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WO2003087352A3 - Enolase polypeptides and structures - Google Patents

Enolase polypeptides and structures Download PDF

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Publication number
WO2003087352A3
WO2003087352A3 PCT/CA2003/000506 CA0300506W WO03087352A3 WO 2003087352 A3 WO2003087352 A3 WO 2003087352A3 CA 0300506 W CA0300506 W CA 0300506W WO 03087352 A3 WO03087352 A3 WO 03087352A3
Authority
WO
WIPO (PCT)
Prior art keywords
seq
structures
polypeptides
enolase polypeptides
provides
Prior art date
Application number
PCT/CA2003/000506
Other languages
French (fr)
Other versions
WO2003087352A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Megan Domagala
Kathleen Nethery
Kristina Buzadzija
Simon Houston
Ivy Ng
Francois Vallee
Donald Awrey
Bryan Beattie
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Megan Domagala
Kathleen Nethery
Kristina Buzadzija
Simon Houston
Ivy Ng
Francois Vallee
Donald Awrey
Bryan Beattie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Megan Domagala, Kathleen Nethery, Kristina Buzadzija, Simon Houston, Ivy Ng, Francois Vallee, Donald Awrey, Bryan Beattie filed Critical Affinium Pharm Inc
Priority to AU2003218563A priority Critical patent/AU2003218563A1/en
Publication of WO2003087352A2 publication Critical patent/WO2003087352A2/en
Publication of WO2003087352A3 publication Critical patent/WO2003087352A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified proteins comprising the amino acid sequences set forth in SEQ ID NO: 7, SEQ ID NO: 16 and SEQ ID NO: 25. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention, including structural data.
PCT/CA2003/000506 2002-04-09 2003-04-09 Enolase polypeptides and structures WO2003087352A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003218563A AU2003218563A1 (en) 2002-04-09 2003-04-09 Enolase polypeptides and structures

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US37113202P 2002-04-09 2002-04-09
US60/371,132 2002-04-09
US37136502P 2002-04-10 2002-04-10
US60/371,365 2002-04-10
US37191102P 2002-04-11 2002-04-11
US60/371,911 2002-04-11

Publications (2)

Publication Number Publication Date
WO2003087352A2 WO2003087352A2 (en) 2003-10-23
WO2003087352A3 true WO2003087352A3 (en) 2004-02-05

Family

ID=29255326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/000506 WO2003087352A2 (en) 2002-04-09 2003-04-09 Enolase polypeptides and structures

Country Status (2)

Country Link
AU (1) AU2003218563A1 (en)
WO (1) WO2003087352A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012065034A1 (en) * 2010-11-12 2012-05-18 Merck Sharp & Dohme Corp. Enolase peptide conjugate vaccines against staphylococcus aureus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047639A2 (en) * 1998-03-20 1999-09-23 Human Genome Sciences, Inc. Staphylococcus aureus genes and polypeptides
WO2001070955A2 (en) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047639A2 (en) * 1998-03-20 1999-09-23 Human Genome Sciences, Inc. Staphylococcus aureus genes and polypeptides
WO2001070955A2 (en) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KUHNEL KARIN ET AL: "Crystal structure of the Escherichia coli RNA degradosome component enolase.", JOURNAL OF MOLECULAR BIOLOGY, vol. 313, no. 3, 2001, pages 583 - 592, XP002252288, ISSN: 0022-2836 *

Also Published As

Publication number Publication date
WO2003087352A2 (en) 2003-10-23
AU2003218563A8 (en) 2003-10-27
AU2003218563A1 (en) 2003-10-27

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