Nothing Special   »   [go: up one dir, main page]

SI3393468T1 - Postopki za zdravljenje bolezni imunske pomanjkljivosti - Google Patents

Postopki za zdravljenje bolezni imunske pomanjkljivosti

Info

Publication number
SI3393468T1
SI3393468T1 SI201631645T SI201631645T SI3393468T1 SI 3393468 T1 SI3393468 T1 SI 3393468T1 SI 201631645 T SI201631645 T SI 201631645T SI 201631645 T SI201631645 T SI 201631645T SI 3393468 T1 SI3393468 T1 SI 3393468T1
Authority
SI
Slovenia
Prior art keywords
methods
immunodeficiency disease
treating immunodeficiency
treating
disease
Prior art date
Application number
SI201631645T
Other languages
English (en)
Inventor
Robert D Arbeit
Paula Marie Ragan
Original Assignee
X4 Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by X4 Pharmaceuticals, Inc. filed Critical X4 Pharmaceuticals, Inc.
Publication of SI3393468T1 publication Critical patent/SI3393468T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/12Keratolytics, e.g. wart or anti-corn preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201631645T 2015-12-22 2016-12-22 Postopki za zdravljenje bolezni imunske pomanjkljivosti SI3393468T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562271087P 2015-12-22 2015-12-22
US201662428964P 2016-12-01 2016-12-01
PCT/US2016/068394 WO2017112894A1 (en) 2015-12-22 2016-12-22 Methods for treating immunodeficiency disease
EP16880113.2A EP3393468B1 (en) 2015-12-22 2016-12-22 Methods for treating immunodeficiency disease

Publications (1)

Publication Number Publication Date
SI3393468T1 true SI3393468T1 (sl) 2023-01-31

Family

ID=59091243

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201631645T SI3393468T1 (sl) 2015-12-22 2016-12-22 Postopki za zdravljenje bolezni imunske pomanjkljivosti

Country Status (12)

Country Link
US (3) US10610527B2 (sl)
EP (1) EP3393468B1 (sl)
JP (2) JP7055380B2 (sl)
CN (1) CN108883091A (sl)
CA (1) CA3009176A1 (sl)
DK (1) DK3393468T3 (sl)
ES (1) ES2935834T3 (sl)
HU (1) HUE060517T2 (sl)
PL (1) PL3393468T3 (sl)
PT (1) PT3393468T (sl)
SI (1) SI3393468T1 (sl)
WO (1) WO2017112894A1 (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6958820B2 (ja) 2015-12-14 2021-11-02 エックス4 ファーマシューティカルズ, インコーポレイテッド がんを処置する方法
JP6864296B2 (ja) 2015-12-14 2021-04-28 エックス4 ファーマシューティカルズ, インコーポレイテッド がんを処置する方法
US10610527B2 (en) 2015-12-22 2020-04-07 X4 Pharmaceuticals, Inc. Methods for treating immunodeficiency disease
CN109153722A (zh) 2016-04-08 2019-01-04 X4 制药有限公司 用于治疗癌症的方法
EP3471727B1 (en) 2016-06-21 2020-12-09 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
WO2017223229A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
WO2017223243A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
RU2758473C2 (ru) * 2019-12-31 2021-10-28 Евгений Юрьевич Дашевский Способ выращивания растений методом проточной гидропоники и устройство для его осуществления
JP2023517956A (ja) * 2020-03-10 2023-04-27 エックス4 ファーマシューティカルズ, インコーポレイテッド 好中球減少症を処置する方法

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
US4933447A (en) 1987-09-24 1990-06-12 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
US6001826A (en) 1989-12-21 1999-12-14 Anormed, Inc. Chemical compounds
US5021409A (en) 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
GB9200245D0 (en) 1992-01-07 1992-02-26 British Bio Technology Compounds
US5235056A (en) 1992-04-22 1993-08-10 Ciba-Geigy Corporation Substituted 1-hydroxy-2,6-diaryl-4-piperidone ketals and polymer compositions stabilized therewith
GB9400411D0 (en) 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
GB9511357D0 (en) 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds
US6506770B1 (en) 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
AU6887996A (en) 1995-09-01 1997-04-01 Washington University School Of Medicine Method of reducing neurotoxic injury with zinc chelators
EA001207B1 (ru) 1996-03-22 2000-12-25 Дюпон Фармасьютикалз Компани Способ получения r-альфа-пропил-пиперониламина и его аналогов, промежуточные продукты, используемые в этом способе
CN1231215C (zh) 1997-06-02 2005-12-14 詹森药业有限公司 (咪唑-5-基)甲基-2-喹啉酮衍生物用作平滑肌细胞增殖抑制剂
WO1999004794A1 (en) 1997-07-25 1999-02-04 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
WO1999016747A1 (fr) 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Derives sulfonyle
GB9726229D0 (en) 1997-12-12 1998-02-11 Zeneca Ltd Resolution of chiral amines
AU748064B2 (en) 1997-12-19 2002-05-30 Takeda Chemical Industries Ltd. Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative
US6607799B1 (en) 1998-10-15 2003-08-19 3M Innovative Properties Company Surgical dressing with delivery system and method of manufacture
US6635278B1 (en) 1998-12-15 2003-10-21 Gilead Sciences, Inc. Pharmaceutical formulations
TWI230618B (en) * 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
US6365583B1 (en) 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
JP2003524620A (ja) 1999-03-24 2003-08-19 アノーメッド インコーポレイティド ケモカインレセプター結合複素環化合物
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
US6683192B2 (en) 2000-03-30 2004-01-27 Curis, Inc. Small organic molecule regulators of cell proliferation
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
EP1317445B1 (en) 2000-09-15 2009-03-11 Anormed Inc. Chemokine receptor binding heterocyclic compounds
EP1752455B1 (en) 2000-09-15 2010-11-10 Anormed Inc. Chemokine receptor binding heterocyclic compounds
CA2419219A1 (en) 2000-09-15 2002-03-21 Anormed Inc. Chemokine receptor binding heterocyclic compounds
AU2001297717B2 (en) 2000-12-11 2006-02-23 Amgen Inc. CXCR3 antagonists
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
US6794379B2 (en) 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
SI2371361T1 (sl) 2001-07-31 2019-10-30 Genzyme Corp Metode za mobilizacijo predniških/matičnih celic
US7169750B2 (en) 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
US8178123B2 (en) 2001-08-29 2012-05-15 Femina Pharma Incorporated Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
PL372705A1 (en) 2001-09-12 2005-07-25 Anormed Inc. Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
US7354932B2 (en) 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
IL161784A0 (en) 2001-12-21 2005-11-20 Anormed Inc Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US7491544B2 (en) 2002-05-20 2009-02-17 New York University Chiral piperidine and quinucledine ligands
DE60325740D1 (de) 2002-08-14 2009-02-26 Silence Therapeutics Ag Verwendung von protein-kinase-n-beta
JP4666256B2 (ja) 2002-12-10 2011-04-06 小野薬品工業株式会社 含窒素複素環化合物およびその医薬用途
US7291631B2 (en) 2003-04-11 2007-11-06 Genzyme Corporation CXCR4 chemokine receptor binding compounds
WO2004093817A2 (en) 2003-04-22 2004-11-04 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US7501518B2 (en) 2003-04-22 2009-03-10 Genzyme Corporation Methods of making 2,6-diaryl piperidine derivatives
US7498346B2 (en) 2003-12-11 2009-03-03 Genzyme Corporation Chemokine receptor binding compounds
CN1930127B (zh) 2004-03-15 2012-11-21 阿诺麦德股份有限公司 用于合成cxcr4拮抗剂的方法
WO2005100340A2 (en) 2004-04-13 2005-10-27 Icagen, Inc. Polycyclic pyridines as potassium ion channel modulators
DE102004021716A1 (de) 2004-04-30 2005-12-01 Grünenthal GmbH Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen
MX2007001514A (es) 2004-08-02 2007-03-27 Smithkline Beecham Corp Compuestos quimicos.
JP2008510006A (ja) 2004-08-16 2008-04-03 スミスクライン ビーチャム コーポレーション 化合物
JP2008511669A (ja) 2004-09-02 2008-04-17 スミスクライン ビーチャム コーポレーション 化合物
JP2008514622A (ja) 2004-09-24 2008-05-08 スミスクライン ビーチャム コーポレーション 化合物
TW200619206A (en) 2004-09-29 2006-06-16 Anormed Inc Chemokine-binding heterocyclic compound salts, and methods of use thereof
EP1853604A4 (en) 2005-03-04 2010-02-24 Smithkline Beecham Corp CHEMICAL COMPOUNDS
EP1904645B1 (en) 2005-07-08 2010-08-04 Siemens Healthcare Diagnostics GmbH Method for predicting and monitoring direct response to cancer therapy
JP2009500451A (ja) 2005-07-11 2009-01-08 スミスクライン ビーチャム コーポレーション ピラノピリジン化合物
BRPI0614256B1 (pt) 2005-08-02 2018-10-16 Ineos Europe Ltd processo para a produção de homopolímeros ou copolímeros de dienos conjugados
JP2009507795A (ja) 2005-08-31 2009-02-26 スミスクライン ビーチャム コーポレーション 化合物
EP1961744B1 (en) 2005-11-18 2013-04-17 Ono Pharmaceutical Co., Ltd. Basic group-containing compound and use thereof
AR063656A1 (es) 2005-11-30 2009-02-11 Schering Corp Composiciones que comprenden una combinacion de antagonistas de ccr5 y cxcr4
EP1984376A4 (en) 2006-01-25 2009-04-08 Smithkline Beecham Corp CHEMICAL COMPOUNDS
EP1984375A2 (en) 2006-01-25 2008-10-29 Smithkline Beecham Corporation Chemical compounds
GB0605786D0 (en) 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
BRPI0712843A2 (pt) 2006-06-12 2012-07-31 Pfizer Prod Inc antagonista de ccr5 e seus usos
TWI482772B (zh) 2006-08-21 2015-05-01 Astrazeneca Ab 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
WO2008141239A1 (en) 2007-05-10 2008-11-20 Acadia Pharmaceuticals Inc. Imidazol [1,2-a] pyridines and related compounds with activity at cannabinoid cb2 receptors
WO2009026251A1 (en) 2007-08-17 2009-02-26 The General Hospital Corporation Detecting ions and measuring ion concentrations
MX2010010619A (es) 2008-03-28 2010-12-17 Altiris Therapeutics Moduladores de quimioquina.
WO2009151910A2 (en) 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
JP2010016628A (ja) 2008-07-03 2010-01-21 Canon Inc 画像処理装置及び画像処理方法
EA201692167A1 (ru) 2008-12-09 2017-07-31 Джилид Сайэнс, Инк. Модуляторы толл-подобных рецепторов
US9119790B2 (en) 2009-09-28 2015-09-01 Zenbury International Limited Pharmaceutical composition
CA2706292A1 (en) 2010-05-28 2011-11-28 Pharmascience Inc. A stable pharmaceutical formulation comprising telmisartan and hydrochlorothiazide
US20110293521A1 (en) 2010-05-28 2011-12-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-viral compositions and methods for administration
US9155723B2 (en) 2010-06-28 2015-10-13 The General Hospital Corporation Anti-CXCR4 as a sensitizer to cancer therapeutics
GB201017345D0 (en) 2010-10-14 2010-11-24 Proximagen Ltd Receptor antagonists
US9267934B2 (en) 2010-10-26 2016-02-23 University Of South Alabama Methods and compositions for ameliorating pancreatic cancer
US8969381B2 (en) 2010-12-03 2015-03-03 Emory University Chemokine CXCR4 receptor modulators and used related thereto
EP2648754A4 (en) 2010-12-07 2016-02-24 Philadelphia Health & Educatio METHODS OF INHIBITING THE METASTASIS OF CANCER
TR201820015T4 (tr) 2010-12-09 2019-01-21 Univ Pennsylvania Kanser Tedavisi İçin Kimerik Antijen Reseptörü-Modifiye Edilmiş T Hücrelerinin Kullanılması
JP6087836B2 (ja) 2011-01-11 2017-03-01 ディメリックス バイオサイエンス プロプライアタリー リミテッド 併用療法
MX365242B (es) * 2011-05-16 2019-05-28 Genzyme Corp El uso del antagonista cxcr4: 1,1´-[1,4-fenileno-bis-(metileno)-bi s-1, 4, 8, 11-tetraazaciclotetradecano (plerixaflor) para el tratamiento del síndrome de whim.
AR087364A1 (es) 2011-07-29 2014-03-19 Pf Medicament Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP2802315A1 (en) 2012-01-12 2014-11-19 Gilead Sciences, Inc. Pharmaceutical compositions and methods for their preparation
US20150301058A1 (en) 2012-11-26 2015-10-22 Caris Science, Inc. Biomarker compositions and methods
US10064826B2 (en) 2013-03-15 2018-09-04 Navinta, Llc Direct compression and dry granulation processes for preparing carglumic acid tablets having less impurities than those produced by wet granulation process
AU2014274864B2 (en) 2013-06-05 2018-10-18 Salk Institute For Biological Studies Vitamin D receptor agonists to treat diseases involving CXCL12 activity
WO2015019284A2 (en) 2013-08-05 2015-02-12 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy
JP2016529293A (ja) * 2013-08-27 2016-09-23 ギリアド ファーマセット エルエルシー 2つの抗ウイルス化合物の組合せ製剤
CA3206628A1 (en) 2013-09-12 2015-03-19 Dana-Farber Cancer Institute, Inc. Methods for evaluating and treating waldenstrom's macroglobulinemia
WO2015069770A1 (en) 2013-11-05 2015-05-14 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer
US10280183B2 (en) 2014-03-18 2019-05-07 The Research Foundation For The State University Of New York Therapeutic agent for treating tumors
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
EP3157921A1 (en) 2014-06-23 2017-04-26 Dr. Reddy's Laboratories Ltd. Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain
HUE045108T2 (hu) 2014-07-16 2019-12-30 Transgene Sa Onkolitikus vírus immunellenõrzõpont-modulátorok expresszálására
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
CN108026173A (zh) 2015-06-12 2018-05-11 百时美施贵宝公司 通过联合阻断pd-1和cxcr4信号传导途径治疗癌症
AU2016322552B2 (en) 2015-09-14 2021-03-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
US10379661B2 (en) 2015-09-25 2019-08-13 Samsung Electronics Co., Ltd. Coordinate measuring apparatus and coordinate measuring system having the same
JP6958820B2 (ja) 2015-12-14 2021-11-02 エックス4 ファーマシューティカルズ, インコーポレイテッド がんを処置する方法
JP6864296B2 (ja) * 2015-12-14 2021-04-28 エックス4 ファーマシューティカルズ, インコーポレイテッド がんを処置する方法
US10610527B2 (en) 2015-12-22 2020-04-07 X4 Pharmaceuticals, Inc. Methods for treating immunodeficiency disease
CA3010617A1 (en) 2016-01-22 2017-07-27 X4 Pharmaceuticals, Inc. Methods for treating cancer
CN109153722A (zh) 2016-04-08 2019-01-04 X4 制药有限公司 用于治疗癌症的方法
WO2017181073A1 (en) 2016-04-14 2017-10-19 Creatv Microtech, Inc. Methods of using pd-l1 expression in treatment decisions for cancer therapy
EP3471727B1 (en) 2016-06-21 2020-12-09 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
WO2017223243A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
WO2017223229A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
CN110996952A (zh) 2017-06-21 2020-04-10 X4 制药有限公司 用于治疗癌症的方法
WO2019094392A1 (en) 2017-11-07 2019-05-16 X4 Pharmaceuticals, Inc. Cancer biomarkers and methods of use thereof
US20210009557A1 (en) 2017-12-19 2021-01-14 X4 Pharmaceuticals, Inc. Acyclic cxcr4 inhibitors and uses thereof
WO2019200223A1 (en) 2018-04-13 2019-10-17 X4 Pharmaceuticals, Inc. Cancer serum biomarkers and methods of use thereof
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use

Also Published As

Publication number Publication date
CA3009176A1 (en) 2017-06-29
US10610527B2 (en) 2020-04-07
JP2021181501A (ja) 2021-11-25
CN108883091A (zh) 2018-11-23
ES2935834T3 (es) 2023-03-10
US11219621B2 (en) 2022-01-11
JP7454255B2 (ja) 2024-03-22
JP2018538337A (ja) 2018-12-27
WO2017112894A1 (en) 2017-06-29
PT3393468T (pt) 2023-01-19
US20200268739A1 (en) 2020-08-27
US20190083485A1 (en) 2019-03-21
EP3393468A1 (en) 2018-10-31
PL3393468T3 (pl) 2023-01-23
US20220257586A1 (en) 2022-08-18
JP7055380B2 (ja) 2022-04-18
EP3393468A4 (en) 2019-07-31
HUE060517T2 (hu) 2023-03-28
DK3393468T3 (da) 2022-12-19
EP3393468B1 (en) 2022-09-14

Similar Documents

Publication Publication Date Title
LT3386511T (lt) Hantingtono ligos gydymo būdai
GB201500989D0 (en) Process
PL3393468T3 (pl) Metody leczenia niedoboru odporności
HK1244217A1 (zh) 用於治療蛋白質病的方法
IL278247B (en) mct4 inhibitors to treat the disease
GB201502894D0 (en) Process
GB201502893D0 (en) Process
HK1253238A1 (zh) 用於治療疾病的gls1抑制劑
HK1248133A1 (zh) 治療神經母細胞瘤的方法
GB201505311D0 (en) Process
GB201401430D0 (en) Treatment process
GB201506572D0 (en) Process
GB201501952D0 (en) Process
PT3164394T (pt) Inibidores gls1 para o tratamento de doenças
GB201507170D0 (en) Process
GB201501953D0 (en) Process
GB201503635D0 (en) Process
GB201500990D0 (en) Process
GB201504948D0 (en) Process
GB201502814D0 (en) Process
GB201501423D0 (en) Process
GB201520379D0 (en) Process
GB201617424D0 (en) Process
GB201603253D0 (en) Process
GB201506536D0 (en) Process