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WO2000014254A3 - Component of bromelain - Google Patents

Component of bromelain Download PDF

Info

Publication number
WO2000014254A3
WO2000014254A3 PCT/GB1999/002792 GB9902792W WO0014254A3 WO 2000014254 A3 WO2000014254 A3 WO 2000014254A3 GB 9902792 W GB9902792 W GB 9902792W WO 0014254 A3 WO0014254 A3 WO 0014254A3
Authority
WO
WIPO (PCT)
Prior art keywords
bromelain
component
components
erk
majority
Prior art date
Application number
PCT/GB1999/002792
Other languages
French (fr)
Other versions
WO2000014254A2 (en
Inventor
Tracey Lehanne Mynott
Keith Peek
David Robert Tyreman
Original Assignee
Cortecs Uk Ltd
Tracey Lehanne Mynott
Keith Peek
David Robert Tyreman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortecs Uk Ltd, Tracey Lehanne Mynott, Keith Peek, David Robert Tyreman filed Critical Cortecs Uk Ltd
Publication of WO2000014254A2 publication Critical patent/WO2000014254A2/en
Publication of WO2000014254A3 publication Critical patent/WO2000014254A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A fraction of bromelain has been separated into various components. The components responsible for the majority of the anti-ERK-2 and anti-IL-2 activity of bromelain have been identified. The active components contain various different proteins, some of which are novel.
PCT/GB1999/002792 1998-09-02 1999-08-24 Component of bromelain WO2000014254A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9819137.2 1998-09-02
GBGB9819137.2A GB9819137D0 (en) 1998-09-02 1998-09-02 Component of bromelain

Publications (2)

Publication Number Publication Date
WO2000014254A2 WO2000014254A2 (en) 2000-03-16
WO2000014254A3 true WO2000014254A3 (en) 2000-07-27

Family

ID=10838237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002792 WO2000014254A2 (en) 1998-09-02 1999-08-24 Component of bromelain

Country Status (2)

Country Link
GB (1) GB9819137D0 (en)
WO (1) WO2000014254A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008062136B4 (en) * 2008-12-16 2012-05-03 Kamamed Ug Pharmaceutical composition based on peptide of camel milk
JP2018527025A (en) * 2015-08-20 2018-09-20 アナタラ ライフサイエンシズ リミテッド Enzyme fraction with anti-inflammatory activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000169A1 (en) * 1993-06-25 1995-01-05 Cortecs Limited Medical use of stem bromelain protease
WO1996000082A1 (en) * 1994-06-24 1996-01-04 Cortecs Limited Medical use of bromelain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000169A1 (en) * 1993-06-25 1995-01-05 Cortecs Limited Medical use of stem bromelain protease
WO1996000082A1 (en) * 1994-06-24 1996-01-04 Cortecs Limited Medical use of bromelain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARRACH ET AL: "ISOLATION AND PARTIAL CHARACTERIZATION OF BASIC PROTEINASES FROM STEM BROMELAIN", JOURNAL OF PROTEIN CHEMISTRY, vol. 14, no. 1, 1995, pages 41 - 52, XP002069063, ISSN: 0277-8033 *
MUNZIG ET AL: "BROMELAIN PROTEASE F9 REDUCES THE CD44 MEDIATED ADHESION OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES TO HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS", FEBS LETTERS, vol. 351, 1994, pages 215 - 218, XP002069064, ISSN: 0014-5793 *
RITONJA ET AL.: "Bromelain, stem (EC 3.4.22.32)", EMBL SEQUENCE DATABASE, 1 January 1990 (1990-01-01), HEIDELBERG DE, XP002136918 *

Also Published As

Publication number Publication date
GB9819137D0 (en) 1998-10-28
WO2000014254A2 (en) 2000-03-16

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