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WO2002043766A1 - Medicinal compositions and process for producing the same - Google Patents

Medicinal compositions and process for producing the same Download PDF

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Publication number
WO2002043766A1
WO2002043766A1 PCT/JP2001/010417 JP0110417W WO0243766A1 WO 2002043766 A1 WO2002043766 A1 WO 2002043766A1 JP 0110417 W JP0110417 W JP 0110417W WO 0243766 A1 WO0243766 A1 WO 0243766A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
same
medicinal compositions
antagonist
nonpeptidic
Prior art date
Application number
PCT/JP2001/010417
Other languages
French (fr)
Japanese (ja)
Inventor
Yutaka Yamagata
Yoshio Hata
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to AU2002218494A priority Critical patent/AU2002218494A1/en
Publication of WO2002043766A1 publication Critical patent/WO2002043766A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions wherein the release of a nonpeptidic GnRH agonist and antagonist having a particularly low solubility is accelerated. Namely, compositions containing a hardly water-soluble nonpeptidic gonadotropin-releasing hormone agonist or antagonist and an aromatic hydroxycarboxylic acid or its salt.
PCT/JP2001/010417 2000-11-29 2001-11-29 Medicinal compositions and process for producing the same WO2002043766A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002218494A AU2002218494A1 (en) 2000-11-29 2001-11-29 Medicinal compositions and process for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000362727 2000-11-29
JP2000-362727 2000-11-29

Publications (1)

Publication Number Publication Date
WO2002043766A1 true WO2002043766A1 (en) 2002-06-06

Family

ID=18833953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/010417 WO2002043766A1 (en) 2000-11-29 2001-11-29 Medicinal compositions and process for producing the same

Country Status (2)

Country Link
AU (1) AU2002218494A1 (en)
WO (1) WO2002043766A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002092A3 (en) * 2001-06-29 2003-04-10 Takeda Chemical Industries Ltd Controlled release composition comprising lactic acid polymer and hydroxynaphthoic acid, and method of producing the same
WO2003064429A1 (en) * 2002-01-30 2003-08-07 Takeda Chemical Industries, Ltd. Thienopyrimidines, process for preparing the same and use thereof
WO2004067535A1 (en) * 2003-01-29 2004-08-12 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
EP2329823A1 (en) * 2008-09-03 2011-06-08 Takeda Pharmaceutical Company Limited Method for improving absorbability of preparation, and preparation having improved absorbability
US8921326B2 (en) 2006-12-18 2014-12-30 Takeda Pharmaceutical Company Limited Sustained-release composition and method for producing the same

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5734822B2 (en) * 1975-02-12 1982-07-26
JPS6393714A (en) * 1986-10-09 1988-04-25 Sekisui Chem Co Ltd Plaster for transcutaneous absorption
EP0503583A1 (en) * 1991-03-12 1992-09-16 Takeda Chemical Industries, Ltd. Composition for sustained release of erythropoietin
EP0566135A1 (en) * 1992-04-17 1993-10-20 Takeda Chemical Industries, Ltd. Transmucosal composition comprising a peptide and a cytidine derivative
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation
WO1994025460A1 (en) * 1993-04-28 1994-11-10 Janssen Pharmaceutica N.V. Risperidone pamoate
JPH07196510A (en) * 1993-12-28 1995-08-01 Nippon Seiyaku Kk A sustained release lipid emulsion for analgesic-containing injection solution
WO1995028405A1 (en) * 1994-04-19 1995-10-26 Takeda Chemical Industries, Ltd. Bicyclic thiophene derivatives and use as gonadotropin releasing hormone antagonists
JPH1045616A (en) * 1996-08-02 1998-02-17 Shionogi & Co Ltd Sustained release preparation for injection
WO1998032423A1 (en) * 1997-01-29 1998-07-30 Takeda Chemical Industries, Ltd. Sustained-release microspheres, their production and use
WO1999036099A1 (en) * 1998-01-16 1999-07-22 Takeda Chemical Industries, Ltd. Sustained release compositions, process for producing the same and utilization thereof
JPH11199521A (en) * 1997-12-26 1999-07-27 Lion Corp Preparation for external use for skin
WO2000056739A1 (en) * 1999-03-24 2000-09-28 Takeda Chemical Industries, Ltd. Thienopyrimidine compounds, their production and use

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5734822B2 (en) * 1975-02-12 1982-07-26
JPS6393714A (en) * 1986-10-09 1988-04-25 Sekisui Chem Co Ltd Plaster for transcutaneous absorption
EP0503583A1 (en) * 1991-03-12 1992-09-16 Takeda Chemical Industries, Ltd. Composition for sustained release of erythropoietin
EP0566135A1 (en) * 1992-04-17 1993-10-20 Takeda Chemical Industries, Ltd. Transmucosal composition comprising a peptide and a cytidine derivative
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation
WO1994025460A1 (en) * 1993-04-28 1994-11-10 Janssen Pharmaceutica N.V. Risperidone pamoate
JPH07196510A (en) * 1993-12-28 1995-08-01 Nippon Seiyaku Kk A sustained release lipid emulsion for analgesic-containing injection solution
WO1995028405A1 (en) * 1994-04-19 1995-10-26 Takeda Chemical Industries, Ltd. Bicyclic thiophene derivatives and use as gonadotropin releasing hormone antagonists
JPH1045616A (en) * 1996-08-02 1998-02-17 Shionogi & Co Ltd Sustained release preparation for injection
WO1998032423A1 (en) * 1997-01-29 1998-07-30 Takeda Chemical Industries, Ltd. Sustained-release microspheres, their production and use
JPH11199521A (en) * 1997-12-26 1999-07-27 Lion Corp Preparation for external use for skin
WO1999036099A1 (en) * 1998-01-16 1999-07-22 Takeda Chemical Industries, Ltd. Sustained release compositions, process for producing the same and utilization thereof
WO2000056739A1 (en) * 1999-03-24 2000-09-28 Takeda Chemical Industries, Ltd. Thienopyrimidine compounds, their production and use

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067030B2 (en) 2001-06-29 2011-11-29 Takeda Pharmaceutical Company Limited Controlled release composition and method of producing the same
US8815801B2 (en) 2001-06-29 2014-08-26 Takeda Pharmaceutical Company Limited Controlled release composition and method of producing the same
EP1491236A1 (en) * 2001-06-29 2004-12-29 Takeda Chemical Industries, Ltd. Controlled release composition comprising lactic acid polymer and hydroxynaphthoic acid, and method of producing the same
US8246987B2 (en) 2001-06-29 2012-08-21 Takeda Pharmaceutical Company Limited Controlled release composition and method of producing the same
WO2003002092A3 (en) * 2001-06-29 2003-04-10 Takeda Chemical Industries Ltd Controlled release composition comprising lactic acid polymer and hydroxynaphthoic acid, and method of producing the same
US7429559B2 (en) 2001-06-29 2008-09-30 Takeda Pharmaceutical Company Limited Controlled release composition and method of producing the same
EP1949936A3 (en) * 2001-06-29 2008-10-08 Takeda Pharmaceutical Company Limited Controlled release composition and method of producing the same
WO2003064429A1 (en) * 2002-01-30 2003-08-07 Takeda Chemical Industries, Ltd. Thienopyrimidines, process for preparing the same and use thereof
CN100360538C (en) * 2003-01-29 2008-01-09 武田药品工业株式会社 Thienopyrimidine compound and use of the same
KR101074462B1 (en) * 2003-01-29 2011-10-18 다케다 야쿠힌 고교 가부시키가이샤 Thienopyrimidine compounds and use thereof
US8058280B2 (en) 2003-01-29 2011-11-15 Takeda Pharmaceutical Company Limited Substituted thieno[2,3-d]pyrimidin-2,4-dione compounds and uses thereof
US7300935B2 (en) 2003-01-29 2007-11-27 Takeda Pharmaceutical Company Thienopyrimidine compounds and use thereof
US8735401B2 (en) 2003-01-29 2014-05-27 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
WO2004067535A1 (en) * 2003-01-29 2004-08-12 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
US9346822B2 (en) 2003-01-29 2016-05-24 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
US8921326B2 (en) 2006-12-18 2014-12-30 Takeda Pharmaceutical Company Limited Sustained-release composition and method for producing the same
US9617303B2 (en) 2006-12-18 2017-04-11 Takeda Pharmaceutical Company Limited Sustained-release composition and method for producing the same
US9713595B2 (en) 2006-12-18 2017-07-25 Takeda Pharmaceuticals Company Limited Sustained-release composition and method for producing the same
EP2329823A1 (en) * 2008-09-03 2011-06-08 Takeda Pharmaceutical Company Limited Method for improving absorbability of preparation, and preparation having improved absorbability
EP2329823A4 (en) * 2008-09-03 2013-04-03 Takeda Pharmaceutical Method for improving absorbability of preparation, and preparation having improved absorbability

Also Published As

Publication number Publication date
AU2002218494A1 (en) 2002-06-11

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