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TR201804897T4 - Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler - Google Patents

Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler Download PDF

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Publication number
TR201804897T4
TR201804897T4 TR2018/04897T TR201804897T TR201804897T4 TR 201804897 T4 TR201804897 T4 TR 201804897T4 TR 2018/04897 T TR2018/04897 T TR 2018/04897T TR 201804897 T TR201804897 T TR 201804897T TR 201804897 T4 TR201804897 T4 TR 201804897T4
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region
methods
polypeptides containing
changes
function due
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TR2018/04897T
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s johnson Leslie
Jonah Anderson Rainey Godfrey
Lerner Laura
Gorlatov Sergey
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Macrogenics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43857148&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201804897(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of TR201804897T4 publication Critical patent/TR201804897T4/tr

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    • C—CHEMISTRY; METALLURGY
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

FUKOSİLASYON ÖLÇÜSÜNÜN DEĞİŞİMLERİNDEN DOLAYI GELİŞMİŞ EFEKTÖR İŞLEVİ SERGİLEYEN FC BÖLGESİNİ İÇEREN POLİPEPTİTLER VE BUNLARIN KULLANIMLARINA YÖNELİK YÖNTEMLER Mevcut buluş, fukosilasyon ölçüsünün değişimlerinden dolayı gelişmiş efektör işlevi sergileyen Fc bölgesini içeren polipeptitlerle ve kanserin ve diğer hastalıkların tedavi edilmesine veya önlenmesine yönelik bu tarz polipeptitlerin kullanımına yönelik yöntemlerle ilgilidir. Fc bölgesini içeren polipeptitler tercihen immünoglobulinlerdir (örn. antikorlar), burada Fc bölgesi, bir sokak türü Fc bölgesinin ilgili amino asit sekansına göre en az bir aminoyu ve ikameyi içermektedir ve dönüşüm sonrası fukosilasyonu hafifletmek ve bir aktif hale getirici Fc reseptörüne gelişmiş bağlantıyı ve bir inhibitör Fc reseptörüne azaltılmış bağlantıyı yönlendirmek için yeterlidir. Buluşun yöntemleri, Fc&#947#&R ile yönlendirilen efektör hücre işlevinin gelişmiş bir verimliliğinin arzu edildiği (örn. kanser, bulaşıcı hastalık) veya Fc&#947#&R ile yönlendirilen bir inhibe edilmiş efektör hücresi yanıtının arzu edildiği (örn. inflamasyon, otoimmün hastalık) bir hastalıkla, rahatsızlıkla veya enfeksiyonla ilişkili bir veya birden fazla semptomun önlenmesinde, tedavi edilmesinde veya hafifletilmesinde özellikle kullanışlıdır.
TR2018/04897T 2009-10-07 2010-10-07 Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler TR201804897T4 (tr)

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US24951009P 2009-10-07 2009-10-07

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ID=43857148

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TR2018/04897T TR201804897T4 (tr) 2009-10-07 2010-10-07 Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler

Country Status (22)

Country Link
US (1) US9096877B2 (tr)
EP (1) EP2486141B1 (tr)
JP (1) JP5898082B2 (tr)
KR (1) KR101808602B1 (tr)
CN (1) CN102666874B (tr)
AU (1) AU2010303415B2 (tr)
BR (1) BR112012007760A2 (tr)
CA (1) CA2776385C (tr)
DK (1) DK2486141T3 (tr)
ES (1) ES2672121T3 (tr)
HR (1) HRP20180574T1 (tr)
HU (1) HUE036549T2 (tr)
IL (1) IL219059B (tr)
LT (1) LT2486141T (tr)
MX (1) MX2012004029A (tr)
NO (1) NO2486141T3 (tr)
PL (1) PL2486141T3 (tr)
PT (1) PT2486141T (tr)
RU (1) RU2583298C2 (tr)
SI (1) SI2486141T1 (tr)
TR (1) TR201804897T4 (tr)
WO (1) WO2011044368A1 (tr)

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IL219059B (en) 2018-06-28
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