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US3598122A - Bandage for administering drugs - Google Patents

Bandage for administering drugs Download PDF

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Publication number
US3598122A
US3598122A US812116A US3598122DA US3598122A US 3598122 A US3598122 A US 3598122A US 812116 A US812116 A US 812116A US 3598122D A US3598122D A US 3598122DA US 3598122 A US3598122 A US 3598122A
Authority
US
United States
Prior art keywords
bandage
reservoir layer
release rate
systemically active
rate controlling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US812116A
Inventor
Alejandro Zaffaroni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of US3598122A publication Critical patent/US3598122A/en
Application granted granted Critical
Publication of US3598122B1 publication Critical patent/US3598122B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bandage for use in the continuous administration of systemically active drugs by absorption through the skin or oral mucosa comprising a backing member having on one surface thereof a reservoir containing a systemically active drug. The reservoir has a wall distant from the backing member and permeable to passage of the drug. A pressure-sensitive adhesive layer, also permeable to passage of the drug, is carried by the reservoir. The drug is in a form acceptable for absorption through the skin or the mucosa of the mouth.

Claims (15)

1. A medical bandage for use in the continuous administration to circulation of controlled quantities of systemically active drugs over a prolonged period of time by absorption through the external body skin or mucosa, said bandage comprising a sandwich including (1) a backing member; (2) a discrete, middle reservoir layer containing a systemically active drug, which reservoir layer is comprised of systemically active drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drug from the said reservoir to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time; and (3) a surface of a pressure-sensitive adhesive adapted for contact with the skin or mucosa of a patient.
2. The bandage as defined by claim 1, wherein the reservoir layer (2) is comprised of a walled container having an interior chamber containing the systemically active drug formulation.
3. The bandage as defined by claim 1, wherein the reservoir layer (2) is comprised of a matrix of the drug release rate controlling wall material, said matrix having the systemically active drug formulation distributed therethrough.
4. The bandage as defined by claim 1, wherein the systemically active drug formulation is soluble in the drug release rate controlling material.
5. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is permeable to passage of the systemically active drug formulation.
6. The bandage as defined by claim 1, wherein the drug formulation comprises a pharmacologically acceptable solvent.
7. The bandages as defined by claim 1, further comprising a solubility membrane (4) interposed between said reservoir layer (2) and said surface of pressure-sensitive adhesive (3).
8. The bandage as defined by claim 1, wherein said drug release rate controlling material is silicone rubber.
9. The bandage as defined by claim 1, wherein said drug release rate controlling material is a hydrophilic polymer of an ester of an olefinic acid.
10. The bandage as defined by claim 1, wherein at least that portion of the wall member comprising the reservoir layer (2) which is adapted to be brought contiguous the skin as mucosa is formed from the drug release rate controlling material.
11. The bandage as defined by claim 1, wherein the wall member comprising the reservoir layer (2) consists of drug release rate controlling material.
12. The bandage as defined by claim 1, wherein the outer surface of the wall member comprising the reservoir layer (2) also defines the said backing member (1).
13. The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is adapted to provide a liquidtight adhesive seal between the skin or mucosa and the bandage.
14. The bandage as defined by claim 1, wherein the surface of a pressure-sensitive adhesive (3) is covered with a protective release coating (5).
15. The bandage as defined by claim 1, wherein the outer surface of the backing member (1) is coated with a low-adhesion backsize (6).
US812116A 1969-04-01 1969-04-01 Bandage for administering drugs Expired - Lifetime US3598122A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81211669A 1969-04-01 1969-04-01
ZA714095A ZA714095B (en) 1969-04-01 1971-06-22 Bandage for administering drugs

Publications (2)

Publication Number Publication Date
US3598122A true US3598122A (en) 1971-08-10
US3598122B1 US3598122B1 (en) 1982-11-23

Family

ID=27123569

Family Applications (1)

Application Number Title Priority Date Filing Date
US812116A Expired - Lifetime US3598122A (en) 1969-04-01 1969-04-01 Bandage for administering drugs

Country Status (2)

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US (1) US3598122A (en)
ZA (1) ZA714095B (en)

Cited By (439)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) * 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3807398A (en) * 1972-09-19 1974-04-30 B Grucza Ocular implant
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3896819A (en) * 1969-04-01 1975-07-29 Alejandro Zaffaroni IUD having a replenishing drug reservoir
US3951622A (en) * 1974-12-04 1976-04-20 Wilk Immanuel J Time release perfume method and device
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3961628A (en) * 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
US3986510A (en) * 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3993073A (en) * 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
DE2647581A1 (en) * 1976-10-21 1978-04-27 Henkel Kgaa BLISTER PACK
US4191743A (en) * 1976-11-02 1980-03-04 Merck Patent Gesellschaft Mit Beschrankter Haftung Antibacterial wound dressing
US4201211A (en) * 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
US4336243A (en) * 1980-08-11 1982-06-22 G. D. Searle & Co. Transdermal nitroglycerin pad
EP0065370A1 (en) * 1981-05-02 1982-11-24 Smith and Nephew Associated Companies p.l.c. Sterile dressing and preparation thereof
FR2508318A1 (en) * 1981-06-29 1982-12-31 Alza Corp BANDAGE FOR THE ADMINISTRATION OF A PHARMACEUTICAL SUBSTANCE
US4435180A (en) 1982-05-25 1984-03-06 Alza Corporation Elastomeric active agent delivery system and method of use
US4460371A (en) * 1981-11-24 1984-07-17 Dennison Manufacturing Company Silicone pressure sensitive adhesive and uses
DE3500508A1 (en) * 1984-03-05 1985-09-12 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka PREPARATION FOR PERCUTANEOUS ADMINISTRATION OF MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF
FR2562800A1 (en) * 1984-04-11 1985-10-18 Fournier Laboratoires Device for percutaneous administration of medicaments
US4563184A (en) * 1983-10-17 1986-01-07 Bernard Korol Synthetic resin wound dressing and method of treatment using same
WO1986000532A1 (en) * 1984-07-07 1986-01-30 Flexcon Company, Inc. Silicone pressure sensitive adhesive and uses
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4594240A (en) * 1982-09-10 1986-06-10 Teikoku Seiyaku Kabushiki Kaisha Sheet-shape adhesive preparation
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4608249A (en) * 1982-11-02 1986-08-26 Nitto Electric Industrial Co., Ltd. Hydrophilic therapeutic material
US4614787A (en) * 1984-11-13 1986-09-30 Thermedics, Inc. Drug dispensing wound dressing
US4615697A (en) * 1983-11-14 1986-10-07 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
US4638043A (en) * 1984-11-13 1987-01-20 Thermedics, Inc. Drug release system
US4649075A (en) * 1984-08-09 1987-03-10 Leonora Jost Transdermal and transmucosal vortexed foam devices and the method of making
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
WO1987003477A1 (en) * 1985-12-12 1987-06-18 Flexcon Company, Inc. Transdermal methods and adhesives
EP0236266A1 (en) * 1986-02-14 1987-09-09 Ciba-Geigy Ag Dermal and transdermal therapeutic system having a discontinuous-pattern adhesive layer and method of manufacturing thereof
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
EP0249343A1 (en) * 1986-06-13 1987-12-16 Alza Corporation Moisture activation of transdermal drug delivery system
EP0249475A2 (en) * 1986-06-13 1987-12-16 Alza Corporation Delayed percutaneous delivery
EP0250125A2 (en) * 1986-06-03 1987-12-23 Smith & Nephew plc Drug delivery device, its preparation and use
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4727868A (en) * 1984-11-13 1988-03-01 Thermedics, Inc. Anisotropic wound dressing
EP0259136A2 (en) 1986-09-02 1988-03-09 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US4738848A (en) * 1985-06-04 1988-04-19 Nitto Electric Industrial Co., Ltd. Anti-inflammatory analgesic adhesive preparation
US4743249A (en) * 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
FR2607003A1 (en) * 1986-11-20 1988-05-27 Marchandise Jean Homeopathic skin card
US4751133A (en) * 1984-11-13 1988-06-14 Thermedics, Inc. Medical patches and processes for producing same
US4752478A (en) * 1984-12-17 1988-06-21 Merck & Co., Inc. Transdermal system for timolol
EP0273004A2 (en) * 1986-11-20 1988-06-29 Ciba-Geigy Ag User-activated therapeutical system
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
EP0279977A2 (en) * 1987-02-26 1988-08-31 Alza Corporation Transdermal administration of progesterone, estradiol esters and mixtures thereof
US4769028A (en) * 1983-04-27 1988-09-06 Lohmann Gmbh & Co. Kg Pharmaceutical product, in medical bandage form
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4795436A (en) * 1983-11-14 1989-01-03 Bio-Mimetics, Inc. Bioadhesive composition and method of treatment therewith
US4797284A (en) * 1986-03-12 1989-01-10 Merck & Co., Inc. Transdermal drug delivery system
US4812305A (en) * 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4820720A (en) * 1987-08-24 1989-04-11 Alza Corporation Transdermal drug composition with dual permeation enhancers
US4834979A (en) * 1981-06-29 1989-05-30 Alza Corporation Medical bandage for administering beneficial drug
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4839174A (en) * 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
US4840796A (en) * 1988-04-22 1989-06-20 Dow Corning Corporation Block copolymer matrix for transdermal drug release
US4844903A (en) * 1986-11-07 1989-07-04 Mepha Ag Process for the production of an adhesive plaster
USRE32991E (en) * 1984-11-13 1989-07-18 Thermedics, Inc. Drug dispensing wound dressing
US4863738A (en) * 1987-11-23 1989-09-05 Alza Corporation Skin permeation enhancer compositions using glycerol monooleate
WO1989007959A1 (en) * 1988-02-23 1989-09-08 John Mark Tucker Occlusive body for administering a physiologically active substance
US4865848A (en) * 1987-02-26 1989-09-12 Alza Corporation Skin permeation enhancer compositions using sucrose esters
AT389049B (en) * 1982-07-16 1989-10-10 Koezponti Valto Hitelbank Process for the production of pharmaceutical products which can be attached to uninjured skin, in particular of antispastic and antirheumatic products
US4877618A (en) * 1988-03-18 1989-10-31 Reed Jr Fred D Transdermal drug delivery device
US4879275A (en) * 1987-09-30 1989-11-07 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agent
US4880690A (en) * 1984-11-13 1989-11-14 Thermedics, Inc. Perfume patch
US4885154A (en) * 1988-03-01 1989-12-05 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US4889720A (en) * 1986-09-01 1989-12-26 Teikoku Seiyaku Kabushiki Kaisha Sustained release dosage form for use with tissues of the oral cavity
US4898592A (en) * 1986-08-23 1990-02-06 Latzke Arno W Means for the application of transdermally absorbable active substances
US4900555A (en) * 1987-02-26 1990-02-13 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4900552A (en) * 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4909244A (en) * 1986-11-26 1990-03-20 The Kendall Company Hydrogel wound dressing
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
US4917895A (en) * 1987-11-02 1990-04-17 Alza Corporation Transdermal drug delivery device
US4920101A (en) * 1987-09-30 1990-04-24 Nelson Research & Development Co. Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
US4925671A (en) * 1981-11-24 1990-05-15 Flexcon Company, Inc. Silicone pressure sensitive adhesive and uses
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4942037A (en) * 1988-06-02 1990-07-17 Merck & Co., Inc. Transdermal delivery systems
US4943435A (en) * 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
US4951657A (en) * 1988-04-22 1990-08-28 Dow Corning Corporation Heat sealable membrane for transdermal drug release
US4956171A (en) * 1989-07-21 1990-09-11 Paco Pharmaceutical Services, Inc. Transdermal drug delivery using a dual permeation enhancer and method of performing the same
US4959208A (en) * 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
US4969871A (en) * 1989-02-15 1990-11-13 Alza Corporation Intravenous system for delivering a beneficial agent
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US4979946A (en) * 1987-12-14 1990-12-25 The Kendall Company Environmental absorbent dressing
GB2232892A (en) * 1988-02-23 1991-01-02 John Mark Tucker Occlusive body for administering a physiologically active substance
US4985016A (en) * 1989-02-15 1991-01-15 Alza Corporation Intravenous system for delivering a beneficial agent
US4997655A (en) * 1987-06-22 1991-03-05 Biogal Gyogyszergyar Pharmaceutical formulation ensuring the transdermal absorption of the active ingredient and process for preparing same
US5000956A (en) * 1987-03-09 1991-03-19 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
DE3939703A1 (en) * 1989-12-01 1991-06-06 Boehringer Ingelheim Kg IMPROVED TRANSDERMAL APPLICATION OF PHARMACOLOGICALLY ACTIVE COMPOUNDS
US5034386A (en) * 1986-01-31 1991-07-23 Whitby Research, Inc. Methods for administration using 1-substituted azacycloalkanes
US5035886A (en) * 1987-10-19 1991-07-30 Ppg Industries, Inc. Active agent delivery device
US5045059A (en) * 1989-02-15 1991-09-03 Alza Corporation Intravenous system for delivering a beneficial agent
US5049387A (en) * 1987-03-09 1991-09-17 Alza Corporation Inducing skin tolerance to a sensitizing drug
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5059189A (en) * 1987-09-08 1991-10-22 E. R. Squibb & Sons, Inc. Method of preparing adhesive dressings containing a pharmaceutically active ingredient
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5068226A (en) * 1987-12-07 1991-11-26 Cyclex, Inc. Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies
US5071645A (en) * 1987-10-19 1991-12-10 Ppg Industries, Inc. Process of producing an active agent delivery device
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
US5077054A (en) * 1987-03-09 1991-12-31 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5118509A (en) * 1987-03-09 1992-06-02 Alza Corporation Inducing skin tolerance to a sensitizing drug
US5120545A (en) * 1990-08-03 1992-06-09 Alza Corporation Reduction or prevention of sensitization to drugs
US5124157A (en) * 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5130139A (en) * 1990-07-06 1992-07-14 Alza Corporation Reduction or prevention of skin irritation by drugs
US5149539A (en) * 1990-08-03 1992-09-22 Alza Corporation Reduction or prevention of sensitization to drugs
US5160741A (en) * 1990-07-06 1992-11-03 Alza Corporation Reduction or prevention of skin irritation by drugs
US5171576A (en) * 1987-03-09 1992-12-15 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5173302A (en) * 1990-09-28 1992-12-22 Medtronic, Inc. Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs
US5189986A (en) * 1991-09-23 1993-03-02 Alza Corporation Veterinary transdermal active agent delivery device
US5196202A (en) * 1986-09-01 1993-03-23 Teikoku Seiyaku Kabushiki Kaisha Sustained release dosage form
US5198223A (en) * 1990-10-29 1993-03-30 Alza Corporation Transdermal formulations, methods and devices
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US5203768A (en) * 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5223261A (en) * 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
WO1993012799A1 (en) * 1991-12-20 1993-07-08 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermally administered system containing acetylsalicylic acid for thrombosis therapy and cancer prophylaxis
US5230896A (en) * 1989-10-12 1993-07-27 Warner-Lambert Company Transdermal nicotine delivery system
US5234690A (en) * 1991-08-23 1993-08-10 Cygnus Therapeutic Systems Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
US5250028A (en) * 1989-02-15 1993-10-05 Alza Corporation Intravenous system for delivering a beneficial agent using permeability enhancers
US5268179A (en) * 1992-02-14 1993-12-07 Ciba-Geigy Corporation Ultrasonically sealed transdermal drug delivery systems
US5273755A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset
US5273756A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
US5286748A (en) * 1981-01-05 1994-02-15 Eby Iii George A General method of shortening the duration of common colds by application of medicaments to tissues of oral cavity
US5298257A (en) * 1987-05-01 1994-03-29 Elan Transdermal Limited Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
US5314694A (en) * 1990-10-29 1994-05-24 Alza Corporation Transdermal formulations, methods and devices
US5320850A (en) * 1990-10-29 1994-06-14 Alza Corporation Transdermal delivery of the gestogen ST-1435 and devices therefor
US5322695A (en) * 1987-01-09 1994-06-21 Hercon Laboratories Corporation Moisture-vapor-permeable dressing
US5342623A (en) * 1986-09-12 1994-08-30 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
WO1994018966A1 (en) * 1993-02-26 1994-09-01 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system with active substances which represent sources of nitrogen oxide
US5364634A (en) * 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
US5364628A (en) * 1985-05-31 1994-11-15 Sandoz Ltd. Pharmaceutical compositions
US5376377A (en) * 1990-10-29 1994-12-27 Alza Corporation Transdermal contraceptive formulations, methods and devices
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
US5402777A (en) * 1991-06-28 1995-04-04 Alza Corporation Methods and devices for facilitated non-invasive oxygen monitoring
US5411740A (en) * 1992-05-13 1995-05-02 Alza Corporation Transdermal administration of oxybutynin
DE4421433C1 (en) * 1994-06-18 1995-06-08 Lohmann Therapie Syst Lts Transdermal therapeutic system for treatment of, e.g., hypertension
US5445607A (en) * 1989-10-23 1995-08-29 Theratech, Inc. Iontophoresis device and method using a rate-controlling electrically sensitive membrane
US5451407A (en) * 1993-06-21 1995-09-19 Alza Corporation Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
US5490415A (en) * 1994-04-15 1996-02-13 Pharmetrix Corporation Diffusion test apparatus and method
US5498417A (en) * 1994-05-12 1996-03-12 Coating Sciences, Inc. Transdermal delivery of appetite suppressant drug
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5508039A (en) * 1991-10-18 1996-04-16 Alza Corporation Controlled transdermal administration of melatonin
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5560922A (en) * 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
US5589192A (en) * 1993-12-03 1996-12-31 Lintec Corporation Gel pharmaceutical formulation for local anesthesia
US5599554A (en) * 1994-06-23 1997-02-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms
US5633009A (en) * 1990-11-28 1997-05-27 Sano Corporation Transdermal administration of azapirones
US5641504A (en) * 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
US5650165A (en) * 1994-11-15 1997-07-22 Nitto Denko Corporation Percutaneous absorption preparation
US5662928A (en) * 1995-04-21 1997-09-02 Ciba-Geigy Corporation Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system
US5662925A (en) * 1994-12-21 1997-09-02 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
US5691377A (en) * 1993-07-30 1997-11-25 University Of Maryland Eastern Shore And University Of Maryland College Park Use of N-methyl-aspartic acid for enhancing growth and altering body composition
US5705186A (en) * 1994-02-07 1998-01-06 Lts Lohmann Therapie-Systeme Gmbh Pharmaceutical composition for the systemic transdermal administration having the active substance morphine-6-glucuronide
US5707663A (en) * 1993-05-28 1998-01-13 Alza Corporation Sustained antiepileptic therapy
US5733255A (en) * 1995-10-18 1998-03-31 Novartis Finance Corporation Thermopile powered transdermal drug delivery device
US5747065A (en) * 1993-09-29 1998-05-05 Lee; Eun Soo Monoglyceride/lactate ester permeation enhancer for oxybutynin
US5763425A (en) * 1991-04-03 1998-06-09 Gundersen Clinic, Ltd. Suppression of thromboxane levels by percutaneous administration of aspirin
US5770220A (en) * 1993-12-04 1998-06-23 Lts Lohmann Therapie Systeme Gmbh Active substance-containing patch
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US5788983A (en) * 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5804214A (en) * 1993-07-08 1998-09-08 Cygnus, Inc. Monolithic matrix transdermal delivery system for delivering ketorolac tromethamine
US5820876A (en) * 1986-08-28 1998-10-13 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system
US5840327A (en) * 1995-08-21 1998-11-24 Alza Corporation Transdermal drug delivery device having enhanced adhesion
US5882676A (en) * 1995-05-26 1999-03-16 Alza Corporation Skin permeation enhancer compositions using acyl lactylates
US5895660A (en) * 1993-12-22 1999-04-20 Lts Lohmann Therapie-Systeme Gmbh Deuterated active substances in transdermal application
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
US5919478A (en) * 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
US5942243A (en) * 1996-11-12 1999-08-24 Polytherapeutics, Inc. Mucoadhesive compositions for administration of biologically active agents to animal tissue
US5962011A (en) * 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US6001390A (en) * 1995-06-07 1999-12-14 Alza Corporation Formulations for transdermal delivery of pergolide
US6007837A (en) * 1996-07-03 1999-12-28 Alza Corporation Drug delivery devices and process of manufacture
US6068853A (en) * 1994-04-13 2000-05-30 Novartis Corporation Temporally controlled drug delivery systems
US6071896A (en) * 1992-06-16 2000-06-06 Gundersen Clinic, Ltd. Suppression of thromboxane levels by percutaneous administration of aspirin
US6110499A (en) * 1997-07-24 2000-08-29 Alza Corporation Phenytoin therapy
US6126963A (en) * 1986-08-28 2000-10-03 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6174545B1 (en) 1997-07-01 2001-01-16 Alza Corporation Drug delivery devices and process of manufacture
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
US6238700B1 (en) 1995-12-01 2001-05-29 Alza Corporation Method for preventing crystal formation in a dispersion of a liquid in a matrix
US6264980B1 (en) 1994-12-24 2001-07-24 Lts Lohmann Therapie-Systeme Gmbh Transdermal resorption of active substances from supercooled masses of levulic acid
US20010038856A1 (en) * 1994-07-07 2001-11-08 Sonya Merrill Hydromorphone therapy
US6344211B1 (en) 1994-12-24 2002-02-05 Lts Lohmann Therapie-Systeme Gmbh Transdermal absorption of active substances from subcooled melts
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US6469227B1 (en) 1999-12-10 2002-10-22 Lectec Corporation Antipruritic patch
USRE37934E1 (en) 1986-08-28 2002-12-10 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
US20030008852A1 (en) * 1999-12-11 2003-01-09 Franke Hanshermann Transdermal system containing acetylsalicylic acid for treatment of migraine
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
US6569448B1 (en) 1995-12-01 2003-05-27 Alza Corporation Method for preventing crystal formation in a dispersion of a liquid in a matrix
US20030107149A1 (en) * 2001-10-12 2003-06-12 International Fluidics. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US6592892B1 (en) 1999-08-30 2003-07-15 Tepha, Inc. Flushable disposable polymeric products
US20030224051A1 (en) * 2002-05-31 2003-12-04 Fink Tracy A. Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US20040010000A1 (en) * 2002-04-29 2004-01-15 Ayer Atul D. Methods and dosage forms for controlled delivery of oxycodone
GB2353219B (en) * 1999-08-16 2004-02-11 Johnson & Johnson Medical Ltd Easy to remove adhesive sheets
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US20040081684A1 (en) * 1996-02-19 2004-04-29 Monash University Topical delivery of antifungal agents
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
US20040191301A1 (en) * 2003-03-27 2004-09-30 Van Duren Albert Philip Transdermal device having a phase change material
US20040234576A1 (en) * 2003-05-08 2004-11-25 Tepha, Inc., State Of Incorporation Delaware Polyhydroxyalkanoate medical textiles and fibers
US20040234585A1 (en) * 1998-12-18 2004-11-25 Gale Robert M. Transparent transdermal nicotine delivery devices
WO2004105854A1 (en) * 2003-06-03 2004-12-09 Nadler, Joseph Device and method for dispensing medication to tissue lining a body cavity
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
US20050002997A1 (en) * 2003-04-30 2005-01-06 Howard Stephen A. Tamper resistant transdermal dosage form
US20050025809A1 (en) * 2003-07-08 2005-02-03 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US20050037055A1 (en) * 2002-04-11 2005-02-17 Monosolrx Llc. Polyethylene oxide-based films and drug delivery systems made therefrom
US20050048104A1 (en) * 1999-04-01 2005-03-03 Venkatraman Subramanian S. Transdermal drug delivery devices comprising a polyurethane drug reservoir
US20050065062A1 (en) * 2003-09-24 2005-03-24 3M Innovative Properties Company Method of formulating a pharmaceutical composition
US20050142475A1 (en) * 2003-12-30 2005-06-30 Moudry Ronald J. Dry toner comprising encapsulated pigment, methods and uses
US20050191340A1 (en) * 2002-08-09 2005-09-01 Gruenenthal Gmbh Opioid-receptor antagonists in transdermal systems having buprenorphine
US20050234024A1 (en) * 2004-04-14 2005-10-20 Clarke David E Materials and methods for the treatment of ulcerative colitis
US20060008432A1 (en) * 2004-07-07 2006-01-12 Sebastiano Scarampi Gilsonite derived pharmaceutical delivery compositions and methods: nail applications
US20060039958A1 (en) * 2003-05-28 2006-02-23 Monosolrx, Llc. Multi-layer films having uniform content
US20060051391A1 (en) * 2004-09-09 2006-03-09 Dvoskin Victor O Device for the controlled administration of substances to be inserted in a body cavity
US20060058470A1 (en) * 2004-08-03 2006-03-16 Tepha, Inc. Non-curling polyhydroxyalkanoate sutures
US7063859B1 (en) 1999-04-28 2006-06-20 Noven Pharmaceuticals, Inc. Barrier film lined backing layer composition and method for topical administration of active agents
EP1674068A1 (en) 1996-02-19 2006-06-28 Acrux DDS Pty Ltd Dermal penetration enhancers and drug delivery systems involving same
US20060142722A1 (en) * 2004-12-29 2006-06-29 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US20060147493A1 (en) * 2002-07-22 2006-07-06 Yang Robert K Packaging and dispensing of rapid dissolve dosage form
US20060177513A1 (en) * 2005-01-28 2006-08-10 Tepha, Inc. Embolization using poly-4-hydroxybutyrate particles
US20060217790A1 (en) * 2005-03-28 2006-09-28 Ohshin Mlp Co., Ltd. Sheet-like face pack and kits for face packs
US20060257461A1 (en) * 2005-05-13 2006-11-16 Jansen Rolf R Multilayer galantamine delivery system with barrier against reservoir material flow
US20060287659A1 (en) * 2003-08-22 2006-12-21 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US20070065463A1 (en) * 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
WO2007035939A2 (en) 2005-09-23 2007-03-29 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
US20070071740A1 (en) * 2005-09-27 2007-03-29 Bio-Tissue, Inc. Purified amniotic membrane compositions and methods of use
US20070071828A1 (en) * 2005-09-27 2007-03-29 Bio-Tissue, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US20070082038A1 (en) * 2005-09-23 2007-04-12 Gale Robert M Transdermal nicotine salt delivery system
US20070122455A1 (en) * 2001-10-12 2007-05-31 Monosolrx, Llc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
WO2007062266A2 (en) 2005-11-28 2007-05-31 Marinus Pharmaceuticals Ganaxolone formulations and methods for the making and use thereof
US20070134310A1 (en) * 2005-09-23 2007-06-14 Nedberge Diane E Transdermal risperidone delivery system
US20070149731A1 (en) * 2001-10-12 2007-06-28 Monosolrx, Llc. PH modulated films for delivery of actives
US20070148195A1 (en) * 2000-04-26 2007-06-28 Ebert Charles D Compositions and methods for transdermal oxybutynin therapy
US20070154527A1 (en) * 2001-10-12 2007-07-05 Monosoirx, Llc Topical film compositions for delivery of actives
US20070172515A1 (en) * 2006-01-20 2007-07-26 Monosolrx, Llc Film bandage for mucosal administration of actives
US20070179210A1 (en) * 2006-01-31 2007-08-02 Tyco Healthcare Group Lp Super soft foams
US20070185180A1 (en) * 2005-12-05 2007-08-09 Tamar Blumberg Pharmaceutical formulation containing phenytoin sodium and magnesium stearate
US20070190157A1 (en) * 2006-01-20 2007-08-16 Monosoirx, Llc. Film lined packaging and method of making same
US20070237812A1 (en) * 2006-04-11 2007-10-11 Tyco Healthcare Group Multi-layer wound dressings
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US20070281003A1 (en) * 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US20070278289A1 (en) * 2006-05-31 2007-12-06 Toshiba Tec Kabushiki Kaisha Payment adjusting apparatus and program therefor
US20080014259A1 (en) * 2006-05-16 2008-01-17 Knopp Neurosciences, Inc. Compositions of R(+) and S(-) Pramipexole and Methods of Using the Same
WO2008021368A2 (en) 2006-08-11 2008-02-21 The Johns Hopkins University Compositions and methods for neuroprotection
US20080044454A1 (en) * 2002-04-11 2008-02-21 Monosolrx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20080051490A1 (en) * 1999-03-25 2008-02-28 Williams Simon F Medical Devices and Applications of Polyhydroxyalkanoate Polymers
US20080075825A1 (en) * 2006-09-20 2008-03-27 Fuisz Richard C Edible Water-Soluble Film Containing a Foam Reducing Flavoring Agent
US20080081071A1 (en) * 2006-09-29 2008-04-03 Pradeep Sanghvi Film Embedded Packaging and Method of Making Same
WO2008039218A2 (en) 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20080090894A1 (en) * 2001-06-05 2008-04-17 Ronald Aung-Din Transdermal migraine therapy
WO2008066899A2 (en) 2006-11-28 2008-06-05 Marinus Pharmaceuticals Nanoparticulate formulations and methods for the making and use thereof
US20080132602A1 (en) * 2006-12-01 2008-06-05 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20080131466A1 (en) * 2006-09-26 2008-06-05 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US20080160065A1 (en) * 2006-07-12 2008-07-03 Janet Anne Halliday Drug delivery polymer with hydrochloride salt of clindamycin
US20080227985A1 (en) * 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazoles
US20080260809A1 (en) * 2002-04-11 2008-10-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20090005443A1 (en) * 2007-06-22 2009-01-01 Malcolm Philip Young Treatment of Depression
WO2009013480A2 (en) 2007-07-20 2009-01-29 E-Therapeutics Plc Antibacterial combination therapy
US20090042956A1 (en) * 2006-04-10 2009-02-12 Knopp Neurosciences, Inc. Compositions and methods of using (r)-pramipexole
US20090054504A1 (en) * 2006-12-14 2009-02-26 Knopp Neurosciences, Inc. Modified Release Formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and Methods of Using the Same
WO2009035818A1 (en) 2007-09-10 2009-03-19 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20090098069A1 (en) * 2007-09-14 2009-04-16 Drugtech Corporation Transdermal, alcohol-free, pharmaceutical compositions
US20090169602A1 (en) * 2005-11-23 2009-07-02 Universität Zürich Allergy Treatment by Epicutaneous Allergen Administration
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US20090286246A1 (en) * 2008-05-07 2009-11-19 Wintherix Llc Methods for Identifying Compounds that Affect Expression of Cancer-Related Protein Isoforms
US20090291120A1 (en) * 2006-07-05 2009-11-26 Jukka Tuominen Hydrophilic Polyurethane Compositions
US20090304776A1 (en) * 2008-06-06 2009-12-10 Totada Shantha Transmucosal delivery of therapeutic agents and methods of use thereof
US20090311311A1 (en) * 2008-06-16 2009-12-17 Shantha Totada R Transdermal local anesthetic patch with injection port
US20090324692A1 (en) * 2006-07-08 2009-12-31 Controlled Therapeutics (Scotland) Limited Polyurethane Elastomers
WO2010005507A1 (en) 2008-06-30 2010-01-14 Afgin Pharma, Llc Topical regional neuro-affective therapy
US20100021526A1 (en) * 2001-10-12 2010-01-28 Monosol Rx, Llc Ph modulated films for delivery of actives
US20100055437A1 (en) * 2008-08-28 2010-03-04 Tyco Healthcare Group Lp Anti-microbial fibers and related articles and methods
WO2010027875A2 (en) 2008-08-27 2010-03-11 Calcimedica Inc. Compounds that modulate intracellular calcium
US20100069437A1 (en) * 2002-11-18 2010-03-18 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US20100068708A1 (en) * 2008-05-07 2010-03-18 Wintherix Llc Methods for Identifying Compounds that Modulate WNT Signaling in Cancer Cells
US20100112050A1 (en) * 2008-11-03 2010-05-06 Je Phil Ryoo Dosage Form For Insertion Into The Mouth
US20100121297A1 (en) * 2008-11-10 2010-05-13 Kenrico Ltd Skin patch for absorbing toxins from the body
US20100143270A1 (en) * 2007-02-21 2010-06-10 University Of Louisville Research Foubdation Therapeutic cotinine compositions
WO2010071866A2 (en) 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Combination therapy for arthritis with tranilast
US20100209484A1 (en) * 2009-02-13 2010-08-19 Hoo-Kyun Choi Transdermal Triptan Delivery System
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
WO2010141861A1 (en) 2009-06-05 2010-12-09 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
US20110009460A1 (en) * 2009-06-19 2011-01-13 Valentin Gribkoff Compositions and methods for treating amyotrophic lateral sclerosis
US20110008411A1 (en) * 2008-07-15 2011-01-13 Griffin Santea B Method of treating pruritis
US20110021596A1 (en) * 2009-07-27 2011-01-27 Ronald Aung-Din Topical therapy for migraine
US20110020217A1 (en) * 2007-10-10 2011-01-27 E-Therapeutics Plc Treatment of melanoma
US20110033541A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US20110033542A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US20110033376A1 (en) * 2007-07-06 2011-02-10 Malcolm Philip Young Treatment of Melanoma
US20110046578A1 (en) * 2007-03-13 2011-02-24 Biry Jean-Francois Device for the cutaneous application of substances
WO2011030106A1 (en) 2009-09-10 2011-03-17 E-Therapeutics Plc Cancer cell apoptosis
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
US20110212173A1 (en) * 2008-06-17 2011-09-01 e-Therapeutics Ple Controlled Release Treatment of Depression
WO2011119894A2 (en) 2010-03-24 2011-09-29 Kinagen, Inc Heterocyclic compounds useful for kinase inhibition
WO2011130689A1 (en) 2010-04-15 2011-10-20 Tracon Pharmaceuticals, Inc. Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
WO2011130455A1 (en) 2010-04-13 2011-10-20 Najib Babul Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
WO2011139489A2 (en) 2010-04-27 2011-11-10 Calcimedica Inc. Compounds that modulate intracellular calcium
WO2011139765A2 (en) 2010-04-27 2011-11-10 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2011143152A2 (en) 2010-05-11 2011-11-17 Questcor Pharmaceuticals Acth for treatment of amyotrophic lateral sclerosis
WO2011153514A2 (en) 2010-06-03 2011-12-08 Pharmacyclics, Inc. The use of inhibitors of bruton's tyrosine kinase (btk)
JP4889172B2 (en) * 1999-06-11 2012-03-07 リンテック株式会社 Moisture sensitive transdermal formulation
WO2012046006A2 (en) 2010-10-08 2012-04-12 University Of Dundee Cancer targets
WO2012094638A1 (en) 2011-01-07 2012-07-12 Skinmedica, Inc. Melanin modification compositions and methods of use
WO2012104589A1 (en) 2011-02-02 2012-08-09 University Of Edinburgh Weight related disorders
US20120245538A1 (en) * 2009-12-04 2012-09-27 Michael Horstmann Transdermal Therapeutic System for the Administration of Peptides
EP2508231A2 (en) 2006-11-16 2012-10-10 E-Therapeutics Plc Imidazoles for treating multi-drug resistant bacterial infections
US8460707B2 (en) 2004-08-05 2013-06-11 Ferring B.V. Stabilised prostaglandin composition
WO2013119856A1 (en) 2012-02-07 2013-08-15 Infectious Disease Research Institute Improved adjuvant formulations comprising tlr4 agonists and methods of using the same
DE102013202928A1 (en) 2012-02-23 2013-08-29 Golden Biotechnology Corporation Methods and compositions for treating cancer metastasis
US8524254B2 (en) 2006-10-18 2013-09-03 Ferring B.V. Bioresorbable polymers
WO2013148701A1 (en) 2012-03-26 2013-10-03 Golden Biotechnology Corporation Methods and compositions for treating arteriosclerotic vascular diseases
US8557281B2 (en) 2002-09-27 2013-10-15 Ferring B.V. Water-swellable polymers
EP2650294A1 (en) 2009-10-12 2013-10-16 Pharmacyclics, Inc. Inhibitors of Bruton's Tyrosine Kinase
WO2013160645A1 (en) 2012-04-26 2013-10-31 E-Therapeutics Plc Dexanabinol or a derivative thereof for use in the treatment of cancer in dose ranges of 2-30 mg/kg
WO2013164561A1 (en) 2012-05-04 2013-11-07 E-Therapeutics Plc Tramadol for treating depression
US8614179B2 (en) 2008-07-18 2013-12-24 E-Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
DE102013107024A1 (en) 2011-11-15 2014-05-15 Golden Biotechnology Corporation Methods and compositions for treating, modifying, and managing bone cancer pain
WO2014081675A1 (en) 2012-11-21 2014-05-30 Golden Biotechnology Corporation Methods and compositions for treating neurodegenerative diseases
DE102013107025A1 (en) 2011-12-30 2014-07-03 Golden Biotechnology Corporation METHODS AND COMPOSITIONS FOR THE MANAGEMENT OF DIABETIS
WO2014110491A1 (en) 2013-01-11 2014-07-17 Theratrophix Llc Prodrugs of treprostinil
US8790689B2 (en) 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
US8796416B1 (en) 2010-10-25 2014-08-05 Questcor Pharmaceuticals, Inc ACTH prophylactic treatment of renal disorders
WO2014130619A2 (en) 2013-02-20 2014-08-28 Golden Biotechnology Corporation Methods and compositions for treating leukemia
WO2014172637A1 (en) 2013-04-18 2014-10-23 Immune Design Corp. Gla monotherapy for use in cancer treatment
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8974826B2 (en) 2010-06-10 2015-03-10 Monosol Rx, Llc Nanoparticle film delivery systems
US9044420B2 (en) 2011-04-08 2015-06-02 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
WO2015084998A1 (en) 2013-12-05 2015-06-11 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
US9072747B2 (en) 2013-03-10 2015-07-07 Peritech Pharma Ltd. Topical compositions and methods of treatment of anorectal disorders
WO2015112485A1 (en) 2014-01-21 2015-07-30 Immune Design Corp. Compositions for use in the treatment of allergic conditions
WO2015138919A1 (en) 2014-03-14 2015-09-17 The University Of North Carolina At Chapel Hill Small molecules for inhibiting male fertility
US9175066B2 (en) 2009-04-24 2015-11-03 Tissuetech, Inc. Compositions containing HC-HA complex and methods of use thereof
WO2016010538A1 (en) 2014-07-16 2016-01-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9260417B2 (en) 2010-02-08 2016-02-16 Amitech Therapeutic Solutions, Inc. Therapeutic methods and compositions involving allosteric kinase inhibition
US9265749B2 (en) 2014-02-10 2016-02-23 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US9273051B2 (en) 2011-12-30 2016-03-01 Pharmacyclics Llc Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
WO2016086063A1 (en) 2014-11-25 2016-06-02 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists
US9393192B2 (en) 2002-07-29 2016-07-19 Alza Corporation Methods and dosage forms for controlled delivery of paliperidone and risperidone
WO2016138479A1 (en) 2015-02-27 2016-09-01 Curtana Pharmaceuticals, Inc. Inhibition of olig2 activity
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
EP3078374A1 (en) 2011-10-17 2016-10-12 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
US9480770B2 (en) 2002-10-23 2016-11-01 Covidien Lp Methods for preparation of medical dressing containing antimicrobial agent
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
WO2016205202A1 (en) 2015-06-17 2016-12-22 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9526770B2 (en) 2011-04-28 2016-12-27 Tissuetech, Inc. Methods of modulating bone remodeling
WO2017011611A1 (en) 2015-07-14 2017-01-19 Lipp Life Sciences Llc Pharmaceutical administration system for the transdermal application of vardenafil
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
WO2017040617A1 (en) 2015-08-31 2017-03-09 Pharmacyclics Llc Btk inhibitor combinations for treating multiple myeloma
US9611263B2 (en) 2013-10-08 2017-04-04 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2017068349A1 (en) 2015-10-23 2017-04-27 E-Therapeutics Plc Cannabinoid for use in immunotherapy
US9642840B2 (en) 2013-08-13 2017-05-09 Knopp Biosciences, Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9682068B2 (en) 2013-05-20 2017-06-20 Mylan Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US9682044B2 (en) 2011-06-10 2017-06-20 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
US9700522B2 (en) 2007-03-19 2017-07-11 Vita Sciences Llc Transdermal patch and method for delivery of vitamin B12
US9701616B2 (en) 2015-06-17 2017-07-11 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9758533B2 (en) 2014-04-23 2017-09-12 The Research Foundation For The State University Of New York Rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjunction therewith
US9763918B2 (en) 2013-08-13 2017-09-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
US9808491B2 (en) 2014-06-03 2017-11-07 Tissuetech, Inc. Compositions of morselized umbilical cord and/or amniotic membrane and methods of use thereof
WO2017197240A1 (en) 2016-05-12 2017-11-16 The Regents Of The University Of Michigan Ash1l inhibitors and methods of treatment therewith
WO2017200957A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Pegylated liposomes and methods of use
WO2017200852A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Formulation containing tlr agonist and methods of use
WO2017205766A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205762A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205769A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017210364A1 (en) 2016-06-01 2017-12-07 Infectious Disease Research Institute Nanoalum particles containing a sizing agent
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
US9895435B2 (en) 2012-05-16 2018-02-20 Immune Design Corp. Vaccines for HSV-2
US20180126058A1 (en) * 2016-08-08 2018-05-10 Universiti Brunei Darussalam Medicated Patch for Preventing Exit Site Infections during Peritoneal Dialysis
US9993444B2 (en) 2011-01-10 2018-06-12 Invion, Inc. Use of beta-adrenergic inverse agonists for smoking cessation
WO2018106632A1 (en) 2016-12-05 2018-06-14 Corsair Pharma, Inc. Dermal and transdermal administration of treprostinil and salts thereof
US10040821B2 (en) 2012-07-11 2018-08-07 Tissuetech, Inc. Compositions containing HC-HA/PTX3 complexes and methods of use thereof
US10172809B2 (en) 2015-03-02 2019-01-08 Afgin Pharma Llc Topical regional neuro-affective therapy in mammals with cannabinoids
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
US10232018B2 (en) 2013-03-14 2019-03-19 Mallinckrodt Ard Ip Limited ACTH for treatment of acute respiratory distress syndrome
US10238625B2 (en) 2015-08-07 2019-03-26 Respivant Sciences Gmbh Methods for the treatment of mast cell related disorders with mast cell stabilizers
US10265267B2 (en) 2016-08-31 2019-04-23 Respivant Sciences Gmbh Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
WO2019094772A1 (en) 2017-11-10 2019-05-16 The Regents Of The University Of Michigan Ash1l degraders and methods of treatment therewith
WO2019113469A1 (en) 2017-12-07 2019-06-13 The Regents Of The University Of Michigan Nsd family inhibitors and methods of treatment therewith
US10336738B2 (en) 2010-08-27 2019-07-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
US10342831B2 (en) 2015-05-20 2019-07-09 Tissuetech, Inc. Composition and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
US10383857B2 (en) 2013-07-12 2019-08-20 Knopp Biosciences Llc Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
WO2019236957A1 (en) 2018-06-07 2019-12-12 The Regents Of The University Of Michigan Prc1 inhibitors and methods of treatment therewith
US10561635B2 (en) 2016-10-07 2020-02-18 Respivant Sciences Gmbh Cromolyn compositions for treatment of pulmonary fibrosis
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2020142557A1 (en) 2018-12-31 2020-07-09 Biomea Fusion, Llc Irreversible inhibitors of menin-mll interaction
US10717712B2 (en) 2018-07-27 2020-07-21 Concentric Analgesics, Inc. Pegylated prodrugs of phenolic TRPV1 agonists
WO2020190890A1 (en) 2019-03-15 2020-09-24 Unicycive Therapeutics Inc. Nicorandil derivatives
US10821105B2 (en) 2016-05-25 2020-11-03 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
US10828266B2 (en) 2016-08-16 2020-11-10 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US10835512B2 (en) 2014-02-10 2020-11-17 Respivant Sciences Gmbh Methods of treating respiratory syncytial virus infections
US10851123B2 (en) 2016-02-23 2020-12-01 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
US11077068B2 (en) 2001-10-12 2021-08-03 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US11191737B2 (en) 2016-05-05 2021-12-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US11242323B2 (en) 2016-08-26 2022-02-08 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
WO2022133064A1 (en) 2020-12-16 2022-06-23 Biomea Fusion, Inc. Fused pyrimidine compounds as inhibitors of menin-mll interaction
WO2023018825A1 (en) 2021-08-11 2023-02-16 Biomea Fusion, Inc. Covalent inhibitors of menin-mll interaction for diabetes mellitus
US11590265B2 (en) 2015-02-23 2023-02-28 Biotissue Holdings Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
WO2023027966A1 (en) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Pyrazine compounds as irreversible inhibitors of flt3
WO2023039240A1 (en) 2021-09-13 2023-03-16 Biomea Fusion, Inc. IRREVERSIBLE INHIBITORS OF KRas
WO2023086341A1 (en) 2021-11-09 2023-05-19 Biomea Fusion, Inc. Inhibitors of kras
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
US11707492B2 (en) 2016-01-29 2023-07-25 Biotissue Holdings Inc. Fetal support tissue products and methods of use
US11739054B2 (en) 2017-06-11 2023-08-29 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
WO2023235618A1 (en) 2022-06-03 2023-12-07 Biomea Fusion, Inc. Fused pyrimidine compounds as inhibitors of menin
US11858925B2 (en) 2020-07-10 2024-01-02 The Regents Of The University Of Michigan GAS41 inhibitors and methods of use thereof
US12138249B2 (en) 2023-03-06 2024-11-12 Areteia Therapeutics, Inc. Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2629378A (en) * 1951-05-07 1953-02-24 James Frenkil Wet compress and container
US3053255A (en) * 1957-12-19 1962-09-11 Meyer Friedrich Process of percutaneously administering exact doses of physiologically active agents and composite unit therefor
US3249109A (en) * 1963-11-01 1966-05-03 Maeth Harry Topical dressing
US3339546A (en) * 1963-12-13 1967-09-05 Squibb & Sons Inc Bandage for adhering to moist surfaces
US3444858A (en) * 1965-05-14 1969-05-20 Higham S Russell Method and means for administering drugs
US3464413A (en) * 1967-05-26 1969-09-02 United Merchants & Mfg Medical bandages
US3518340A (en) * 1968-04-15 1970-06-30 Dow Corning Method of forming silicone rubber drug carriers
US3520949A (en) * 1966-07-26 1970-07-21 Nat Patent Dev Corp Hydrophilic polymers,articles and methods of making same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2629378A (en) * 1951-05-07 1953-02-24 James Frenkil Wet compress and container
US3053255A (en) * 1957-12-19 1962-09-11 Meyer Friedrich Process of percutaneously administering exact doses of physiologically active agents and composite unit therefor
US3249109A (en) * 1963-11-01 1966-05-03 Maeth Harry Topical dressing
US3339546A (en) * 1963-12-13 1967-09-05 Squibb & Sons Inc Bandage for adhering to moist surfaces
US3444858A (en) * 1965-05-14 1969-05-20 Higham S Russell Method and means for administering drugs
US3520949A (en) * 1966-07-26 1970-07-21 Nat Patent Dev Corp Hydrophilic polymers,articles and methods of making same
US3464413A (en) * 1967-05-26 1969-09-02 United Merchants & Mfg Medical bandages
US3518340A (en) * 1968-04-15 1970-06-30 Dow Corning Method of forming silicone rubber drug carriers

Cited By (746)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3993073A (en) * 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3896819A (en) * 1969-04-01 1975-07-29 Alejandro Zaffaroni IUD having a replenishing drug reservoir
US3710795A (en) * 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US3986510A (en) * 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3807398A (en) * 1972-09-19 1974-04-30 B Grucza Ocular implant
US3961628A (en) * 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US3951622A (en) * 1974-12-04 1976-04-20 Wilk Immanuel J Time release perfume method and device
DE2647581A1 (en) * 1976-10-21 1978-04-27 Henkel Kgaa BLISTER PACK
US4191743A (en) * 1976-11-02 1980-03-04 Merck Patent Gesellschaft Mit Beschrankter Haftung Antibacterial wound dressing
US4201211A (en) * 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
US4336243A (en) * 1980-08-11 1982-06-22 G. D. Searle & Co. Transdermal nitroglycerin pad
US5286748A (en) * 1981-01-05 1994-02-15 Eby Iii George A General method of shortening the duration of common colds by application of medicaments to tissues of oral cavity
EP0065370A1 (en) * 1981-05-02 1982-11-24 Smith and Nephew Associated Companies p.l.c. Sterile dressing and preparation thereof
FR2508318A1 (en) * 1981-06-29 1982-12-31 Alza Corp BANDAGE FOR THE ADMINISTRATION OF A PHARMACEUTICAL SUBSTANCE
US4834979A (en) * 1981-06-29 1989-05-30 Alza Corporation Medical bandage for administering beneficial drug
US4460371A (en) * 1981-11-24 1984-07-17 Dennison Manufacturing Company Silicone pressure sensitive adhesive and uses
US4925671A (en) * 1981-11-24 1990-05-15 Flexcon Company, Inc. Silicone pressure sensitive adhesive and uses
US4435180A (en) 1982-05-25 1984-03-06 Alza Corporation Elastomeric active agent delivery system and method of use
AT389049B (en) * 1982-07-16 1989-10-10 Koezponti Valto Hitelbank Process for the production of pharmaceutical products which can be attached to uninjured skin, in particular of antispastic and antirheumatic products
US4594240A (en) * 1982-09-10 1986-06-10 Teikoku Seiyaku Kabushiki Kaisha Sheet-shape adhesive preparation
US4767787A (en) * 1982-09-10 1988-08-30 Kaken Pharmaceutical Co., Ltd. Sheet-shape adhesive preparation
US4608249A (en) * 1982-11-02 1986-08-26 Nitto Electric Industrial Co., Ltd. Hydrophilic therapeutic material
US4769028A (en) * 1983-04-27 1988-09-06 Lohmann Gmbh & Co. Kg Pharmaceutical product, in medical bandage form
US4563184A (en) * 1983-10-17 1986-01-07 Bernard Korol Synthetic resin wound dressing and method of treatment using same
US4615697A (en) * 1983-11-14 1986-10-07 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
US4795436A (en) * 1983-11-14 1989-01-03 Bio-Mimetics, Inc. Bioadhesive composition and method of treatment therewith
DE3500508A1 (en) * 1984-03-05 1985-09-12 Nitto Electric Industrial Co., Ltd., Ibaraki, Osaka PREPARATION FOR PERCUTANEOUS ADMINISTRATION OF MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF
US4719226A (en) * 1984-03-05 1988-01-12 Nitto Electric Industrial Co., Ltd. Percutaneous absorption type preparation and process for preparing the same
FR2562800A1 (en) * 1984-04-11 1985-10-18 Fournier Laboratoires Device for percutaneous administration of medicaments
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
WO1986000532A1 (en) * 1984-07-07 1986-01-30 Flexcon Company, Inc. Silicone pressure sensitive adhesive and uses
US4649075A (en) * 1984-08-09 1987-03-10 Leonora Jost Transdermal and transmucosal vortexed foam devices and the method of making
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
USRE32991E (en) * 1984-11-13 1989-07-18 Thermedics, Inc. Drug dispensing wound dressing
US4751133A (en) * 1984-11-13 1988-06-14 Thermedics, Inc. Medical patches and processes for producing same
US4880690A (en) * 1984-11-13 1989-11-14 Thermedics, Inc. Perfume patch
US4727868A (en) * 1984-11-13 1988-03-01 Thermedics, Inc. Anisotropic wound dressing
US4614787A (en) * 1984-11-13 1986-09-30 Thermedics, Inc. Drug dispensing wound dressing
US4638043A (en) * 1984-11-13 1987-01-20 Thermedics, Inc. Drug release system
US4752478A (en) * 1984-12-17 1988-06-21 Merck & Co., Inc. Transdermal system for timolol
US4597961A (en) * 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US5364628A (en) * 1985-05-31 1994-11-15 Sandoz Ltd. Pharmaceutical compositions
US4738848A (en) * 1985-06-04 1988-04-19 Nitto Electric Industrial Co., Ltd. Anti-inflammatory analgesic adhesive preparation
WO1987003477A1 (en) * 1985-12-12 1987-06-18 Flexcon Company, Inc. Transdermal methods and adhesives
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US5034386A (en) * 1986-01-31 1991-07-23 Whitby Research, Inc. Methods for administration using 1-substituted azacycloalkanes
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
US4743249A (en) * 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
EP0236266A1 (en) * 1986-02-14 1987-09-09 Ciba-Geigy Ag Dermal and transdermal therapeutic system having a discontinuous-pattern adhesive layer and method of manufacturing thereof
US4797284A (en) * 1986-03-12 1989-01-10 Merck & Co., Inc. Transdermal drug delivery system
EP0498468A1 (en) * 1986-05-23 1992-08-12 New Mexico Tech Research Foundation Device for transcutaneous application of nicotine
EP0246385A1 (en) * 1986-05-23 1987-11-25 New Mexico Tech Research Foundation Transcutaneous application of nicotine
US5560922A (en) * 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
EP0250125A2 (en) * 1986-06-03 1987-12-23 Smith & Nephew plc Drug delivery device, its preparation and use
EP0250125A3 (en) * 1986-06-03 1989-04-19 Smith And Nephew Associated Companies P.L.C. Drug delivery device, its preparation and use
GB2191943A (en) * 1986-06-03 1987-12-31 Smith & Nephew Ass Topical drug delivery device
GB2191943B (en) * 1986-06-03 1991-02-13 Smith & Nephew Ass Drug delivery device, its preparation and use
AU609398B2 (en) * 1986-06-03 1991-05-02 Smith & Nephew Plc Drug delivery device, its preparation and use
EP0249475A2 (en) * 1986-06-13 1987-12-16 Alza Corporation Delayed percutaneous delivery
EP0249343A1 (en) * 1986-06-13 1987-12-16 Alza Corporation Moisture activation of transdermal drug delivery system
US5284660A (en) * 1986-06-13 1994-02-08 Alza Corporation Delayed onset transdermal delivery device
EP0249475A3 (en) * 1986-06-13 1989-10-11 Alza Corporation Delayed percutaneous delivery
US5141750A (en) * 1986-06-13 1992-08-25 Alza Corporation Delayed onset transdermal delivery device
US4898592A (en) * 1986-08-23 1990-02-06 Latzke Arno W Means for the application of transdermally absorbable active substances
US4994049A (en) * 1986-08-23 1991-02-19 Latzke Arno W Device for applying a substance to the skin
US6126963A (en) * 1986-08-28 2000-10-03 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
USRE37934E1 (en) 1986-08-28 2002-12-10 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US5820876A (en) * 1986-08-28 1998-10-13 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system
US5196202A (en) * 1986-09-01 1993-03-23 Teikoku Seiyaku Kabushiki Kaisha Sustained release dosage form
US4889720A (en) * 1986-09-01 1989-12-26 Teikoku Seiyaku Kabushiki Kaisha Sustained release dosage form for use with tissues of the oral cavity
EP0259136A2 (en) 1986-09-02 1988-03-09 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US5342623A (en) * 1986-09-12 1994-08-30 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4844903A (en) * 1986-11-07 1989-07-04 Mepha Ag Process for the production of an adhesive plaster
EP0273004A3 (en) * 1986-11-20 1988-07-13 Ciba-Geigy Ag User-activated therapeutical system
FR2607003A1 (en) * 1986-11-20 1988-05-27 Marchandise Jean Homeopathic skin card
EP0273004A2 (en) * 1986-11-20 1988-06-29 Ciba-Geigy Ag User-activated therapeutical system
US4909244A (en) * 1986-11-26 1990-03-20 The Kendall Company Hydrogel wound dressing
US5322695A (en) * 1987-01-09 1994-06-21 Hercon Laboratories Corporation Moisture-vapor-permeable dressing
US4917688A (en) * 1987-01-14 1990-04-17 Nelson Research & Development Co. Bandage for transdermal delivery of systemically-active drug
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
US4865848A (en) * 1987-02-26 1989-09-12 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
US4900555A (en) * 1987-02-26 1990-02-13 Alza Corporation Skin permeation enhancer compositions using sucrose esters
EP0279977A2 (en) * 1987-02-26 1988-08-31 Alza Corporation Transdermal administration of progesterone, estradiol esters and mixtures thereof
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
EP0279977A3 (en) * 1987-02-26 1989-03-29 Alza Corporation Transdermal administration of progesterone, estradiol esters and mixtures thereof
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
US5049387A (en) * 1987-03-09 1991-09-17 Alza Corporation Inducing skin tolerance to a sensitizing drug
US5171576A (en) * 1987-03-09 1992-12-15 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5286491A (en) * 1987-03-09 1994-02-15 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5118509A (en) * 1987-03-09 1992-06-02 Alza Corporation Inducing skin tolerance to a sensitizing drug
US5077054A (en) * 1987-03-09 1991-12-31 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5000956A (en) * 1987-03-09 1991-03-19 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5298257A (en) * 1987-05-01 1994-03-29 Elan Transdermal Limited Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
US4997655A (en) * 1987-06-22 1991-03-05 Biogal Gyogyszergyar Pharmaceutical formulation ensuring the transdermal absorption of the active ingredient and process for preparing same
US4820720A (en) * 1987-08-24 1989-04-11 Alza Corporation Transdermal drug composition with dual permeation enhancers
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers
US5059189A (en) * 1987-09-08 1991-10-22 E. R. Squibb & Sons, Inc. Method of preparing adhesive dressings containing a pharmaceutically active ingredient
US4879275A (en) * 1987-09-30 1989-11-07 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agent
US4920101A (en) * 1987-09-30 1990-04-24 Nelson Research & Development Co. Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
US4839174A (en) * 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
US4943435A (en) * 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
US5035886A (en) * 1987-10-19 1991-07-30 Ppg Industries, Inc. Active agent delivery device
US4959208A (en) * 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
US5071645A (en) * 1987-10-19 1991-12-10 Ppg Industries, Inc. Process of producing an active agent delivery device
US4917895A (en) * 1987-11-02 1990-04-17 Alza Corporation Transdermal drug delivery device
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4812305A (en) * 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
USRE39588E1 (en) 1987-11-09 2007-04-24 Alza Corporation Transdermal drug delivery device
US4863738A (en) * 1987-11-23 1989-09-05 Alza Corporation Skin permeation enhancer compositions using glycerol monooleate
US5068226A (en) * 1987-12-07 1991-11-26 Cyclex, Inc. Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies
US4979946A (en) * 1987-12-14 1990-12-25 The Kendall Company Environmental absorbent dressing
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
WO1989007959A1 (en) * 1988-02-23 1989-09-08 John Mark Tucker Occlusive body for administering a physiologically active substance
GB2232892A (en) * 1988-02-23 1991-01-02 John Mark Tucker Occlusive body for administering a physiologically active substance
US5254346A (en) * 1988-02-23 1993-10-19 Tucker Mark J Occlusive body for administering a physiologically active substance
EP0336543A1 (en) * 1988-02-23 1989-10-11 John Mark Tucker Occlusive body for administering a physiologically active substance
GB2232892B (en) * 1988-02-23 1991-07-24 John Mark Tucker Occlusive body for administering a physiologically active substance
US5223261A (en) * 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
US5304379A (en) * 1988-03-01 1994-04-19 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US4885154A (en) * 1988-03-01 1989-12-05 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US4877618A (en) * 1988-03-18 1989-10-31 Reed Jr Fred D Transdermal drug delivery device
US4900552A (en) * 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
WO1991006270A1 (en) * 1988-03-30 1991-05-16 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US4951657A (en) * 1988-04-22 1990-08-28 Dow Corning Corporation Heat sealable membrane for transdermal drug release
US4840796A (en) * 1988-04-22 1989-06-20 Dow Corning Corporation Block copolymer matrix for transdermal drug release
US4942037A (en) * 1988-06-02 1990-07-17 Merck & Co., Inc. Transdermal delivery systems
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
US5641504A (en) * 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
US5633008A (en) * 1988-06-14 1997-05-27 Osborne; James L. Method of administering nicotine transdermally
US6165497A (en) * 1988-06-14 2000-12-26 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5250028A (en) * 1989-02-15 1993-10-05 Alza Corporation Intravenous system for delivering a beneficial agent using permeability enhancers
US5045059A (en) * 1989-02-15 1991-09-03 Alza Corporation Intravenous system for delivering a beneficial agent
US4985016A (en) * 1989-02-15 1991-01-15 Alza Corporation Intravenous system for delivering a beneficial agent
US5160320A (en) * 1989-02-15 1992-11-03 Alza Corporation Intravenous system for delivering a beneficial agent
US4969871A (en) * 1989-02-15 1990-11-13 Alza Corporation Intravenous system for delivering a beneficial agent
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5788983A (en) * 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US4956171A (en) * 1989-07-21 1990-09-11 Paco Pharmaceutical Services, Inc. Transdermal drug delivery using a dual permeation enhancer and method of performing the same
US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5124157A (en) * 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
LT3753B (en) 1989-08-18 1996-03-25 Cygnus Therapeutic System Device for administering dexmedetomidine transdermally
US5230896A (en) * 1989-10-12 1993-07-27 Warner-Lambert Company Transdermal nicotine delivery system
US5445607A (en) * 1989-10-23 1995-08-29 Theratech, Inc. Iontophoresis device and method using a rate-controlling electrically sensitive membrane
DE3939703C2 (en) * 1989-12-01 1998-07-02 Boehringer Ingelheim Kg Improved transdermal application of pharmacologically active compounds
DE3939703A1 (en) * 1989-12-01 1991-06-06 Boehringer Ingelheim Kg IMPROVED TRANSDERMAL APPLICATION OF PHARMACOLOGICALLY ACTIVE COMPOUNDS
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
US5130139A (en) * 1990-07-06 1992-07-14 Alza Corporation Reduction or prevention of skin irritation by drugs
US5160741A (en) * 1990-07-06 1992-11-03 Alza Corporation Reduction or prevention of skin irritation by drugs
US5120545A (en) * 1990-08-03 1992-06-09 Alza Corporation Reduction or prevention of sensitization to drugs
US5149539A (en) * 1990-08-03 1992-09-22 Alza Corporation Reduction or prevention of sensitization to drugs
US5173302A (en) * 1990-09-28 1992-12-22 Medtronic, Inc. Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
US5376377A (en) * 1990-10-29 1994-12-27 Alza Corporation Transdermal contraceptive formulations, methods and devices
US5198223A (en) * 1990-10-29 1993-03-30 Alza Corporation Transdermal formulations, methods and devices
US5314694A (en) * 1990-10-29 1994-05-24 Alza Corporation Transdermal formulations, methods and devices
US5320850A (en) * 1990-10-29 1994-06-14 Alza Corporation Transdermal delivery of the gestogen ST-1435 and devices therefor
US5837280A (en) * 1990-11-28 1998-11-17 Sano Corporation Transdermal administration of azapirones
US5817331A (en) * 1990-11-28 1998-10-06 Sano Corporation Transdermal administration of azapirones
US5633009A (en) * 1990-11-28 1997-05-27 Sano Corporation Transdermal administration of azapirones
US5763425A (en) * 1991-04-03 1998-06-09 Gundersen Clinic, Ltd. Suppression of thromboxane levels by percutaneous administration of aspirin
US5402777A (en) * 1991-06-28 1995-04-04 Alza Corporation Methods and devices for facilitated non-invasive oxygen monitoring
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
US5203768A (en) * 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5273755A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset
US5273756A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
US5234690A (en) * 1991-08-23 1993-08-10 Cygnus Therapeutic Systems Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
US5189986A (en) * 1991-09-23 1993-03-02 Alza Corporation Veterinary transdermal active agent delivery device
US5508039A (en) * 1991-10-18 1996-04-16 Alza Corporation Controlled transdermal administration of melatonin
US5364634A (en) * 1991-11-08 1994-11-15 Southwest Research Institute Controlled-release PH sensitive capsule and adhesive system and method
WO1993012799A1 (en) * 1991-12-20 1993-07-08 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermally administered system containing acetylsalicylic acid for thrombosis therapy and cancer prophylaxis
US6264978B1 (en) 1991-12-20 2001-07-24 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal application system containing acetylsalicylic acid for antithrombotic therapy and cancer prophylaxis
US5861170A (en) * 1991-12-20 1999-01-19 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Acetylsalicyclic acid-containing transdermal application system for antithrombotic therapy
US5268179A (en) * 1992-02-14 1993-12-07 Ciba-Geigy Corporation Ultrasonically sealed transdermal drug delivery systems
US5411740A (en) * 1992-05-13 1995-05-02 Alza Corporation Transdermal administration of oxybutynin
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
US5500222A (en) * 1992-05-13 1996-03-19 Alza Corporation Transdermal administration of oxybutynin
US6071896A (en) * 1992-06-16 2000-06-06 Gundersen Clinic, Ltd. Suppression of thromboxane levels by percutaneous administration of aspirin
WO1994018966A1 (en) * 1993-02-26 1994-09-01 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system with active substances which represent sources of nitrogen oxide
US20070009600A1 (en) * 1993-05-27 2007-01-11 Edgren David E Antidepressant dosage form
US8084059B2 (en) 1993-05-27 2011-12-27 Alza Corporation Antidepressant dosage form
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US5707663A (en) * 1993-05-28 1998-01-13 Alza Corporation Sustained antiepileptic therapy
US6287598B1 (en) 1993-05-28 2001-09-11 Alza Corporation Method for providing sustained antiepileptic therapy
US5980943A (en) * 1993-05-28 1999-11-09 Alza Corporation Sustained antiepileptic therapy
US5451407A (en) * 1993-06-21 1995-09-19 Alza Corporation Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
US5919478A (en) * 1993-06-25 1999-07-06 Alza Corporation Incorporating poly-N-vinyl amide in a transdermal system
US5804214A (en) * 1993-07-08 1998-09-08 Cygnus, Inc. Monolithic matrix transdermal delivery system for delivering ketorolac tromethamine
US5962013A (en) * 1993-07-08 1999-10-05 Cygnus, Inc. Monolithic matrix transdermal delivery system for administering molsidomine
US5691377A (en) * 1993-07-30 1997-11-25 University Of Maryland Eastern Shore And University Of Maryland College Park Use of N-methyl-aspartic acid for enhancing growth and altering body composition
US5750137A (en) * 1993-09-29 1998-05-12 Taskovich; Lina Tormen Monoglyceride/lactate ester permeation enhancer
US5747065A (en) * 1993-09-29 1998-05-05 Lee; Eun Soo Monoglyceride/lactate ester permeation enhancer for oxybutynin
US5589192A (en) * 1993-12-03 1996-12-31 Lintec Corporation Gel pharmaceutical formulation for local anesthesia
US5770220A (en) * 1993-12-04 1998-06-23 Lts Lohmann Therapie Systeme Gmbh Active substance-containing patch
US5962011A (en) * 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US5895660A (en) * 1993-12-22 1999-04-20 Lts Lohmann Therapie-Systeme Gmbh Deuterated active substances in transdermal application
US5705186A (en) * 1994-02-07 1998-01-06 Lts Lohmann Therapie-Systeme Gmbh Pharmaceutical composition for the systemic transdermal administration having the active substance morphine-6-glucuronide
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US6096334A (en) * 1994-03-30 2000-08-01 Lectec Corporation Adhesive patch for applying medication to the skin and method
US6096333A (en) * 1994-03-30 2000-08-01 Lectec Corporation Method of forming adhesive patch for applying medication to the skin
US5741510A (en) * 1994-03-30 1998-04-21 Lectec Corporation Adhesive patch for applying analgesic medication to the skin
US6068853A (en) * 1994-04-13 2000-05-30 Novartis Corporation Temporally controlled drug delivery systems
US5490415A (en) * 1994-04-15 1996-02-13 Pharmetrix Corporation Diffusion test apparatus and method
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
US5498417A (en) * 1994-05-12 1996-03-12 Coating Sciences, Inc. Transdermal delivery of appetite suppressant drug
WO1995035105A1 (en) * 1994-06-18 1995-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system with active substances constituting sources of carbon monoxide
DE4421433C1 (en) * 1994-06-18 1995-06-08 Lohmann Therapie Syst Lts Transdermal therapeutic system for treatment of, e.g., hypertension
US5882674A (en) * 1994-06-18 1999-03-16 Lts Lohmann Therapie-Systeme Gmbh Transdermal therapeutic system comprising active substances representing carbon monoxide sources
US5599554A (en) * 1994-06-23 1997-02-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms
US20100028389A1 (en) * 1994-07-07 2010-02-04 Sonya Merrill Hydromorphone therapy
US20010038856A1 (en) * 1994-07-07 2001-11-08 Sonya Merrill Hydromorphone therapy
US5650165A (en) * 1994-11-15 1997-07-22 Nitto Denko Corporation Percutaneous absorption preparation
US5662925A (en) * 1994-12-21 1997-09-02 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
US6264980B1 (en) 1994-12-24 2001-07-24 Lts Lohmann Therapie-Systeme Gmbh Transdermal resorption of active substances from supercooled masses of levulic acid
US6344211B1 (en) 1994-12-24 2002-02-05 Lts Lohmann Therapie-Systeme Gmbh Transdermal absorption of active substances from subcooled melts
US5662928A (en) * 1995-04-21 1997-09-02 Ciba-Geigy Corporation Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system
US5882676A (en) * 1995-05-26 1999-03-16 Alza Corporation Skin permeation enhancer compositions using acyl lactylates
US6572879B1 (en) 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
US5843468A (en) * 1995-06-07 1998-12-01 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US20040209909A1 (en) * 1995-06-07 2004-10-21 Su Il Yum Novel formulations for transdermal delivery of pergolide
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US6001390A (en) * 1995-06-07 1999-12-14 Alza Corporation Formulations for transdermal delivery of pergolide
US5840327A (en) * 1995-08-21 1998-11-24 Alza Corporation Transdermal drug delivery device having enhanced adhesion
US5733255A (en) * 1995-10-18 1998-03-31 Novartis Finance Corporation Thermopile powered transdermal drug delivery device
US6238700B1 (en) 1995-12-01 2001-05-29 Alza Corporation Method for preventing crystal formation in a dispersion of a liquid in a matrix
US7169409B2 (en) 1995-12-01 2007-01-30 Alza Corporation Method for preventing crystal formation in a dispersion of a liquid in a matrix
US6569448B1 (en) 1995-12-01 2003-05-27 Alza Corporation Method for preventing crystal formation in a dispersion of a liquid in a matrix
US20040081684A1 (en) * 1996-02-19 2004-04-29 Monash University Topical delivery of antifungal agents
US7094422B2 (en) 1996-02-19 2006-08-22 Acrux Dds Pty Ltd. Topical delivery of antifungal agents
EP1674068A1 (en) 1996-02-19 2006-06-28 Acrux DDS Pty Ltd Dermal penetration enhancers and drug delivery systems involving same
US6007837A (en) * 1996-07-03 1999-12-28 Alza Corporation Drug delivery devices and process of manufacture
US7011844B2 (en) 1996-07-15 2006-03-14 Alza Corporation Formulations for the administration of fluoxetine
US20050186277A1 (en) * 1996-07-15 2005-08-25 Gale Robert M. Novel formulations for the administration of fluoxetine
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
US5942243A (en) * 1996-11-12 1999-08-24 Polytherapeutics, Inc. Mucoadhesive compositions for administration of biologically active agents to animal tissue
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
US6174545B1 (en) 1997-07-01 2001-01-16 Alza Corporation Drug delivery devices and process of manufacture
US6110499A (en) * 1997-07-24 2000-08-29 Alza Corporation Phenytoin therapy
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6960353B2 (en) 1998-07-24 2005-11-01 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
US7622136B2 (en) 1998-12-18 2009-11-24 Alza Corporation Transparent transdermal nicotine delivery devices
US8999379B2 (en) 1998-12-18 2015-04-07 Alza Corporation Transparent transdermal nicotine delivery devices
US20040234585A1 (en) * 1998-12-18 2004-11-25 Gale Robert M. Transparent transdermal nicotine delivery devices
EP2158903A2 (en) 1998-12-18 2010-03-03 ALZA Corporation Transparent Transdermal Nicotine Delivery Devices
US8663680B2 (en) 1998-12-18 2014-03-04 Alza Corporation Transparent transdermal nicotine delivery devices
US20080031933A1 (en) * 1998-12-18 2008-02-07 Alza Corporation Transparent transdermal nicotine delivery devices
US8075911B2 (en) 1998-12-18 2011-12-13 Alza Corporation Transparent transdermal nicotine delivery devices
US9205059B2 (en) 1998-12-18 2015-12-08 Alza Corporation Transparent transdermal nicotine delivery devices
US20080095823A1 (en) * 1999-03-25 2008-04-24 Metabolix, Inc. Medical Devices and Applications of Polyhydroxyalkanoate Polymers
US7553923B2 (en) 1999-03-25 2009-06-30 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US20080051490A1 (en) * 1999-03-25 2008-02-28 Williams Simon F Medical Devices and Applications of Polyhydroxyalkanoate Polymers
US20050048104A1 (en) * 1999-04-01 2005-03-03 Venkatraman Subramanian S. Transdermal drug delivery devices comprising a polyurethane drug reservoir
US7063859B1 (en) 1999-04-28 2006-06-20 Noven Pharmaceuticals, Inc. Barrier film lined backing layer composition and method for topical administration of active agents
JP4889172B2 (en) * 1999-06-11 2012-03-07 リンテック株式会社 Moisture sensitive transdermal formulation
GB2353219B (en) * 1999-08-16 2004-02-11 Johnson & Johnson Medical Ltd Easy to remove adhesive sheets
US6592892B1 (en) 1999-08-30 2003-07-15 Tepha, Inc. Flushable disposable polymeric products
US6469227B1 (en) 1999-12-10 2002-10-22 Lectec Corporation Antipruritic patch
US20030008852A1 (en) * 1999-12-11 2003-01-09 Franke Hanshermann Transdermal system containing acetylsalicylic acid for treatment of migraine
US20070148195A1 (en) * 2000-04-26 2007-06-28 Ebert Charles D Compositions and methods for transdermal oxybutynin therapy
US8241662B2 (en) 2000-04-26 2012-08-14 Watson Laboratories, Inc. Unoccluded topical oxybutynin gel composition and methods for transdermal oxybutynin therapy
US20080090894A1 (en) * 2001-06-05 2008-04-17 Ronald Aung-Din Transdermal migraine therapy
US9012480B2 (en) 2001-06-05 2015-04-21 Afgin Pharma Llc Topical therapy for migraine
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US8685437B2 (en) 2001-10-12 2014-04-01 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20100021526A1 (en) * 2001-10-12 2010-01-28 Monosol Rx, Llc Ph modulated films for delivery of actives
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20090181069A1 (en) * 2001-10-12 2009-07-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US8652378B1 (en) 2001-10-12 2014-02-18 Monosol Rx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US11077068B2 (en) 2001-10-12 2021-08-03 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20080260805A1 (en) * 2001-10-12 2008-10-23 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20070069416A1 (en) * 2001-10-12 2007-03-29 Monosolrx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20050184427A1 (en) * 2001-10-12 2005-08-25 Monosolrx, Llc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8906277B2 (en) 2001-10-12 2014-12-09 Monosol Rx, Llc Process for manufacturing a resulting pharmaceutical film
US7824588B2 (en) 2001-10-12 2010-11-02 Monosol Rx, Llc Method of making self-supporting therapeutic active-containing film
US20070122455A1 (en) * 2001-10-12 2007-05-31 Monosolrx, Llc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US10888499B2 (en) 2001-10-12 2021-01-12 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20070149731A1 (en) * 2001-10-12 2007-06-28 Monosolrx, Llc. PH modulated films for delivery of actives
US9855221B2 (en) 2001-10-12 2018-01-02 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20070154527A1 (en) * 2001-10-12 2007-07-05 Monosoirx, Llc Topical film compositions for delivery of actives
US9931305B2 (en) 2001-10-12 2018-04-03 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US9108340B2 (en) 2001-10-12 2015-08-18 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20030107149A1 (en) * 2001-10-12 2003-06-12 International Fluidics. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US20070281003A1 (en) * 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US20080260809A1 (en) * 2002-04-11 2008-10-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US20080044454A1 (en) * 2002-04-11 2008-02-21 Monosolrx Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10111810B2 (en) 2002-04-11 2018-10-30 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20050037055A1 (en) * 2002-04-11 2005-02-17 Monosolrx Llc. Polyethylene oxide-based films and drug delivery systems made therefrom
US20040010000A1 (en) * 2002-04-29 2004-01-15 Ayer Atul D. Methods and dosage forms for controlled delivery of oxycodone
US20030224051A1 (en) * 2002-05-31 2003-12-04 Fink Tracy A. Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone
US20060147493A1 (en) * 2002-07-22 2006-07-06 Yang Robert K Packaging and dispensing of rapid dissolve dosage form
US9393192B2 (en) 2002-07-29 2016-07-19 Alza Corporation Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20050191340A1 (en) * 2002-08-09 2005-09-01 Gruenenthal Gmbh Opioid-receptor antagonists in transdermal systems having buprenorphine
US8628798B2 (en) 2002-09-27 2014-01-14 Ferring B.V. Water-swellable polymers
US8557281B2 (en) 2002-09-27 2013-10-15 Ferring B.V. Water-swellable polymers
US9987364B2 (en) 2002-09-27 2018-06-05 Ferring B.V. Water-swellable polymers
US9480770B2 (en) 2002-10-23 2016-11-01 Covidien Lp Methods for preparation of medical dressing containing antimicrobial agent
US8026254B2 (en) 2002-11-18 2011-09-27 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
US20100069437A1 (en) * 2002-11-18 2010-03-18 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US20040191301A1 (en) * 2003-03-27 2004-09-30 Van Duren Albert Philip Transdermal device having a phase change material
US20090035357A1 (en) * 2003-03-27 2009-02-05 Arizant Healthcare Inc. Method of drug delivery using a transdermal device having a phase change material
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
US8778382B2 (en) 2003-04-30 2014-07-15 Purdue Pharma L.P. Tamper resistant transdermal dosage form
US20050002997A1 (en) * 2003-04-30 2005-01-06 Howard Stephen A. Tamper resistant transdermal dosage form
US8790689B2 (en) 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
US10314683B2 (en) 2003-05-08 2019-06-11 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US10111738B2 (en) 2003-05-08 2018-10-30 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US9333066B2 (en) 2003-05-08 2016-05-10 Tepha, Inc. Method of making a medical textile from polyhydroxyalkanoate fibers
US10136982B2 (en) 2003-05-08 2018-11-27 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US8034270B2 (en) 2003-05-08 2011-10-11 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US9125719B2 (en) 2003-05-08 2015-09-08 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US8758657B2 (en) 2003-05-08 2014-06-24 Tepha, Inc. Process of making polyhydroxyalkanoate medical textiles
US20040234576A1 (en) * 2003-05-08 2004-11-25 Tepha, Inc., State Of Incorporation Delaware Polyhydroxyalkanoate medical textiles and fibers
US20060039958A1 (en) * 2003-05-28 2006-02-23 Monosolrx, Llc. Multi-layer films having uniform content
WO2004105854A1 (en) * 2003-06-03 2004-12-09 Nadler, Joseph Device and method for dispensing medication to tissue lining a body cavity
US20070065463A1 (en) * 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
US8883830B2 (en) 2003-06-20 2014-11-11 Afgin Pharma LLC. Topical therapy for the treatment of migraines, muscle sprains, muscle spasms, spasticity and related conditions
US20050025809A1 (en) * 2003-07-08 2005-02-03 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US20060287659A1 (en) * 2003-08-22 2006-12-21 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US20090209983A1 (en) * 2003-08-22 2009-08-20 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US20050065062A1 (en) * 2003-09-24 2005-03-24 3M Innovative Properties Company Method of formulating a pharmaceutical composition
US20050142475A1 (en) * 2003-12-30 2005-06-30 Moudry Ronald J. Dry toner comprising encapsulated pigment, methods and uses
US20050234024A1 (en) * 2004-04-14 2005-10-20 Clarke David E Materials and methods for the treatment of ulcerative colitis
US20060008432A1 (en) * 2004-07-07 2006-01-12 Sebastiano Scarampi Gilsonite derived pharmaceutical delivery compositions and methods: nail applications
US20100093237A1 (en) * 2004-08-03 2010-04-15 Tepha, Inc. Non-curling polyhydroxyalkanoate sutures
US20060058470A1 (en) * 2004-08-03 2006-03-16 Tepha, Inc. Non-curling polyhydroxyalkanoate sutures
US7641825B2 (en) 2004-08-03 2010-01-05 Tepha, Inc. Method of making a polyhydroxyalkanoate filament
US8084125B2 (en) 2004-08-03 2011-12-27 Tepha, Inc. Non-curling polyhydroxyalkanoate sutures
US8709482B2 (en) 2004-08-05 2014-04-29 Ferring B.V. Stabilised prostaglandin composition
US8491934B2 (en) 2004-08-05 2013-07-23 Ferring B.V. Stabilised prostaglandin composition
US8460707B2 (en) 2004-08-05 2013-06-11 Ferring B.V. Stabilised prostaglandin composition
US20060051391A1 (en) * 2004-09-09 2006-03-09 Dvoskin Victor O Device for the controlled administration of substances to be inserted in a body cavity
US20110022015A1 (en) * 2004-12-29 2011-01-27 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US20110022016A1 (en) * 2004-12-29 2011-01-27 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US7833208B2 (en) * 2004-12-29 2010-11-16 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US8353888B2 (en) 2004-12-29 2013-01-15 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US20060142722A1 (en) * 2004-12-29 2006-06-29 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US20060177513A1 (en) * 2005-01-28 2006-08-10 Tepha, Inc. Embolization using poly-4-hydroxybutyrate particles
US20060217790A1 (en) * 2005-03-28 2006-09-28 Ohshin Mlp Co., Ltd. Sheet-like face pack and kits for face packs
US20060257462A1 (en) * 2005-05-13 2006-11-16 Jansen Rolf R Multilayer drug delivery system with barrier against reservoir material flow
EP2316437A1 (en) 2005-05-13 2011-05-04 Alza Corporation Multilayer drug delivery system with barrier against reservoir material flow
US8632800B2 (en) 2005-05-13 2014-01-21 Alza Corporation Multilayer drug delivery system with barrier against reservoir material flow
US20060257461A1 (en) * 2005-05-13 2006-11-16 Jansen Rolf R Multilayer galantamine delivery system with barrier against reservoir material flow
US20070134310A1 (en) * 2005-09-23 2007-06-14 Nedberge Diane E Transdermal risperidone delivery system
US8758808B2 (en) 2005-09-23 2014-06-24 Alza Corporation Method of making a high enhancer-loading polyacrylate formulation for transdermal applications
US8383149B2 (en) 2005-09-23 2013-02-26 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
US9446004B2 (en) 2005-09-23 2016-09-20 Alza Corporation Transdermal nicotine salt delivery system
EP2308480A2 (en) 2005-09-23 2011-04-13 ALZA Corporation High Enhancer-Loading Polyacrylate Formulation for Transdermal Applications
US20070098771A1 (en) * 2005-09-23 2007-05-03 Jay Audett High enhancer-loading polyacrylate formulation for transdermal applications
US20070098772A1 (en) * 2005-09-23 2007-05-03 Westcott Tyler D Transdermal norelgestromin delivery system
WO2007035939A2 (en) 2005-09-23 2007-03-29 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
US9056061B2 (en) 2005-09-23 2015-06-16 Alza Corporation Transdermal nicotine salt delivery system
US9205090B2 (en) 2005-09-23 2015-12-08 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
US20070082038A1 (en) * 2005-09-23 2007-04-12 Gale Robert M Transdermal nicotine salt delivery system
US20070071828A1 (en) * 2005-09-27 2007-03-29 Bio-Tissue, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US8182840B2 (en) 2005-09-27 2012-05-22 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US8455009B2 (en) 2005-09-27 2013-06-04 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and anti-inflammation methods
US8440235B2 (en) 2005-09-27 2013-05-14 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US8460714B2 (en) 2005-09-27 2013-06-11 Tissuetech, Inc. Purified amniotic membrane compositions and methods of use
US8182841B2 (en) 2005-09-27 2012-05-22 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-inflammation methods
US8420126B2 (en) 2005-09-27 2013-04-16 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US8153162B2 (en) 2005-09-27 2012-04-10 Tissuetech, Inc. Purified amniotic membrane compositions and methods of use
US9750771B2 (en) 2005-09-27 2017-09-05 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and anti-inflammation methods
US20070071740A1 (en) * 2005-09-27 2007-03-29 Bio-Tissue, Inc. Purified amniotic membrane compositions and methods of use
US20070231401A1 (en) * 2005-09-27 2007-10-04 Bio-Tissue, Inc. Amniotic membrane preparations and purified compositions and anti-inflammation methods
US9750772B2 (en) 2005-09-27 2017-09-05 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US9198939B2 (en) 2005-09-27 2015-12-01 Tissuetech, Inc. Purified amniotic membrane compositions and methods of use
EP2664337A1 (en) 2005-09-27 2013-11-20 TissueTech, Inc. Amniotic membrane preparations and purified compositions and methods of use
US9956252B2 (en) 2005-09-27 2018-05-01 Tissuetech, Inc. Purified amniotic membrane compositions and methods of use
US10632155B2 (en) 2005-09-27 2020-04-28 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US9724370B2 (en) 2005-09-27 2017-08-08 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US20080299087A1 (en) * 2005-09-27 2008-12-04 Bio-Tissue, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US9161956B2 (en) 2005-09-27 2015-10-20 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and anti-inflammation methods
US10272119B2 (en) 2005-09-27 2019-04-30 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US9161954B2 (en) 2005-09-27 2015-10-20 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US9161955B2 (en) 2005-09-27 2015-10-20 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
US8187639B2 (en) 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US20090169602A1 (en) * 2005-11-23 2009-07-02 Universität Zürich Allergy Treatment by Epicutaneous Allergen Administration
WO2007062266A2 (en) 2005-11-28 2007-05-31 Marinus Pharmaceuticals Ganaxolone formulations and methods for the making and use thereof
US20070185180A1 (en) * 2005-12-05 2007-08-09 Tamar Blumberg Pharmaceutical formulation containing phenytoin sodium and magnesium stearate
US8377979B2 (en) 2005-12-05 2013-02-19 Taro Pharmaceuticals North America, Inc. Pharmaceutical formulation containing phenytoin sodium and magnesium stearate
US20070172515A1 (en) * 2006-01-20 2007-07-26 Monosolrx, Llc Film bandage for mucosal administration of actives
US20070190157A1 (en) * 2006-01-20 2007-08-16 Monosoirx, Llc. Film lined packaging and method of making same
US20070179210A1 (en) * 2006-01-31 2007-08-02 Tyco Healthcare Group Lp Super soft foams
US9808554B2 (en) 2006-01-31 2017-11-07 Covidien Lp Super soft foams
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US20090042956A1 (en) * 2006-04-10 2009-02-12 Knopp Neurosciences, Inc. Compositions and methods of using (r)-pramipexole
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070237812A1 (en) * 2006-04-11 2007-10-11 Tyco Healthcare Group Multi-layer wound dressings
US8017598B2 (en) 2006-05-16 2011-09-13 Knopp Neurosciences, Inc. Compositions of R(+) and S(−) pramipexole and methods of using the same
US20080014259A1 (en) * 2006-05-16 2008-01-17 Knopp Neurosciences, Inc. Compositions of R(+) and S(-) Pramipexole and Methods of Using the Same
US8445474B2 (en) 2006-05-16 2013-05-21 Knopp Neurosciences, Inc. Compositions of R(+) and S(−) pramipexole and methods of using the same
US20070278289A1 (en) * 2006-05-31 2007-12-06 Toshiba Tec Kabushiki Kaisha Payment adjusting apparatus and program therefor
US20090291120A1 (en) * 2006-07-05 2009-11-26 Jukka Tuominen Hydrophilic Polyurethane Compositions
US8974813B2 (en) 2006-07-05 2015-03-10 Ferring B.V. Hydrophilic polyurethane compositions
US10105445B2 (en) 2006-07-05 2018-10-23 Ferring B.V. Hydrophilic polyurethane compositions
US20090324692A1 (en) * 2006-07-08 2009-12-31 Controlled Therapeutics (Scotland) Limited Polyurethane Elastomers
US8361272B2 (en) 2006-07-08 2013-01-29 Ferring B.V. Polyurethane elastomers
US8361273B2 (en) 2006-07-08 2013-01-29 Ferring B.V. Polyurethane elastomers
US20080160065A1 (en) * 2006-07-12 2008-07-03 Janet Anne Halliday Drug delivery polymer with hydrochloride salt of clindamycin
WO2008021368A2 (en) 2006-08-11 2008-02-21 The Johns Hopkins University Compositions and methods for neuroprotection
US20080075825A1 (en) * 2006-09-20 2008-03-27 Fuisz Richard C Edible Water-Soluble Film Containing a Foam Reducing Flavoring Agent
US7972618B2 (en) 2006-09-20 2011-07-05 Monosol Rx, Llc Edible water-soluble film containing a foam reducing flavoring agent
EP2529622A1 (en) 2006-09-22 2012-12-05 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2530083A1 (en) 2006-09-22 2012-12-05 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2529621A1 (en) 2006-09-22 2012-12-05 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2526933A2 (en) 2006-09-22 2012-11-28 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2201840A1 (en) 2006-09-22 2010-06-30 Pharmacyclics, Inc. Inhibitors of Bruton's Tyrosine Kinase
EP2532235A1 (en) 2006-09-22 2012-12-12 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2532234A1 (en) 2006-09-22 2012-12-12 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2526934A2 (en) 2006-09-22 2012-11-28 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2008039218A2 (en) 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2526771A1 (en) 2006-09-22 2012-11-28 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2443929A1 (en) 2006-09-22 2012-04-25 Pharmacyclics, Inc. Inhibitors of Bruton's Tyrosine Kinase
US20110070290A1 (en) * 2006-09-26 2011-03-24 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US9987355B2 (en) 2006-09-26 2018-06-05 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US8609114B2 (en) 2006-09-26 2013-12-17 Infectious Diesease Research Institute Methods of using a vaccine composition containing synthetic adjuvant
US9950063B2 (en) 2006-09-26 2018-04-24 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US20110014274A1 (en) * 2006-09-26 2011-01-20 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US8343512B2 (en) 2006-09-26 2013-01-01 Infectious Disease Research Institute Treatment of allergic conditions using a composition containing synthetic adjuvant
US10765736B2 (en) 2006-09-26 2020-09-08 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US9907845B2 (en) 2006-09-26 2018-03-06 Infectious Disease Research Institute Methods of using a vaccine composition containing synthetic adjuvant
US20080131466A1 (en) * 2006-09-26 2008-06-05 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US8273361B2 (en) 2006-09-26 2012-09-25 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
EP2486938A1 (en) 2006-09-26 2012-08-15 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US8840908B2 (en) 2006-09-26 2014-09-23 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
EP3403667A1 (en) 2006-09-26 2018-11-21 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US10792359B2 (en) 2006-09-26 2020-10-06 Infectious Disease Research Institute Methods of using a vaccine composition containing synthetic adjuvant
EP3795173A1 (en) 2006-09-26 2021-03-24 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US20080081071A1 (en) * 2006-09-29 2008-04-03 Pradeep Sanghvi Film Embedded Packaging and Method of Making Same
US8524254B2 (en) 2006-10-18 2013-09-03 Ferring B.V. Bioresorbable polymers
EP2508231A2 (en) 2006-11-16 2012-10-10 E-Therapeutics Plc Imidazoles for treating multi-drug resistant bacterial infections
WO2008066899A2 (en) 2006-11-28 2008-06-05 Marinus Pharmaceuticals Nanoparticulate formulations and methods for the making and use thereof
US20080132602A1 (en) * 2006-12-01 2008-06-05 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20110189475A1 (en) * 2006-12-01 2011-08-04 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8753555B2 (en) 2006-12-01 2014-06-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20090054504A1 (en) * 2006-12-14 2009-02-26 Knopp Neurosciences, Inc. Modified Release Formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and Methods of Using the Same
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US20100143270A1 (en) * 2007-02-21 2010-06-10 University Of Louisville Research Foubdation Therapeutic cotinine compositions
US8574205B2 (en) * 2007-03-13 2013-11-05 Dbv Technologies Device for the cutaneous application of substances
US20110046578A1 (en) * 2007-03-13 2011-02-24 Biry Jean-Francois Device for the cutaneous application of substances
US20080227985A1 (en) * 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazoles
US8519148B2 (en) 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
US10179774B2 (en) 2007-03-14 2019-01-15 Knopp Biosciences Llc Synthesis of chirally purified substituted benzothiazole diamines
US9700522B2 (en) 2007-03-19 2017-07-11 Vita Sciences Llc Transdermal patch and method for delivery of vitamin B12
US20090005443A1 (en) * 2007-06-22 2009-01-01 Malcolm Philip Young Treatment of Depression
EP2014282A2 (en) 2007-06-22 2009-01-14 E-Therapeutics plc Treatment of depression
US20110033376A1 (en) * 2007-07-06 2011-02-10 Malcolm Philip Young Treatment of Melanoma
EP2529733A1 (en) 2007-07-20 2012-12-05 E-Therapeutics Plc Antibacterial combination therapy
EP2529737A1 (en) 2007-07-20 2012-12-05 E-Therapeutics plc Antibacterial combination therapy
WO2009013480A2 (en) 2007-07-20 2009-01-29 E-Therapeutics Plc Antibacterial combination therapy
US20110039906A1 (en) * 2007-07-20 2011-02-17 E-Therapeutics Plc Antibacterial combination therapy
WO2009035818A1 (en) 2007-09-10 2009-03-19 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20090098069A1 (en) * 2007-09-14 2009-04-16 Drugtech Corporation Transdermal, alcohol-free, pharmaceutical compositions
US20110020217A1 (en) * 2007-10-10 2011-01-27 E-Therapeutics Plc Treatment of melanoma
US20100068708A1 (en) * 2008-05-07 2010-03-18 Wintherix Llc Methods for Identifying Compounds that Modulate WNT Signaling in Cancer Cells
US20090286246A1 (en) * 2008-05-07 2009-11-19 Wintherix Llc Methods for Identifying Compounds that Affect Expression of Cancer-Related Protein Isoforms
EP3251680A1 (en) 2008-05-22 2017-12-06 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US20090304776A1 (en) * 2008-06-06 2009-12-10 Totada Shantha Transmucosal delivery of therapeutic agents and methods of use thereof
US7883487B2 (en) 2008-06-16 2011-02-08 Shantha Totada R Transdermal local anesthetic patch with injection port
US20090311311A1 (en) * 2008-06-16 2009-12-17 Shantha Totada R Transdermal local anesthetic patch with injection port
US20110212173A1 (en) * 2008-06-17 2011-09-01 e-Therapeutics Ple Controlled Release Treatment of Depression
US8592424B2 (en) 2008-06-30 2013-11-26 Afgin Pharma Llc Topical regional neuro-affective therapy
WO2010005507A1 (en) 2008-06-30 2010-01-14 Afgin Pharma, Llc Topical regional neuro-affective therapy
US20110008411A1 (en) * 2008-07-15 2011-01-13 Griffin Santea B Method of treating pruritis
US8235929B2 (en) 2008-07-15 2012-08-07 Griffin Santea B Method of treating pruritis
US8614179B2 (en) 2008-07-18 2013-12-24 E-Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections
US9849116B2 (en) 2008-08-19 2017-12-26 Knopp Biosciences Llc Compositions and methods of using (R)-pramipexole
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
WO2010027875A2 (en) 2008-08-27 2010-03-11 Calcimedica Inc. Compounds that modulate intracellular calcium
US20100055437A1 (en) * 2008-08-28 2010-03-04 Tyco Healthcare Group Lp Anti-microbial fibers and related articles and methods
US9119776B2 (en) 2008-11-03 2015-09-01 Nal Pharmaceuticals, Ltd. Dosage form for insertion into the mouth
US8715715B2 (en) 2008-11-03 2014-05-06 Nal Pharmaceuticals Ltd. Dosage form for insertion into the mouth
US9579295B2 (en) 2008-11-03 2017-02-28 Nal Pharmaceutical Group Limited Dosage form for insertion into the mouth
US20100112050A1 (en) * 2008-11-03 2010-05-06 Je Phil Ryoo Dosage Form For Insertion Into The Mouth
US9114073B2 (en) 2008-11-03 2015-08-25 Nal Pharmaceuticals, Ltd. Dosage form for insertion into the mouth
US8771736B2 (en) 2008-11-03 2014-07-08 Nal Pharmaceuticals, Ltd. Dosage form for insertion into the mouth
US9114075B2 (en) 2008-11-03 2015-08-25 Nal Pharmaceuticals, Ltd. Dosage form for insertion into the mouth
US9114074B2 (en) 2008-11-03 2015-08-25 Nal Pharmaceuticals, Ltd. Dosage form for insertion into the mouth
US8317762B2 (en) * 2008-11-10 2012-11-27 Nurman Salim Skin patch for absorbing toxins from the body
US20100121297A1 (en) * 2008-11-10 2010-05-13 Kenrico Ltd Skin patch for absorbing toxins from the body
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
WO2010071866A2 (en) 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Combination therapy for arthritis with tranilast
US20100209484A1 (en) * 2009-02-13 2010-08-19 Hoo-Kyun Choi Transdermal Triptan Delivery System
US9175066B2 (en) 2009-04-24 2015-11-03 Tissuetech, Inc. Compositions containing HC-HA complex and methods of use thereof
US10632191B2 (en) 2009-06-05 2020-04-28 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
WO2010141861A1 (en) 2009-06-05 2010-12-09 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
US8722064B2 (en) 2009-06-05 2014-05-13 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
EP3124491A1 (en) 2009-06-05 2017-02-01 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them
US9814772B2 (en) 2009-06-05 2017-11-14 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
US9480740B2 (en) 2009-06-05 2016-11-01 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
US20110009460A1 (en) * 2009-06-19 2011-01-13 Valentin Gribkoff Compositions and methods for treating amyotrophic lateral sclerosis
US20110021596A1 (en) * 2009-07-27 2011-01-27 Ronald Aung-Din Topical therapy for migraine
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US10034833B2 (en) 2009-08-07 2018-07-31 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US20110033542A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US20110033541A1 (en) * 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US11135216B2 (en) 2009-08-07 2021-10-05 Indivior Uk Limited Sublingual and buccal film compositions
US10821074B2 (en) 2009-08-07 2020-11-03 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US9687454B2 (en) 2009-08-07 2017-06-27 Indivior Uk Limited Sublingual and buccal film compositions
WO2011030106A1 (en) 2009-09-10 2011-03-17 E-Therapeutics Plc Cancer cell apoptosis
EP2650294A1 (en) 2009-10-12 2013-10-16 Pharmacyclics, Inc. Inhibitors of Bruton's Tyrosine Kinase
US20120245538A1 (en) * 2009-12-04 2012-09-27 Michael Horstmann Transdermal Therapeutic System for the Administration of Peptides
US10772845B2 (en) * 2009-12-04 2020-09-15 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the administration of peptides
US9260417B2 (en) 2010-02-08 2016-02-16 Amitech Therapeutic Solutions, Inc. Therapeutic methods and compositions involving allosteric kinase inhibition
US10214513B2 (en) 2010-03-24 2019-02-26 Amitech Therapeutic Solutions, Inc. Heterocyclic compounds useful for kinase inhibition
US8957216B2 (en) 2010-03-24 2015-02-17 Amitech Therapeutic Solutions, Inc. Heterocyclic compounds useful for kinase inhibition
WO2011119894A2 (en) 2010-03-24 2011-09-29 Kinagen, Inc Heterocyclic compounds useful for kinase inhibition
US9212151B2 (en) 2010-03-24 2015-12-15 Amitech Therapeutic Solutions, Inc. Heterocyclic compounds useful for kinase inhibition
WO2011130455A1 (en) 2010-04-13 2011-10-20 Najib Babul Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
US11607407B2 (en) 2010-04-13 2023-03-21 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2′,6′-pipecoloxylidide and method of use
WO2011130689A1 (en) 2010-04-15 2011-10-20 Tracon Pharmaceuticals, Inc. Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
WO2011139765A2 (en) 2010-04-27 2011-11-10 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2011139489A2 (en) 2010-04-27 2011-11-10 Calcimedica Inc. Compounds that modulate intracellular calcium
WO2011143152A2 (en) 2010-05-11 2011-11-17 Questcor Pharmaceuticals Acth for treatment of amyotrophic lateral sclerosis
WO2011153514A2 (en) 2010-06-03 2011-12-08 Pharmacyclics, Inc. The use of inhibitors of bruton's tyrosine kinase (btk)
US8974826B2 (en) 2010-06-10 2015-03-10 Monosol Rx, Llc Nanoparticle film delivery systems
US10336738B2 (en) 2010-08-27 2019-07-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2012046006A2 (en) 2010-10-08 2012-04-12 University Of Dundee Cancer targets
US10940626B2 (en) 2010-10-22 2021-03-09 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US10272607B2 (en) 2010-10-22 2019-04-30 Aquestive Therapeutics, Inc. Manufacturing of small film strips
US9550822B2 (en) 2010-10-25 2017-01-24 Questcor Pharmaceuticals, Inc. ACTH prophylactic treatment of renal disorders
US8796416B1 (en) 2010-10-25 2014-08-05 Questcor Pharmaceuticals, Inc ACTH prophylactic treatment of renal disorders
US10286041B2 (en) 2010-10-25 2019-05-14 Mallinckrodt Ard Ip Limited ACTH prophylactic treatment of renal disorders
WO2012094638A1 (en) 2011-01-07 2012-07-12 Skinmedica, Inc. Melanin modification compositions and methods of use
US8778315B2 (en) 2011-01-07 2014-07-15 Allergan, Inc. Melanin modification compositions and methods of use
US9044404B2 (en) 2011-01-07 2015-06-02 Allergan, Inc. Melanin modification compositions and methods of use
US8236288B2 (en) 2011-01-07 2012-08-07 Skinmedica, Inc. Melanin modification compositions and methods of use
US9993444B2 (en) 2011-01-10 2018-06-12 Invion, Inc. Use of beta-adrenergic inverse agonists for smoking cessation
EP3513787A1 (en) 2011-01-10 2019-07-24 Invion, Inc Use of beta-adrenergic inverse agonists for smoking cessation
WO2012104589A1 (en) 2011-02-02 2012-08-09 University Of Edinburgh Weight related disorders
US9044420B2 (en) 2011-04-08 2015-06-02 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
US9526770B2 (en) 2011-04-28 2016-12-27 Tissuetech, Inc. Methods of modulating bone remodeling
US9675733B2 (en) 2011-04-28 2017-06-13 Tissuetech, Inc. Methods of modulating bone remodeling
US10426731B2 (en) 2011-06-10 2019-10-01 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
US9682044B2 (en) 2011-06-10 2017-06-20 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
EP3078374A1 (en) 2011-10-17 2016-10-12 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer
DE102013107024A1 (en) 2011-11-15 2014-05-15 Golden Biotechnology Corporation Methods and compositions for treating, modifying, and managing bone cancer pain
US10208003B2 (en) 2011-12-22 2019-02-19 Knopp Biosciences Llc Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
DE102013107025A1 (en) 2011-12-30 2014-07-03 Golden Biotechnology Corporation METHODS AND COMPOSITIONS FOR THE MANAGEMENT OF DIABETIS
US9273051B2 (en) 2011-12-30 2016-03-01 Pharmacyclics Llc Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
WO2013119856A1 (en) 2012-02-07 2013-08-15 Infectious Disease Research Institute Improved adjuvant formulations comprising tlr4 agonists and methods of using the same
EP3563834A1 (en) 2012-02-07 2019-11-06 Infectious Disease Research Institute Improved adjuvant formulations comprising tlr4 agonists and methods of using the same
US11510875B2 (en) 2012-02-07 2022-11-29 Access To Advanced Health Institute Adjuvant formulations comprising TLR4 agonists and methods of using the same
DE102013202928A1 (en) 2012-02-23 2013-08-29 Golden Biotechnology Corporation Methods and compositions for treating cancer metastasis
WO2013148701A1 (en) 2012-03-26 2013-10-03 Golden Biotechnology Corporation Methods and compositions for treating arteriosclerotic vascular diseases
WO2013160645A1 (en) 2012-04-26 2013-10-31 E-Therapeutics Plc Dexanabinol or a derivative thereof for use in the treatment of cancer in dose ranges of 2-30 mg/kg
WO2013164561A1 (en) 2012-05-04 2013-11-07 E-Therapeutics Plc Tramadol for treating depression
US9895435B2 (en) 2012-05-16 2018-02-20 Immune Design Corp. Vaccines for HSV-2
US10253065B2 (en) 2012-07-11 2019-04-09 Tissuetech, Inc. Compositions containing HC-HA/PTX3 complexes and methods of use thereof
US10717763B2 (en) 2012-07-11 2020-07-21 Tissuetech, Inc. Compositions containing HC-HA/PTX3 complexes and methods of use thereof
US11518782B2 (en) 2012-07-11 2022-12-06 Tissuetech, Inc. Compositions containing HC-HA/PTX3 complexes and methods of use thereof
US10040821B2 (en) 2012-07-11 2018-08-07 Tissuetech, Inc. Compositions containing HC-HA/PTX3 complexes and methods of use thereof
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2014081675A1 (en) 2012-11-21 2014-05-30 Golden Biotechnology Corporation Methods and compositions for treating neurodegenerative diseases
US10344012B2 (en) 2013-01-11 2019-07-09 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US10752605B2 (en) 2013-01-11 2020-08-25 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
WO2014110491A1 (en) 2013-01-11 2014-07-17 Theratrophix Llc Prodrugs of treprostinil
US11505535B2 (en) 2013-01-11 2022-11-22 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
EP3712142A1 (en) 2013-01-11 2020-09-23 Corsair Pharma, Inc. Prodrugs of treprostinil
EP4137127A1 (en) 2013-01-11 2023-02-22 Corsair Pharma, Inc. Prodrugs of treprostinil
US10450290B2 (en) 2013-01-11 2019-10-22 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9845305B2 (en) 2013-01-11 2017-12-19 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US11958822B2 (en) 2013-01-11 2024-04-16 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9776982B2 (en) 2013-01-11 2017-10-03 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US11339139B2 (en) 2013-01-11 2022-05-24 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US11046666B2 (en) 2013-01-11 2021-06-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
WO2014130619A2 (en) 2013-02-20 2014-08-28 Golden Biotechnology Corporation Methods and compositions for treating leukemia
US9956206B2 (en) 2013-02-28 2018-05-01 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US10285981B2 (en) 2013-02-28 2019-05-14 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US10085994B2 (en) 2013-03-10 2018-10-02 Peritech Pharma Ltd. Topical compositions and methods of treatment of topical disorders
US10085995B2 (en) 2013-03-10 2018-10-02 Peritech Pharma Ltd. Topical compositions and methods of treatment of anorectal disorders
US9072747B2 (en) 2013-03-10 2015-07-07 Peritech Pharma Ltd. Topical compositions and methods of treatment of anorectal disorders
US10232018B2 (en) 2013-03-14 2019-03-19 Mallinckrodt Ard Ip Limited ACTH for treatment of acute respiratory distress syndrome
WO2014172637A1 (en) 2013-04-18 2014-10-23 Immune Design Corp. Gla monotherapy for use in cancer treatment
US8957047B2 (en) 2013-04-18 2015-02-17 Immune Design Corp. GLA monotherapy for use in cancer treatment
EP3711768A1 (en) 2013-04-18 2020-09-23 Immune Design Corp. Gla monotherapy for use in cancer treatment
US8962593B2 (en) 2013-04-18 2015-02-24 Immune Design Corp. GLA monotherapy for use in cancer treatment
US10342815B2 (en) 2013-04-18 2019-07-09 Immune Design Corp. GLA monotherapy for use in cancer treatment
US10993956B2 (en) 2013-04-18 2021-05-04 Immune Design Corp. GLA monotherapy for use in cancer treatment
US9682068B2 (en) 2013-05-20 2017-06-20 Mylan Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
US10383856B2 (en) 2013-07-12 2019-08-20 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
US10980783B2 (en) 2013-07-12 2021-04-20 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
US11612589B2 (en) 2013-07-12 2023-03-28 Areteia Therapeutics, Inc. Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils
US11026928B2 (en) 2013-07-12 2021-06-08 Knopp Biosciences Llc Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils
US10828284B2 (en) 2013-07-12 2020-11-10 Knopp Biosciences Llc Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
US10383857B2 (en) 2013-07-12 2019-08-20 Knopp Biosciences Llc Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils
US9763918B2 (en) 2013-08-13 2017-09-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
US9642840B2 (en) 2013-08-13 2017-05-09 Knopp Biosciences, Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
US10456381B2 (en) 2013-08-13 2019-10-29 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
US10028940B2 (en) 2013-08-13 2018-07-24 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
US10195183B2 (en) 2013-08-13 2019-02-05 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
US9611263B2 (en) 2013-10-08 2017-04-04 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2015084998A1 (en) 2013-12-05 2015-06-11 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2015112485A1 (en) 2014-01-21 2015-07-30 Immune Design Corp. Compositions for use in the treatment of allergic conditions
US9707206B2 (en) 2014-02-10 2017-07-18 Patara Pharma, LLC Mast cell stabilizers treatment for systemic disorders
US9962363B2 (en) 2014-02-10 2018-05-08 Patara Pharma, LLC Mast cell stabilizers treatment for systemic disorders
EP3653207A1 (en) 2014-02-10 2020-05-20 Respivant Sciences GmbH Mast cell stabilizers treatment for systemic disorders
US10238628B2 (en) 2014-02-10 2019-03-26 Respivant Sciences Gmbh Mast cell stabilizers treatment for systemic disorders
US9265749B2 (en) 2014-02-10 2016-02-23 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10835512B2 (en) 2014-02-10 2020-11-17 Respivant Sciences Gmbh Methods of treating respiratory syncytial virus infections
US10398673B2 (en) 2014-02-10 2019-09-03 Respivant Services GmbH Mast cell stabilizers treatment for systemic disorders
US9968586B2 (en) 2014-02-10 2018-05-15 Patara Pharma, LLC Mast cell stabilizers treatment for systemic disorders
WO2015138919A1 (en) 2014-03-14 2015-09-17 The University Of North Carolina At Chapel Hill Small molecules for inhibiting male fertility
US9758533B2 (en) 2014-04-23 2017-09-12 The Research Foundation For The State University Of New York Rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjunction therewith
US10435418B2 (en) 2014-04-23 2019-10-08 The Research Foundation for the State University o Rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjunction therewith
US11116800B2 (en) 2014-06-03 2021-09-14 Tissuetech, Inc. Compositions of morselized umbilical cord and/or amniotic membrane and methods of use thereof
US9808491B2 (en) 2014-06-03 2017-11-07 Tissuetech, Inc. Compositions of morselized umbilical cord and/or amniotic membrane and methods of use thereof
EP3828160A1 (en) 2014-07-16 2021-06-02 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
WO2016010538A1 (en) 2014-07-16 2016-01-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US11426484B2 (en) 2014-08-15 2022-08-30 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US11944709B2 (en) 2014-08-15 2024-04-02 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
EP3872063A1 (en) 2014-11-25 2021-09-01 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists
WO2016086063A1 (en) 2014-11-25 2016-06-02 Concentric Analgesics, Inc. Prodrugs of phenolic trpv1 agonists
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US11828006B2 (en) 2014-12-11 2023-11-28 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10227713B2 (en) 2014-12-11 2019-03-12 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10590566B2 (en) 2014-12-11 2020-03-17 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
US11590265B2 (en) 2015-02-23 2023-02-28 Biotissue Holdings Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
WO2016138479A1 (en) 2015-02-27 2016-09-01 Curtana Pharmaceuticals, Inc. Inhibition of olig2 activity
US11691951B2 (en) 2015-02-27 2023-07-04 Curtana Pharmaceuticals, Inc. Inhibition of Olig2 activity
US10632064B2 (en) 2015-03-02 2020-04-28 Afgin Pharma, Llc Topical regional neuro affective therapy with cannabinoid combination products
US10172809B2 (en) 2015-03-02 2019-01-08 Afgin Pharma Llc Topical regional neuro-affective therapy in mammals with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US10716766B2 (en) 2015-03-02 2020-07-21 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10342831B2 (en) 2015-05-20 2019-07-09 Tissuetech, Inc. Composition and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
US11318169B2 (en) 2015-05-20 2022-05-03 Tissuetech, Inc. Compositions and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
WO2016205202A1 (en) 2015-06-17 2016-12-22 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9701616B2 (en) 2015-06-17 2017-07-11 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10759733B2 (en) 2015-06-17 2020-09-01 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10246403B2 (en) 2015-06-17 2019-04-02 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US11866402B2 (en) 2015-06-17 2024-01-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
EP3835291A1 (en) 2015-06-17 2021-06-16 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US11802105B2 (en) 2015-06-17 2023-10-31 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US11034645B2 (en) 2015-06-17 2021-06-15 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
EP3456715A1 (en) 2015-06-17 2019-03-20 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10053414B2 (en) 2015-06-17 2018-08-21 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10988435B2 (en) 2015-06-17 2021-04-27 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10464877B2 (en) 2015-06-17 2019-11-05 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10464878B2 (en) 2015-06-17 2019-11-05 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US11407707B2 (en) 2015-06-17 2022-08-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9957220B2 (en) 2015-06-17 2018-05-01 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10703706B2 (en) 2015-06-17 2020-07-07 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
WO2017011611A1 (en) 2015-07-14 2017-01-19 Lipp Life Sciences Llc Pharmaceutical administration system for the transdermal application of vardenafil
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10391078B2 (en) 2015-08-07 2019-08-27 Respivant Sciences Gmbh Methods for the treatment of mast cell related disorders with mast cell stabilizers
US10596146B2 (en) 2015-08-07 2020-03-24 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
WO2017027402A1 (en) 2015-08-07 2017-02-16 Patara Pharma, LLC Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10238625B2 (en) 2015-08-07 2019-03-26 Respivant Sciences Gmbh Methods for the treatment of mast cell related disorders with mast cell stabilizers
WO2017040617A1 (en) 2015-08-31 2017-03-09 Pharmacyclics Llc Btk inhibitor combinations for treating multiple myeloma
WO2017068349A1 (en) 2015-10-23 2017-04-27 E-Therapeutics Plc Cannabinoid for use in immunotherapy
US11707492B2 (en) 2016-01-29 2023-07-25 Biotissue Holdings Inc. Fetal support tissue products and methods of use
US10851123B2 (en) 2016-02-23 2020-12-01 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12023309B2 (en) 2016-05-05 2024-07-02 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11191737B2 (en) 2016-05-05 2021-12-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11883381B2 (en) 2016-05-12 2024-01-30 The Regents Of The University Of Michigan ASH1L inhibitors and methods of treatment therewith
WO2017197240A1 (en) 2016-05-12 2017-11-16 The Regents Of The University Of Michigan Ash1l inhibitors and methods of treatment therewith
EP4112638A1 (en) 2016-05-16 2023-01-04 Access to Advanced Health Institute Formulation containing tlr agonist and methods of use
WO2017200852A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Formulation containing tlr agonist and methods of use
WO2017200957A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Pegylated liposomes and methods of use
US10821105B2 (en) 2016-05-25 2020-11-03 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
US11464767B2 (en) 2016-05-25 2022-10-11 Concentric Analgesics, Inc. Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
WO2017205762A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205766A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205769A1 (en) 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017210364A1 (en) 2016-06-01 2017-12-07 Infectious Disease Research Institute Nanoalum particles containing a sizing agent
US10773008B2 (en) * 2016-08-08 2020-09-15 Universiti Brunei Darussalam Medicated patch for preventing exit site infections during peritoneal dialysis
US20180126058A1 (en) * 2016-08-08 2018-05-10 Universiti Brunei Darussalam Medicated Patch for Preventing Exit Site Infections during Peritoneal Dialysis
US10828266B2 (en) 2016-08-16 2020-11-10 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US11242323B2 (en) 2016-08-26 2022-02-08 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
US10265267B2 (en) 2016-08-31 2019-04-23 Respivant Sciences Gmbh Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
US10463613B2 (en) 2016-08-31 2019-11-05 Respivant Sciences Gmbh Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis
US10583113B2 (en) 2016-10-07 2020-03-10 Respivant Sciences Gmbh Cromolyn compositions for treatment of pulmonary fibrosis
US10561635B2 (en) 2016-10-07 2020-02-18 Respivant Sciences Gmbh Cromolyn compositions for treatment of pulmonary fibrosis
WO2018106632A1 (en) 2016-12-05 2018-06-14 Corsair Pharma, Inc. Dermal and transdermal administration of treprostinil and salts thereof
US11739054B2 (en) 2017-06-11 2023-08-29 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
US11147885B2 (en) 2017-11-10 2021-10-19 The Regents Of The University Of Michigan ASH1L inhibitors and methods of treatment therewith
WO2019094772A1 (en) 2017-11-10 2019-05-16 The Regents Of The University Of Michigan Ash1l degraders and methods of treatment therewith
US10632209B2 (en) 2017-11-10 2020-04-28 The Regents Of The University Of Michigan ASH1L inhibitors and methods of treatment therewith
US11786602B2 (en) 2017-11-10 2023-10-17 The Regents Of The University Of Michigan ASH1L degraders and methods of treatment therewith
US11833210B2 (en) 2017-11-10 2023-12-05 The Regents Of The University Of Michigan ASH1L inhibitors and methods of treatment therewith
WO2019094773A1 (en) 2017-11-10 2019-05-16 The Regents Of The University Of Michigan Ash1l inhibitors and methods of treatment therewith
US11110177B2 (en) 2017-11-10 2021-09-07 The Regents Of The University Of Michigan ASH1L degraders and methods of treatment therewith
WO2019113469A1 (en) 2017-12-07 2019-06-13 The Regents Of The University Of Michigan Nsd family inhibitors and methods of treatment therewith
WO2019236957A1 (en) 2018-06-07 2019-12-12 The Regents Of The University Of Michigan Prc1 inhibitors and methods of treatment therewith
EP4155293A1 (en) 2018-06-07 2023-03-29 The Regents of The University of Michigan Prc1 inhibitors and methods of treatment therewith
US11319302B2 (en) 2018-06-07 2022-05-03 The Regents Of The University Of Michigan PRC1 inhibitors and methods of treatment therewith
US10717712B2 (en) 2018-07-27 2020-07-21 Concentric Analgesics, Inc. Pegylated prodrugs of phenolic TRPV1 agonists
US11242325B2 (en) 2018-07-27 2022-02-08 Concentric Analgesics, Inc. Pegylated prodrugs of phenolic TRPV1 agonists
WO2020142557A1 (en) 2018-12-31 2020-07-09 Biomea Fusion, Llc Irreversible inhibitors of menin-mll interaction
WO2020190890A1 (en) 2019-03-15 2020-09-24 Unicycive Therapeutics Inc. Nicorandil derivatives
US11858925B2 (en) 2020-07-10 2024-01-02 The Regents Of The University Of Michigan GAS41 inhibitors and methods of use thereof
WO2022133064A1 (en) 2020-12-16 2022-06-23 Biomea Fusion, Inc. Fused pyrimidine compounds as inhibitors of menin-mll interaction
WO2023018825A1 (en) 2021-08-11 2023-02-16 Biomea Fusion, Inc. Covalent inhibitors of menin-mll interaction for diabetes mellitus
WO2023027966A1 (en) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Pyrazine compounds as irreversible inhibitors of flt3
WO2023039240A1 (en) 2021-09-13 2023-03-16 Biomea Fusion, Inc. IRREVERSIBLE INHIBITORS OF KRas
WO2023086341A1 (en) 2021-11-09 2023-05-19 Biomea Fusion, Inc. Inhibitors of kras
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
WO2023235618A1 (en) 2022-06-03 2023-12-07 Biomea Fusion, Inc. Fused pyrimidine compounds as inhibitors of menin
US12138249B2 (en) 2023-03-06 2024-11-12 Areteia Therapeutics, Inc. Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils

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