TWI769830B - Manufacturing method of hydrophilic film structure for biochemical detection sheet and product thereof - Google Patents

Abstract

A manufacturing method of hydrophilic film structure for biochemical detection sheet includes a) providing a backing tape including an adhesive layer, a first release paper and a second release paper, the first surface of the adhesive layer being combined with the first release paper, and the second surface being combined with the second release paper; b) punching the backing tape to form a plurality of runner holes, and removing the first release paper; c) providing a hydrophilic film and attach it to the first surface; d) performing the printing to the hydrophilic film and forming the testing pattern; e) cutting the waste area outside the testing pattern and keeping the second release paper, and removing the adhesive tape and hydrophilic film in the waste area; and f) cutting the second release paper and the adhesive tape to form a hydrophilic film structure with a single testing pattern. Thereby, a fast and precise hydrophilic membrane structure is provided.

Description

Manufacturing method of hydrophilic membrane structure for biochemical detection sheet and its finished product

The present invention relates to a biochemical detection device, in particular to a manufacturing method of a hydrophilic membrane structure for a biochemical detection sheet and its finished product.

The biochemical detection device is used to obtain the physiological information of the analyte as a reference for analyzing the analyte. Most of the current biosensing test pieces are provided with a detection opening and a detection flow channel on the plastic plate, so that the object to be detected is dropped into the detection opening and flows into the detection flow channel, and then the test object is measured and relevant data is obtained.

Furthermore, the biosensing test piece is provided with a resistance part and a hydrophilic film. The hydrophilic membrane is made of hydrophilic material, which is arranged in the reaction area of the biosensor test piece and covers the resistance parts, so as to strengthen the capillary action of the inner wall of the reaction area. In addition, the hydrophilic membrane is arranged according to the structure of the resistance parts, the detection opening and the detection flow channel of the biosensing test piece. In this regard, how to provide a fast and precise hydrophilic membrane structure to cover the biosensing test piece is the creative motivation of the inventor.

In view of this, the inventor of the present invention has devoted himself to the study of the above-mentioned prior art and cooperated with the application of theories, trying his best to solve the above-mentioned problems, which is the goal of the present inventor's improvement.

One objective of the present invention is to provide a method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet, so as to provide a hydrophilic membrane structure that can be fabricated quickly and with a precise structure.

In order to achieve the above-mentioned purpose, the present invention is a manufacturing method of a hydrophilic membrane structure for a biochemical detection sheet, comprising: a) providing a backing tape, including an adhesive layer, a first release paper and a second release paper, the adhesive layer It has an opposite first surface and a second surface, the first surface is combined with a first release paper, and the second surface is combined with a second release paper; b) Punch the backing tape to form a structure corresponding to the biochemical detection sheet Plural flow channel holes, and remove the first release paper; c) provide a hydrophilic film, and attach the hydrophilic film to the first surface; d) print the hydrophilic film and form a plurality of test piece patterns, and these test piece patterns are Corresponding to the structural setting of the biochemical test piece; e) cutting for the first time, cutting the waste area outside the test piece pattern and retaining the second release paper, and removing the adhesive tape and hydrophilic film in the waste area; and f) The second cutting is performed, and the second release paper and the adhesive tape are cut to divide the pattern of the test piece on the hydrophilic film and form a hydrophilic film structure with a single pattern of the test piece.

Compared with the prior art, the manufacturing process of the hydrophilic membrane structure of the present invention is to provide a self-adhesive tape laminated with a first release paper, an adhesive layer and a second release paper, and punch holes to form a plurality of flow channel holes, and Remove the first release paper; then, attach the hydrophilic film to the adhesive layer, and print the hydrophilic film to form a test piece pattern, continue to cut the waste area and keep the second release paper, and finally apply the second release paper. The pattern paper and the adhesive tape are cut for the second time to form a hydrophilic membrane structure with a single detection pattern.

1: Hydrophilic membrane structure

2: Biochemical test piece

3: Boss

4: Detect the flow channel

5: SMT parts hole

10: Adhesive tape

100: Process electric eye mark

101: runner hole

102: Alignment hole

1021: Machine positioning hole

1022: Test piece positioning hole

11: Adhesive layer

111: First surface

112: Second Surface

12: The first release paper

13: Second release paper

20: Hydrophilic film

30: Test piece graphics

300: extension direction

301: First side

302: Second side

303: Stomata position

31: Waste Area

311: First Waste Area

312: Second Waste Area

a~f: steps

FIG. 1 is a schematic flow chart of the manufacturing method of the hydrophilic membrane structure used for the biochemical detection sheet according to the present invention.

FIG. 2 is a schematic exploded perspective view of the biochemical detection sheet of the present invention.

FIG. 3 is a top view of the biochemical detection sheet of the present invention.

4 is a cross-sectional view of the adhesive tape combined with the release paper of the present invention.

FIG. 5 is a top view of the adhesive tape of the present invention combined with the release paper.

Figure 6 is a top view of the adhesive tape of the present invention after punching.

Fig. 7 is a partial enlarged schematic view of the adhesive tape of the present invention after punching.

8 is a partial cross-sectional view of the adhesive tape of the present invention after punching.

FIG. 9 is a cross-sectional view of the adhesive tape combined with the hydrophilic film of the present invention.

Figure 10 is a top view of the pattern of the hydrophilic film printed test piece of the present invention.

Fig. 11 is a partial enlarged schematic diagram of the pattern of the hydrophilic membrane printing test piece of the present invention.

Fig. 12 is a partial cross-sectional view of the pattern of the hydrophilic film printed test piece of the present invention.

Fig. 13 is a top view of the first cutting of the hydrophilic membrane of the present invention.

Fig. 14 is a partial enlarged schematic view of the first cutting of the hydrophilic membrane of the present invention.

Fig. 15 is a partial cross-sectional view of the first cutting of the hydrophilic membrane of the present invention.

Figure 16 is a top view of the waste removal area of the hydrophilic membrane of the present invention after the first cut.

FIG. 17 is a partial enlarged schematic view of the waste removal area of the hydrophilic membrane of the present invention after the first cutting.

Figure 18 is a partial cross-sectional view of the waste removal area of the hydrophilic membrane of the present invention after the first cut.

Figure 19 is a top view of the waste removal area of the hydrophilic membrane of the present invention after the second trimming.

FIG. 20 is a partial enlarged schematic view of the waste removal area of the hydrophilic membrane of the present invention after the second cutting.

Figure 21 is a partial cross-sectional view of the waste removal area of the hydrophilic membrane of the present invention after the second cut.

The detailed description and technical content of the present invention are described below in conjunction with the drawings. However, the accompanying drawings are only for reference and description, and are not intended to limit the present invention.

Please refer to FIG. 1 to FIG. 3 , which are a schematic flow chart of a manufacturing method of a hydrophilic membrane structure for a biochemical detection sheet of the present invention, a schematic exploded perspective view of the biochemical detection sheet, and a top view of the biochemical detection sheet, respectively. As shown in FIG. 1 , the present invention provides a method for manufacturing a hydrophilic membrane structure 1 . 2 and 3, the hydrophilic membrane structure 1 is used for a biochemical detection sheet 2, and the biochemical detection sheet 2 is provided with a boss 3, a plurality of detection flow channels 4 and an SMT for setting resistance components and the like Parts hole 5, etc. The hydrophilic membrane structure 1 is arranged corresponding to the structure of the biochemical detection sheet 2 , and is used to fit on the biochemical detection sheet 2 to cover the detection flow channels 4 and expose the convex seat 3 . The manufacturing method of the hydrophilic membrane structure 1 will be described in detail later.

Please refer to FIG. 4 and FIG. 5 , which are the cross-sectional view and the top view of the adhesive tape combined with the release paper of the present invention. The manufacturing method of the hydrophilic membrane structure of the present invention includes: a) providing a self-adhesive tape 10 including an adhesive layer 11 , a first release paper 12 and a second release paper 13 . The adhesive layer 11 has a first surface 111 and a second surface 112 opposite to each other. The first surface 111 is combined with a first release paper 12 . The second surface 112 is combined with the second release paper 13 . In addition, in step a), the adhesive tape 10 is provided with a plurality of process electric eye marks 100 , and the arrangement of the process electric eye marks 100 can be used for positioning and calibration through the electric eye in the subsequent process. In this embodiment, the process electric eye markers 100 are a plurality of through holes.

Please also refer to FIG. 6 to FIG. 8 , which are the top view, partial enlarged schematic view and partial cross-sectional view of the adhesive tape of the present invention after punching. As shown in FIG. 6 , the manufacturing method of the hydrophilic membrane structure 1 of the present invention includes: b) punching the adhesive tape 10 to form a plurality of flow channel holes 101 corresponding to the structure of the biochemical detection sheet 2 , and then removing them The first release paper 12 .

It should be noted that, in step b), the adhesive tape 10 is further formed with a plurality of alignment holes 102 . The alignment holes 102 and the flow channel holes 101 are formed through a punching process. More specifically, the alignment holes 102 include machine positioning holes 1021 for machine positioning and test strip positioning holes 1022 for positioning the biochemical detection strip 3 .

Please refer to FIG. 9 again, which is a cross-sectional view of the adhesive tape combined with the hydrophilic film of the present invention. The manufacturing method of the hydrophilic film structure 1 of the present invention further includes: c) providing a hydrophilic film 20 and attaching the hydrophilic film 20 to the first part of the adhesive layer 11 from which the first release paper 12 (refer to FIG. 8 ) has been removed Surface 111.

It should be noted that, in the manufacturing method of the hydrophilic membrane structure 1 of the present invention, the raw materials of the adhesive tape 10 and the hydrophilic membrane 20 are all arranged in rolls, and are carried out in the form of tapes during the manufacturing process.

Please continue to refer to FIGS. 10 to 12 , which are the top view, partial enlarged schematic diagram and partial cross-sectional view of the pattern of the hydrophilic film printing test piece of the present invention. The manufacturing method of the hydrophilic membrane structure 1 of the present invention includes: d) printing the hydrophilic membrane 20 and forming a plurality of test strip patterns 30 , and the test strip patterns 30 are arranged corresponding to the structure of the biochemical detection strip 2 . In the present embodiment, the test piece patterns 30 are corresponding to the blue layers printed outside the flow channel holes 101 .

It should be noted that, in this embodiment, the adhesive tape 10 has an extending direction 300 . In addition, the test strip patterns 30 have a first side 301 perpendicular to the extending direction 300 and a second side 302 parallel to the extending direction 300 . Also, in step d), the test piece patterns 30 include a plurality of air hole positions 303 .

Please refer to FIG. 13 to FIG. 15 , which are the top view, the partial enlarged schematic view and the partial cross-sectional view of the hydrophilic membrane of the present invention which is cut for the first time. The manufacturing method of the hydrophilic membrane structure 1 of the present invention includes: e) first cutting, cutting a waste area 31 outside the test strip patterns 30 and retaining the second cutting The release paper 13 is removed, and the adhesive tape 10 and the hydrophilic film 20 in the waste area 31 are removed. In addition, in step e), the first sides 301 of the test piece patterns 30 are cut.

In this embodiment, the test piece patterns 30 are arranged at intervals and a plurality of first waste regions 311 are formed; and a plurality of second waste regions 312 are formed between the test piece patterns 30 and the marks 100 . In step e), the waste area 31 includes the first waste areas 311 and the second waste areas 312 .

Please refer to FIG. 16 to FIG. 18 at the same time, which are the top view, the partial enlarged schematic view and the partial cross-sectional view of the waste removal area of the hydrophilic membrane of the present invention after the first cutting. Further, in step e), only the adhesive layer 11 and the hydrophilic film 20 in the waste area 31 are cut, and the second release paper 13 is retained to make the test pieces on the hydrophilic film 20 Graphics 30 remain continuous without separation.

Please refer to FIG. 19 to FIG. 21 , which are the top view, partial enlarged schematic view and partial cross-sectional view of the waste removal area of the hydrophilic membrane of the present invention after the second cutting. The manufacturing method of the hydrophilic membrane structure 1 of the present invention further includes: f) performing a second cutting, cutting the second release paper 13 and the adhesive tape 10 to separate the test strip patterns 30 on the hydrophilic membrane 20 , and a hydrophilic membrane structure 1 having a single test piece pattern 30 is formed.

It should be noted that, in step f), the second sides 302 of the test strip patterns 30 are cut according to the shape of the biochemical detection strips 2 . In addition, step f) further includes the steps of corresponding to the alignment holes 102 on the hydrophilic membrane 20 (including the machine positioning holes 1021 for machine positioning and the test strip positioning holes 1022 for positioning the biochemical detection strip 3 ). Punch holes at the location. In addition, step f) also includes punching these air hole positions 303 on the hydrophilic membrane 20 .

Accordingly, the present invention completes the hydrophilic membrane structure 1 according to the aforementioned manufacturing method. The hydrophilic membrane structure 1 is used for the biochemical detection sheet 2 (refer to FIG. 2 ), and includes an adhesive layer 11 , a hydrophilic membrane 20 and a release paper (second release paper 13 ). The adhesive layer 11 has a first surface 111 and a second surface 112 opposite to each other.

In addition, the hydrophilic film 20 is attached to the first surface 111 , and the hydrophilic film 20 is printed with a test strip pattern 30 corresponding to the structure of the biochemical detection strip 2 .

Furthermore, the release paper (the second release paper 13 ) is attached to the second surface 112 . The release paper and the adhesive layer 11 constitute a back adhesive tape 10 . The adhesive tape 10 forms a plurality of flow channel holes 101 corresponding to the structure of the biochemical detection sheet 2 .

In addition, it should be noted that after the fabrication of the hydrophilic membrane structure 1 of the present invention is completed, a monitoring camera (CCD) is used for visual inspection to confirm that the fabricated product meets the specifications. After confirming that the product is correct, the second release paper 13 of the hydrophilic film structure 1 is then torn off to expose the adhesive layer 11 and the hydrophilic film 20 (printed with a single test piece pattern 30) attached to the adhesive layer 11. ). Thereby, the hydrophilic membrane 20 can be adhered on the biochemical detection sheet 2 by the adhesive layer 11 .

The above descriptions are only preferred embodiments of the present invention and are not intended to define the patent scope of the present invention. Other equivalent changes using the patent spirit of the present invention shall all belong to the patent scope of the present invention.

a~f: steps

Claims (9)

A method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet, comprising: a) providing a backing tape, comprising an adhesive layer, a first release paper and a second release paper, the adhesive layer having a relative first release paper a surface and a second surface, the first surface is combined with the first release paper, and the second surface is combined with the second release paper; b) punching the adhesive tape to correspond to the biochemical detection The structure of the sheet forms a plurality of flow channel holes, and removes the first release paper; c) provides a hydrophilic film, and attaches the hydrophilic film to the first surface; d) prints the hydrophilic film and forms a plurality of tests Sheet graphics, these test sheet graphics are corresponding to the structural settings of the biochemical detection sheet; e) cutting for the first time, cutting a waste area outside these test sheet graphics and retaining the second release paper, And remove the adhesive tape and the hydrophilic film in the waste area; and f) carry out a second cut, cut the second release paper and the adhesive tape to separate each of the test pieces on the hydrophilic film A sheet pattern is formed, and a hydrophilic membrane structure with a single test sheet pattern is formed. The method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet according to claim 1, wherein in step a), the adhesive tape is provided with a plurality of process electric eye marks, and the process electric eye marks are used for d) print job in steps. The method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet according to claim 1, wherein in step b), the adhesive tape is further formed with a plurality of alignment holes, and the alignment holes are connected with the flow holes. The hole is formed by punching. The method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet according to claim 3, wherein in step b) the alignment holes comprise machine positioning holes for machine positioning and a machine positioning hole for the biochemical detection sheet Locating the test piece positioning holes. The method for manufacturing a hydrophilic membrane structure for a biochemical test strip as claimed in claim 1, wherein the adhesive tape has an extending direction, and the test strip patterns have a first side edge perpendicular to the extending direction and parallel to the extending direction. A second side edge in the extending direction is cut off the first side edge in the step e), and the second side edge is cut in the step f). The method for manufacturing a hydrophilic membrane structure for a biochemical test strip as claimed in claim 2, wherein the test strip patterns are arranged at intervals and a plurality of first waste areas are formed, and a plurality of first waste regions are formed between the test strip patterns and the marks. There are a plurality of second waste areas, and in step e), the waste areas include the first waste areas and the second waste areas. The method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet according to claim 3, wherein in step f), the hydrophilic membrane is cut to correspond to the positions of the alignment holes. The method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet according to claim 1, wherein the adhesive tape and the hydrophilic membrane are arranged in a roll shape. A hydrophilic membrane structure for a biochemical detection sheet, comprising: an adhesive layer having an opposite first surface and a second surface; a hydrophilic membrane attached to the first surface, the hydrophilic membrane corresponding to the biochemical The structure of the test piece is printed with a test piece pattern; and a release paper, which is attached to the second surface, the release paper and the adhesive layer form a back adhesive tape, and the back adhesive tape corresponds to the biochemical test piece. The structure forms a plurality of flow channel holes.

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