (en) 2003-11-04 2004-11-04 Method for distinguishing aml-specific flt3 length mutations from tkd mutations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025341.3 2003-11-04
EP03025341 2003-11-04

Publications (2)

Publication Number Publication Date
WO2005043168A2 WO2005043168A2 (en) 2005-05-12
WO2005043168A3 true WO2005043168A3 (en) 2005-08-11

Family

ID=34530667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/012470 WO2005043168A2 (en) 2003-11-04 2004-11-04 Method for distinguishing aml-specific flt3 length mutations from tkd mutations

Country Status (3)

Country Link
US (1) US20070292970A1 (en)
EP (1) EP1682903A2 (en)
WO (1) WO2005043168A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009120905A2 (en) * 2008-03-26 2009-10-01 Cellerant Therapeutics, Inc. Immunoglobulin and/or toll-like receptor proteins associated with myelogenous haematological proliferative disorders and uses thereof
CN103103251A (en) * 2011-11-15 2013-05-15 中山大学达安基因股份有限公司 Kit for detecting FLT3-ITD (Fms-like tyrosine kinase 3-internal tandem duplication) gene mutation by using fluorescence PCR (Polymerase Chain Reaction) capillary electrophoresis
CN108410981B (en) * 2018-01-23 2021-05-25 北京旌准医疗科技有限公司 Kit for detecting FLT3-D835 gene and application
CN113684277B (en) * 2021-09-06 2022-05-17 南方医科大学南方医院 Method for predicting ovarian cancer homologous recombination defect based on biomarker of genome copy number variation and application

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP1043676A2 (en) * 1999-04-09 2000-10-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes
EP1109020A1 (en) * 1998-08-20 2001-06-20 Chugai Seiyaku Kabushiki Kaisha Method for screening candidate compounds for drug against tumor
WO2003039443A2 (en) * 2001-11-05 2003-05-15 Deutsches Krebsforschungszentrum Novel genetic markers for leukemias

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US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
ATE428801T1 (en) * 1996-06-04 2009-05-15 Univ Utah Res Found MONITORING HYBRIDIZATION DURING PCR
WO2002101357A2 (en) * 2001-06-10 2002-12-19 Irm Llc Molecular signatures of commonly fatal carcinomas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1109020A1 (en) * 1998-08-20 2001-06-20 Chugai Seiyaku Kabushiki Kaisha Method for screening candidate compounds for drug against tumor
EP1043676A2 (en) * 1999-04-09 2000-10-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes
WO2003039443A2 (en) * 2001-11-05 2003-05-15 Deutsches Krebsforschungszentrum Novel genetic markers for leukemias

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
ALIZADEH A ET AL: "THE LYMPHOCHIP: A SPECIALIZED CDNA MICROARRAY FOR THE GENOMIC-SCALE ANALYSIS OF GENE EXPRESSION IN NORMAL AND MALIGNANT LYMPHOCYTES", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 64, no. 1, 1999, pages 71 - 78, XP001099007, ISSN: 0091-7451 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002, pages Abstract No. 1203, ISSN: 0006-4971 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002, pages Abstract No. 2172, ISSN: 0006-4971 *
BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), 44th Annual Meeting of the American Society of Hematology;Philadelphia, PA, USA; December 06-10, 2002, pages Abstract No. 310, ISSN: 0006-4971 *
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BLOOD, vol. 98, no. 11 Part 1, 16 November 2001 (2001-11-16), 43rd Annual Meeting of the American Society of Hematology, Part 1;Orlando, Florida, USA; December 07-11, 2001, pages 717a - 718a, ISSN: 0006-4971 *
BLOOD, vol. 98, no. 11 Part 2, 16 November 2001 (2001-11-16), 43rd Annual Meeting of the American Society of Hematology, Part 2;Orlando, Florida, USA; December 07-11, 2001, pages 190b, ISSN: 0006-4971 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), KOTTARIDIS PANAGIOTIS D ET AL: "Changes in the pattern of FLT3 mutations between diagnosis and relapse restricts their potential use as markers of minimal residual disease in patients with acute myeloid leukaemia", XP002272706, Database accession no. PREV200200220615 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2001 (2001-11-16), NIGRO CRISTIANA LO ET AL: "Internal tandem duplication and D385 mutation analysis of Flt3 gene in AML patients", XP002272703, Database accession no. PREV200200152170 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), KOHLMANN ALEXANDER ET AL: "A Simplified and Partially Automated Target Preparation Method for Gene Expression Profiling.", XP002269495, Database accession no. PREV200300367771 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), LACAYO NORMAN J ET AL: "Gene Expression Profiling of Pediatric Acute Myeloid Leukemia (AML) in De Novo and Relapsed Patients Reveals an Expression Signature That Correlates with FLT3-Internal Tandem Duplications (ITD), FLT3 Point Mutations, and KIT Point Mutations.", XP002272704, Database accession no. PREV200300356395 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), NEBEN KAI ET AL: "Acute Myeloid Leukemia with Normal Karyotype and Mutation of the FLT3 or MLL Gene Are Characterized by Specific Gene Expression Profiles.", XP002270208, Database accession no. PREV200300336869 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), SCHNITTGER SUSANNE ET AL: "Acute Myeloid Leukemia (AML) with FLT3-Length Mutations (FLT3-LM) Can Be Discriminated from AML without FLT3-LM in Distinct AML-Subtypes Based on Specific Gene Expression Profiles.", XP002272702, Database accession no. PREV200300335803 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2002 (2002-11-16), SCHNITTGER SUSANNE ET AL: "Networks of Molecular Mutations in Acute Myeloid Leukemia and Their Correlations to Cytogenetics and Morphology.", XP002272705, Database accession no. PREV200300357666 *
DEUTSCH J M: "Evolutionary algorithms for finding optimal gene sets in microarray prediction.", BIOINFORMATICS (OXFORD), vol. 19, no. 1, January 2003 (2003-01-01), pages 45 - 52, XP002272405, ISSN: 1367-4803 *
DUGAS M ET AL: "A comprehensive leukemia database: integration of cytogenetics, molecular genetics and microarray data with clinical information, cytomorphology and immunophenotyping", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 15, no. 12, December 2001 (2001-12-01), pages 1805 - 1810, XP002263731, ISSN: 0887-6924 *
DUGAS MARTIN ET AL: "Impact of integrating clinical and genetic information.", IN SILICO BIOLOGY, vol. 2, no. 3, 2002, pages 383 - 391, XP001179418, ISSN: 1386-6338 (ISSN print) *
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075 *
HAFERLACH T ET AL: "The Diagnosis of 14 Specific Subtypes of Leukemia Is Possible Based on Gene Expression Profiles: A Study on 263 Patients with AML, ALL, CML, or CLL", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 100, no. 11, 16 November 2002 (2002-11-16), pages 139A, XP002263227, ISSN: 0006-4971 *
KIYOI HITOSHI ET AL: "FLT3 in human hematologic malignancies.", LEUKEMIA & LYMPHOMA. ENGLAND AUG 2002, vol. 43, no. 8, August 2002 (2002-08-01), pages 1541 - 1547, XP009027222, ISSN: 1042-8194 *

Also Published As

Publication number Publication date
EP1682903A2 (en) 2006-07-26
US20070292970A1 (en) 2007-12-20
WO2005043168A2 (en) 2005-05-12

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