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WO2000039149A3 - Secreted proteins and uses thereof - Google Patents

Secreted proteins and uses thereof Download PDF

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Publication number
WO2000039149A3
WO2000039149A3 PCT/US1999/031157 US9931157W WO0039149A3 WO 2000039149 A3 WO2000039149 A3 WO 2000039149A3 US 9931157 W US9931157 W US 9931157W WO 0039149 A3 WO0039149 A3 WO 0039149A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
secreted proteins
provides isolated
high temperature
Prior art date
Application number
PCT/US1999/031157
Other languages
French (fr)
Other versions
WO2000039149A2 (en
Inventor
Thomas M Barnes
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Priority to AU23966/00A priority Critical patent/AU2396600A/en
Priority to EP99967734A priority patent/EP1140976A4/en
Publication of WO2000039149A2 publication Critical patent/WO2000039149A2/en
Publication of WO2000039149A3 publication Critical patent/WO2000039149A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides isolated nucleic acid molecules, designated HtrA-2 (high temperature requirement-2) nucleic acid molecules which encode wholly secreted proteins with homology to the human HtrA (high temperature requirement) protein. The invention also provides isolated nucleic acid molecules, designated TANGO 219 nucleic acid molecules which encode wholly secreted proteins. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
PCT/US1999/031157 1998-12-30 1999-12-29 Secreted proteins and uses thereof WO2000039149A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU23966/00A AU2396600A (en) 1998-12-30 1999-12-29 Secreted proteins and uses thereof
EP99967734A EP1140976A4 (en) 1998-12-30 1999-12-29 Secreted proteins and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22424698A 1998-12-30 1998-12-30
US09/224,246 1998-12-30

Publications (2)

Publication Number Publication Date
WO2000039149A2 WO2000039149A2 (en) 2000-07-06
WO2000039149A3 true WO2000039149A3 (en) 2000-11-16

Family

ID=22839862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/031157 WO2000039149A2 (en) 1998-12-30 1999-12-29 Secreted proteins and uses thereof

Country Status (3)

Country Link
EP (1) EP1140976A4 (en)
AU (1) AU2396600A (en)
WO (1) WO2000039149A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030099947A1 (en) 1998-09-21 2003-05-29 Bazan J. Fernando Mammalian cytokines; related reagents and methods
PT1129190E (en) 1998-11-13 2007-08-08 Immunex Corp Human tslp dna and polypeptides
MXPA04000631A (en) 2001-07-23 2004-06-25 Immunex Corp Modified human thymic stromal lymphopoietin.
AUPR670701A0 (en) * 2001-07-30 2001-08-23 Prince Henry's Institute Of Medical Research Novel serine protease
AU2003280642A1 (en) * 2002-11-01 2004-05-25 Takeda Pharmaceutical Company Limited Apoptosis inducer
DE102004004924B4 (en) * 2004-01-27 2007-04-26 Eberhard-Karls-Universität Tübingen Universitätsklinikum A141S and G399S mutation in the Omi / HtrA2 protein in Parkinson's disease
WO2008076255A2 (en) 2006-12-14 2008-06-26 Schering-Plough Ltd. Canine thymic stromal lymphopoietin protein and uses thereof
AR064333A1 (en) 2006-12-14 2009-04-01 Schering Corp ANTI-TSLP DESIGN ANTIBODY
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
KR20240093808A (en) 2008-12-09 2024-06-24 제넨테크, 인크. Anti-pd-l1 antibodies and their use to enhance t-cell function
EP2213682A1 (en) 2009-01-30 2010-08-04 Institut Curie TSLP promotes immune evasion and persistence of viruses
CN102782149B (en) 2009-11-04 2014-11-12 默沙东公司 Engineered anti-TSLP antibody

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09107980A (en) * 1995-08-17 1997-04-28 Japan Tobacco Inc New physiologically active protein
EP0828003A2 (en) * 1996-09-06 1998-03-11 Smithkline Beecham Plc Human serine protease
WO1998025959A2 (en) * 1996-12-11 1998-06-18 Chiron Corporation Secreted human proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09107980A (en) * 1995-08-17 1997-04-28 Japan Tobacco Inc New physiologically active protein
EP0828003A2 (en) * 1996-09-06 1998-03-11 Smithkline Beecham Plc Human serine protease
WO1998025959A2 (en) * 1996-12-11 1998-06-18 Chiron Corporation Secreted human proteins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK, 4 June 1997 (1997-06-04), HILLIER L., XP002931399 *
DATABASE GENBANK, XP002931400 *
HU ET AL.: "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed genen product in osteoarthritic cartilage", THE JOURNAL OF BIOLOGICAL CHEMISTRY,, vol. 273, no. 51, 18 December 1998 (1998-12-18), pages 34406 - 34412, XP002931380 *
See also references of EP1140976A4 *
ZUMBRUNN ET AL.: "Primary structure of a putative serine protease specific for IGF-binding proteins", FEBS LETTERS,, vol. 398, 1996, pages 187 - 192, XP002931381 *

Also Published As

Publication number Publication date
EP1140976A4 (en) 2003-05-21
WO2000039149A2 (en) 2000-07-06
EP1140976A2 (en) 2001-10-10
AU2396600A (en) 2000-07-31

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