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WO2003003984A9 - Novel proteins and nucleic acids encoding same - Google Patents

Novel proteins and nucleic acids encoding same Download PDF

Info

Publication number
WO2003003984A9
WO2003003984A9 PCT/US2002/021268 US0221268W WO03003984A9 WO 2003003984 A9 WO2003003984 A9 WO 2003003984A9 US 0221268 W US0221268 W US 0221268W WO 03003984 A9 WO03003984 A9 WO 03003984A9
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
acids encoding
encoding same
novel proteins
proteins
Prior art date
Application number
PCT/US2002/021268
Other languages
French (fr)
Other versions
WO2003003984A2 (en
WO2003003984A8 (en
Inventor
Elma R Fernandes
Corine A M Vernet
Richard A Shimkets
David W Anderson
Muralidhara Padigaru
Ferenc L Boldog
Li Li
Suresh G Shenoy
Stacie J Casman
Luca Rastelli
John P Ii Alsobrook
Catherine E Burgess
William M Grosse
Vladimir Y Gusev
Weizhen Ji
Denise M Lepley
Xiaohong Liu
Amanda J Mezick
Meera Patturajan
Lei Shen
Steven K Spaderna
Kimberly A Spytek
Edward S Szekeres Jr
Raymond J Taupier Jr
Velizar T Tchernev
Bryan D Zerhusen
Edward Z Voss
Original Assignee
Curagen Corp
Elma R Fernandes
Corine A M Vernet
Richard A Shimkets
David W Anderson
Muralidhara Padigaru
Ferenc L Boldog
Li Li
Suresh G Shenoy
Stacie J Casman
Luca Rastelli
John P Ii Alsobrook
Catherine E Burgess
William M Grosse
Vladimir Y Gusev
Weizhen Ji
Denise M Lepley
Xiaohong Liu
Amanda J Mezick
Meera Patturajan
Lei Shen
Steven K Spaderna
Kimberly A Spytek
Edward S Szekeres Jr
Raymond J Taupier Jr
Velizar T Tchernev
Bryan D Zerhusen
Edward Z Voss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/965,212 external-priority patent/US20030003462A1/en
Application filed by Curagen Corp, Elma R Fernandes, Corine A M Vernet, Richard A Shimkets, David W Anderson, Muralidhara Padigaru, Ferenc L Boldog, Li Li, Suresh G Shenoy, Stacie J Casman, Luca Rastelli, John P Ii Alsobrook, Catherine E Burgess, William M Grosse, Vladimir Y Gusev, Weizhen Ji, Denise M Lepley, Xiaohong Liu, Amanda J Mezick, Meera Patturajan, Lei Shen, Steven K Spaderna, Kimberly A Spytek, Edward S Szekeres Jr, Raymond J Taupier Jr, Velizar T Tchernev, Bryan D Zerhusen, Edward Z Voss filed Critical Curagen Corp
Priority to AU2002327198A priority Critical patent/AU2002327198A1/en
Publication of WO2003003984A2 publication Critical patent/WO2003003984A2/en
Publication of WO2003003984A9 publication Critical patent/WO2003003984A9/en
Publication of WO2003003984A8 publication Critical patent/WO2003003984A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US2002/021268 2001-07-05 2002-07-03 Novel proteins and nucleic acids encoding same WO2003003984A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002327198A AU2002327198A1 (en) 2001-07-05 2002-07-03 Novel proteins and nucleic acids encoding same

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
US30316801P 2001-07-05 2001-07-05
US30324101P 2001-07-05 2001-07-05
US60/303,168 2001-07-05
US60/303,241 2001-07-05
US09/965,212 US20030003462A1 (en) 1999-04-09 2001-09-26 Novel human interleukin-like proteins and polynucleotides encoding them
US09/966,545 US20020172999A1 (en) 1999-04-09 2001-09-26 Novel KIAA1061-like cell adhesion molecule-like proteins and polynucleotides encoding them
US09/966,546 2001-09-26
US09/965,212 2001-09-26
US09/966,546 US20020168716A1 (en) 1999-04-09 2001-09-26 Novel amino acid sequences for human microfibril glycoprotein 4-like polypeptides
US09/966,545 2001-09-26
US36899602P 2002-04-01 2002-04-01
US36906502P 2002-04-01 2002-04-01
US60/368,996 2002-04-01
US60/369,065 2002-04-01
US37873002P 2002-05-08 2002-05-08
US60/378,730 2002-05-08
US38432702P 2002-05-30 2002-05-30
US60/384,327 2002-05-30
US38681602P 2002-06-07 2002-06-07
US60/386,816 2002-06-07
US17437202A 2002-06-17 2002-06-17
US10/174,372 2002-06-17

Publications (3)

Publication Number Publication Date
WO2003003984A2 WO2003003984A2 (en) 2003-01-16
WO2003003984A9 true WO2003003984A9 (en) 2009-05-22
WO2003003984A8 WO2003003984A8 (en) 2009-08-13

Family

ID=27581222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021268 WO2003003984A2 (en) 2001-07-05 2002-07-03 Novel proteins and nucleic acids encoding same

Country Status (1)

Country Link
WO (1) WO2003003984A2 (en)

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US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

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CA2481039A1 (en) * 2002-04-01 2003-10-16 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP3434275A1 (en) 2003-11-06 2019-01-30 Seattle Genetics, Inc. Assay for cancer cells based on the use of auristatin conjugates with antibodies
CN102973947A (en) 2004-06-01 2013-03-20 健泰科生物技术公司 Antibody-drug conjugates and methods
AU2005286607B2 (en) 2004-09-23 2011-01-27 Genentech, Inc. Cysteine engineered antibodies and conjugates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
CA2809819A1 (en) 2009-09-09 2011-03-17 Centrose, Llc Extracellular targeted drug conjugates
ES2430567T3 (en) 2010-04-15 2013-11-21 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
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ES2544608T3 (en) 2010-11-17 2015-09-02 Genentech, Inc. Antibody and alaninyl-maitansinol conjugates
RU2638806C2 (en) 2011-05-12 2017-12-15 Дженентек, Инк. Lc-ms/ms method for multiple reactions monitoring to identify therapeutic antibodies in animal species using framework signature peptides
WO2013055987A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
MX364327B (en) 2012-10-12 2019-04-23 Medimmune Ltd Pyrrolobenzodiazepine-anti-cd22 antibody conjugates.
AU2013328619B2 (en) 2012-10-12 2016-11-17 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-PSMA antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP2906250B1 (en) 2012-10-12 2018-05-30 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-psma antibody conjugates
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US9821074B2 (en) 2013-03-13 2017-11-21 Genentech, Inc. Pyrrolobenzodiazepines and conjugates thereof
CN105142674B (en) 2013-03-13 2018-11-13 麦迪穆有限责任公司 Pyrrolobenzodiazepines Zhuo and its conjugate
CN105636612B (en) 2013-08-12 2020-01-14 基因泰克公司 Antibody-drug conjugates and methods of use and treatment
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
MX371092B (en) 2013-12-16 2020-01-16 Genentech Inc Peptidomimetic compounds and antibody-drug conjugates thereof.
PE20161394A1 (en) 2013-12-16 2017-01-06 Genentech Inc PEPTIDOMIMETIC COMPOUNDS AND THEIR ANTIBODY-DRUG CONJUGATES
BR112016013258A2 (en) 2013-12-16 2018-01-16 Genentech Inc antibody-drug conjugate, pharmaceutical composition, method for treating cancer and kit
JP6531166B2 (en) 2014-09-10 2019-06-12 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Pyrrolobenzodiazepine and its conjugate
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
WO2016040825A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
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BR112017005393A2 (en) 2014-09-17 2017-12-05 Genentech Inc compound of formula I, method of preparing a conjugate of formula a, conjugate of formula a1, composition comprising a mixture of antibody-drug conjugate compounds, pharmaceutical composition, and use of a conjugate or composition
KR20170101895A (en) 2014-11-25 2017-09-06 에이디씨 테라퓨틱스 에스에이 Pyrrolobenzodiazepine-antibody conjugates
WO2016090050A1 (en) 2014-12-03 2016-06-09 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
MA43345A (en) 2015-10-02 2018-08-08 Hoffmann La Roche PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
MA43354A (en) 2015-10-16 2018-08-22 Genentech Inc CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE
MA45326A (en) 2015-10-20 2018-08-29 Genentech Inc CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
US20170315132A1 (en) 2016-03-25 2017-11-02 Genentech, Inc. Multiplexed total antibody and antibody-conjugated drug quantification assay
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN118436801A (en) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 PROTAC antibody conjugates and methods of use thereof
WO2017205741A1 (en) 2016-05-27 2017-11-30 Genentech, Inc. Bioanalytical method for the characterization of site-specific antibody-drug conjugates
US10639378B2 (en) 2016-06-06 2020-05-05 Genentech, Inc. Silvestrol antibody-drug conjugates and methods of use
WO2018031662A1 (en) 2016-08-11 2018-02-15 Genentech, Inc. Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
JP7050770B2 (en) 2016-10-05 2022-04-08 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Method for preparing antibody drug conjugate
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
WO2018146189A1 (en) 2017-02-08 2018-08-16 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
RS63502B1 (en) 2017-04-18 2022-09-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
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JP7145891B2 (en) 2017-06-14 2022-10-03 アーデーセー セラピューティクス ソシエテ アノニム Dosing Regimens for Administering Anti-CD19 ADCs
HRP20220311T1 (en) 2017-08-18 2022-05-13 Medimmune Limited Pyrrolobenzodiazepine conjugates
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JP2022513198A (en) 2018-12-10 2022-02-07 ジェネンテック， インコーポレイテッド Photocrosslinkable peptide for site-specific conjugation to Fc-containing proteins
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GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
WO2024138128A2 (en) 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof
WO2024220546A2 (en) 2023-04-17 2024-10-24 Peak Bio, Inc. Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Also Published As

Publication number Publication date
WO2003003984A2 (en) 2003-01-16
WO2003003984A8 (en) 2009-08-13

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