Nothing Special   »   [go: up one dir, main page]

WO1999031128A3 - Human tumor necrosis factor-r2-like proteins - Google Patents

Human tumor necrosis factor-r2-like proteins Download PDF

Info

Publication number
WO1999031128A3
WO1999031128A3 PCT/US1998/025649 US9825649W WO9931128A3 WO 1999031128 A3 WO1999031128 A3 WO 1999031128A3 US 9825649 W US9825649 W US 9825649W WO 9931128 A3 WO9931128 A3 WO 9931128A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
necrosis factor
tumor necrosis
human tumor
tr2p
Prior art date
Application number
PCT/US1998/025649
Other languages
French (fr)
Other versions
WO1999031128A2 (en
Inventor
Olga Bandman
Jennifer L Hillman
Janice Au-Young
Y Tom Tang
Matthew R Kaser
Original Assignee
Incyte Pharma Inc
Olga Bandman
Jennifer L Hillman
Au Young Janice
Y Tom Tang
Matthew R Kaser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Olga Bandman, Jennifer L Hillman, Au Young Janice, Y Tom Tang, Matthew R Kaser filed Critical Incyte Pharma Inc
Priority to JP2000539051A priority Critical patent/JP2002508168A/en
Priority to EP98959662A priority patent/EP1037908A2/en
Priority to AU15416/99A priority patent/AU1541699A/en
Priority to CA002314884A priority patent/CA2314884A1/en
Publication of WO1999031128A2 publication Critical patent/WO1999031128A2/en
Publication of WO1999031128A3 publication Critical patent/WO1999031128A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides human tumor necrosis factor-R2-like proteins (TR2P) and polynucleotides which identify and encode TR2P. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of TR2P.
PCT/US1998/025649 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins WO1999031128A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000539051A JP2002508168A (en) 1997-12-16 1998-12-02 Human tumor necrosis factor R2-like protein
EP98959662A EP1037908A2 (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins
AU15416/99A AU1541699A (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins
CA002314884A CA2314884A1 (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99194597A 1997-12-16 1997-12-16
US08/991,945 1997-12-16

Publications (2)

Publication Number Publication Date
WO1999031128A2 WO1999031128A2 (en) 1999-06-24
WO1999031128A3 true WO1999031128A3 (en) 1999-10-07

Family

ID=25537754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025649 WO1999031128A2 (en) 1997-12-16 1998-12-02 Human tumor necrosis factor-r2-like proteins

Country Status (5)

Country Link
EP (1) EP1037908A2 (en)
JP (1) JP2002508168A (en)
AU (1) AU1541699A (en)
CA (1) CA2314884A1 (en)
WO (1) WO1999031128A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1247567A (en) 1997-01-14 2000-03-15 人体基因组科学有限公司 Tumor necrosis factor receptor alfa 6 and receptor beta 6
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
US6949358B1 (en) 1997-06-11 2005-09-27 Human Genome Sciences, Inc. Human tumor necrosis factor receptor TR9
US6358508B1 (en) 1997-06-11 2002-03-19 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR9
JP4303883B2 (en) 1997-09-18 2009-07-29 ジェネンテック・インコーポレーテッド TNFR homologue of DcR3 polypeptide
DE19809978A1 (en) * 1998-03-09 1999-09-16 Basf Ag New soluble member of tumor necrosis factor receptor family, useful for identification specific modulators and for treating disease e.g. tumors
GB9812607D0 (en) * 1998-06-12 1998-08-12 Zeneca Ltd Protein
US20040220103A1 (en) 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
US6521422B1 (en) 1999-08-04 2003-02-18 Amgen Inc. Fhm, a novel member of the TNF ligand supergene family
WO2001010908A1 (en) 1999-08-04 2001-02-15 Amgen Inc. Ntr3, a member of the tnf-receptor supergene family

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023614A1 (en) * 1995-12-22 1997-07-03 Amgen Inc. Osteoprotegerin
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
WO1999007738A2 (en) * 1997-08-06 1999-02-18 Regeneron Pharmaceuticals, Inc. Human orphan receptor ntr-1
WO1999014330A1 (en) * 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023614A1 (en) * 1995-12-22 1997-07-03 Amgen Inc. Osteoprotegerin
WO1998030694A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
EP0861850A1 (en) * 1997-02-04 1998-09-02 Smithkline Beecham Corporation Tumor necrosis related receptor, TR4
WO1999004001A1 (en) * 1997-07-21 1999-01-28 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-5
WO1999007738A2 (en) * 1997-08-06 1999-02-18 Regeneron Pharmaceuticals, Inc. Human orphan receptor ntr-1
WO1999014330A1 (en) * 1997-09-18 1999-03-25 Genentech, Inc. DcR3 POLYPEPTIDE, A TNFR HOMOLOG

Also Published As

Publication number Publication date
CA2314884A1 (en) 1999-06-24
WO1999031128A2 (en) 1999-06-24
JP2002508168A (en) 2002-03-19
EP1037908A2 (en) 2000-09-27
AU1541699A (en) 1999-07-05

Similar Documents

Publication Publication Date Title
WO1999036550A3 (en) Human protease molecules
WO1999015658A3 (en) Human regulatory molecules
WO1998058052A3 (en) Disease associated protein kinases
WO2000015793A3 (en) Human gpcr proteins
WO2000018922A3 (en) Human carbohydrate-associated proteins
WO2000034477A3 (en) Neuron-associated proteins
WO1999058692A3 (en) Human apoptosis associated proteins
WO2000009709A3 (en) Proteases and associated proteins
WO2000012703A3 (en) Protein transport-associated molecules
WO2000017355A3 (en) Human cytoskeleton associated proteins
WO1999049038A3 (en) Human calcium-binding proteins
WO2001005970A3 (en) Gtp-binding protein associated factors
WO2001020004A3 (en) Protein phosphatase and kinase proteins
WO2000014251A3 (en) Human transferase proteins
WO2000052151A3 (en) Human secretory proteins
WO2000044900A3 (en) Nucleic-acid binding proteins
WO1999031128A3 (en) Human tumor necrosis factor-r2-like proteins
WO1998055509A3 (en) Two human dnaj-like proteins
WO1999009182A3 (en) Rab proteins
WO1999038981A3 (en) Human protein kinase molecules
WO1999041373A3 (en) Human transport-associated molecules
WO2000023589A3 (en) Proliferation and apoptosis related proteins
WO2000028045A3 (en) Human hydrolase proteins
WO1999031225A3 (en) Human phosphatases
WO2000065054A3 (en) Human membrane-associated proteins

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 539051

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref document number: 2314884

Country of ref document: CA

Ref country code: CA

Ref document number: 2314884

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 1998959662

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1998959662

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1998959662

Country of ref document: EP