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WO2001049662A3 - Carbazole derivatives as inhibitors of spla2 - Google Patents

Carbazole derivatives as inhibitors of spla2 Download PDF

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Publication number
WO2001049662A3
WO2001049662A3 PCT/US2001/010850 US0110850W WO0149662A3 WO 2001049662 A3 WO2001049662 A3 WO 2001049662A3 US 0110850 W US0110850 W US 0110850W WO 0149662 A3 WO0149662 A3 WO 0149662A3
Authority
WO
WIPO (PCT)
Prior art keywords
spla2
inhibitors
carbazole derivatives
compounds
class
Prior art date
Application number
PCT/US2001/010850
Other languages
French (fr)
Other versions
WO2001049662A2 (en
Inventor
Ho-Shen Lin
Michael Enrico Richett
Original Assignee
Lilly Co Eli
Ho-Shen Lin
Michael Enrico Richett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Ho-Shen Lin, Michael Enrico Richett filed Critical Lilly Co Eli
Priority to EP01918984A priority Critical patent/EP1248769A2/en
Priority to AU45996/01A priority patent/AU4599601A/en
Publication of WO2001049662A2 publication Critical patent/WO2001049662A2/en
Publication of WO2001049662A3 publication Critical patent/WO2001049662A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A class of novel indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
PCT/US2001/010850 2000-01-07 2001-01-05 Carbazole derivatives as inhibitors of spla2 WO2001049662A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01918984A EP1248769A2 (en) 2000-01-07 2001-01-05 Carbazole derivatives as inhibitors of spla2
AU45996/01A AU4599601A (en) 2000-01-07 2001-01-05 Substituted tricyclics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17502800P 2000-01-07 2000-01-07
US60/175,028 2000-01-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/168,152 A-371-Of-International US20030096854A1 (en) 2000-01-07 2001-01-05 Substituted tricyclics
US10/830,380 Division US20040204473A1 (en) 2000-01-07 2004-04-22 Substituted tricyclics

Publications (2)

Publication Number Publication Date
WO2001049662A2 WO2001049662A2 (en) 2001-07-12
WO2001049662A3 true WO2001049662A3 (en) 2002-06-27

Family

ID=22638535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010850 WO2001049662A2 (en) 2000-01-07 2001-01-05 Carbazole derivatives as inhibitors of spla2

Country Status (3)

Country Link
EP (1) EP1248769A2 (en)
AU (1) AU4599601A (en)
WO (1) WO2001049662A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1395554B1 (en) 2001-03-28 2007-02-14 Eli Lilly And Company Substituted carbazoles as inhibitors of spla2
EP1678137A1 (en) * 2003-10-15 2006-07-12 Chiron Corporation Compositions and methods for viral inhibition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654326A (en) * 1994-04-01 1997-08-05 Eli Lilly And Company 1H-indole-3-glyoxylamide SPLA2 inhibitors
WO1999025340A1 (en) * 1997-11-14 1999-05-27 Eli Lilly And Company Treatment for alzheimer's disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654326A (en) * 1994-04-01 1997-08-05 Eli Lilly And Company 1H-indole-3-glyoxylamide SPLA2 inhibitors
WO1999025340A1 (en) * 1997-11-14 1999-05-27 Eli Lilly And Company Treatment for alzheimer's disease

Also Published As

Publication number Publication date
WO2001049662A2 (en) 2001-07-12
EP1248769A2 (en) 2002-10-16
AU4599601A (en) 2001-07-16

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