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WO2002026984A3 - Potassium channel interactors and uses therefor - Google Patents

Potassium channel interactors and uses therefor Download PDF

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Publication number
WO2002026984A3
WO2002026984A3 PCT/US2001/030463 US0130463W WO0226984A3 WO 2002026984 A3 WO2002026984 A3 WO 2002026984A3 US 0130463 W US0130463 W US 0130463W WO 0226984 A3 WO0226984 A3 WO 0226984A3
Authority
WO
WIPO (PCT)
Prior art keywords
pcip
nucleic acid
acid molecules
potassium channel
proteins
Prior art date
Application number
PCT/US2001/030463
Other languages
French (fr)
Other versions
WO2002026984A2 (en
Inventor
Kenneth Rhodes
Maria Betty
Huai-Ping Ling
Wenqian An
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/670,756 external-priority patent/US7078481B1/en
Priority to AU2001296393A priority Critical patent/AU2001296393A1/en
Priority to EP01977260A priority patent/EP1322759A2/en
Priority to IL15496201A priority patent/IL154962A0/en
Priority to CA002420960A priority patent/CA2420960A1/en
Priority to BR0114383-2A priority patent/BR0114383A/en
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Priority to JP2002530747A priority patent/JP2004525610A/en
Priority to KR10-2003-7004460A priority patent/KR20030074604A/en
Priority to EA200300420A priority patent/EA200300420A1/en
Priority to MXPA03002557A priority patent/MXPA03002557A/en
Publication of WO2002026984A2 publication Critical patent/WO2002026984A2/en
Publication of WO2002026984A3 publication Critical patent/WO2002026984A3/en
Priority to NO20031369A priority patent/NO20031369L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2001/030463 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor WO2002026984A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
MXPA03002557A MXPA03002557A (en) 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor.
EP01977260A EP1322759A2 (en) 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor
IL15496201A IL154962A0 (en) 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor
CA002420960A CA2420960A1 (en) 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor
BR0114383-2A BR0114383A (en) 2000-09-27 2001-09-27 Potassium channel interactors and applications thereof
AU2001296393A AU2001296393A1 (en) 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor
JP2002530747A JP2004525610A (en) 2000-09-27 2001-09-27 Potassium channel interactor and method of using the same
KR10-2003-7004460A KR20030074604A (en) 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor
EA200300420A EA200300420A1 (en) 2000-09-27 2001-09-27 Isolated nucleic acid molecules, isolated polypeptides AND METHOD FOR PRODUCTION THEREOF, METHOD FOR DETECTING THEM present in the sample (VARIANTS) host cell (VARIANTS) antibody kit (OPTIONS), a method of modulating activity of a polypeptide, IDENTIFICATION METHOD (VARIANTS) AND APPLICATION OF COMPOUNDS METHOD OF IDENTIFICATION OF THE SUBJECT (OPTIONS) AND METHOD OF TREATING THE SUBJECT WITH DAMAGE ASSOCIATED WITH POTASSIUM CHANNELS (OPTIONS)
NO20031369A NO20031369L (en) 2000-09-27 2003-03-26 Potassium-channel interacting compounds, and applications thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/670,756 US7078481B1 (en) 1998-11-20 2000-09-27 Potassium channel interactors and uses therefor
US09/670,756 2000-09-27
US09/703,094 US7556938B1 (en) 1998-11-20 2000-10-31 Nucleic acids encoding potassium channel interactors
US09/703,094 2000-10-31

Publications (2)

Publication Number Publication Date
WO2002026984A2 WO2002026984A2 (en) 2002-04-04
WO2002026984A3 true WO2002026984A3 (en) 2003-03-13

Family

ID=27100393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/030463 WO2002026984A2 (en) 2000-09-27 2001-09-27 Potassium channel interactors and uses therefor

Country Status (13)

Country Link
EP (1) EP1322759A2 (en)
JP (1) JP2004525610A (en)
KR (1) KR20030074604A (en)
CN (1) CN1498271A (en)
AU (1) AU2001296393A1 (en)
BR (1) BR0114383A (en)
CA (1) CA2420960A1 (en)
CZ (1) CZ20031154A3 (en)
EA (1) EA200300420A1 (en)
IL (1) IL154962A0 (en)
MX (1) MXPA03002557A (en)
NO (1) NO20031369L (en)
WO (1) WO2002026984A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067312B1 (en) 2001-09-19 2006-06-27 Myriad Genetics, Inc. PN7718 nucleic acids and use thereof
AU2003287383A1 (en) * 2002-11-01 2004-06-07 Decode Genetics Ehf. HUMAN TYPE II DIABETES GENE-Kv CHANNEL-INTERACTING PROTEIN (KChIP1) LOCATED ON CHROMOSOME 5
AU2009312751B8 (en) * 2008-11-06 2015-04-09 Basf Se A screening assay for insecticides
CN105483276B (en) * 2016-02-01 2019-06-11 成都望路医药技术有限公司 The application of KCNIP4 gene and its expression product in rectal adenocarcinoma diagnosis and treatment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016185A2 (en) * 1996-10-17 1998-04-23 Nps Pharmaceuticals, Inc. Potassium channel blocking compounds and their use
WO1999049038A2 (en) * 1998-03-26 1999-09-30 Incyte Pharmaceuticals, Inc. Human calcium-binding proteins
WO2000031133A2 (en) * 1998-11-20 2000-06-02 Millennium Pharmaceuticals, Inc. Potassium channel interactors and uses therefor
WO2000070049A2 (en) * 1999-05-19 2000-11-23 Incyte Genomics, Inc. Extracellular signaling molecules
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016185A2 (en) * 1996-10-17 1998-04-23 Nps Pharmaceuticals, Inc. Potassium channel blocking compounds and their use
WO1999049038A2 (en) * 1998-03-26 1999-09-30 Incyte Pharmaceuticals, Inc. Human calcium-binding proteins
WO2000031133A2 (en) * 1998-11-20 2000-06-02 Millennium Pharmaceuticals, Inc. Potassium channel interactors and uses therefor
WO2000070049A2 (en) * 1999-05-19 2000-11-23 Incyte Genomics, Inc. Extracellular signaling molecules
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AN W FRANK ET AL: "Modulation of A-type potassium channels by a family of calcium sensors.", NATURE (LONDON), vol. 403, no. 6769, 3 February 2000 (2000-02-03), pages 553 - 556, XP002209980, ISSN: 0028-0836 *
BUXBAUM ET AL.: "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment", NATURE MEDICINE, vol. 10, October 1998 (1998-10-01), pages 1177 - 1181, XP002132975 *
CARRION ET AL.: "DREAM is a Ca2+-regulated transcriptional repressor", NATURE, vol. 398, 4 March 1999 (1999-03-04), pages 80 - 84, XP000700251 *
CASTAGNA ET AL.: "Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis", THE JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 200, 1997, pages 269 - 286, XP002132978 *
LOMBARDI ET AL.: "Structure-activity relationships of the Kvbeta1 inactivation domain and its putative receptor probed using peptide analogs of voltage-gated potassium channel alpha- and beta-subunits", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30092 - 30096, XP002132979 *
VAN HILLE ET AL.: "Identification of two subunit A isoforms of the vacuolar H+-ATPase in human osteoclastoma", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 10, 1993, pages 7075 - 7080, XP002132977 *

Also Published As

Publication number Publication date
WO2002026984A2 (en) 2002-04-04
NO20031369L (en) 2003-05-22
BR0114383A (en) 2005-04-12
IL154962A0 (en) 2003-10-31
CN1498271A (en) 2004-05-19
CA2420960A1 (en) 2002-04-04
KR20030074604A (en) 2003-09-19
CZ20031154A3 (en) 2003-09-17
MXPA03002557A (en) 2004-09-10
EP1322759A2 (en) 2003-07-02
JP2004525610A (en) 2004-08-26
EA200300420A1 (en) 2004-04-29
AU2001296393A1 (en) 2002-04-08
NO20031369D0 (en) 2003-03-26

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