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SI1487832T2 - Mikroniziran kristalinični tiotropijev bromid - Google Patents

Mikroniziran kristalinični tiotropijev bromid

Info

Publication number
SI1487832T2
SI1487832T2 SI200330973T SI200330973T SI1487832T2 SI 1487832 T2 SI1487832 T2 SI 1487832T2 SI 200330973 T SI200330973 T SI 200330973T SI 200330973 T SI200330973 T SI 200330973T SI 1487832 T2 SI1487832 T2 SI 1487832T2
Authority
SI
Slovenia
Prior art keywords
tiotropium bromide
crystalline tiotropium
micronized crystalline
micronized
bromide
Prior art date
Application number
SI200330973T
Other languages
English (en)
Other versions
SI1487832T1 (sl
Inventor
Helmut Bender
Hagen Graebner
Konrad Schindler
Michael Josef Friedrich Trunk
Michael Walz
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1487832(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg
Publication of SI1487832T1 publication Critical patent/SI1487832T1/sl
Publication of SI1487832T2 publication Critical patent/SI1487832T2/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Hybrid Cells (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI200330973T 2002-03-20 2003-03-10 Mikroniziran kristalinični tiotropijev bromid SI1487832T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10212264A DE10212264A1 (de) 2002-03-20 2002-03-20 Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
PCT/EP2003/002422 WO2003078429A1 (de) 2002-03-20 2003-03-10 Kristallines mikronisat des tiotropiumbromids
EP03708206.2A EP1487832B9 (de) 2002-03-20 2003-03-10 Kristallines mikronisat des tiotropiumbromids

Publications (2)

Publication Number Publication Date
SI1487832T1 SI1487832T1 (sl) 2007-12-31
SI1487832T2 true SI1487832T2 (sl) 2018-11-30

Family

ID=27797948

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200330973T SI1487832T2 (sl) 2002-03-20 2003-03-10 Mikroniziran kristalinični tiotropijev bromid

Country Status (37)

Country Link
EP (3) EP1487832B9 (sl)
JP (1) JP4331619B2 (sl)
KR (2) KR101021430B1 (sl)
CN (2) CN101220025A (sl)
AR (1) AR039017A1 (sl)
AT (1) ATE369365T1 (sl)
AU (1) AU2003212327B2 (sl)
BR (1) BRPI0308513B8 (sl)
CA (1) CA2479652C (sl)
CO (1) CO5611105A2 (sl)
CY (2) CY1106923T1 (sl)
DE (2) DE10212264A1 (sl)
DK (2) DK1487832T4 (sl)
EA (1) EA007064B1 (sl)
EC (1) ECSP045310A (sl)
ES (2) ES2615460T3 (sl)
HK (1) HK1078871A1 (sl)
HR (1) HRP20040855B1 (sl)
HU (1) HUE031876T2 (sl)
IL (2) IL163841A0 (sl)
LT (1) LT1785422T (sl)
ME (1) ME02764B (sl)
MX (1) MXPA04009056A (sl)
MY (1) MY139720A (sl)
NO (2) NO346754B1 (sl)
NZ (1) NZ535808A (sl)
PE (1) PE20030838A1 (sl)
PL (1) PL220730B1 (sl)
PT (2) PT1785422T (sl)
RS (1) RS57551B1 (sl)
SA (1) SA03240098B1 (sl)
SI (1) SI1487832T2 (sl)
TW (1) TWI345975B (sl)
UA (1) UA78295C2 (sl)
UY (1) UY27725A1 (sl)
WO (1) WO2003078429A1 (sl)
ZA (1) ZA200405636B (sl)

Families Citing this family (25)

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US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DK1682543T3 (da) 2003-11-03 2010-12-13 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af nye tiotropiumsalte
DE502004010885D1 (de) 2003-11-03 2010-04-22 Boehringer Ingelheim Pharma Verfahren zur herstellung von tiotropiumsalzen
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024451A1 (de) 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten
CA2606552A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
BRPI0609295A2 (pt) 2005-05-02 2010-03-23 Boehringer Ingelheim Int formas cristalinas de brometo de tiotràpio, composiÇço farmacÊutica, uso e mÉtodo para preparar as mesmas
PL1917253T3 (pl) 2005-08-15 2015-06-30 Boehringer Ingelheim Int Sposób wytwarzania betamimetyków
US20070086957A1 (en) * 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
JP5086267B2 (ja) 2005-12-19 2012-11-28 シコール インコーポレイティド 臭化チオトロピウムの新規な形態およびそれを製造する方法
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2011093815A2 (en) * 2010-01-29 2011-08-04 Mahmut Bilgic Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
WO2014007768A1 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscorinic antagonists
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
SI3191081T1 (sl) 2014-09-09 2020-07-31 Vectura Limited Formulacija, ki vsebuje glikopirolat, postopek in naprava
WO2017068119A1 (en) * 2015-10-23 2017-04-27 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
BR112018008083A2 (pt) * 2015-10-23 2018-10-23 Arven Ilac Sanayi Ve Ticaret As blister para formulação inalável de brometo de tiotrópio
CN115737610B (zh) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

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CN102127069A (zh) 2010-01-20 2011-07-20 鲁南制药集团股份有限公司 噻托溴铵晶体

Also Published As

Publication number Publication date
WO2003078429A1 (de) 2003-09-25
EP1487832B9 (de) 2019-01-23
BR0308513A (pt) 2005-01-04
CA2479652C (en) 2012-07-10
NO344427B1 (no) 2019-12-02
EP1487832A1 (de) 2004-12-22
RS57551B1 (sr) 2018-10-31
KR101094091B1 (ko) 2011-12-15
PL371799A1 (en) 2005-06-27
IL163841A0 (en) 2005-12-18
PT1785422T (pt) 2017-02-17
JP2005526776A (ja) 2005-09-08
EP1785422A8 (de) 2010-06-23
TWI345975B (en) 2011-08-01
CA2479652A1 (en) 2003-09-25
MEP46708A (en) 2011-02-10
LT1785422T (lt) 2017-02-10
ES2291619T5 (es) 2018-12-07
NZ535808A (en) 2005-09-30
DE10212264A1 (de) 2003-10-02
HRP20040855B1 (en) 2012-11-30
DE50307883D1 (de) 2007-09-20
DK1487832T3 (da) 2007-11-05
EA200401142A1 (ru) 2005-04-28
DK1487832T4 (en) 2018-12-10
ES2615460T3 (es) 2017-06-07
EA007064B1 (ru) 2006-06-30
KR20100135983A (ko) 2010-12-27
IL163841A (en) 2015-10-29
CO5611105A2 (es) 2006-02-28
AU2003212327A1 (en) 2003-09-29
BRPI0308513B1 (pt) 2016-04-19
PE20030838A1 (es) 2003-11-21
EP3053921A1 (de) 2016-08-10
HUE031876T2 (en) 2017-08-28
ZA200405636B (en) 2006-01-25
DK1785422T3 (en) 2017-02-27
HRP20040855A2 (en) 2005-06-30
UY27725A1 (es) 2003-10-31
NO346754B1 (no) 2022-12-12
AR039017A1 (es) 2005-02-02
NO20044003L (no) 2004-10-14
PL220730B1 (pl) 2015-12-31
BRPI0308513B8 (pt) 2021-05-25
MXPA04009056A (es) 2005-01-25
CN1642952A (zh) 2005-07-20
NO20190824A1 (no) 2004-10-14
ECSP045310A (es) 2004-10-26
MY139720A (en) 2009-10-30
ES2291619T3 (es) 2008-03-01
PT1487832E (pt) 2007-08-27
KR20050008662A (ko) 2005-01-21
CY1106923T1 (el) 2012-09-26
CY1118855T1 (el) 2018-01-10
CN101220025A (zh) 2008-07-16
JP4331619B2 (ja) 2009-09-16
UA78295C2 (en) 2007-03-15
EP1785422B1 (de) 2016-11-16
TW200305421A (en) 2003-11-01
EP1487832B2 (de) 2018-08-29
AU2003212327B2 (en) 2009-02-05
HK1078871A1 (en) 2006-03-24
KR101021430B1 (ko) 2011-03-15
ME02764B (me) 2011-05-10
EP1487832B1 (de) 2007-08-08
ATE369365T1 (de) 2007-08-15
SI1487832T1 (sl) 2007-12-31
EP1785422A1 (de) 2007-05-16
CN100368410C (zh) 2008-02-13
SA03240098B1 (ar) 2008-03-24

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