TNSN91049A1 - SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE - Google Patents
SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USEInfo
- Publication number
- TNSN91049A1 TNSN91049A1 TNTNSN91049A TNSN91049A TNSN91049A1 TN SN91049 A1 TNSN91049 A1 TN SN91049A1 TN TNSN91049 A TNTNSN91049 A TN TNSN91049A TN SN91049 A TNSN91049 A TN SN91049A TN SN91049 A1 TNSN91049 A1 TN SN91049A1
- Authority
- TN
- Tunisia
- Prior art keywords
- carbon atoms
- processes
- preparation
- pharmaceutical use
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
LES COMPOSES NOUVEAU AYANT LA FORMULE I OU R1 ET R2, QUI SONT DIFFERENTS, SONT CHACUN H, ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE OU - C(O)-R6 ; PARMI R1 ET R2 L'UN EST TOUJOURS SELECTIONNE A PARTIR DU GROUPE -C (O)-R6 ; DANS LEQUEL R6 EST ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE OU ALKOXY CONTENANT 1 A 4 ATOMES DE CARBONE, R3 EST LE GROUPE - CH2OCOOR7, OU R7 EST ALKYLE CONTENANT 1 A 6 ATOMES DE CARBONE OU BENZYLE ; R4 ET R5 SONT LES MEMES OU DIFFERENTS ET PEUVENT ETRE OCH3. FORMENT ENSEMBLE AVEC LES ATOMES D'OXYGENE ADJACENTS FIXES AU NOYAU PYRIDINE ET AVEC LES ATOMES DE CARBONE DU NOYAU PYRIDINE UN NOYAU, DANS LEQUEL LA PARTIE CONSTITUEE PAR R4 ET R5 EST -CH2CH2-CH2, -CH2CH2- OU - CH2-, AINSI QUE DES COMPOSITIONS PHARMACEUTIQUES CONTENANT LES DITS COMPOSES COMME INGREDIENTS ACTIFS, ET L'EMPLOI DE CES COMPOSES EN MEDECINETHE NEW COMPOUNDS WITH THE FORMULA I OR R1 AND R2, WHICH ARE DIFFERENT, ARE EACH H, ALKYL CONTAINING 1 TO 4 CARBON ATOMS OR - C (O) -R6; AMONG R1 AND R2 ONE IS ALWAYS SELECTED FROM THE GROUP -C (O) -R6; IN WHICH R6 IS ALKYL CONTAINING 1 TO 4 CARBON ATOMS OR ALKOXY CONTAINING 1 TO 4 CARBON ATOMS, R3 IS THE GROUP - CH2OCOOR7, OR R7 IS ALKYL CONTAINING 1 TO 6 CARBON OR BENZYL ATOMS; R4 AND R5 ARE THE SAME OR DIFFERENT AND MAY BE OCH3. FORMED TOGETHER WITH THE ATOMS OF OXYGEN ADJACENT FIXED TO THE PYRIDINE CORE AND WITH THE CARBON ATOMS OF THE PYRIDINE CORE A CORE, IN WHICH THE PART CONSISTING OF R4 AND R5 IS -CH2CH2-CH2, -CH2CH2- OR - CH2-, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS AS ACTIVE INGREDIENTS, AND THE USE OF SUCH COMPOUNDS IN MEDICINE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9002206A SE9002206D0 (en) | 1990-06-20 | 1990-06-20 | NEW COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN91049A1 true TNSN91049A1 (en) | 1992-10-25 |
Family
ID=20379831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN91049A TNSN91049A1 (en) | 1990-06-20 | 1991-06-19 | SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0535081A1 (en) |
| JP (1) | JPH05507713A (en) |
| CN (1) | CN1058212A (en) |
| AP (1) | AP215A (en) |
| AU (1) | AU649453B2 (en) |
| BG (1) | BG97200A (en) |
| CA (1) | CA2083714A1 (en) |
| CZ (1) | CZ279772B6 (en) |
| FI (1) | FI925766A (en) |
| HU (1) | HUT62881A (en) |
| IE (1) | IE912025A1 (en) |
| IL (1) | IL98470A0 (en) |
| IS (1) | IS3721A7 (en) |
| LT (2) | LT3977B (en) |
| LV (1) | LV10953A (en) |
| MA (1) | MA22199A1 (en) |
| NO (1) | NO924775D0 (en) |
| NZ (1) | NZ238546A (en) |
| OA (1) | OA09682A (en) |
| PT (1) | PT98035A (en) |
| RO (1) | RO110493B1 (en) |
| SE (1) | SE9002206D0 (en) |
| TN (1) | TNSN91049A1 (en) |
| TW (1) | TW216418B (en) |
| WO (1) | WO1991019711A1 (en) |
| YU (1) | YU104191A (en) |
| ZA (2) | ZA914296B (en) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9002043D0 (en) * | 1990-06-07 | 1990-06-07 | Astra Ab | IMPROVED METHOD FOR SYNTHESIS |
| SE9103776D0 (en) * | 1991-12-19 | 1991-12-19 | Astra Ab | NEW COMPOUNDS |
| IS4232A (en) * | 1993-12-06 | 1995-06-07 | Astra Aktiebolag | Substituted benzimidazole, its methods of manufacture and pharmacological use |
| SE9500422D0 (en) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| SE9500478D0 (en) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
| SE9600070D0 (en) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| MXPA02008232A (en) | 2000-02-24 | 2004-04-05 | Kopran Res Lab Ltd | Orally administrable acid stable anti ulcer benzimidazole derivatives. |
| SE0101379D0 (en) | 2001-04-18 | 2001-04-18 | Diabact Ab | Composition that inhibits gastric acid secretion |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| IL164222A0 (en) | 2002-04-09 | 2005-12-18 | Flamel Tech Sa | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
| SE0203065D0 (en) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
| AU2004314693B2 (en) | 2003-09-26 | 2011-04-07 | Alza Corporation | Drug coating providing high drug loading and methods for providing the same |
| TW200606163A (en) | 2004-04-22 | 2006-02-16 | Eisai Co Ltd | Imidazopyridine compound |
| US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| US20070015782A1 (en) * | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
| US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
| US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| WO2007122686A1 (en) * | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | Benzimidazole compounds |
| AU2007278986B2 (en) | 2006-07-25 | 2010-09-16 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI |
| JP5492417B2 (en) * | 2006-10-13 | 2014-05-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Benzimidazole compound having gastric acid secretion inhibitory action |
| EA201100313A1 (en) | 2008-09-09 | 2011-10-31 | Астразенека Аб | METHOD OF DELIVERY OF THE PHARMACEUTICAL COMPOSITION TO THE PATIENT NEEDING THIS |
| SG176724A1 (en) | 2009-06-25 | 2012-01-30 | Astrazeneca Ab | Method for treating a patient at risk for developing an nsaid-associated ulcer |
| WO2011080501A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
| WO2011080500A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
| WO2011080502A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
| EP2601947A1 (en) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Fixed-dose combination for treatment of helicobacter pylori associated diseases |
| WO2013101897A2 (en) | 2011-12-28 | 2013-07-04 | Pozen Inc. | Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
| CN110234635B (en) * | 2016-09-14 | 2023-03-10 | 宇凤·简·曾 | Novel substituted benzimidazole derivatives as D-amino oxidase (DAAO) inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE418966B (en) | 1974-02-18 | 1981-07-06 | Haessle Ab | ANALOGY PROCEDURE FOR THE PREPARATION OF COMPOUNDS WITH Gastric Acid Secretion Inhibitory Effects |
| SE416649B (en) | 1974-05-16 | 1981-01-26 | Haessle Ab | PROCEDURE FOR THE PREPARATION OF SUBSTANCES WHICH PREVENT Gastric acid secretion |
| IN148930B (en) | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
| SE7804231L (en) | 1978-04-14 | 1979-10-15 | Haessle Ab | Gastric acid secretion |
| US4359465A (en) | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| CH644116A5 (en) | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | IMIDAZOLE DERIVATIVES. |
| SE8300736D0 (en) | 1983-02-11 | 1983-02-11 | Haessle Ab | NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS |
| SE8301182D0 (en) | 1983-03-04 | 1983-03-04 | Haessle Ab | NOVEL COMPOUNDS |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| US4738975A (en) | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
| SE8505112D0 (en) * | 1985-10-29 | 1985-10-29 | Haessle Ab | NOVEL PHARMACOLOGICAL COMPOUNDS |
| NZ234564A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| DE3722810A1 (en) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | SUBSTITUTED BENZIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF, THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THE USE THEREOF |
| JPH02501930A (en) * | 1987-10-30 | 1990-06-28 | アクチエボラゲツト・ヘツスレ | Novel uses for pharmaceutical compounds |
| ZA889194B (en) * | 1987-12-11 | 1989-08-30 | Byk Gulden Lomberg Chemisch Fa | Novel benzimidazole derivatives |
| AU3690289A (en) * | 1988-05-25 | 1989-12-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New fluoralkoxy compounds |
-
1990
- 1990-06-20 SE SE9002206A patent/SE9002206D0/en unknown
-
1991
- 1991-06-05 ZA ZA914296A patent/ZA914296B/en unknown
- 1991-06-05 ZA ZA914297A patent/ZA914297B/en unknown
- 1991-06-11 RO RO92-01581A patent/RO110493B1/en unknown
- 1991-06-11 AU AU80097/91A patent/AU649453B2/en not_active Ceased
- 1991-06-11 EP EP91911659A patent/EP0535081A1/en not_active Withdrawn
- 1991-06-11 JP JP91511435A patent/JPH05507713A/en active Pending
- 1991-06-11 HU HU924033A patent/HUT62881A/en unknown
- 1991-06-11 WO PCT/SE1991/000415 patent/WO1991019711A1/en not_active Application Discontinuation
- 1991-06-11 CA CA002083714A patent/CA2083714A1/en not_active Abandoned
- 1991-06-12 TW TW080104582A patent/TW216418B/zh active
- 1991-06-12 IL IL98470A patent/IL98470A0/en unknown
- 1991-06-12 YU YU104191A patent/YU104191A/en unknown
- 1991-06-14 NZ NZ238546A patent/NZ238546A/en unknown
- 1991-06-14 IE IE202591A patent/IE912025A1/en unknown
- 1991-06-18 MA MA22462A patent/MA22199A1/en unknown
- 1991-06-19 PT PT98035A patent/PT98035A/en not_active Application Discontinuation
- 1991-06-19 TN TNTNSN91049A patent/TNSN91049A1/en unknown
- 1991-06-19 AP APAP/P/1991/000285A patent/AP215A/en active
- 1991-06-20 IS IS3721A patent/IS3721A7/en unknown
- 1991-06-20 CN CN91105024A patent/CN1058212A/en active Pending
- 1991-06-20 CZ CS911894A patent/CZ279772B6/en unknown
-
1992
- 1992-11-27 OA OA60306A patent/OA09682A/en unknown
- 1992-12-10 NO NO924775A patent/NO924775D0/en unknown
- 1992-12-18 BG BG097200A patent/BG97200A/en unknown
- 1992-12-18 FI FI925766A patent/FI925766A/en not_active Application Discontinuation
-
1993
- 1993-08-27 LV LV931045A patent/LV10953A/en unknown
- 1993-12-30 LT LTIP1713A patent/LT3977B/en not_active IP Right Cessation
- 1993-12-30 LT LTIP1712A patent/LT3952B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA914297B (en) | 1992-03-25 |
| PT98035A (en) | 1992-03-31 |
| IE912025A1 (en) | 1992-01-01 |
| IS3721A7 (en) | 1991-12-21 |
| OA09682A (en) | 1993-05-15 |
| CS189491A3 (en) | 1992-04-15 |
| SE9002206D0 (en) | 1990-06-20 |
| HUT62881A (en) | 1993-06-28 |
| AU649453B2 (en) | 1994-05-26 |
| ZA914296B (en) | 1992-03-25 |
| CA2083714A1 (en) | 1991-12-21 |
| YU104191A (en) | 1994-01-20 |
| EP0535081A1 (en) | 1993-04-07 |
| LT3977B (en) | 1996-06-25 |
| LTIP1712A (en) | 1995-08-25 |
| JPH05507713A (en) | 1993-11-04 |
| BG97200A (en) | 1993-12-24 |
| AP9100285A0 (en) | 1991-07-31 |
| WO1991019711A1 (en) | 1991-12-26 |
| AP215A (en) | 1992-09-02 |
| TW216418B (en) | 1993-11-21 |
| NO924775L (en) | 1992-12-10 |
| NZ238546A (en) | 1994-03-25 |
| LV10953A (en) | 1995-12-20 |
| AU8009791A (en) | 1992-01-07 |
| NO924775D0 (en) | 1992-12-10 |
| MA22199A1 (en) | 1992-04-01 |
| LTIP1713A (en) | 1995-08-25 |
| FI925766A0 (en) | 1992-12-18 |
| CN1058212A (en) | 1992-01-29 |
| IL98470A0 (en) | 1992-07-15 |
| HU9204033D0 (en) | 1993-03-29 |
| RO110493B1 (en) | 1996-01-30 |
| CZ279772B6 (en) | 1995-06-14 |
| FI925766A (en) | 1992-12-18 |
| LT3952B (en) | 1996-05-27 |
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