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WO2002078672A3 - Liposomal tumor necrosis factor compositions and methods - Google Patents

Liposomal tumor necrosis factor compositions and methods Download PDF

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Publication number
WO2002078672A3
WO2002078672A3 PCT/US2002/009926 US0209926W WO02078672A3 WO 2002078672 A3 WO2002078672 A3 WO 2002078672A3 US 0209926 W US0209926 W US 0209926W WO 02078672 A3 WO02078672 A3 WO 02078672A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
necrosis factor
tumor necrosis
factor compositions
liposomal
Prior art date
Application number
PCT/US2002/009926
Other languages
French (fr)
Other versions
WO2002078672A2 (en
Inventor
Daila S Gridley
Dong W Kim
Hagen Timo L Ten
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of WO2002078672A2 publication Critical patent/WO2002078672A2/en
Publication of WO2002078672A3 publication Critical patent/WO2002078672A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Liposome compositions containing an entrapped TNF compound and a method of using the same for effective upregulation of immunological factors are described. Also disclosed is a method of combination therapy where a conventional anti-tumor therapy and the liposome-entrapped TNF compound are administered to achieve an enhanced anti-tumor effect.
PCT/US2002/009926 2001-03-30 2002-03-29 Liposomal tumor necrosis factor compositions and methods WO2002078672A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28054001P 2001-03-30 2001-03-30
US60/280,540 2001-03-30
US34300201P 2001-12-19 2001-12-19
US60/343,002 2001-12-19

Publications (2)

Publication Number Publication Date
WO2002078672A2 WO2002078672A2 (en) 2002-10-10
WO2002078672A3 true WO2002078672A3 (en) 2003-03-20

Family

ID=26960351

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/009926 WO2002078672A2 (en) 2001-03-30 2002-03-29 Liposomal tumor necrosis factor compositions and methods

Country Status (1)

Country Link
WO (1) WO2002078672A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05006579A (en) * 2002-12-19 2005-12-14 Johnson & Johnson Method of treating angiogenic tissue growth.
WO2015061206A2 (en) 2013-10-21 2015-04-30 North Carolina State University Methods and constructs for compound delivery

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338679A2 (en) * 1988-03-24 1989-10-25 Genentech, Inc. Tumour necrosis factor in the treatment of bladder cancer
EP0546951A1 (en) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Combination of liposome encapsulated antineoplastic agents, such as doxorubicin with colony stimulating factors
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
WO1998007409A1 (en) * 1996-08-23 1998-02-26 Sequus Pharmaceuticals, Inc. Liposomes containing a cisplatin compound
WO1999027908A1 (en) * 1997-12-04 1999-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
US6043094A (en) * 1996-10-11 2000-03-28 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338679A2 (en) * 1988-03-24 1989-10-25 Genentech, Inc. Tumour necrosis factor in the treatment of bladder cancer
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
EP0546951A1 (en) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Combination of liposome encapsulated antineoplastic agents, such as doxorubicin with colony stimulating factors
WO1998007409A1 (en) * 1996-08-23 1998-02-26 Sequus Pharmaceuticals, Inc. Liposomes containing a cisplatin compound
US6043094A (en) * 1996-10-11 2000-03-28 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method
WO1999027908A1 (en) * 1997-12-04 1999-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines

Also Published As

Publication number Publication date
WO2002078672A2 (en) 2002-10-10

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