SI1847539T1 - Kinazolinski derivati - Google Patents

Kinazolinski derivati

Info

Publication number: SI1847539T1
Authority: SI; Slovenia
Prior art keywords: quinazoline derivatives; quinazoline; derivatives
Prior art date: 2002-12-24

Application number

SI200331673T

Other languages

English (en)

Inventor

Nicola Murdoch Heron

Andrew Austen Mortlock

Frederic Henri Jung

Georges Rene Pasquet

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-24

Filing date

2003-12-22

Publication date

2010-01-29

2003-12-22 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2010-01-29 Publication of SI1847539T1 publication Critical patent/SI1847539T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SI200331673T 2002-12-24 2003-12-22 Kinazolinski derivati SI1847539T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP02293238		2002-12-24
EP03291315		2003-06-02
EP07009390A EP1847539B1 (en)	2002-12-24	2003-12-22	Quinazoline derivatives

Publications (1)

Publication Number	Publication Date
SI1847539T1 true SI1847539T1 (sl)	2010-01-29

Family

ID=32683824

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI200330965T SI1578755T1 (sl)	2002-12-24	2003-12-22	Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba
SI200331673T SI1847539T1 (sl)	2002-12-24	2003-12-22	Kinazolinski derivati

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SI200330965T SI1578755T1 (sl)	2002-12-24	2003-12-22	Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba

Country Status (30)

Country	Link
US (4)	US7528121B2 (sl)
EP (2)	EP1847539B1 (sl)
JP (3)	JP4422102B2 (sl)
KR (1)	KR101010299B1 (sl)
AR (2)	AR042668A1 (sl)
AT (2)	ATE370958T1 (sl)
AU (1)	AU2003290313B2 (sl)
BR (1)	BRPI0317717B8 (sl)
CA (1)	CA2511613C (sl)
CL (1)	CL2003002731A1 (sl)
CY (2)	CY1107775T1 (sl)
DE (2)	DE60328735D1 (sl)
DK (2)	DK1847539T3 (sl)
ES (2)	ES2329623T3 (sl)
HK (2)	HK1080481A1 (sl)
IL (2)	IL169112A (sl)
IS (2)	IS2504B (sl)
MX (1)	MXPA05006918A (sl)
MY (2)	MY136174A (sl)
NO (2)	NO335193B1 (sl)
NZ (1)	NZ540698A (sl)
PL (2)	PL223998B1 (sl)
PT (2)	PT1847539E (sl)
RU (3)	RU2357971C2 (sl)
SA (1)	SA04240504B1 (sl)
SI (2)	SI1578755T1 (sl)
TW (2)	TWI336327B (sl)
UA (1)	UA83814C2 (sl)
UY (1)	UY28149A1 (sl)
WO (1)	WO2004058781A1 (sl)

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CN100491372C (zh) *	2001-12-24	2009-05-27	阿斯特拉曾尼卡有限公司	作为欧若拉激酶抑制剂的取代喹唑啉衍生物
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CN1809557B (zh) *	2003-04-16	2012-07-04	阿斯利康(瑞典)有限公司	化合物
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CN101072758B (zh) *	2004-10-12	2013-07-31	阿斯利康(瑞典)有限公司	喹唑啉衍生物
WO2006040526A1 (en) *	2004-10-12	2006-04-20	Astrazeneca Ab	Quinazoline derivatives for use against cancer
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GB0609619D0 (en) *	2006-05-16	2006-06-21	Astrazeneca Ab	Combination
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TWI547494B (zh)	2011-08-18	2016-09-01	葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之胺基喹唑啉類
TW201425307A (zh)	2012-09-13	2014-07-01	Glaxosmithkline Llc	作為激酶抑制劑之胺基－喹啉類
AR092529A1 (es)	2012-09-13	2015-04-22	Glaxosmithkline Llc	Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
CA2900652C (en)	2013-02-15	2021-05-04	Kala Pharmaceuticals, Inc.	Therapeutic compounds and uses thereof
US9688688B2 (en)	2013-02-20	2017-06-27	Kala Pharmaceuticals, Inc.	Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
US9353123B2 (en)	2013-02-20	2016-05-31	Kala Pharmaceuticals, Inc.	Therapeutic compounds and uses thereof
TWI630203B (zh) *	2013-02-21	2018-07-21	葛蘭素史克智慧財產發展有限公司	做為激酶抑制劑的喹唑啉類
SI3311845T1 (sl) *	2013-09-16	2020-06-30	Astrazeneca Ab	Terapevtski polimerni nanodelci in postopki njihove izdelave in uporabe
EP3062618B1 (en)	2013-11-01	2020-02-05	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en)	2013-11-01	2018-02-13	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
JP6525474B2 (ja)	2013-12-06	2019-06-05	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	オーロラキナーゼ阻害剤と抗ｃｄ３０抗体の併用
JP2018524292A (ja)	2015-07-21	2018-08-30	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	オーロラキナーゼインヒビターと化学療法剤の投与
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US10253036B2 (en)	2016-09-08	2019-04-09	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
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2003
- 2003-12-22 RU RU2005123485/04A patent/RU2357971C2/ru active
- 2003-12-22 AT AT03782672T patent/ATE370958T1/de active
- 2003-12-22 PT PT07009390T patent/PT1847539E/pt unknown
- 2003-12-22 EP EP07009390A patent/EP1847539B1/en not_active Expired - Lifetime
- 2003-12-22 ES ES07009390T patent/ES2329623T3/es not_active Expired - Lifetime
- 2003-12-22 RU RU2007121850/04A patent/RU2350611C1/ru active
- 2003-12-22 MX MXPA05006918A patent/MXPA05006918A/es active IP Right Grant
- 2003-12-22 JP JP2005509716A patent/JP4422102B2/ja not_active Expired - Lifetime
- 2003-12-22 DE DE60328735T patent/DE60328735D1/de not_active Expired - Lifetime
- 2003-12-22 ES ES03782672T patent/ES2290529T3/es not_active Expired - Lifetime
- 2003-12-22 SI SI200330965T patent/SI1578755T1/sl unknown
- 2003-12-22 SI SI200331673T patent/SI1847539T1/sl unknown
- 2003-12-22 AT AT07009390T patent/ATE438644T1/de active
- 2003-12-22 CA CA2511613A patent/CA2511613C/en not_active Expired - Lifetime
- 2003-12-22 MY MYPI20034944A patent/MY136174A/en unknown
- 2003-12-22 BR BRPI0317717A patent/BRPI0317717B8/pt not_active IP Right Cessation
- 2003-12-22 AU AU2003290313A patent/AU2003290313B2/en not_active Expired
- 2003-12-22 CL CL200302731A patent/CL2003002731A1/es unknown
- 2003-12-22 PL PL412704A patent/PL223998B1/pl unknown
- 2003-12-22 US US10/539,220 patent/US7528121B2/en active Active
- 2003-12-22 DE DE60315892T patent/DE60315892T2/de not_active Expired - Lifetime
- 2003-12-22 DK DK07009390T patent/DK1847539T3/da active
- 2003-12-22 UA UAA200507294A patent/UA83814C2/ru unknown
- 2003-12-22 EP EP03782672A patent/EP1578755B1/en not_active Expired - Lifetime
- 2003-12-22 MY MYPI20071321A patent/MY147761A/en unknown
- 2003-12-22 KR KR1020057012015A patent/KR101010299B1/ko active IP Right Grant
- 2003-12-22 PL PL377680A patent/PL221490B1/pl unknown
- 2003-12-22 PT PT03782672T patent/PT1578755E/pt unknown
- 2003-12-22 NZ NZ540698A patent/NZ540698A/en not_active IP Right Cessation
- 2003-12-22 DK DK03782672T patent/DK1578755T3/da active
- 2003-12-22 WO PCT/GB2003/005613 patent/WO2004058781A1/en active Application Filing
- 2003-12-23 UY UY28149A patent/UY28149A1/es not_active Application Discontinuation
- 2003-12-23 TW TW092136601A patent/TWI336327B/zh not_active IP Right Cessation
- 2003-12-23 AR ARP030104824A patent/AR042668A1/es active IP Right Grant
- 2003-12-23 TW TW099134275A patent/TWI393710B/zh not_active IP Right Cessation
2004
- 2004-02-18 SA SA04240504A patent/SA04240504B1/ar unknown
2005
- 2005-06-09 IL IL169112A patent/IL169112A/en active IP Right Grant
- 2005-06-13 NO NO20052855A patent/NO335193B1/no not_active IP Right Cessation
- 2005-07-20 IS IS7948A patent/IS2504B/is unknown
2006
- 2006-01-10 HK HK06100400A patent/HK1080481A1/xx not_active IP Right Cessation
2007
- 2007-05-16 AR ARP070102117A patent/AR057753A2/es not_active Application Discontinuation
- 2007-06-13 RU RU2007121850/04K patent/RU2007121850A/ru unknown
- 2007-06-28 JP JP2007169891A patent/JP4906608B2/ja not_active Expired - Lifetime
- 2007-08-09 IL IL185176A patent/IL185176A/en active IP Right Grant
- 2007-10-24 CY CY20071101369T patent/CY1107775T1/el unknown
2008
- 2008-02-13 IS IS8714A patent/IS2884B/is unknown
- 2008-02-27 HK HK08102177.3A patent/HK1111417A1/xx not_active IP Right Cessation
- 2008-10-15 JP JP2008265949A patent/JP4503090B2/ja not_active Expired - Lifetime
2009
- 2009-04-28 US US12/431,165 patent/US8268841B2/en active Active
- 2009-10-13 CY CY20091101054T patent/CY1109479T1/el unknown
2012
- 2012-08-21 US US13/590,662 patent/US9018191B2/en not_active Expired - Lifetime
2013
- 2013-11-01 NO NO20131444A patent/NO335446B1/no not_active IP Right Cessation
2015
- 2015-03-18 US US14/661,657 patent/US9567358B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CY1107775T1 (el)	2013-06-19
SI1578755T1 (sl)	2007-12-31
HK1111417A1 (en)	2008-08-08
IL185176A (en)	2011-10-31
DE60315892T2 (de)	2008-08-14
JP2006512418A (ja)	2006-04-13
IL169112A (en)	2010-12-30
US9018191B2 (en)	2015-04-28
NO335446B1 (no)	2014-12-15
UY28149A1 (es)	2004-07-30
BRPI0317717B8 (pt)	2021-05-25
IS8714A (is)	2008-02-13
US20150307534A1 (en)	2015-10-29
NO335193B1 (no)	2014-10-20
JP4503090B2 (ja)	2010-07-14
IS2504B (is)	2009-04-15
EP1847539B1 (en)	2009-08-05
NO20052855D0 (no)	2005-06-13
KR101010299B1 (ko)	2011-01-25
DE60328735D1 (de)	2009-09-17
EP1578755B1 (en)	2007-08-22
EP1578755A1 (en)	2005-09-28
PT1578755E (pt)	2007-10-19
ES2290529T3 (es)	2008-02-16
US20060116357A1 (en)	2006-06-01
PT1847539E (pt)	2009-10-06
MY136174A (en)	2008-08-29
AU2003290313B2 (en)	2007-05-10
BR0317717A (pt)	2005-11-22
TWI393710B (zh)	2013-04-21
BRPI0317717B1 (pt)	2017-12-19
ATE370958T1 (de)	2007-09-15
WO2004058781A1 (en)	2004-07-15
PL223998B1 (pl)	2016-11-30
CY1109479T1 (el)	2014-08-13
ES2329623T3 (es)	2009-11-27
IL169112A0 (en)	2009-02-11
RU2350611C1 (ru)	2009-03-27
HK1080481A1 (en)	2006-04-28
JP2009046514A (ja)	2009-03-05
EP1847539A1 (en)	2007-10-24
PL377680A1 (pl)	2006-02-06
TW200510342A (en)	2005-03-16
DK1578755T3 (da)	2007-11-12
JP4906608B2 (ja)	2012-03-28
UA83814C2 (ru)	2008-08-26
TW201102369A (en)	2011-01-16
RU2007121850A (ru)	2008-12-20
US20140162984A1 (en)	2014-06-12
JP4422102B2 (ja)	2010-02-24
US8268841B2 (en)	2012-09-18
NO20131444L (no)	2005-08-03
CA2511613C (en)	2012-10-02
NZ540698A (en)	2008-05-30
IS7948A (is)	2005-07-20
MY147761A (en)	2013-01-31
US20100069412A1 (en)	2010-03-18
PL412704A1 (pl)	2015-10-12
PL221490B1 (pl)	2016-04-29
SA04240504A (ar)	2005-12-03
IL185176A0 (en)	2007-12-03
KR20050088333A (ko)	2005-09-05
JP2007326862A (ja)	2007-12-20
MXPA05006918A (es)	2005-08-18
TWI336327B (en)	2011-01-21
ATE438644T1 (de)	2009-08-15
US9567358B2 (en)	2017-02-14
SA04240504B1 (ar)	2008-04-01
DK1847539T3 (da)	2009-11-09
AR042668A1 (es)	2005-06-29
AR057753A2 (es)	2007-12-19
RU2357971C2 (ru)	2009-06-10
AU2003290313A1 (en)	2004-07-22
IS2884B (is)	2014-06-15
US7528121B2 (en)	2009-05-05
CA2511613A1 (en)	2004-07-15
CL2003002731A1 (es)	2005-01-07
DE60315892D1 (de)	2007-10-04
NO20052855L (no)	2005-08-03
RU2005123485A (ru)	2006-03-10

Publication	Publication Date	Title
HK1111417A1 (en)	2008-08-08	Quinazoline derivatives
GB0215823D0 (en)	2002-08-14	Quinazoline derivatives
GB0322409D0 (en)	2003-10-29	Quinazoline derivatives
IL174534A0 (en)	2006-08-01	Quinazoline derivatives
IL174257A0 (en)	2006-08-01	Quinazoline derivatives
ZA200602264B (en)	2007-12-26	Quinazoline derivatives
GB0321648D0 (en)	2003-10-15	Quinazoline derivatives
IL175421A0 (en)	2006-09-05	Quinazoline derivatives
AP1850A (en)	2008-05-26	Spiroindolineplperidine derivatives
EG24050A (en)	2008-04-13	Heterocylocarboxamide derivatives
HK1070367A1 (en)	2005-06-17	Quinazoline compounds
IL174390A0 (en)	2011-08-01	Quinazoline derivatives
EP1522540A4 (en)	2011-08-10	AZAARENE DERIVATIVES
GB0330002D0 (en)	2004-01-28	Quinazoline derivatives
PL377474A1 (pl)	2006-02-06	Pochodne 3H-chinazolin-4-onu
ZA200603039B (en)	2007-09-26	Quinazoline derivatives
GB2410025B (en)	2007-03-28	Quinazolin-4-one derivatives
AU2003222659A8 (en)	2003-11-03	23-o-substituted 5-o-mycaminosyltylonide derivatives
PL374817A1 (en)	2005-10-31	Quinazoline derivatives
EP1531854A4 (en)	2006-06-28	O-DERIVATED NOCATHIACIN DERIVATIVES
GB0321620D0 (en)	2003-10-15	Quinazoline derivatives
GB0213488D0 (en)	2002-07-24	2-Naphthamide derivatives
AU2003243397A8 (en)	2003-12-19	Homo-camptothecin derivatives
GB0215825D0 (en)	2002-08-14	Quinazoline derivatives
AU2003290279A1 (en)	2004-07-14	Quinazoline derivatives