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WO2004005315A3 - Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design - Google Patents

Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design Download PDF

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Publication number
WO2004005315A3
WO2004005315A3 PCT/IB2003/003101 IB0303101W WO2004005315A3 WO 2004005315 A3 WO2004005315 A3 WO 2004005315A3 IB 0303101 W IB0303101 W IB 0303101W WO 2004005315 A3 WO2004005315 A3 WO 2004005315A3
Authority
WO
WIPO (PCT)
Prior art keywords
pin1
prolyl isomerase
peptidyl
crystal structures
drug design
Prior art date
Application number
PCT/IB2003/003101
Other languages
French (fr)
Other versions
WO2004005315A2 (en
Inventor
David Allan Matthews
Eleanor Ferronyalka Dagostino
Rose Ann Ferre
Smita Gaur
Chuangxing Guo
Xinjun Hou
Stephen Margosiak
Barbara Mroczkowski
Grace Reiko Nakayama
Hans Erich Parge
Jeff Xianchao Zhu
Original Assignee
Pfizer
David Allan Matthews
Eleanor Ferronyalka Dagostino
Rose Ann Ferre
Smita Gaur
Chuangxing Guo
Xinjun Hou
Stephen Margosiak
Barbara Mroczkowski
Grace Reiko Nakayama
Hans Erich Parge
Jeff Xianchao Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, David Allan Matthews, Eleanor Ferronyalka Dagostino, Rose Ann Ferre, Smita Gaur, Chuangxing Guo, Xinjun Hou, Stephen Margosiak, Barbara Mroczkowski, Grace Reiko Nakayama, Hans Erich Parge, Jeff Xianchao Zhu filed Critical Pfizer
Priority to EP03740984A priority Critical patent/EP1521825A2/en
Priority to CA002491591A priority patent/CA2491591A1/en
Priority to JP2004519118A priority patent/JP2005532061A/en
Priority to BRPI0312555-6A priority patent/BR0312555A/en
Priority to AU2003281358A priority patent/AU2003281358A1/en
Publication of WO2004005315A2 publication Critical patent/WO2004005315A2/en
Publication of WO2004005315A3 publication Critical patent/WO2004005315A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Polypeptides containing the PIN1 peptidyl-prolyl isomerase domain but not containing the PIN1 WW domain are described. Also described are crystal structures of these polypeptides, including the crystal structure of a PIN1 PPlaseaigand complex. The structure coordinate data derived from these crystals provides a three-dimensional description of the substrate-binding site of PIN1 peptidyl-prolyl isomerase useful in drug discovery and design for the identification and design of modulators of PIN1 peptidyl-prolyl isomerase activity.
PCT/IB2003/003101 2002-07-09 2003-06-27 Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design WO2004005315A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP03740984A EP1521825A2 (en) 2002-07-09 2003-06-27 Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design
CA002491591A CA2491591A1 (en) 2002-07-09 2003-06-27 Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design
JP2004519118A JP2005532061A (en) 2002-07-09 2003-06-27 PIN1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and their use for drug design
BRPI0312555-6A BR0312555A (en) 2002-07-09 2003-06-27 pin1 peptidyl prolyl isomerase polypeptides, their crystal structures and their use for drug design
AU2003281358A AU2003281358A1 (en) 2002-07-09 2003-06-27 Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39488902P 2002-07-09 2002-07-09
US60/394,889 2002-07-09

Publications (2)

Publication Number Publication Date
WO2004005315A2 WO2004005315A2 (en) 2004-01-15
WO2004005315A3 true WO2004005315A3 (en) 2004-07-01

Family

ID=30115784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/003101 WO2004005315A2 (en) 2002-07-09 2003-06-27 Pin1 peptidyl-prolyl isomerase polypeptides, their crystal structures, and use thereof for drug design

Country Status (7)

Country Link
US (1) US20040171019A1 (en)
EP (1) EP1521825A2 (en)
JP (1) JP2005532061A (en)
AU (1) AU2003281358A1 (en)
BR (1) BR0312555A (en)
CA (1) CA2491591A1 (en)
WO (1) WO2004005315A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972697A (en) * 1995-11-13 1999-10-26 The Salk Institute For Biological Studies NIMA interacting proteins
US7125677B2 (en) * 1995-11-13 2006-10-24 The Salk Institute For Biological Studies NIMA interacting proteins
EP1603926A1 (en) * 2003-03-10 2005-12-14 Pfizer Inc. Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1)
EP1771556A2 (en) * 2004-07-15 2007-04-11 Vernalis PLC Determination of a phosphorylation site in ppiase domain of pin1 and uses therefor
JP2008540571A (en) * 2005-05-12 2008-11-20 ウィスコンシン・アルムニ・リサーチ・ファウンデーション Pin1 blockade prevents cytokine production by activated immune cells
NZ595213A (en) * 2009-02-17 2014-03-28 Mcalister Technologies Llc Electrolytic cell and method of use thereof
WO2010134975A2 (en) * 2009-05-18 2010-11-25 The Scripps Research Institute Methods for enhancing infectivity of retroviruses
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
WO2017063757A1 (en) 2015-10-12 2017-04-20 Polyphor Ag Conformationally constrained macrocyclic compounds
WO2017063755A1 (en) 2015-10-12 2017-04-20 Polyphor Ag Conformationally constrained macrocyclic compounds
WO2017063754A1 (en) 2015-10-12 2017-04-20 Polyphor Ag Conformationally constrained macrocyclic compounds as pin1 modulators
CN110334416B (en) * 2019-06-18 2022-04-19 西北工业大学 Optimized design method for prefabricated blank during forging of dual-performance disc
CN116178568A (en) * 2022-11-29 2023-05-30 西南大学 Biological probe for detecting Pin1 isomerism activity and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999063931A2 (en) * 1998-06-09 1999-12-16 The Salk Institute For Biological Studies Peptidyl-prolyl cis-trans isomerase inhibitors and uses therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999063931A2 (en) * 1998-06-09 1999-12-16 The Salk Institute For Biological Studies Peptidyl-prolyl cis-trans isomerase inhibitors and uses therefor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BAYER ELENA ET AL: "Structural analysis of the mitotic regulator hPin1 in solution. Insights into domain architecture and substrate binding.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 28, 29 April 2003 (2003-04-29), &, pages 26183 - 26193, XP002276308, ISSN: 0021-9258 *
DATABASE SWISSPROT [online] 15 June 2002 (2002-06-15), "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Rotamase Pin1) (PPIase Pin1)", XP002276309, retrieved from NCBI Database accession no. Q13526 *
LU PEI-JUNG ET AL: "Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 4, 25 January 2002 (2002-01-25), &, pages 2381 - 2384, XP002276306, ISSN: 0021-9258 *
LU PEI-JUNG ET AL: "Function of WW domains as phosphoserine- or phosphothreonine-binding modules", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 283, no. 5406, 26 February 1999 (1999-02-26), pages 1325 - 1328, XP002148139, ISSN: 0036-8075 *
MESSENGER MOIRA M ET AL: "Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 25, 21 June 2002 (2002-06-21), &, pages 23054 - 23064, XP002276305, ISSN: 0021-9258 *
RANGANATHAN R ET AL: "Structural and functional analysis of the mitotic rotamase Pin1 suggessts substrate recognition is phosphorylation dependent", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 89, 13 June 1997 (1997-06-13), pages 875 - 886, XP002090538, ISSN: 0092-8674 *
VERDECIA MARK A ET AL: "Structural basis for phosphoserine-proline recognition by group IV WW domains", NATURE STRUCTURAL BIOLOGY, vol. 7, no. 8, August 2000 (2000-08-01), &, pages 639 - 643, XP002276307, ISSN: 1072-8368 *

Also Published As

Publication number Publication date
JP2005532061A (en) 2005-10-27
AU2003281358A1 (en) 2004-01-23
AU2003281358A8 (en) 2004-01-23
WO2004005315A2 (en) 2004-01-15
CA2491591A1 (en) 2004-01-15
EP1521825A2 (en) 2005-04-13
BR0312555A (en) 2007-06-19
US20040171019A1 (en) 2004-09-02

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