Nothing Special   »   [go: up one dir, main page]

US20150110908A1 - Compositions, Kits, and Methods for Ameliorating Oculoplastic Post-Procedural Effects - Google Patents

Compositions, Kits, and Methods for Ameliorating Oculoplastic Post-Procedural Effects Download PDF

Info

Publication number
US20150110908A1
US20150110908A1 US14/059,262 US201314059262A US2015110908A1 US 20150110908 A1 US20150110908 A1 US 20150110908A1 US 201314059262 A US201314059262 A US 201314059262A US 2015110908 A1 US2015110908 A1 US 2015110908A1
Authority
US
United States
Prior art keywords
composition
oculoplastic
procedure
post
glycerin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/059,262
Inventor
Nat Adkins, JR.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ocusoft Inc
Original Assignee
Ocusoft Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocusoft Inc filed Critical Ocusoft Inc
Priority to US14/059,262 priority Critical patent/US20150110908A1/en
Assigned to OCUSOFT, INC. reassignment OCUSOFT, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ADKINS, NAT, JR.
Publication of US20150110908A1 publication Critical patent/US20150110908A1/en
Priority to US14/748,684 priority patent/US9999642B2/en
Priority to US16/001,651 priority patent/US11260094B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Definitions

  • compositions for topical application to the skin which comprise escin, arnica and phytonadione.
  • a composition formulated to minimize one or more post-procedural effects associated with an oculoplastic procedure, includes escin, arnica and phytonadione.
  • a method of minimizing one or more post-procedural effects associated with an oculoplastic procedure includes applying a therapeutically effective of a composition at or around the site of the oculoplastic procedure.
  • the topical composition includes escin, arnica and phytonadione.
  • a post-oculoplastic procedure recovery kit includes a composition consisting essentially of escin; arnica; phytonadione; glycerin stearate; glyceryl stearate citrate; glycerin; stearic acid; sunflower oil; phenoxyethanol; dimethicone; tocopheryl acetate; allantoin; retinyl palmitate; cholecalciferol; sodium ascorbyl phosphate; cetearyl alcohol; lecithin; potassium sorbate; caprylic triglyceride; xanthan gum; sodium bicarbonate; and deionized water.
  • Oculoplastics or oculoplastic surgery, includes a variety of procedures, including surgical procedures, that deal with the orbit (eye socket), eyelids, tear ducts, and the face.
  • Oculoplastic procedures include blepharoplasty and other cosmetic surgeries that involve, for example, cosmetic filler injections and botulinum toxin injections to temporarily improve the appearance of vertical frown lines.
  • Blepharoplasty is sometimes performed in conjunction with facial resurfacing, in which lines around the eyes are removed with a laser or a chemical peel.
  • Oculoplastic procedures can result in unsightly post-procedural effects. For example, many patients or subjects experience some degree of bruising or swelling at and/or around the treated area or site.
  • the injection needle when the injection needle is inserted into the facial muscles, it may puncture a blood vessel. This may cause blood to hemorrhage from the capillaries.
  • the intradermal cutaneous hemorrhage can show up as a bruise.
  • Physicians or clinicians typically apply pressure on the injected site to stop any bleeding and prevent bruising. However, if the bleeding cannot be completely stopped, the patient may experience bruising. In some instances, patients may experience delayed bruising. This is due to the fact that, in these patients, it may be a while before the blood inside their skin migrates to the surface of the skin.
  • the term “bruise” includes red or bluish-black marks, or any discoloration of the skin due to the release of blood from the capillaries into the tissues under the skin as a result of the oculoplastic procedure.
  • the physician's skill may play a role in minimizing these side-effects, it is almost impossible to eliminate some bruising and other side-effects of an oculoplastic procedure. These side-effects can last from a few hours to a few days.
  • Post-procedure the patient can apply makeup to conceal any minor bruising and ice to reduce any swelling.
  • the patient may be advised to take oxidant rich foods and supplements until the patient is free of bruising.
  • the supplements may not be regulated by the Food and Drug Administration (FDA).
  • FDA Food and Drug Administration
  • a non-ingestible composition that helps reduce or eliminate bruising, scarring, swelling and other similar effects caused by an oculoplastic procedure.
  • Such a composition should be able to minimize skin discoloration and reduce bruising.
  • Such a composition must also be non-toxic.
  • Embodiments of the present invention include non-toxic compositions, kits and methods for treating or minimizing one or more post-procedural effects associated with an oculoplastic procedure.
  • the composition can be administered to a patient in a pharmacologically acceptable form selected from creams, ointments, gels, lotions, solutions and emulsions.
  • a therapeutically effective amount of the composition can be administered to a patient prior to or soon after an oculoplastic procedure.
  • the term “therapeutically effective” indicates that a pre-determined amount of the composition is applied to the skin, wherein the amount is sufficient to reduce the time required to heal a post-oculoplastic procedure bruise, scar or swelling.
  • the required dosage and duration of administration can be adjusted based on, for example, the age of the patient, visible improvements in the appearance of the bruise and other physiological indicators.
  • Administration of the composition can result in a visible improvement in one or more unsightly post-procedural effect, including, bruising, skin discolorations and swelling.
  • the composition can be administered topically or locally to the skin at and/or around the site/area of the oculoplastic procedure.
  • the term “administration” means applying a therapeutically effective amount of the composition to the skin such that any unsightly post-procedural effects, such as, bruising, skin discolorations and swelling are treated to speed up their resolution.
  • the composition can include escin, arnica and phytonadione in a pharmaceutically acceptable carrier.
  • the composition includes at least 2% escin or aescin.
  • Escin improves circulation and eases post-procedural swelling.
  • Escin is derived from horse chestnut ( Aesculus hippocastanum ).
  • Arnica is extracted from the plant Arnica Montana.
  • Arnica reduces inflammation and bruising.
  • Phytonadione or Vitamin K is a fat-soluble vitamin that the body needs for blood coagulation. Vitamin K is associated with veins and blood because it is a factor in the blood's ability to clot. Vitamin K can minimize skin discolorations.
  • the composition including escin, arnica and phtyonadione reduces bruising and eases swelling by strengthening capillaries and improving circulation.
  • the composition further includes one or more vitamins or antioxidants to eliminate scars and reduce bruising.
  • the composition can include one or more of tocopheryl acetate, cholecalciferol, rose hip seed oil, retinyl palmitate and sodium ascorbyl phosphate to minimize scarring and bruising when applied to the skin.
  • the composition includes shea butter and deionized water.
  • the composition can further include a stabilizer and one or more emulsifiers such as an amphoteric, anionic, cationic or nonionic emulsifier, used alone or as a mixture, and optionally a co-emulsifier.
  • the emulsifiers are chosen in an appropriate manner according to the emulsion to be obtained.
  • the composition can include vegetable derived glycerine to reduce redness and increase moisture.
  • the composition can include a vegetable derived glucoside-based emulsifier.
  • the composition can include cetostearyl alcohol, cetearyl alcohol or cetylstearyl alcohol, glyceryl monostearate or glyceryl stearate, glyceryl stearate citrate and stearic acid.
  • the composition can further include xanthan gum for ensuring flowability of the composition.
  • the composition further includes one or more emollients.
  • the composition includes aloe barbanesis leaf juice or aloe vera. Aloe is known to have healthful benefits and can ease swelling or inflammation and help speed up the healing recovery process.
  • the composition can further include sunflower oil, dimethicone, lecithin and caprylic/capric triglyceride and/or combinations thereof.
  • the composition further includes one or more antibacterial agents such as potassium sorbate and phenoxyethanol and a sulfur compound such as methylsulfonylmethane.
  • the composition may further include allantoin. Allantoin is anti-irritant and skin protectant that also promotes the healing of scars.
  • the composition can further include a stabilizer such as xanthan gum and a buffer such as sodium bicarbonate.
  • the composition consists essentially of escin, arnica, phytonadione, glycerin stearate, glyceryl stearate citrate, glycerin, stearic acid, sunflower oil, phenoxyethanol, dimethicone, tocopheryl acetate, allantoin, retinyl palmitate, cholecalciferol, sodium ascorbyl phosphate, cetearyl alcohol, lecithin, potassium sorbate, caprylic triglyceride, xanthan gum, sodium bicarbonate, and deionized water.
  • composition can be devoid of dextran sulfate mixtures and/or a steroid.
  • a patient recommended for an oculoplastic procedure is identified as a candidate for receiving post procedure treatment.
  • the patient may be known to be easily susceptible to bruising.
  • Some patients may be susceptible to bruising due thinning and/or loss of elasticity of the skin due to illness or aging.
  • Such patients can be administered a therapeutically effective amount of the composition in a pharmaceutically acceptable medium prior to and/or after the oculoplastic procedure.
  • a cream or lotion can be administered by gently rubbing onto the skin at or around the site of the oculoplastic procedure. The composition is allowed to penetrate the skin such that any unsightly post-procedural effects, such as, bruising, skin discolorations and swelling are treated, inhibited or reduced.
  • the composition is non-toxic and any residue can be safely left on the skin.
  • the composition can be re-applied, as needed, periodically.
  • the composition used may be administered more than once daily.
  • the composition ameliorates the undesired effects of an oculoplastic procedure.
  • the composition can accelerate/reduce the time required to heal a bruise, swelling or scar caused by the oculoplastic procedure.
  • the application of the composition can have a curative effect.
  • a post-oculoplastic procedure recovery kit includes a topical composition consisting essentially of escin, arnica, phytonadione, glycerin stearate, glyceryl stearate citrate, glycerin, stearic acid, sunflower oil, phenoxyethanol, dimethicone, tocopheryl acetate, allantoin, retinyl palmitate, cholecalciferol, sodium ascorbyl phosphate, cetearyl alcohol, lecithin, potassium sorbate, caprylic triglyceride, xanthan gum, sodium bicarbonate, and deionized water.
  • the kit further includes housing for the composition.
  • the kit can further include instructions for the application of the composition.
  • compositions for cosmetic and therapeutic uses. It will also be appreciated that the composition can be employed in combination therapies, that is, administered concurrently with, prior to, or subsequent to, one or more other desired therapeutics or medical procedures taking into account the desired therapeutic effect to be achieved.
  • the present invention is well adapted to attain the ends and advantages mentioned as well as those that are inherent therein.
  • the particular embodiments disclosed above are illustrative only, as the present invention may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein.
  • the composition can also be used to treat any bruising caused by any (non-oculoplastic) procedure that causes blood to escape into surrounding tissue.
  • no limitations are intended to the details of construction or design herein shown, other than as described in the claims below. It is, therefore, evident that the particular illustrative embodiments disclosed above may be altered or modified and all such variations are considered within the scope and spirit of the present invention.
  • compositions, kits and methods are described in terms of “comprising,” “containing,” or “including” various components or steps, the compositions, kits and methods also can “consist essentially of” or “consist of” the various components and steps.
  • every range of values (of the form, “from about a to about b,” or, equivalently, “from approximately a to b”) disclosed herein is to be understood to set forth every number and range encompassed within the broader range of values.
  • the terms in the claims have their plain, ordinary meaning unless otherwise explicitly and clearly defined by the patentee.
  • the indefinite articles “a” or “an”, as used in the claims are defined herein to mean one or more than one of the element that it introduces. If there is any conflict in the usages of a word or term in this specification and one or more patent(s) or other documents that may be incorporated herein by reference, the definitions that are consistent with this specification should be adopted.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Embodiments of the invention are directed to compositions, kits and methods for minimizing unsightly post-procedural effects associated with an oculoplastic procedure. The composition can include escin, arnica and phytonadione in a pharmacologically acceptable carrier.

Description

    FIELD OF THE INVENTION
  • Compositions for topical application to the skin which comprise escin, arnica and phytonadione.
    • SUMMARY
  • According to one embodiment, a composition, formulated to minimize one or more post-procedural effects associated with an oculoplastic procedure, includes escin, arnica and phytonadione.
  • According to another embodiment, a method of minimizing one or more post-procedural effects associated with an oculoplastic procedure includes applying a therapeutically effective of a composition at or around the site of the oculoplastic procedure. The topical composition includes escin, arnica and phytonadione.
  • According to yet another embodiment, a post-oculoplastic procedure recovery kit includes a composition consisting essentially of escin; arnica; phytonadione; glycerin stearate; glyceryl stearate citrate; glycerin; stearic acid; sunflower oil; phenoxyethanol; dimethicone; tocopheryl acetate; allantoin; retinyl palmitate; cholecalciferol; sodium ascorbyl phosphate; cetearyl alcohol; lecithin; potassium sorbate; caprylic triglyceride; xanthan gum; sodium bicarbonate; and deionized water.
  • These and other aspects of the present invention will be better understood by reference to the following detailed description.
    • DETAILED DESCRIPTION
  • All terms used herein are intended to have their ordinary meaning unless otherwise provided.
  • Oculoplastics, or oculoplastic surgery, includes a variety of procedures, including surgical procedures, that deal with the orbit (eye socket), eyelids, tear ducts, and the face. Oculoplastic procedures include blepharoplasty and other cosmetic surgeries that involve, for example, cosmetic filler injections and botulinum toxin injections to temporarily improve the appearance of vertical frown lines. Blepharoplasty is sometimes performed in conjunction with facial resurfacing, in which lines around the eyes are removed with a laser or a chemical peel. Oculoplastic procedures can result in unsightly post-procedural effects. For example, many patients or subjects experience some degree of bruising or swelling at and/or around the treated area or site. During cosmetic procedures, when the injection needle is inserted into the facial muscles, it may puncture a blood vessel. This may cause blood to hemorrhage from the capillaries. The intradermal cutaneous hemorrhage can show up as a bruise. Physicians or clinicians typically apply pressure on the injected site to stop any bleeding and prevent bruising. However, if the bleeding cannot be completely stopped, the patient may experience bruising. In some instances, patients may experience delayed bruising. This is due to the fact that, in these patients, it may be a while before the blood inside their skin migrates to the surface of the skin. As used herein, the term “bruise” includes red or bluish-black marks, or any discoloration of the skin due to the release of blood from the capillaries into the tissues under the skin as a result of the oculoplastic procedure.
  • Although the physician's skill may play a role in minimizing these side-effects, it is almost impossible to eliminate some bruising and other side-effects of an oculoplastic procedure. These side-effects can last from a few hours to a few days. Post-procedure, the patient can apply makeup to conceal any minor bruising and ice to reduce any swelling. In some case, the patient may be advised to take oxidant rich foods and supplements until the patient is free of bruising. In some cases, the supplements may not be regulated by the Food and Drug Administration (FDA). Some patients may experience adverse side-effects (due to reactions with other medications) from ingesting some of these non-FDA regulated supplements. Therefore, there is a need for a non-ingestible composition that helps reduce or eliminate bruising, scarring, swelling and other similar effects caused by an oculoplastic procedure. Such a composition should be able to minimize skin discoloration and reduce bruising. Such a composition must also be non-toxic.
  • Embodiments of the present invention include non-toxic compositions, kits and methods for treating or minimizing one or more post-procedural effects associated with an oculoplastic procedure. The composition can be administered to a patient in a pharmacologically acceptable form selected from creams, ointments, gels, lotions, solutions and emulsions. A therapeutically effective amount of the composition can be administered to a patient prior to or soon after an oculoplastic procedure. For the purposes of this application, the term “therapeutically effective” indicates that a pre-determined amount of the composition is applied to the skin, wherein the amount is sufficient to reduce the time required to heal a post-oculoplastic procedure bruise, scar or swelling. The required dosage and duration of administration can be adjusted based on, for example, the age of the patient, visible improvements in the appearance of the bruise and other physiological indicators.
  • Administration of the composition can result in a visible improvement in one or more unsightly post-procedural effect, including, bruising, skin discolorations and swelling. The composition can be administered topically or locally to the skin at and/or around the site/area of the oculoplastic procedure. As used herein, the term “administration” means applying a therapeutically effective amount of the composition to the skin such that any unsightly post-procedural effects, such as, bruising, skin discolorations and swelling are treated to speed up their resolution.
  • In an embodiment, the composition can include escin, arnica and phytonadione in a pharmaceutically acceptable carrier. In one embodiment, the composition includes at least 2% escin or aescin. Escin improves circulation and eases post-procedural swelling. Escin is derived from horse chestnut (Aesculus hippocastanum). Arnica is extracted from the plant Arnica Montana. Arnica reduces inflammation and bruising. Phytonadione or Vitamin K is a fat-soluble vitamin that the body needs for blood coagulation. Vitamin K is associated with veins and blood because it is a factor in the blood's ability to clot. Vitamin K can minimize skin discolorations. Accordingly, in one embodiment, the composition including escin, arnica and phtyonadione reduces bruising and eases swelling by strengthening capillaries and improving circulation.
  • The composition further includes one or more vitamins or antioxidants to eliminate scars and reduce bruising. For example, in one embodiment, the composition can include one or more of tocopheryl acetate, cholecalciferol, rose hip seed oil, retinyl palmitate and sodium ascorbyl phosphate to minimize scarring and bruising when applied to the skin.
  • The composition includes shea butter and deionized water. The composition can further include a stabilizer and one or more emulsifiers such as an amphoteric, anionic, cationic or nonionic emulsifier, used alone or as a mixture, and optionally a co-emulsifier. The emulsifiers are chosen in an appropriate manner according to the emulsion to be obtained. The composition can include vegetable derived glycerine to reduce redness and increase moisture. The composition can include a vegetable derived glucoside-based emulsifier. In one embodiment, the composition can include cetostearyl alcohol, cetearyl alcohol or cetylstearyl alcohol, glyceryl monostearate or glyceryl stearate, glyceryl stearate citrate and stearic acid. The composition can further include xanthan gum for ensuring flowability of the composition.
  • The composition further includes one or more emollients. In one embodiment, the composition includes aloe barbanesis leaf juice or aloe vera. Aloe is known to have healthful benefits and can ease swelling or inflammation and help speed up the healing recovery process. The composition can further include sunflower oil, dimethicone, lecithin and caprylic/capric triglyceride and/or combinations thereof.
  • The composition further includes one or more antibacterial agents such as potassium sorbate and phenoxyethanol and a sulfur compound such as methylsulfonylmethane. The composition may further include allantoin. Allantoin is anti-irritant and skin protectant that also promotes the healing of scars. The composition can further include a stabilizer such as xanthan gum and a buffer such as sodium bicarbonate.
  • According to one embodiment, the composition consists essentially of escin, arnica, phytonadione, glycerin stearate, glyceryl stearate citrate, glycerin, stearic acid, sunflower oil, phenoxyethanol, dimethicone, tocopheryl acetate, allantoin, retinyl palmitate, cholecalciferol, sodium ascorbyl phosphate, cetearyl alcohol, lecithin, potassium sorbate, caprylic triglyceride, xanthan gum, sodium bicarbonate, and deionized water. This specific list of ingredients, which includes a high number of active ingredients, specifically and comprehensively addresses the need for a topical composition that can minimize bruising or swelling after an oculoplastic procedure in a single cosmetic product. In one embodiment, the composition can be devoid of dextran sulfate mixtures and/or a steroid.
  • According to another embodiment, a patient recommended for an oculoplastic procedure is identified as a candidate for receiving post procedure treatment. For instance, the patient may be known to be easily susceptible to bruising. Some patients may be susceptible to bruising due thinning and/or loss of elasticity of the skin due to illness or aging. Such patients can be administered a therapeutically effective amount of the composition in a pharmaceutically acceptable medium prior to and/or after the oculoplastic procedure. For example, a cream or lotion can be administered by gently rubbing onto the skin at or around the site of the oculoplastic procedure. The composition is allowed to penetrate the skin such that any unsightly post-procedural effects, such as, bruising, skin discolorations and swelling are treated, inhibited or reduced.
  • The composition is non-toxic and any residue can be safely left on the skin. The composition can be re-applied, as needed, periodically. For example, the composition used may be administered more than once daily. When topically applied, the composition ameliorates the undesired effects of an oculoplastic procedure. The composition can accelerate/reduce the time required to heal a bruise, swelling or scar caused by the oculoplastic procedure. Thus, the application of the composition can have a curative effect.
  • According to yet another embodiment, a post-oculoplastic procedure recovery kit includes a topical composition consisting essentially of escin, arnica, phytonadione, glycerin stearate, glyceryl stearate citrate, glycerin, stearic acid, sunflower oil, phenoxyethanol, dimethicone, tocopheryl acetate, allantoin, retinyl palmitate, cholecalciferol, sodium ascorbyl phosphate, cetearyl alcohol, lecithin, potassium sorbate, caprylic triglyceride, xanthan gum, sodium bicarbonate, and deionized water. The kit further includes housing for the composition. The kit can further include instructions for the application of the composition.
  • The embodiments of the invention provide methods, kits and compositions for cosmetic and therapeutic uses. It will also be appreciated that the composition can be employed in combination therapies, that is, administered concurrently with, prior to, or subsequent to, one or more other desired therapeutics or medical procedures taking into account the desired therapeutic effect to be achieved.
  • Therefore, the present invention is well adapted to attain the ends and advantages mentioned as well as those that are inherent therein. The particular embodiments disclosed above are illustrative only, as the present invention may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein. For instance, the composition can also be used to treat any bruising caused by any (non-oculoplastic) procedure that causes blood to escape into surrounding tissue. Furthermore, no limitations are intended to the details of construction or design herein shown, other than as described in the claims below. It is, therefore, evident that the particular illustrative embodiments disclosed above may be altered or modified and all such variations are considered within the scope and spirit of the present invention. While composition, kits and methods are described in terms of “comprising,” “containing,” or “including” various components or steps, the compositions, kits and methods also can “consist essentially of” or “consist of” the various components and steps. In particular, every range of values (of the form, “from about a to about b,” or, equivalently, “from approximately a to b”) disclosed herein is to be understood to set forth every number and range encompassed within the broader range of values. Also, the terms in the claims have their plain, ordinary meaning unless otherwise explicitly and clearly defined by the patentee. Moreover, the indefinite articles “a” or “an”, as used in the claims, are defined herein to mean one or more than one of the element that it introduces. If there is any conflict in the usages of a word or term in this specification and one or more patent(s) or other documents that may be incorporated herein by reference, the definitions that are consistent with this specification should be adopted.

Claims (20)

What is claimed is:
1. A topical composition comprising:
escin;
arnica; and
phytonadione,
wherein the composition is formulated to minimize one or more post-procedural effects associated with an oculoplastic procedure.
2. The composition according to claim 1, further comprising deionized water.
3. The composition according to claim 1, further comprising glycerin.
4. The composition according to claim 1, further comprising glycerin stearate and/or glyceryl stearate citrate.
5. The composition according to claim 1, further comprising:
stearic acid;
sunflower oil;
phenoxyethanol;
dimethicone;
tocopheryl acetate;
allantoin;
retinyl palmitate;
cholecalciferol;
sodium ascorbyl phosphate;
cetearyl alcohol;
lecithin;
potassium sorbate; and
caprylic/capric triglyceride.
6. The composition according to claim 1, further comprising xanthan gum.
7. The composition according to claim 1, further comprising sodium bicarbonate.
8. A method of minimizing one or more post-procedural effects associated with an oculoplastic procedure in a subject, comprising:
administering a therapeutically effective amount of a composition comprising:
escin;
arnica; and
phytonadione.
9. The method according to claim 8, wherein the composition is administered after the oculoplastic procedure.
10. The method according to claim 8, wherein the composition is administered prior to the oculoplastic procedure.
11. The method according to claim 8, wherein the composition further comprises glycerin, stearate and/or glyceryl stearate citrate.
12. The method according to claim 8, wherein the composition further comprises:
deionized water;
stearic acid;
sunflower oil;
phenoxyethanol;
dimethicone;
tocopheryl acetate;
allantoin;
retinyl palmitate;
cholecalciferol;
sodium ascorbyl phosphate;
cetearyl alcohol;
lecithin;
xanthan gum;
potassium sorbate; and
caprylic triglyceride.
13. The method according to claim 8, wherein the oculoplastic procedure comprises a facial procedure.
14. The method according to claim 8, wherein the composition is topically applied to the skin.
15. The method according to claim 8, wherein the composition is topically applied at or around a site of the oculoplastic procedure.
16. The method according to claim 8, wherein the composition is administered in a pharmacologically acceptable form selected from creams, ointments, gels, lotions, solutions and emulsions.
17. The method according to claim 8, wherein the applied amount of the composition is sufficient to reduce the healing time of a post-procedural bruise and/or scar.
18. The method according to claim 8, further comprises identifying a patient recommended for an oculoplastic procedure.
19. A post-oculoplastic procedure recovery kit comprising:
a topical composition consisting essentially of:
escin;
arnica;
phytonadione;
glycerin stearate;
glyceryl stearate citrate;
glycerin;
stearic acid;
sunflower oil;
phenoxyethanol;
dimethicone;
tocopheryl acetate;
allantoin;
retinyl palmitate;
cholecalciferol;
sodium ascorbyl phosphate;
cetearyl alcohol;
lecithin;
potassium sorbate;
caprylic triglyceride;
xanthan gum;
sodium bicarbonate; and
deionized water,
wherein the composition is formulated to minimize one or more post-procedural effects associated with an oculoplastic procedure.
20. The kit according to claim 19, wherein the kit further comprises housing for the topical composition.
US14/059,262 2013-10-21 2013-10-21 Compositions, Kits, and Methods for Ameliorating Oculoplastic Post-Procedural Effects Abandoned US20150110908A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/059,262 US20150110908A1 (en) 2013-10-21 2013-10-21 Compositions, Kits, and Methods for Ameliorating Oculoplastic Post-Procedural Effects
US14/748,684 US9999642B2 (en) 2013-10-21 2015-06-24 Compositions, kits, and methods for ameliorating oculoplastic post-procedural effects
US16/001,651 US11260094B2 (en) 2013-10-21 2018-06-06 Compositions, kits and methods for ameliorating oculoplastic post-procedural effects

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14/059,262 US20150110908A1 (en) 2013-10-21 2013-10-21 Compositions, Kits, and Methods for Ameliorating Oculoplastic Post-Procedural Effects

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/748,684 Continuation US9999642B2 (en) 2013-10-21 2015-06-24 Compositions, kits, and methods for ameliorating oculoplastic post-procedural effects

Publications (1)

Publication Number Publication Date
US20150110908A1 true US20150110908A1 (en) 2015-04-23

Family

ID=52826402

Family Applications (3)

Application Number Title Priority Date Filing Date
US14/059,262 Abandoned US20150110908A1 (en) 2013-10-21 2013-10-21 Compositions, Kits, and Methods for Ameliorating Oculoplastic Post-Procedural Effects
US14/748,684 Active 2034-11-29 US9999642B2 (en) 2013-10-21 2015-06-24 Compositions, kits, and methods for ameliorating oculoplastic post-procedural effects
US16/001,651 Active 2034-12-28 US11260094B2 (en) 2013-10-21 2018-06-06 Compositions, kits and methods for ameliorating oculoplastic post-procedural effects

Family Applications After (2)

Application Number Title Priority Date Filing Date
US14/748,684 Active 2034-11-29 US9999642B2 (en) 2013-10-21 2015-06-24 Compositions, kits, and methods for ameliorating oculoplastic post-procedural effects
US16/001,651 Active 2034-12-28 US11260094B2 (en) 2013-10-21 2018-06-06 Compositions, kits and methods for ameliorating oculoplastic post-procedural effects

Country Status (1)

Country Link
US (3) US20150110908A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120121675A1 (en) * 2009-07-24 2012-05-17 Lipotec, S.A. Compounds which inhibit muscle contraction

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1503388A (en) 1975-07-01 1978-03-08 Inverni Della Beffa Spa Pharmaceutically active complexes and pharmaceutical compositions containing them
IT1203515B (en) 1987-02-26 1989-02-15 Indena Spa SAPONINE COMPLEXES WITH PHOSPHOLIPIDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
HU202743B (en) 1988-06-24 1991-04-29 Richter Gedeon Vegyeszet Active ingredient composition comprising medicinal herb extracts, cosmetics comprising such active ingredient and process for producing medicinal and veterinary compositions
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
FR2799369B1 (en) 1999-10-08 2001-12-21 Oreal COMBINATION OF ESCINE AND DEXTRAN SULFATE AND THE USE THEREOF
US6555118B1 (en) 2001-02-22 2003-04-29 Sarfaraz K Niazi Pharmaceutical preparation for the treatment of topical wounds and ulcers
WO2003080636A1 (en) 2002-03-25 2003-10-02 Council Of Scientific And Industrial Research A simple process for obtaining beta-aescin from indian horse chestnut (aesculus indica)
US7544375B1 (en) 2006-06-12 2009-06-09 Swiss Skin Repair, Inc. Composition
US8410079B2 (en) 2010-08-06 2013-04-02 Island Kinetics Chirally correct retinal cyclodextrin hemiacetals for clarifying skin complexion

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120121675A1 (en) * 2009-07-24 2012-05-17 Lipotec, S.A. Compounds which inhibit muscle contraction

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nutrition Aid Center 2010 (http://web.archive.org/web/20100105054135/http://totalnutritionaid.com/nature-pure-anti-redness-botanical-serum-1-oz-serum-npl-42.html) *

Also Published As

Publication number Publication date
US20180280460A1 (en) 2018-10-04
US20150290269A1 (en) 2015-10-15
US11260094B2 (en) 2022-03-01
US9999642B2 (en) 2018-06-19

Similar Documents

Publication Publication Date Title
JP7150120B2 (en) Compositions and methods for invasive and non-invasive therapeutic skin care
US11241405B2 (en) Methods to enhance a non-surgical medical treatment
Lee et al. Mesotherapy, microneedling, and chemical peels
EP1711190B1 (en) Agent for treating inflammatory diseases
Han et al. Subdermal minimal surgery with hyaluronic acid as an effective treatment for neck wrinkles
US8802085B2 (en) Compositions for topical treatment of medical conditions including wounds and inflammation
EP2763686A1 (en) Composition for the treatment of skin lesions
US9579274B2 (en) Vitamin C composition for use in the prevention and treatment of stretch marks, radiation dermatitis, and other skin conditions and methods of using the same
WO2014190179A2 (en) Urea silicon gel for scars and hydration treatment and method of using same
US11260094B2 (en) Compositions, kits and methods for ameliorating oculoplastic post-procedural effects
US9173940B1 (en) Mixture of betamethasone and tranilast with a transdermal gel for scar treatment
EP3706714B1 (en) N-acetylcysteine and urea-based formulation for the treatment of dermatological disorders
ES2884787T3 (en) Use of rhamnose derivatives as antifungal agents
US8969411B2 (en) Vitamin C composition for use in the prevention and treatment of stretch other skin conditions and methods of using the same
AU2023203452B1 (en) Topical formulations
JP2024516316A (en) Kynurenine and its derivatives for treating atrophic scars - Patents.com
Vyas et al. Rosacea Treatment using Essential oils and Plant Extract
Sadgrove et al. Use of post-procedural hydrogel and natural ingredient masks (Maskād™) to improve clinical outcome of cryogen therapy with micro-needling: A split-face case study

Legal Events

Date Code Title Description
AS Assignment

Owner name: OCUSOFT, INC., TEXAS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ADKINS, NAT, JR.;REEL/FRAME:031450/0043

Effective date: 20131018

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION