TW200621257A - Pyrimidine derivative fused with nonaromatic ring - Google Patents

Pyrimidine derivative fused with nonaromatic ring

Info

Publication number: TW200621257A
Authority: TW; Taiwan
Prior art keywords: insulin; pyrimidine derivative; action; nonaromatic ring; diabetes
Prior art date: 2004-10-20

Application number

TW094135952A

Other languages

English (en)

Inventor

Yasuhiro Yonetoku

Kenji Negoro

Kenichi Onda

Masahiko Hayakawa

Daisuke Sasuga

Hiroyuki Moritomo

Shigeru Yoshida

Original Assignee

Astellas Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-20

Filing date

2005-10-14

Publication date

2006-07-01

2005-10-14 Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc

2006-07-01 Publication of TW200621257A publication Critical patent/TW200621257A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

TW094135952A 2004-10-20 2005-10-14 Pyrimidine derivative fused with nonaromatic ring TW200621257A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2004305374		2004-10-20

Publications (1)

Publication Number	Publication Date
TW200621257A true TW200621257A (en)	2006-07-01

Family

ID=36202906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW094135952A TW200621257A (en)	2004-10-20	2005-10-14	Pyrimidine derivative fused with nonaromatic ring

Country Status (15)

Country	Link
US (1)	US7947690B2 (zh)
EP (1)	EP1803710A4 (zh)
JP (1)	JP4775767B2 (zh)
KR (1)	KR20070084035A (zh)
CN (1)	CN101044123B (zh)
AU (1)	AU2005297743A1 (zh)
BR (1)	BRPI0516237A (zh)
CA (1)	CA2584666C (zh)
IL (1)	IL182641A0 (zh)
MX (1)	MX2007004769A (zh)
NO (1)	NO20072542L (zh)
RU (1)	RU2007118653A (zh)
TW (1)	TW200621257A (zh)
WO (1)	WO2006043490A1 (zh)
ZA (1)	ZA200703947B (zh)

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US9409886B2 (en)	2007-07-05	2016-08-09	Array Biopharma Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
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BRPI0907372A2 (pt)	2008-01-09	2015-07-14	Array Biopharma Inc	Pirimidil ciclopentano hidroxilado como inibidor de proteína quinase akt
EP2108960A1 (en)	2008-04-07	2009-10-14	Arena Pharmaceuticals, Inc.	Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
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CN102480961A (zh) *	2009-06-24	2012-05-30	健泰科生物技术公司	与含氧杂环稠合的嘧啶化合物、组合物和使用方法
US20110021515A1 (en) *	2009-07-24	2011-01-27	Takeda Pharmaceutical Company Limited	Dihyrofuropyrmindine compounds
CN102020657A (zh) *	2009-09-11	2011-04-20	上海艾力斯医药科技有限公司	稠合杂芳基衍生物、制备方法及其应用
MX2012005225A (es) *	2009-11-12	2012-07-25	Hoffmann La Roche	Compuestos y composiciones de purina n-7 sustituida y pirazolopirimidina, y metodos de uso.
ES2596654T3 (es) *	2009-11-12	2017-01-11	F. Hoffmann-La Roche Ag	Compuestos de purina N-9-sustituida, composiciones y métodos de uso
WO2012026529A1 (ja) *	2010-08-26	2012-03-01	興和株式会社	イソキノリン誘導体又はその塩の新規製造方法
EP3323818A1 (en)	2010-09-22	2018-05-23	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012099581A1 (en)	2011-01-19	2012-07-26	Takeda Pharmaceutical Company Limited	Dihydrofuropyrimidine compounds
WO2012135781A1 (en)	2011-04-01	2012-10-04	Genentech, Inc.	Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use
AU2012236164A1 (en)	2011-04-01	2013-11-21	Genentech, Inc.	Combinations of AKT and MEK inhibitor compounds, and methods of use
CN102875567B (zh) *	2011-07-15	2015-03-11	天津药物研究院	一类含哌嗪化合物、制备及用途
WO2014124860A1 (en) *	2013-02-14	2014-08-21	Boehringer Ingelheim International Gmbh	Specific pde4b-inhibitors for the treatment of diabetes mellitus
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PL3310760T3 (pl)	2015-06-22	2023-03-06	Arena Pharmaceuticals, Inc.	Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
US11534424B2 (en)	2017-02-16	2022-12-27	Arena Pharmaceuticals, Inc.	Compounds and methods for treatment of primary biliary cholangitis
JP7182568B2 (ja)	2017-05-22	2022-12-02	トパドゥールファーマアーゲー	新規二重作用モード可溶性グアニル酸シクラーゼ活性化因子およびホスホジエステラーゼ阻害剤ならびにその使用

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2005
- 2005-10-14 TW TW094135952A patent/TW200621257A/zh unknown
- 2005-10-17 BR BRPI0516237-8A patent/BRPI0516237A/pt not_active IP Right Cessation
- 2005-10-17 WO PCT/JP2005/019000 patent/WO2006043490A1/ja active Application Filing
- 2005-10-17 CA CA2584666A patent/CA2584666C/en not_active Expired - Fee Related
- 2005-10-17 AU AU2005297743A patent/AU2005297743A1/en not_active Abandoned
- 2005-10-17 ZA ZA200703947A patent/ZA200703947B/xx unknown
- 2005-10-17 RU RU2007118653/04A patent/RU2007118653A/ru not_active Application Discontinuation
- 2005-10-17 MX MX2007004769A patent/MX2007004769A/es not_active Application Discontinuation
- 2005-10-17 US US11/577,648 patent/US7947690B2/en not_active Expired - Fee Related
- 2005-10-17 EP EP05793361A patent/EP1803710A4/en not_active Withdrawn
- 2005-10-17 JP JP2006542955A patent/JP4775767B2/ja not_active Expired - Fee Related
- 2005-10-17 CN CN2005800357323A patent/CN101044123B/zh not_active Expired - Fee Related
- 2005-10-17 KR KR1020077010353A patent/KR20070084035A/ko not_active Application Discontinuation
2007
- 2007-04-18 IL IL182641A patent/IL182641A0/en unknown
- 2007-05-18 NO NO20072542A patent/NO20072542L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2584666C (en)	2011-12-06
MX2007004769A (es)	2007-06-25
US7947690B2 (en)	2011-05-24
EP1803710A4 (en)	2009-08-26
CA2584666A1 (en)	2006-04-27
RU2007118653A (ru)	2008-11-27
KR20070084035A (ko)	2007-08-24
JPWO2006043490A1 (ja)	2008-05-22
IL182641A0 (en)	2007-07-24
WO2006043490A1 (ja)	2006-04-27
BRPI0516237A (pt)	2008-08-26
EP1803710A1 (en)	2007-07-04
AU2005297743A1 (en)	2006-04-27
CN101044123A (zh)	2007-09-26
ZA200703947B (en)	2008-08-27
US20080070896A1 (en)	2008-03-20
JP4775767B2 (ja)	2011-09-21
CN101044123B (zh)	2010-09-08
NO20072542L (no)	2007-07-18

Publication	Publication Date	Title
TW200621257A (en)	2006-07-01	Pyrimidine derivative fused with nonaromatic ring
EP1806347A4 (en)	2009-07-01	PYRIMIDINE DERIVATIVES FUSED WITH AN AROMATIC RING
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EP1400529A4 (en)	2007-12-19	GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL AND INTERMEDIARY USE THEREOF
EP1803721A4 (en)	2009-05-20	INNOVATIVE GLUCITOL DERIVATIVE, PRECURSOR OF THE MEDICINAL PRODUCT AND SALT THEREOF, AND A THERAPEUTIC AGENT FOR DIABETES CONTAINING THE SAME
WO2007060140A3 (en)	2007-09-13	Inhibitors of diacyglycerol acyltransferase (dgat)
EP1609798A4 (en)	2009-06-17	CONDENSED HETEROCYCLIC DERIVATIVE, MEDICAL COMPOSITION, AND MEDICAL USE THEREOF
WO2003011880A1 (fr)	2003-02-13	Derive de glucopyranosyloxybenzylbenzene, composition medicinale contenant ce derive, usage medicinal de cette composition et produit intermediaire pour produire cette composition
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